IFNA8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IFNA8
Entrez Gene ID	3445
Full Name	interferon alpha 8
Synonyms	IFN-alphaB
General protein information	Preferred Names interferon alpha 8 Names interferon alpha-8 IFN-alpha-8 interferon alpha type 201 interferon alpha-B interferon alpha-B' interferon alpha-B2 leIF B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p21.3
Disorder MIM:	147568

mRNA and Protein(s)

mRNA	Protein	Name
NM_002170.3	NP_002161.2	interferon alpha-8 precursor
NM_002170.4	NP_002161.2	interferon alpha-8 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	IFNA8	NP_002161.2
Pan troglodytes (chimpanzee)	IFNA8	XP_528569.2
	IFNA8	XP_001107458.1

Gene Ontology
Bibliography

Related articles in PubMed

IFN-? exerts opposing effects on activation-induced and IL-7-induced proliferation of T cells that may impair homeostatic maintenance of CD4+ T cell numbers in treated HIV infection.
Cha L, de Jong E, French MA, Fernandez S
Journal of immunology (Baltimore, Md. : 1950)193(5)2178-86(2014 Sep)

Subtypes of type I IFN differentially enhance cytokine expression by suboptimally stimulated CD4(+) T cells.
Hillyer P, Raviv N, Gold DM, Dougherty D, Liu J, Johnson TR, Graham BS, Rabin RL
European journal of immunology43(12)3197-208(2013 Dec)

Reduced interferon (IFN)-? conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality.
Kempaiah P, Anyona SB, Raballah E, Davenport GC, Were T, Hittner JB, Ong'echa JM, Perkins DJ
Human genetics131(8)1375-91(2012 Aug)

Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.
Yang XR, Liang X, Pfeiffer RM, Wheeler W, Maeder D, Burdette L, Yeager M, Chanock S, Tucker MA, Goldstein AM
Familial cancer9(4)625-33(2010 Dec)

Dengue hemorrhagic fever is associated with polymorphisms in JAK1.
Silva LK, Blanton RE, Parrado AR, Melo PS, Morato VG, Reis EA, Dias JP, Castro JM, Vasconcelos PF, Goddard KA, Barreto ML, Reis MG, Teixeira MG
European journal of human genetics : EJHG18(11)1221-7(2010 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data suggest that increased IFN-alpha8 activity may promote the loss of T cells by accelerating cell turnover and activation-induced cell death while decreasing the renewal of T cells by inhibiting the proliferative effect of IL-7.
Title: IFN-? exerts opposing effects on activation-induced and IL-7-induced proliferation of T cells that may impair homeostatic maintenance of CD4+ T cell numbers in treated HIV infection.

IFN-alpha8 and -alpha10 most potently enhanced expression of IFN-gamma, IL-2, and IL-4.
Title: Subtypes of type I IFN differentially enhance cytokine expression by suboptimally stimulated CD4(+) T cells.

variation at IFNA2 -173 and IFNA8 -884 conditions reduced IFN-alpha production, and increased susceptibility to SMA and mortality
Title: Reduced interferon (IFN)-? conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality.

Observational study of gene-disease association. (HuGE Navigator)
Title: Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.

Observational study of gene-disease association. (HuGE Navigator)
Title: Dengue hemorrhagic fever is associated with polymorphisms in JAK1.

The following IFNA8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IFNA8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13429	NM_002170.4 Latest version!	Homo sapiens interferon alpha 8 (IFNA8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu13429	NM_002170.3	Homo sapiens interferon alpha 8 (IFNA8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IFNA8 ( NM_002170.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002161.2 Homo sapiens interferon alpha 8 (IFNA8), mRNA.

