APOC3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	APOC3
Entrez Gene ID	345
Full Name	apolipoprotein C3
Synonyms	APOCIII
General protein information	Preferred Names apolipoprotein C3 Names apolipoprotein C-III
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q23.3
Summary	This gene encodes a protein component of triglyceride (TG)-rich lipoproteins (TRLs) including very low density lipoproteins (VLDL), high density lipoproteins (HDL) and chylomicrons. The encoded protein plays a role in role in the metabolism of these TRLs through multiple modes. This protein has been shown to promote the secretion of VLDL1, inhibit lipoprotein lipase enzyme activity, and delay catabolism of TRL remnants. Mutations in this gene are associated with low plasma triglyceride levels and reduced risk of ischemic cardiovascular disease, and hyperalphalipoproteinemia, which is characterized by elevated levels of high density lipoprotein (HDL) and HDL cholesterol in human patients. This gene and other related genes comprise an apolipoprotein gene cluster on chromosome 11. [provided by RefSeq, Sep 2017].
Disorder MIM:	107720
Disorder Html:	Apolipoprotein C-III deficiency, 614028 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000040.2	NP_000031.1	apolipoprotein C-III precursor
NM_000040.1	NP_000031.1	apolipoprotein C-III precursor
NM_000040.3	NP_000031.1	apolipoprotein C-III precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	APOC3	NP_001001175.1
Pan troglodytes (chimpanzee)	APOC3	XP_529442.3
	APOC3	XP_001090312.1
Homo sapiens (human)	APOC3	NP_000031.1
Canis lupus familiaris (dog)	APOC3	NP_001003369.1

Gene Ontology

The following APOC3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the APOC3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23490	NM_000040.3 Latest version!	Homo sapiens apolipoprotein C3 (APOC3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu23490	NM_000040.1	Homo sapiens apolipoprotein C3 (APOC3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu23490	NM_000040.2	Homo sapiens apolipoprotein C3 (APOC3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

APOC3 ( NM_000040.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000031.1 Homo sapiens apolipoprotein C3 (APOC3), mRNA.

Price & Availability↑

CloneID	OHu23490
Clone ID Related Accession (Same CDS sequence)	NM_000040.2 , NM_000040.1 , NM_000040.3
Accession Version	NM_000040.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 300bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	apolipoprotein C-III precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from H74029.1, X01388.1 and AV657170.1. This sequence is a reference standard in the RefSeqGene project. On Sep 16, 2017 this sequence version replaced NM_000040.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC027977.1, ERR279873.3240.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCAGCCCC GGGTACTCCT TGTTGTTGCC CTCCTGGCGC TCCTGGCCTC TGCCCGAGCT 
TCAGAGGCCG AGGATGCCTC CCTTCTCAGC TTCATGCAGG GTTACATGAA GCACGCCACC 
AAGACCGCCA AGGATGCACT GAGCAGCGTG CAGGAGTCCC AGGTGGCCCA GCAGGCCAGG 
GGCTGGGTGA CCGATGGCTT CAGTTCCCTG AAAGACTACT GGAGCACCGT TAAGGACAAG 
TTCTCTGAGT TCTGGGATTT GGACCCTGAG GTCAGACCAA CTTCAGCCGT GGCTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000031.1
CDS	63..362
Translation	MQPRVLLVVALLALLASARASEAEDASLLSFMQGYMKHATKTAKDALSSVQESQVAQQARGWVTDGFSSLKDYWSTVKDKFSEFWDLDPEVRPTSAVAA

Target ORF information:

RefSeq Version	NM_000040.2
Organism	Homo sapiens(human)
Definition	Homo sapiens apolipoprotein C3 (APOC3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000040.2

ORF Insert Sequence:

ATGCAGCCCC GGGTACTCCT TGTTGTTGCC CTCCTGGCGC TCCTGGCCTC TGCCCGAGCT 
TCAGAGGCCG AGGATGCCTC CCTTCTCAGC TTCATGCAGG GTTACATGAA GCACGCCACC 
AAGACCGCCA AGGATGCACT GAGCAGCGTG CAGGAGTCCC AGGTGGCCCA GCAGGCCAGG 
GGCTGGGTGA CCGATGGCTT CAGTTCCCTG AAAGACTACT GGAGCACCGT TAAGGACAAG 
TTCTCTGAGT TCTGGGATTT GGACCCTGAG GTCAGACCAA CTTCAGCCGT GGCTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

APOC3 ( NM_000040.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_000031.1 Homo sapiens apolipoprotein C3 (APOC3), mRNA.

