H1-7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	H1-7
Entrez Gene ID	341567
Full Name	H1 histone family member N, testis specific
Synonyms	H1.7,H1T2
General protein information	Preferred Names H1 histone family member N, testis specific Names testis-specific H1 histone HANP1 haploid germ cell-specific nuclear protein 1 histone H1t2 testis secretory sperm-binding protein Li 223n
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.11
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. The related mouse gene encodes a testis specific protein that is required for spermatogenesis and male fertility. [provided by RefSeq, Oct 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_181788.1	NP_861453.1	testis-specific H1 histone

Pathways from BioSystems

Homologies

Homo sapiens (human)	H1FNT	NP_861453.1
Pan troglodytes (chimpanzee)	H1FNT	XP_001160555.1
	LOC706043	XP_001101660.1
Bos taurus (cattle)	H1FNT	XP_002687393.3
Bos taurus (cattle)	LOC784038	XP_002687392.3
Canis lupus familiaris (dog)	LOC609303	XP_005637477.1

Gene Ontology
Bibliography

Related articles in PubMed

Role of H1 linker histones in mammalian development and stem cell differentiation.
Pan C, Fan Y
Biochimica et biophysica acta1859(3)496-509(2016 Mar)

Histone variants: key players of chromatin.
Biterge B, Schneider R
Cell and tissue research356(3)457-66(2014 Jun)

A unified phylogeny-based nomenclature for histone variants.
Talbert PB, Ahmad K, Almouzni G, Ausi? J, Berger F, Bhalla PL, Bonner WM, Cande WZ, Chadwick BP, Chan SW, Cross GA, Cui L, Dimitrov SI, Doenecke D, Eirin-L?pez JM, Gorovsky MA, Hake SB, Hamkalo BA, Holec S, Jacobsen SE, Kamieniarz K, Khochbin S, Ladurner AG, Landsman D, Latham JA, Loppin B, Malik HS, Marzluff WF, Pehrson JR, Postberg J, Schneider R, Singh MB, Smith MM, Thompson E, Torres-Padilla ME, Tremethick DJ, Turner BM, Waterborg JH, Wollmann H, Yelagandula R, Zhu B, Henikoff S
Epigenetics & chromatin57(2012 Jun)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

Expression profiles and single-nucleotide polymorphism analysis of human HANP1/H1T2 encoding a histone H1-like protein.
Tanaka H, Matsuoka Y, Onishi M, Kitamura K, Miyagawa Y, Nishimura H, Tsujimura A, Okuyama A, Nishimune Y
International journal of andrology29(2)353-9(2006 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

h-HANP1 is expressed in the testes and its genomic construct also intronless as mouse Hanp1. We found that the h-HANP1 coding region have 5 single-nucleotide polymorphisms in Japanese men.
Title: Expression profiles and single-nucleotide polymorphism analysis of human HANP1/H1T2 encoding a histone H1-like protein.

H1T2 is a protein required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis.
Title: Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis.

The following H1-7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H1-7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu16289	NM_181788.1 Latest version!	Homo sapiens H1.7 linker histone (H1-7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H1-7 ( NM_181788.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_861453.1 Homo sapiens H1.7 linker histone (H1-7), mRNA.

Price & Availability↑

CloneID	OHu16289
Clone ID Related Accession (Same CDS sequence)	NM_181788.1
Accession Version	NM_181788.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 768bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	testis-specific H1 histone
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY302593.1. ##Evidence-Data-START## Transcript is intronless :: AY302593.1, HM005636.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-independent histone :: PMID: 24781148 ##RefSeq-Attributes-END##

ATGGAACAGG CCTTGACTGG TGAGGCCCAA AGCCGGTGGC CCCGCAGAGG CGGGAGTGGG 
GCCATGGCTG AGGCGCCTGG GCCCAGTGGC GAATCCCGAG GACACTCAGC CACTCAGCTG 
CCAGCGGAAA AAACTGTCGG GGGACCATCG AGGGGCTGCT CAAGCTCCGT GCTCAGAGTG 
TCCCAGTTGG TGCTCCAGGC CATCTCCACT CACAAAGGGC TGACTCTGGC AGCTCTCAAG 
AAGGAGCTCC GAAACGCCGG CTACGAAGTG CGCAGGAAGA GCGGCCGCCA CGAAGCGCCC 
AGGGGGCAGG CCAAGGCCAC GCTCCTCCGG GTCAGCGGCA GCGACGCCGC CGGCTACTTC 
AGGGTCTGGA AGGTTCCCAA GCCCAGGAGA AAGCCGGGAC GCGCGAGGCA AGAGGAGGGC 
ACGCGCGCTC CCTGGAGGAC CCCAGCCGCG CCCCGGAGCT CCCGGAGGCG CCGCCAGCCC 
CTTCGCAAGG CGGCCAGGAA GGCCAGAGAA GTGTGGAGAC GGAACGCGAG GGCGAAAGCC 
AAGGCCAATG CCAGGGCGAG GAGGACCAGG AGGGCAAGGC CGAGAGCCAA GGAGCCGCCG 
TGTGCCAGAG CCAAGGAGGA AGCGGGAGCG ACAGCGGCAG ACGAGGGGCG AGGACAGGCC 
GTGAAGGAAG ACACCACGCC GAGGTCAGGG AAGGACAAGA GGCGAAGCTC CAAGCCCAGG 
GAAGAGAAGC AGGAGCCCAA GAAGCCCGCA CAGCGGACCA TCCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_861453.1
CDS	313..1080
Translation	MEQALTGEAQSRWPRRGGSGAMAEAPGPSGESRGHSATQLPAEKTVGGPSRGCSSSVLRVSQLVLQAISTHKGLTLAALKKELRNAGYEVRRKSGRHEAPRGQAKATLLRVSGSDAAGYFRVWKVPKPRRKPGRARQEEGTRAPWRTPAAPRSSRRRRQPLRKAARKAREVWRRNARAKAKANARARRTRRARPRAKEPPCARAKEEAGATAADEGRGQAVKEDTTPRSGKDKRRSSKPREEKQEPKKPAQRTIQ

