IFNA21 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IFNA21
Entrez Gene ID	3452
Full Name	interferon alpha 21
Synonyms	IFN-alphaI,LeIF F,leIF-F
General protein information	Preferred Names interferon alpha 21 Names interferon alpha-21 IFN-alpha-21 interferon alpha-F leukocyte interferon protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p21.3
Summary	This gene is a member of the alpha interferon gene cluster on the short arm of chromosome 9. Interferons are cytokines produced in response to viral infection that mediate the immune response and interfere with viral replication. The encoded protein is a type I interferon and may play a specific role in the antiviral response to rubella virus. [provided by RefSeq, Sep 2011].
Disorder MIM:	147584

mRNA and Protein(s)

mRNA	Protein	Name
NM_002175.2	NP_002166.2	interferon alpha-21 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	IFNA21	XP_528555.1
Homo sapiens (human)	IFNA21	NP_002166.2
	LOC711252	XP_001108051.1

Gene Ontology
Bibliography

Related articles in PubMed

Structural variants of IFN? preferentially promote antiviral functions.
V?zquez N, Schmeisser H, Dolan MA, Bekisz J, Zoon KC, Wahl SM
Blood118(9)2567-77(2011 Sep)

Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.
Yang XR, Liang X, Pfeiffer RM, Wheeler W, Maeder D, Burdette L, Yeager M, Chanock S, Tucker MA, Goldstein AM
Familial cancer9(4)625-33(2010 Dec)

Dengue hemorrhagic fever is associated with polymorphisms in JAK1.
Silva LK, Blanton RE, Parrado AR, Melo PS, Morato VG, Reis EA, Dias JP, Castro JM, Vasconcelos PF, Goddard KA, Barreto ML, Reis MG, Teixeira MG
European journal of human genetics : EJHG18(11)1221-7(2010 Nov)

New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes and immunity11(3)232-8(2010 Apr)

Microarray analyses of differentially expressed human genes and biological processes in ECV304 cells infected with rubella virus.
Mo XY, Ma W, Zhang Y, Zhao H, Deng Y, Yuan W, Wang Y, Li Y, Zhu C, Liu M, Wu X
Journal of medical virology79(11)1783-91(2007 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Structural AA changes in the C-helix interacting with IFNAlphaR1 may change the signaling dynamics leading to elevated APOBEC3 & lower IDO by an engineered mutant derived from the amino-terminal region of IFNalpha21b and the COOH-terminus from IFNalpha2c.
Title: Structural variants of IFN? preferentially promote antiviral functions.

Observational study of gene-disease association. (HuGE Navigator)
Title: Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.

Observational study of gene-disease association. (HuGE Navigator)
Title: Dengue hemorrhagic fever is associated with polymorphisms in JAK1.

Observational study of gene-disease association. (HuGE Navigator)
Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.

Observational study of gene-disease association. (HuGE Navigator)
Title: Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.

The following IFNA21 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IFNA21 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu24298	NM_002175.2 Latest version!	Homo sapiens interferon alpha 21 (IFNA21), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IFNA21 ( NM_002175.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002166.2 Homo sapiens interferon alpha 21 (IFNA21), mRNA.