Price & Availability↑

CloneID	OHu23490
Clone ID Related Accession (Same CDS sequence)	NM_000040.2 , NM_000040.1 , NM_000040.3
Accession Version	NM_000040.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 300bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-04-29
Organism	Homo sapiens(Human)
Product	apolipoprotein C-III precursor
Comment	REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X01388.1. This sequence is a reference standard in the RefSeqGene project. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X01388.1, BC027977.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCAGCCCC GGGTACTCCT TGTTGTTGCC CTCCTGGCGC TCCTGGCCTC TGCCCGAGCT 
TCAGAGGCCG AGGATGCCTC CCTTCTCAGC TTCATGCAGG GTTACATGAA GCACGCCACC 
AAGACCGCCA AGGATGCACT GAGCAGCGTG CAGGAGTCCC AGGTGGCCCA GCAGGCCAGG 
GGCTGGGTGA CCGATGGCTT CAGTTCCCTG AAAGACTACT GGAGCACCGT TAAGGACAAG 
TTCTCTGAGT TCTGGGATTT GGACCCTGAG GTCAGACCAA CTTCAGCCGT GGCTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000031.1
CDS	47..346
Translation	MQPRVLLVVALLALLASARASEAEDASLLSFMQGYMKHATKTAKDALSSVQESQVAQQARGWVTDGFSSLKDYWSTVKDKFSEFWDLDPEVRPTSAVAA

Target ORF information:

RefSeq Version	NM_000040.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens apolipoprotein C3 (APOC3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000040.1

ORF Insert Sequence:

ATGCAGCCCC GGGTACTCCT TGTTGTTGCC CTCCTGGCGC TCCTGGCCTC TGCCCGAGCT 
TCAGAGGCCG AGGATGCCTC CCTTCTCAGC TTCATGCAGG GTTACATGAA GCACGCCACC 
AAGACCGCCA AGGATGCACT GAGCAGCGTG CAGGAGTCCC AGGTGGCCCA GCAGGCCAGG 
GGCTGGGTGA CCGATGGCTT CAGTTCCCTG AAAGACTACT GGAGCACCGT TAAGGACAAG 
TTCTCTGAGT TCTGGGATTT GGACCCTGAG GTCAGACCAA CTTCAGCCGT GGCTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

APOC3 ( NM_000040.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000031.1 Homo sapiens apolipoprotein C3 (APOC3), mRNA.

Price & Availability↑

CloneID	OHu23490
Clone ID Related Accession (Same CDS sequence)	NM_000040.2 , NM_000040.1 , NM_000040.3
Accession Version	NM_000040.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 300bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	apolipoprotein C-III precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from H74029.1, X01388.1 and AV657170.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_000040.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC027977.1, X01388.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000227667.8/ ENSP00000227667.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGCCCC GGGTACTCCT TGTTGTTGCC CTCCTGGCGC TCCTGGCCTC TGCCCGAGCT 
TCAGAGGCCG AGGATGCCTC CCTTCTCAGC TTCATGCAGG GTTACATGAA GCACGCCACC 
AAGACCGCCA AGGATGCACT GAGCAGCGTG CAGGAGTCCC AGGTGGCCCA GCAGGCCAGG 
GGCTGGGTGA CCGATGGCTT CAGTTCCCTG AAAGACTACT GGAGCACCGT TAAGGACAAG 
TTCTCTGAGT TCTGGGATTT GGACCCTGAG GTCAGACCAA CTTCAGCCGT GGCTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000031.1
CDS	48..347
Translation	MQPRVLLVVALLALLASARASEAEDASLLSFMQGYMKHATKTAKDALSSVQESQVAQQARGWVTDGFSSLKDYWSTVKDKFSEFWDLDPEVRPTSAVAA

Target ORF information:

RefSeq Version	NM_000040.3
Organism	Homo sapiens(human)
Definition	Homo sapiens apolipoprotein C3 (APOC3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000040.3

ORF Insert Sequence:

ATGCAGCCCC GGGTACTCCT TGTTGTTGCC CTCCTGGCGC TCCTGGCCTC TGCCCGAGCT 
TCAGAGGCCG AGGATGCCTC CCTTCTCAGC TTCATGCAGG GTTACATGAA GCACGCCACC 
AAGACCGCCA AGGATGCACT GAGCAGCGTG CAGGAGTCCC AGGTGGCCCA GCAGGCCAGG 
GGCTGGGTGA CCGATGGCTT CAGTTCCCTG AAAGACTACT GGAGCACCGT TAAGGACAAG 
TTCTCTGAGT TCTGGGATTT GGACCCTGAG GTCAGACCAA CTTCAGCCGT GGCTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

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APOC3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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