IFNB1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IFNB1
Entrez Gene ID	3456
Full Name	interferon beta 1
Synonyms	IFB,IFF,IFN-beta,IFNB
General protein information	Preferred Names interferon beta 1 Names interferon beta fibroblast interferon interferon, beta 1, fibroblast interferon-beta
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p21.3
Summary	This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015].
Disorder MIM:	147640

mRNA and Protein(s)

mRNA	Protein	Name
NM_002176.3	NP_002167.1	interferon beta precursor
NM_002176.2	NP_002167.1	interferon beta precursor
NM_002176.4	NP_002167.1	interferon beta precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	IFNB1	XP_528553.1
Canis lupus familiaris (dog)	IFNB1	NP_001129259.1
Rattus norvegicus (Norway rat)	Ifnb1	NP_062000.1
Homo sapiens (human)	IFNB1	NP_002167.1
	IFNB1	NP_001129267.1
Mus musculus (house mouse)	Ifnb1	NP_034640.1

Gene Ontology
Bibliography

Related articles in PubMed

Bone Marrow-Derived Mesenchymal Stem Cells From Patients With Systemic Lupus Erythematosus Have a Senescence-Associated Secretory Phenotype Mediated by a Mitochondrial Antiviral Signaling Protein-Interferon-? Feedback Loop.
Gao L, Bird AK, Meednu N, Dauenhauer K, Liesveld J, Anolik J, Looney RJ
Arthritis & rheumatology (Hoboken, N.J.)69(8)1623-1635(2017 08)

Sphingosine 1-Phosphate Lyase Enhances the Activation of IKK? To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection.
Vijayan M, Xia C, Song YE, Ngo H, Studstill CJ, Drews K, Fox TE, Johnson MC, Hiscott J, Kester M, Alexander S, Hahm B
Journal of immunology (Baltimore, Md. : 1950)199(2)677-687(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study demonstrates a novel pathway for elevated IFNbeta signaling in SLE that is not dependent on stimulation by immune complexes but rather is cell intrinsic and critically mediated by IFNbeta and MAVS.
Title: Bone Marrow-Derived Mesenchymal Stem Cells From Patients With Systemic Lupus Erythematosus Have a Senescence-Associated Secretory Phenotype Mediated by a Mitochondrial Antiviral Signaling Protein-Interferon-? Feedback Loop.

results demonstrate that Sphingosine 1-phosphate lyase (SPL) is a host factor that augments type I IFN responses during influenza A virus infection; study delineates the relationship between IKKepsilon and SPL, which provides a mechanistic understanding of the pro-IFN activity of SPL
Title: Sphingosine 1-Phosphate Lyase Enhances the Activation of IKK? To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection.

Overexpression of PKV VP3 blocked IFN-beta-induced activation of the STAT1/STAT2/IRF9 promoter in a dose-dependent manner.
Title: Kobuvirus VP3 protein restricts the IFN-?-triggered signaling pathway by inhibiting STAT2-IRF9 and STAT2-STAT2 complex formation.

Upon influenza virus infection, DPF2 dysregulated IFN-beta induction and expression of cytokines/chemokines and antiviral proteins. This study provides evidence that influenza virus utilizes DPF2 to escape host innate immunity.
Title: Double Plant Homeodomain Fingers 2 (DPF2) Promotes the Immune Escape of Influenza Virus by Suppressing Beta Interferon Production.

Data suggest that EV71 infection in enterocytes does not inhibit phosphorylation of STAT1/2 induced by IFN-beta, but p-STAT1/2 transport into the nucleus is significantly blocked; EV71 infection in enterocytes down-regulates expression of KPNA1 and induces degradation of cellular KPNA1 via caspase-3. [EV17 = Enterovirus 71]
Title: Enterovirus 71 suppresses interferon responses by blocking Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling through inducing karyopherin-?1 degradation.

The following IFNB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IFNB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23402	NM_002176.4 Latest version!	Homo sapiens interferon beta 1 (IFNB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu23402	NM_002176.2	Homo sapiens interferon, beta 1, fibroblast (IFNB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu23402	NM_002176.3	Homo sapiens interferon beta 1 (IFNB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IFNB1 ( NM_002176.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002167.1 Homo sapiens interferon beta 1 (IFNB1), mRNA.