Target ORF information:

RefSeq Version	NM_181788.1
Organism	Homo sapiens(human)
Definition	Homo sapiens H1.7 linker histone (H1-7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181788.1

ORF Insert Sequence:

ATGGAACAGG CCTTGACTGG TGAGGCCCAA AGCCGGTGGC CCCGCAGAGG CGGGAGTGGG 
GCCATGGCTG AGGCGCCTGG GCCCAGTGGC GAATCCCGAG GACACTCAGC CACTCAGCTG 
CCAGCGGAAA AAACTGTCGG GGGACCATCG AGGGGCTGCT CAAGCTCCGT GCTCAGAGTG 
TCCCAGTTGG TGCTCCAGGC CATCTCCACT CACAAAGGGC TGACTCTGGC AGCTCTCAAG 
AAGGAGCTCC GAAACGCCGG CTACGAAGTG CGCAGGAAGA GCGGCCGCCA CGAAGCGCCC 
AGGGGGCAGG CCAAGGCCAC GCTCCTCCGG GTCAGCGGCA GCGACGCCGC CGGCTACTTC 
AGGGTCTGGA AGGTTCCCAA GCCCAGGAGA AAGCCGGGAC GCGCGAGGCA AGAGGAGGGC 
ACGCGCGCTC CCTGGAGGAC CCCAGCCGCG CCCCGGAGCT CCCGGAGGCG CCGCCAGCCC 
CTTCGCAAGG CGGCCAGGAA GGCCAGAGAA GTGTGGAGAC GGAACGCGAG GGCGAAAGCC 
AAGGCCAATG CCAGGGCGAG GAGGACCAGG AGGGCAAGGC CGAGAGCCAA GGAGCCGCCG 
TGTGCCAGAG CCAAGGAGGA AGCGGGAGCG ACAGCGGCAG ACGAGGGGCG AGGACAGGCC 
GTGAAGGAAG ACACCACGCC GAGGTCAGGG AAGGACAAGA GGCGAAGCTC CAAGCCCAGG 
GAAGAGAAGC AGGAGCCCAA GAAGCCCGCA CAGCGGACCA TCCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of H1 linker histones in mammalian development and stem cell differentiation.
Biochimica et biophysica acta1859(3)496-509(2016 Mar)
Pan C,Fan Y

Histone variants: key players of chromatin.
Cell and tissue research356(3)457-66(2014 Jun)
Biterge B,Schneider R

A unified phylogeny-based nomenclature for histone variants.
Epigenetics & chromatin57(2012 Jun)
Talbert PB,Ahmad K,Almouzni G,Ausi? J,Berger F,Bhalla PL,Bonner WM,Cande WZ,Chadwick BP,Chan SW,Cross GA,Cui L,Dimitrov SI,Doenecke D,Eirin-L?pez JM,Gorovsky MA,Hake SB,Hamkalo BA,Holec S,Jacobsen SE,Kamieniarz K,Khochbin S,Ladurner AG,Landsman D,Latham JA,Loppin B,Malik HS,Marzluff WF,Pehrson JR,Postberg J,Schneider R,Singh MB,Smith MM,Thompson E,Torres-Padilla ME,Tremethick DJ,Turner BM,Waterborg JH,Wollmann H,Yelagandula R,Zhu B,Henikoff S

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

Expression profiles and single-nucleotide polymorphism analysis of human HANP1/H1T2 encoding a histone H1-like protein.
International journal of andrology29(2)353-9(2006 Apr)
Tanaka H,Matsuoka Y,Onishi M,Kitamura K,Miyagawa Y,Nishimura H,Tsujimura A,Okuyama A,Nishimune Y

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H1-7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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