SLC6A19 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLC6A19
Entrez Gene ID	340024
Full Name	solute carrier family 6 member 19
Synonyms	B0AT1,HND
General protein information	Preferred Names solute carrier family 6 member 19 Names sodium-dependent neutral amino acid transporter B(0)AT1 sodium-dependent amino acid transporter system B0 solute carrier family 6 (neurotransmitter transporter), member 19 solute carrier family 6 (neutral amino acid transporter), member 19 system B(0) neutral amino acid transporter AT1 system B0 neutral amino acid transporter
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5p15.33
Summary	This gene encodes a system B(0) transmembrane protein that actively transports most neutral amino acids across the apical membrane of epithelial cells. Mutations in this gene result in Hartnup disorder. [provided by RefSeq, Jul 2008].
Disorder MIM:	608893
Disorder Html:	Hartnup disorder, 234500 (3); Iminoglycinuria, digenic, 242600 (3); Hyperglycinuria, 138500 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001003841.3	NP_001003841.1	sodium-dependent neutral amino acid transporter B(0)AT1
NM_001003841.2	NP_001003841.1	sodium-dependent neutral amino acid transporter B(0)AT1

Pathways from BioSystems

Homologies

	SLC6A19	XP_002804345.1
Canis lupus familiaris (dog)	SLC6A19	XP_003434149.1
Mus musculus (house mouse)	Slc6a19	NP_083154.1
Danio rerio (zebrafish)	slc6a19b	NP_956030.1
Pan troglodytes (chimpanzee)	SLC6A19	XP_003950546.1
Danio rerio (zebrafish)	LOC100334171	XP_002665492.2
Homo sapiens (human)	SLC6A19	NP_001003841.1
Bos taurus (cattle)	SLC6A19	XP_002696512.2
Danio rerio (zebrafish)	slc6a19a	NP_001091648.1
Xenopus tropicalis (tropical clawed frog)	slc6a19	NP_001120585.1
Rattus norvegicus (Norway rat)	Slc6a19	NP_001034811.1
Gallus gallus (chicken)	SLC6A19	XP_419056.1

Gene Ontology
Bibliography

Related articles in PubMed

Human intestine luminal ACE2 and amino acid transporter expression increased by ACE-inhibitors.
Vuille-dit-Bille RN, Camargo SM, Emmenegger L, Sasse T, Kummer E, Jando J, Hamie QM, Meier CF, Hunziker S, Forras-Kaufmann Z, Kuyumcu S, Fox M, Schwizer W, Fried M, Lindenmeyer M, G?tze O, Verrey F
Amino acids47(4)693-705(2015 Apr)

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
Wolpin BM, Rizzato C, Kraft P, Kooperberg C, Petersen GM, Wang Z, Arslan AA, Beane-Freeman L, Bracci PM, Buring J, Canzian F, Duell EJ, Gallinger S, Giles GG, Goodman GE, Goodman PJ, Jacobs EJ, Kamineni A, Klein AP, Kolonel LN, Kulke MH, Li D, Malats N, Olson SH, Risch HA, Sesso HD, Visvanathan K, White E, Zheng W, Abnet CC, Albanes D, Andreotti G, Austin MA, Barfield R, Basso D, Berndt SI, Boutron-Ruault MC, Brotzman M, B?chler MW, Bueno-de-Mesquita HB, Bugert P, Burdette L, Campa D, Caporaso NE, Capurso G, Chung C, Cotterchio M, Costello E, Elena J, Funel N, Gaziano JM, Giese NA, Giovannucci EL, Goggins M, Gorman MJ, Gross M, Haiman CA, Hassan M, Helzlsouer KJ, Henderson BE, Holly EA, Hu N, Hunter DJ, Innocenti F, Jenab M, Kaaks R, Key TJ, Khaw KT, Klein EA, Kogevinas M, Krogh V, Kupcinskas J, Kurtz RC, LaCroix A, Landi MT, Landi S, Le Marchand L, Mambrini A, Mannisto S, Milne RL, Nakamura Y, Oberg AL, Owzar K, Patel AV, Peeters PH, Peters U, Pezzilli R, Piepoli A, Porta M, Real FX, Riboli E, Rothman N, Scarpa A, Shu XO, Silverman DT, Soucek P, Sund M, Talar-Wojnarowska R, Taylor PR, Theodoropoulos GE, Thornquist M, Tj?nneland A, Tobias GS, Trichopoulos D, Vodicka P, Wactawski-Wende J, Wentzensen N, Wu C, Yu H, Yu K, Zeleniuch-Jacquotte A, Hoover R, Hartge P, Fuchs C, Chanock SJ, Stolzenberg-Solomon RS, Amundadottir LT
Nature genetics46(9)994-1000(2014 Sep)