Price & Availability↑

CloneID	OHu13429
Clone ID Related Accession (Same CDS sequence)	NM_002170.3 , NM_002170.4
Accession Version	NM_002170.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	interferon alpha-8 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL353732.14. On Oct 6, 2006 this sequence version replaced NM_002170.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: V00550.1, K01900.1 [ECO:0000345] ##Evidence-Data-END##

ATGGCCTTGA CTTTTTATTT ACTGGTGGCC CTAGTGGTGC TCAGCTACAA GTCATTCAGC 
TCTCTGGGCT GTGATCTGCC TCAGACTCAC AGCCTGGGTA ACAGGAGGGC CTTGATACTC 
CTGGCACAAA TGCGAAGAAT CTCTCCTTTC TCCTGCCTGA AGGACAGACA TGACTTTGAA 
TTCCCCCAGG AGGAGTTTGA TGATAAACAG TTCCAGAAGG CTCAAGCCAT CTCTGTCCTC 
CATGAGATGA TCCAGCAGAC CTTCAACCTC TTCAGCACAA AGGACTCATC TGCTGCTTTG 
GATGAGACCC TTCTAGATGA ATTCTACATC GAACTTGACC AGCAGCTGAA TGACCTGGAG 
TCCTGTGTGA TGCAGGAAGT GGGGGTGATA GAGTCTCCCC TGATGTACGA GGACTCCATC 
CTGGCTGTGA GGAAATACTT CCAAAGAATC ACTCTATATC TGACAGAGAA GAAATACAGC 
TCTTGTGCCT GGGAGGTTGT CAGAGCAGAA ATCATGAGAT CCTTCTCTTT ATCAATCAAC 
TTGCAAAAAA GATTGAAGAG TAAGGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002161.2
CDS	31..600
Translation	MALTFYLLVALVVLSYKSFSSLGCDLPQTHSLGNRRALILLAQMRRISPFSCLKDRHDFEFPQEEFDDKQFQKAQAISVLHEMIQQTFNLFSTKDSSAALDETLLDEFYIELDQQLNDLESCVMQEVGVIESPLMYEDSILAVRKYFQRITLYLTEKKYSSCAWEVVRAEIMRSFSLSINLQKRLKSKE

Target ORF information:

RefSeq Version	NM_002170.3
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon alpha 8 (IFNA8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002170.3

ORF Insert Sequence:

ATGGCCTTGA CTTTTTATTT ACTGGTGGCC CTAGTGGTGC TCAGCTACAA GTCATTCAGC 
TCTCTGGGCT GTGATCTGCC TCAGACTCAC AGCCTGGGTA ACAGGAGGGC CTTGATACTC 
CTGGCACAAA TGCGAAGAAT CTCTCCTTTC TCCTGCCTGA AGGACAGACA TGACTTTGAA 
TTCCCCCAGG AGGAGTTTGA TGATAAACAG TTCCAGAAGG CTCAAGCCAT CTCTGTCCTC 
CATGAGATGA TCCAGCAGAC CTTCAACCTC TTCAGCACAA AGGACTCATC TGCTGCTTTG 
GATGAGACCC TTCTAGATGA ATTCTACATC GAACTTGACC AGCAGCTGAA TGACCTGGAG 
TCCTGTGTGA TGCAGGAAGT GGGGGTGATA GAGTCTCCCC TGATGTACGA GGACTCCATC 
CTGGCTGTGA GGAAATACTT CCAAAGAATC ACTCTATATC TGACAGAGAA GAAATACAGC 
TCTTGTGCCT GGGAGGTTGT CAGAGCAGAA ATCATGAGAT CCTTCTCTTT ATCAATCAAC 
TTGCAAAAAA GATTGAAGAG TAAGGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IFNA8 ( NM_002170.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002161.2 Homo sapiens interferon alpha 8 (IFNA8), mRNA.