Price & Availability↑

CloneID	OHu23402
Clone ID Related Accession (Same CDS sequence)	NM_002176.3 , NM_002176.2 , NM_002176.4
Accession Version	NM_002176.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 564bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	interferon beta precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL390882.12 and M28622.1. On Sep 26, 2015 this sequence version replaced NM_002176.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGACCAACA AGTGTCTCCT CCAAATTGCT CTCCTGTTGT GCTTCTCCAC TACAGCTCTT 
TCCATGAGCT ACAACTTGCT TGGATTCCTA CAAAGAAGCA GCAATTTTCA GTGTCAGAAG 
CTCCTGTGGC AATTGAATGG GAGGCTTGAA TACTGCCTCA AGGACAGGAT GAACTTTGAC 
ATCCCTGAGG AGATTAAGCA GCTGCAGCAG TTCCAGAAGG AGGACGCCGC ATTGACCATC 
TATGAGATGC TCCAGAACAT CTTTGCTATT TTCAGACAAG ATTCATCTAG CACTGGCTGG 
AATGAGACTA TTGTTGAGAA CCTCCTGGCT AATGTCTATC ATCAGATAAA CCATCTGAAG 
ACAGTCCTGG AAGAAAAACT GGAGAAAGAA GATTTCACCA GGGGAAAACT CATGAGCAGT 
CTGCACCTGA AAAGATATTA TGGGAGGATT CTGCATTACC TGAAGGCCAA GGAGTACAGT 
CACTGTGCCT GGACCATAGT CAGAGTGGAA ATCCTAAGGA ACTTTTACTT CATTAACAGA 
CTTACAGGTT ACCTCCGAAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002167.1
CDS	95..658
Translation	MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFDIPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLKTVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINRLTGYLRN

Target ORF information:

RefSeq Version	NM_002176.3
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon beta 1 (IFNB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002176.3

ORF Insert Sequence:

ATGACCAACA AGTGTCTCCT CCAAATTGCT CTCCTGTTGT GCTTCTCCAC TACAGCTCTT 
TCCATGAGCT ACAACTTGCT TGGATTCCTA CAAAGAAGCA GCAATTTTCA GTGTCAGAAG 
CTCCTGTGGC AATTGAATGG GAGGCTTGAA TACTGCCTCA AGGACAGGAT GAACTTTGAC 
ATCCCTGAGG AGATTAAGCA GCTGCAGCAG TTCCAGAAGG AGGACGCCGC ATTGACCATC 
TATGAGATGC TCCAGAACAT CTTTGCTATT TTCAGACAAG ATTCATCTAG CACTGGCTGG 
AATGAGACTA TTGTTGAGAA CCTCCTGGCT AATGTCTATC ATCAGATAAA CCATCTGAAG 
ACAGTCCTGG AAGAAAAACT GGAGAAAGAA GATTTCACCA GGGGAAAACT CATGAGCAGT 
CTGCACCTGA AAAGATATTA TGGGAGGATT CTGCATTACC TGAAGGCCAA GGAGTACAGT 
CACTGTGCCT GGACCATAGT CAGAGTGGAA ATCCTAAGGA ACTTTTACTT CATTAACAGA 
CTTACAGGTT ACCTCCGAAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IFNB1 ( NM_002176.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002167.1 Homo sapiens interferon, beta 1, fibroblast (IFNB1), mRNA.

Price & Availability↑

CloneID	OHu23402
Clone ID Related Accession (Same CDS sequence)	NM_002176.3 , NM_002176.2 , NM_002176.4
Accession Version	NM_002176.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 564bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2014-05-10
Organism	Homo sapiens(Human)
Product	interferon beta precursor
Comment

ATGACCAACA AGTGTCTCCT CCAAATTGCT CTCCTGTTGT GCTTCTCCAC TACAGCTCTT 
TCCATGAGCT ACAACTTGCT TGGATTCCTA CAAAGAAGCA GCAATTTTCA GTGTCAGAAG 
CTCCTGTGGC AATTGAATGG GAGGCTTGAA TACTGCCTCA AGGACAGGAT GAACTTTGAC 
ATCCCTGAGG AGATTAAGCA GCTGCAGCAG TTCCAGAAGG AGGACGCCGC ATTGACCATC 
TATGAGATGC TCCAGAACAT CTTTGCTATT TTCAGACAAG ATTCATCTAG CACTGGCTGG 
AATGAGACTA TTGTTGAGAA CCTCCTGGCT AATGTCTATC ATCAGATAAA CCATCTGAAG 
ACAGTCCTGG AAGAAAAACT GGAGAAAGAA GATTTCACCA GGGGAAAACT CATGAGCAGT 
CTGCACCTGA AAAGATATTA TGGGAGGATT CTGCATTACC TGAAGGCCAA GGAGTACAGT 
CACTGTGCCT GGACCATAGT CAGAGTGGAA ATCCTAAGGA ACTTTTACTT CATTAACAGA 
CTTACAGGTT ACCTCCGAAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002167.1
Translation	MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFDIPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLKTVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINRLTGYLRN

Target ORF information:

RefSeq Version	NM_002176.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens interferon, beta 1, fibroblast (IFNB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002176.2

ORF Insert Sequence:

ATGACCAACA AGTGTCTCCT CCAAATTGCT CTCCTGTTGT GCTTCTCCAC TACAGCTCTT 
TCCATGAGCT ACAACTTGCT TGGATTCCTA CAAAGAAGCA GCAATTTTCA GTGTCAGAAG 
CTCCTGTGGC AATTGAATGG GAGGCTTGAA TACTGCCTCA AGGACAGGAT GAACTTTGAC 
ATCCCTGAGG AGATTAAGCA GCTGCAGCAG TTCCAGAAGG AGGACGCCGC ATTGACCATC 
TATGAGATGC TCCAGAACAT CTTTGCTATT TTCAGACAAG ATTCATCTAG CACTGGCTGG 
AATGAGACTA TTGTTGAGAA CCTCCTGGCT AATGTCTATC ATCAGATAAA CCATCTGAAG 
ACAGTCCTGG AAGAAAAACT GGAGAAAGAA GATTTCACCA GGGGAAAACT CATGAGCAGT 
CTGCACCTGA AAAGATATTA TGGGAGGATT CTGCATTACC TGAAGGCCAA GGAGTACAGT 
CACTGTGCCT GGACCATAGT CAGAGTGGAA ATCCTAAGGA ACTTTTACTT CATTAACAGA 
CTTACAGGTT ACCTCCGAAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IFNB1 ( NM_002176.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002167.1 Homo sapiens interferon beta 1 (IFNB1), mRNA.

Price & Availability↑

CloneID	OHu23402
Clone ID Related Accession (Same CDS sequence)	NM_002176.3 , NM_002176.2 , NM_002176.4
Accession Version	NM_002176.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 564bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	interferon beta precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M28622.1 and AL390882.12. On Nov 23, 2018 this sequence version replaced NM_002176.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: M28622.1, V00546.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000380232.4/ ENSP00000369581.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACCAACA AGTGTCTCCT CCAAATTGCT CTCCTGTTGT GCTTCTCCAC TACAGCTCTT 
TCCATGAGCT ACAACTTGCT TGGATTCCTA CAAAGAAGCA GCAATTTTCA GTGTCAGAAG 
CTCCTGTGGC AATTGAATGG GAGGCTTGAA TACTGCCTCA AGGACAGGAT GAACTTTGAC 
ATCCCTGAGG AGATTAAGCA GCTGCAGCAG TTCCAGAAGG AGGACGCCGC ATTGACCATC 
TATGAGATGC TCCAGAACAT CTTTGCTATT TTCAGACAAG ATTCATCTAG CACTGGCTGG 
AATGAGACTA TTGTTGAGAA CCTCCTGGCT AATGTCTATC ATCAGATAAA CCATCTGAAG 
ACAGTCCTGG AAGAAAAACT GGAGAAAGAA GATTTCACCA GGGGAAAACT CATGAGCAGT 
CTGCACCTGA AAAGATATTA TGGGAGGATT CTGCATTACC TGAAGGCCAA GGAGTACAGT 
CACTGTGCCT GGACCATAGT CAGAGTGGAA ATCCTAAGGA ACTTTTACTT CATTAACAGA 
CTTACAGGTT ACCTCCGAAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002167.1
CDS	74..637
Translation	MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFDIPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLKTVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINRLTGYLRN

Target ORF information:

RefSeq Version	NM_002176.4
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon beta 1 (IFNB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002176.4

ORF Insert Sequence:

ATGACCAACA AGTGTCTCCT CCAAATTGCT CTCCTGTTGT GCTTCTCCAC TACAGCTCTT 
TCCATGAGCT ACAACTTGCT TGGATTCCTA CAAAGAAGCA GCAATTTTCA GTGTCAGAAG 
CTCCTGTGGC AATTGAATGG GAGGCTTGAA TACTGCCTCA AGGACAGGAT GAACTTTGAC 
ATCCCTGAGG AGATTAAGCA GCTGCAGCAG TTCCAGAAGG AGGACGCCGC ATTGACCATC 
TATGAGATGC TCCAGAACAT CTTTGCTATT TTCAGACAAG ATTCATCTAG CACTGGCTGG 
AATGAGACTA TTGTTGAGAA CCTCCTGGCT AATGTCTATC ATCAGATAAA CCATCTGAAG 
ACAGTCCTGG AAGAAAAACT GGAGAAAGAA GATTTCACCA GGGGAAAACT CATGAGCAGT 
CTGCACCTGA AAAGATATTA TGGGAGGATT CTGCATTACC TGAAGGCCAA GGAGTACAGT 
CACTGTGCCT GGACCATAGT CAGAGTGGAA ATCCTAAGGA ACTTTTACTT CATTAACAGA 
CTTACAGGTT ACCTCCGAAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Bone Marrow-Derived Mesenchymal Stem Cells From Patients With Systemic Lupus Erythematosus Have a Senescence-Associated Secretory Phenotype Mediated by a Mitochondrial Antiviral Signaling Protein-Interferon-? Feedback Loop.
Arthritis & rheumatology (Hoboken, N.J.)69(8)1623-1635(2017 08)
Gao L,Bird AK,Meednu N,Dauenhauer K,Liesveld J,Anolik J,Looney RJ

Sphingosine 1-Phosphate Lyase Enhances the Activation of IKK? To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection.
Journal of immunology (Baltimore, Md. : 1950)199(2)677-687(2017 Jul)
Vijayan M,Xia C,Song YE,Ngo H,Studstill CJ,Drews K,Fox TE,Johnson MC,Hiscott J,Kester M,Alexander S,Hahm B

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IFNB1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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