Up-regulation of amino acid transporter SLC6A19 activity and surface protein abundance by PKB/Akt and PIKfyve.
Bogatikov E, Munoz C, Pakladok T, Alesutan I, Shojaiefard M, Seebohm G, F?ller M, Palmada M, B?hmer C, Br?er S, Lang F
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology30(6)1538-46(2012)

Stimulation of the amino acid transporter SLC6A19 by JAK2.
Bhavsar SK, Hosseinzadeh Z, Merches K, Gu S, Br?er S, Lang F
Biochemical and biophysical research communications414(3)456-61(2011 Oct)

Loss of solute carriers in T cell-mediated rejection in mouse and human kidneys: an active epithelial injury-repair response.
Einecke G, Kayser D, Vanslambrouck JM, Sis B, Reeve J, Mengel M, Famulski KS, Bailey CG, Rasko JE, Halloran PF
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons10(10)2241-51(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SIT1, B(0)AT1 and ACE2 were co-localized in the brush-border membrane of small intestine enterocytes.
Title: Human intestine luminal ACE2 and amino acid transporter expression increased by ACE-inhibitors.

PKB/Akt up-regulates SLC6A19 activity, which may foster amino acid uptake into PKB/Akt-expressing epithelial and tumor cells.
Title: Up-regulation of amino acid transporter SLC6A19 activity and surface protein abundance by PKB/Akt and PIKfyve.

JAK2 up-regulates SLC6A19 activity which may foster amino acid uptake into JAK2 expressing cells.
Title: Stimulation of the amino acid transporter SLC6A19 by JAK2.

Average loss of solute carrier expression was similar in acute tubular necrosis (77%) and T cell-mediated rejection (75%) with high correlation of individual transcripts.
Title: Loss of solute carriers in T cell-mediated rejection in mouse and human kidneys: an active epithelial injury-repair response.

A novel SLC6A19 gene mutation is associated with late-onset seizures in a Korean patient with Hartnup disorder.
Title: Novel mutation in SLC6A19 causing late-onset seizures in Hartnup disorder.

The following SLC6A19 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC6A19 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26345	NM_001003841.3 Latest version!	Homo sapiens solute carrier family 6 member 19 (SLC6A19), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu26345	NM_001003841.2	Homo sapiens solute carrier family 6 member 19 (SLC6A19), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLC6A19 ( NM_001003841.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001003841.1 Homo sapiens solute carrier family 6 member 19 (SLC6A19), mRNA.