Price & Availability↑

CloneID	OHu24298
Clone ID Related Accession (Same CDS sequence)	NM_002175.2
Accession Version	NM_002175.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	interferon alpha-21 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL390882.12. This sequence is a reference standard in the RefSeqGene project. On Mar 12, 2008 this sequence version replaced NM_002175.1. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000380225.1/ ENSP00000369574.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCCCTGT CCTTTTCTTT ACTGATGGCC GTGCTGGTGC TCAGCTACAA ATCCATCTGT 
TCTCTGGGCT GTGATCTGCC TCAGACCCAC AGCCTGGGTA ATAGGAGGGC CTTGATACTC 
CTGGCACAAA TGGGAAGAAT CTCTCCTTTC TCCTGCCTGA AGGACAGACA TGACTTTGGA 
TTCCCCCAGG AGGAGTTTGA TGGCAACCAG TTCCAGAAGG CTCAAGCCAT CTCTGTCCTC 
CATGAGATGA TCCAGCAGAC CTTCAATCTC TTCAGCACAA AGGACTCATC TGCTACTTGG 
GAACAGAGCC TCCTAGAAAA ATTTTCCACT GAACTTAACC AGCAGCTGAA TGACCTGGAA 
GCCTGCGTGA TACAGGAGGT TGGGGTGGAA GAGACTCCCC TGATGAATGT GGACTCCATC 
CTGGCTGTGA AGAAATACTT CCAAAGAATC ACTCTTTATC TGACAGAGAA GAAATACAGC 
CCTTGTGCCT GGGAGGTTGT CAGAGCAGAA ATCATGAGAT CCTTCTCTTT ATCAAAAATT 
TTTCAAGAAA GATTAAGGAG GAAGGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002166.2
CDS	49..618
Translation	MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISPFSCLKDRHDFGFPQEEFDGNQFQKAQAISVLHEMIQQTFNLFSTKDSSATWEQSLLEKFSTELNQQLNDLEACVIQEVGVEETPLMNVDSILAVKKYFQRITLYLTEKKYSPCAWEVVRAEIMRSFSLSKIFQERLRRKE

Target ORF information:

RefSeq Version	NM_002175.2
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon alpha 21 (IFNA21), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002175.2

ORF Insert Sequence:

ATGGCCCTGT CCTTTTCTTT ACTGATGGCC GTGCTGGTGC TCAGCTACAA ATCCATCTGT 
TCTCTGGGCT GTGATCTGCC TCAGACCCAC AGCCTGGGTA ATAGGAGGGC CTTGATACTC 
CTGGCACAAA TGGGAAGAAT CTCTCCTTTC TCCTGCCTGA AGGACAGACA TGACTTTGGA 
TTCCCCCAGG AGGAGTTTGA TGGCAACCAG TTCCAGAAGG CTCAAGCCAT CTCTGTCCTC 
CATGAGATGA TCCAGCAGAC CTTCAATCTC TTCAGCACAA AGGACTCATC TGCTACTTGG 
GAACAGAGCC TCCTAGAAAA ATTTTCCACT GAACTTAACC AGCAGCTGAA TGACCTGGAA 
GCCTGCGTGA TACAGGAGGT TGGGGTGGAA GAGACTCCCC TGATGAATGT GGACTCCATC 
CTGGCTGTGA AGAAATACTT CCAAAGAATC ACTCTTTATC TGACAGAGAA GAAATACAGC 
CCTTGTGCCT GGGAGGTTGT CAGAGCAGAA ATCATGAGAT CCTTCTCTTT ATCAAAAATT 
TTTCAAGAAA GATTAAGGAG GAAGGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structural variants of IFN? preferentially promote antiviral functions.
Blood118(9)2567-77(2011 Sep)
V?zquez N,Schmeisser H,Dolan MA,Bekisz J,Zoon KC,Wahl SM

Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.
Familial cancer9(4)625-33(2010 Dec)
Yang XR,Liang X,Pfeiffer RM,Wheeler W,Maeder D,Burdette L,Yeager M,Chanock S,Tucker MA,Goldstein AM

Dengue hemorrhagic fever is associated with polymorphisms in JAK1.
European journal of human genetics : EJHG18(11)1221-7(2010 Nov)
Silva LK,Blanton RE,Parrado AR,Melo PS,Morato VG,Reis EA,Dias JP,Castro JM,Vasconcelos PF,Goddard KA,Barreto ML,Reis MG,Teixeira MG

New genetic associations detected in a host response study to hepatitis B vaccine.
Genes and immunity11(3)232-8(2010 Apr)
Davila S,Froeling FE,Tan A,Bonnard C,Boland GJ,Snippe H,Hibberd ML,Seielstad M

Microarray analyses of differentially expressed human genes and biological processes in ECV304 cells infected with rubella virus.
Journal of medical virology79(11)1783-91(2007 Nov)
Mo XY,Ma W,Zhang Y,Zhao H,Deng Y,Yuan W,Wang Y,Li Y,Zhu C,Liu M,Wu X

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IFNA21 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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