Price & Availability↑

CloneID	OHu13429
Clone ID Related Accession (Same CDS sequence)	NM_002170.3 , NM_002170.4
Accession Version	NM_002170.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	interferon alpha-8 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL353732.14. On May 17, 2019 this sequence version replaced NM_002170.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: V00550.1, V00545.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000380205.2/ ENSP00000369553.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCCTTGA CTTTTTATTT ACTGGTGGCC CTAGTGGTGC TCAGCTACAA GTCATTCAGC 
TCTCTGGGCT GTGATCTGCC TCAGACTCAC AGCCTGGGTA ACAGGAGGGC CTTGATACTC 
CTGGCACAAA TGCGAAGAAT CTCTCCTTTC TCCTGCCTGA AGGACAGACA TGACTTTGAA 
TTCCCCCAGG AGGAGTTTGA TGATAAACAG TTCCAGAAGG CTCAAGCCAT CTCTGTCCTC 
CATGAGATGA TCCAGCAGAC CTTCAACCTC TTCAGCACAA AGGACTCATC TGCTGCTTTG 
GATGAGACCC TTCTAGATGA ATTCTACATC GAACTTGACC AGCAGCTGAA TGACCTGGAG 
TCCTGTGTGA TGCAGGAAGT GGGGGTGATA GAGTCTCCCC TGATGTACGA GGACTCCATC 
CTGGCTGTGA GGAAATACTT CCAAAGAATC ACTCTATATC TGACAGAGAA GAAATACAGC 
TCTTGTGCCT GGGAGGTTGT CAGAGCAGAA ATCATGAGAT CCTTCTCTTT ATCAATCAAC 
TTGCAAAAAA GATTGAAGAG TAAGGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002161.2
CDS	61..630
Translation	MALTFYLLVALVVLSYKSFSSLGCDLPQTHSLGNRRALILLAQMRRISPFSCLKDRHDFEFPQEEFDDKQFQKAQAISVLHEMIQQTFNLFSTKDSSAALDETLLDEFYIELDQQLNDLESCVMQEVGVIESPLMYEDSILAVRKYFQRITLYLTEKKYSSCAWEVVRAEIMRSFSLSINLQKRLKSKE

Target ORF information:

RefSeq Version	NM_002170.4
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon alpha 8 (IFNA8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002170.4

ORF Insert Sequence:

ATGGCCTTGA CTTTTTATTT ACTGGTGGCC CTAGTGGTGC TCAGCTACAA GTCATTCAGC 
TCTCTGGGCT GTGATCTGCC TCAGACTCAC AGCCTGGGTA ACAGGAGGGC CTTGATACTC 
CTGGCACAAA TGCGAAGAAT CTCTCCTTTC TCCTGCCTGA AGGACAGACA TGACTTTGAA 
TTCCCCCAGG AGGAGTTTGA TGATAAACAG TTCCAGAAGG CTCAAGCCAT CTCTGTCCTC 
CATGAGATGA TCCAGCAGAC CTTCAACCTC TTCAGCACAA AGGACTCATC TGCTGCTTTG 
GATGAGACCC TTCTAGATGA ATTCTACATC GAACTTGACC AGCAGCTGAA TGACCTGGAG 
TCCTGTGTGA TGCAGGAAGT GGGGGTGATA GAGTCTCCCC TGATGTACGA GGACTCCATC 
CTGGCTGTGA GGAAATACTT CCAAAGAATC ACTCTATATC TGACAGAGAA GAAATACAGC 
TCTTGTGCCT GGGAGGTTGT CAGAGCAGAA ATCATGAGAT CCTTCTCTTT ATCAATCAAC 
TTGCAAAAAA GATTGAAGAG TAAGGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

IFN-? exerts opposing effects on activation-induced and IL-7-induced proliferation of T cells that may impair homeostatic maintenance of CD4+ T cell numbers in treated HIV infection.
Journal of immunology (Baltimore, Md. : 1950)193(5)2178-86(2014 Sep)
Cha L,de Jong E,French MA,Fernandez S

Subtypes of type I IFN differentially enhance cytokine expression by suboptimally stimulated CD4(+) T cells.
European journal of immunology43(12)3197-208(2013 Dec)
Hillyer P,Raviv N,Gold DM,Dougherty D,Liu J,Johnson TR,Graham BS,Rabin RL

Reduced interferon (IFN)-? conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality.
Human genetics131(8)1375-91(2012 Aug)
Kempaiah P,Anyona SB,Raballah E,Davenport GC,Were T,Hittner JB,Ong'echa JM,Perkins DJ

Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.
Familial cancer9(4)625-33(2010 Dec)
Yang XR,Liang X,Pfeiffer RM,Wheeler W,Maeder D,Burdette L,Yeager M,Chanock S,Tucker MA,Goldstein AM

Dengue hemorrhagic fever is associated with polymorphisms in JAK1.
European journal of human genetics : EJHG18(11)1221-7(2010 Nov)
Silva LK,Blanton RE,Parrado AR,Melo PS,Morato VG,Reis EA,Dias JP,Castro JM,Vasconcelos PF,Goddard KA,Barreto ML,Reis MG,Teixeira MG

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IFNA8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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