Price & Availability↑

CloneID	OHu26345
Clone ID Related Accession (Same CDS sequence)	NM_001003841.3 , NM_001003841.2
Accession Version	NM_001003841.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1905bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Homo sapiens(human)
Product	sodium-dependent neutral amino acid transporter B(0)AT1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK290811.1, AY596807.1, AC114291.2 and AI015994.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001003841.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK290811.1, AY591756.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000304460.11/ ENSP00000305302.10 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGAGGC TCGTGCTGCC CAACCCCGGC CTAGACGCCC GGATCCCGTC CCTGGCTGAG 
CTGGAGACCA TCGAGCAGGA GGAGGCCAGC TCCCGGCCGA AGTGGGACAA CAAGGCGCAG 
TACATGCTCA CCTGCCTGGG CTTCTGCGTG GGCCTCGGCA ACGTGTGGCG CTTCCCCTAC 
CTGTGTCAGA GCCACGGAGG AGGAGCCTTC ATGATCCCGT TCCTCATCCT GCTGGTCCTG 
GAGGGCATCC CCCTGCTGTA CCTGGAGTTC GCCATCGGGC AGCGGCTGCG GCGGGGCAGC 
CTGGGTGTGT GGAGCTCCAT CCACCCGGCC CTGAAGGGCC TAGGCCTGGC CTCCATGCTC 
ACGTCCTTCA TGGTGGGACT GTATTACAAC ACCATCATCT CCTGGATCAT GTGGTACTTA 
TTCAACTCCT TCCAGGAGCC TCTGCCCTGG AGCGACTGCC CGCTCAACGA GAACCAGACA 
GGGTATGTGG ACGAGTGCGC CAGGAGCTCC CCTGTGGACT ACTTCTGGTA CCGAGAGACG 
CTCAACATCT CCACGTCCAT CAGCGACTCG GGCTCCATCC AGTGGTGGAT GCTGCTGTGC 
CTGGCCTGCG CATGGAGCGT CCTGTACATG TGCACCATCC GCGGCATCGA GACCACCGGG 
AAGGCCGTGT ACATCACCTC CACGCTGCCC TATGTCGTCC TGACCATCTT CCTCATCCGA 
GGCCTGACGC TGAAGGGCGC CACCAATGGC ATCGTCTTCC TCTTCACGCC CAACGTCACG 
GAGCTGGCCC AGCCGGACAC CTGGCTGGAC GCGGGCGCAC AGGTCTTCTT CTCCTTCTCC 
CTGGCCTTCG GGGGCCTCAT CTCCTTCTCC AGCTACAACT CTGTGCACAA CAACTGCGAG 
AAGGACTCGG TGATTGTGTC CATCATCAAC GGCTTCACAT CGGTGTATGT GGCCATCGTG 
GTCTACTCCG TCATTGGGTT CCGCGCCACA CAGCGCTACG ACGACTGCTT CAGCACGAAC 
ATCCTGACCC TCATCAACGG GTTCGACCTG CCTGAAGGCA ACGTGACCCA GGAGAACTTT 
GTGGACATGC AGCAGCGGTG CAACGCCTCC GACCCCGCGG CCTACGCGCA GCTGGTGTTC 
CAGACCTGCG ACATCAACGC CTTCCTCTCA GAGGCCGTGG AGGGCACAGG CCTGGCCTTC 
ATCGTCTTCA CCGAGGCCAT CACCAAGATG CCGTTGTCCC CACTGTGGTC TGTGCTCTTC 
TTCATTATGC TCTTCTGCCT GGGGCTGTCA TCTATGTTTG GGAACATGGA GGGCGTCGTT 
GTGCCCCTGC AGGACCTCAG AGTCATCCCC CCGAAGTGGC CCAAGGAGGT GCTCACAGGC 
CTCATCTGCC TGGGGACATT CCTCATTGGC TTCATCTTCA CGCTGAACTC CGGCCAGTAC 
TGGCTCTCCC TGCTGGACAG CTATGCCGGC TCCATTCCCC TGCTCATCAT CGCCTTCTGC 
GAGATGTTCT CTGTGGTCTA CGTGTACGGT GTGGACAGGT TCAATAAGGA CATCGAGTTC 
ATGATCGGCC ACAAGCCCAA CATCTTCTGG CAAGTCACGT GGCGCGTGGT CAGCCCCCTG 
CTCATGCTGA TCATCTTCCT CTTCTTCTTC GTGGTAGAGG TCAGTCAGGA GCTGACCTAC 
AGCATCTGGG ACCCTGGCTA CGAGGAATTT CCCAAATCCC AGAAGATCTC CTACCCGAAC 
TGGGTGTATG TGGTGGTGGT GATTGTGGCT GGAGTGCCCT CCCTCACCAT CCCTGGCTAT 
GCCATCTACA AGCTCATCAG GAACCACTGC CAGAAGCCAG GGGACCATCA GGGGCTGGTG 
AGCACACTGT CCACAGCCTC CATGAACGGG GACCTGAAGT ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003841.1
CDS	57..1961
Translation	MVRLVLPNPGLDARIPSLAELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQKPGDHQGLVSTLSTASMNGDLKY

Target ORF information:

RefSeq Version	NM_001003841.3
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 6 member 19 (SLC6A19), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003841.3

ORF Insert Sequence:

ATGGTGAGGC TCGTGCTGCC CAACCCCGGC CTAGACGCCC GGATCCCGTC CCTGGCTGAG 
CTGGAGACCA TCGAGCAGGA GGAGGCCAGC TCCCGGCCGA AGTGGGACAA CAAGGCGCAG 
TACATGCTCA CCTGCCTGGG CTTCTGCGTG GGCCTCGGCA ACGTGTGGCG CTTCCCCTAC 
CTGTGTCAGA GCCACGGAGG AGGAGCCTTC ATGATCCCGT TCCTCATCCT GCTGGTCCTG 
GAGGGCATCC CCCTGCTGTA CCTGGAGTTC GCCATCGGGC AGCGGCTGCG GCGGGGCAGC 
CTGGGTGTGT GGAGCTCCAT CCACCCGGCC CTGAAGGGCC TAGGCCTGGC CTCCATGCTC 
ACGTCCTTCA TGGTGGGACT GTATTACAAC ACCATCATCT CCTGGATCAT GTGGTACTTA 
TTCAACTCCT TCCAGGAGCC TCTGCCCTGG AGCGACTGCC CGCTCAACGA GAACCAGACA 
GGGTATGTGG ACGAGTGCGC CAGGAGCTCC CCTGTGGACT ACTTCTGGTA CCGAGAGACG 
CTCAACATCT CCACGTCCAT CAGCGACTCG GGCTCCATCC AGTGGTGGAT GCTGCTGTGC 
CTGGCCTGCG CATGGAGCGT CCTGTACATG TGCACCATCC GCGGCATCGA GACCACCGGG 
AAGGCCGTGT ACATCACCTC CACGCTGCCC TATGTCGTCC TGACCATCTT CCTCATCCGA 
GGCCTGACGC TGAAGGGCGC CACCAATGGC ATCGTCTTCC TCTTCACGCC CAACGTCACG 
GAGCTGGCCC AGCCGGACAC CTGGCTGGAC GCGGGCGCAC AGGTCTTCTT CTCCTTCTCC 
CTGGCCTTCG GGGGCCTCAT CTCCTTCTCC AGCTACAACT CTGTGCACAA CAACTGCGAG 
AAGGACTCGG TGATTGTGTC CATCATCAAC GGCTTCACAT CGGTGTATGT GGCCATCGTG 
GTCTACTCCG TCATTGGGTT CCGCGCCACA CAGCGCTACG ACGACTGCTT CAGCACGAAC 
ATCCTGACCC TCATCAACGG GTTCGACCTG CCTGAAGGCA ACGTGACCCA GGAGAACTTT 
GTGGACATGC AGCAGCGGTG CAACGCCTCC GACCCCGCGG CCTACGCGCA GCTGGTGTTC 
CAGACCTGCG ACATCAACGC CTTCCTCTCA GAGGCCGTGG AGGGCACAGG CCTGGCCTTC 
ATCGTCTTCA CCGAGGCCAT CACCAAGATG CCGTTGTCCC CACTGTGGTC TGTGCTCTTC 
TTCATTATGC TCTTCTGCCT GGGGCTGTCA TCTATGTTTG GGAACATGGA GGGCGTCGTT 
GTGCCCCTGC AGGACCTCAG AGTCATCCCC CCGAAGTGGC CCAAGGAGGT GCTCACAGGC 
CTCATCTGCC TGGGGACATT CCTCATTGGC TTCATCTTCA CGCTGAACTC CGGCCAGTAC 
TGGCTCTCCC TGCTGGACAG CTATGCCGGC TCCATTCCCC TGCTCATCAT CGCCTTCTGC 
GAGATGTTCT CTGTGGTCTA CGTGTACGGT GTGGACAGGT TCAATAAGGA CATCGAGTTC 
ATGATCGGCC ACAAGCCCAA CATCTTCTGG CAAGTCACGT GGCGCGTGGT CAGCCCCCTG 
CTCATGCTGA TCATCTTCCT CTTCTTCTTC GTGGTAGAGG TCAGTCAGGA GCTGACCTAC 
AGCATCTGGG ACCCTGGCTA CGAGGAATTT CCCAAATCCC AGAAGATCTC CTACCCGAAC 
TGGGTGTATG TGGTGGTGGT GATTGTGGCT GGAGTGCCCT CCCTCACCAT CCCTGGCTAT 
GCCATCTACA AGCTCATCAG GAACCACTGC CAGAAGCCAG GGGACCATCA GGGGCTGGTG 
AGCACACTGT CCACAGCCTC CATGAACGGG GACCTGAAGT ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC6A19 ( NM_001003841.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001003841.1 Homo sapiens solute carrier family 6 member 19 (SLC6A19), mRNA.

Price & Availability↑

CloneID	OHu26345
Clone ID Related Accession (Same CDS sequence)	NM_001003841.3 , NM_001003841.2
Accession Version	NM_001003841.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1905bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	sodium-dependent neutral amino acid transporter B(0)AT1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK290811.1, AY596807.1, AC114291.2 and AI015994.1. This sequence is a reference standard in the RefSeqGene project. On May 13, 2008 this sequence version replaced NM_001003841.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK290811.1, AY591756.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGAGGC TCGTGCTGCC CAACCCCGGC CTAGACGCCC GGATCCCGTC CCTGGCTGAG 
CTGGAGACCA TCGAGCAGGA GGAGGCCAGC TCCCGGCCGA AGTGGGACAA CAAGGCGCAG 
TACATGCTCA CCTGCCTGGG CTTCTGCGTG GGCCTCGGCA ACGTGTGGCG CTTCCCCTAC 
CTGTGTCAGA GCCACGGAGG AGGAGCCTTC ATGATCCCGT TCCTCATCCT GCTGGTCCTG 
GAGGGCATCC CCCTGCTGTA CCTGGAGTTC GCCATCGGGC AGCGGCTGCG GCGGGGCAGC 
CTGGGTGTGT GGAGCTCCAT CCACCCGGCC CTGAAGGGCC TAGGCCTGGC CTCCATGCTC 
ACGTCCTTCA TGGTGGGACT GTATTACAAC ACCATCATCT CCTGGATCAT GTGGTACTTA 
TTCAACTCCT TCCAGGAGCC TCTGCCCTGG AGCGACTGCC CGCTCAACGA GAACCAGACA 
GGGTATGTGG ACGAGTGCGC CAGGAGCTCC CCTGTGGACT ACTTCTGGTA CCGAGAGACG 
CTCAACATCT CCACGTCCAT CAGCGACTCG GGCTCCATCC AGTGGTGGAT GCTGCTGTGC 
CTGGCCTGCG CATGGAGCGT CCTGTACATG TGCACCATCC GCGGCATCGA GACCACCGGG 
AAGGCCGTGT ACATCACCTC CACGCTGCCC TATGTCGTCC TGACCATCTT CCTCATCCGA 
GGCCTGACGC TGAAGGGCGC CACCAATGGC ATCGTCTTCC TCTTCACGCC CAACGTCACG 
GAGCTGGCCC AGCCGGACAC CTGGCTGGAC GCGGGCGCAC AGGTCTTCTT CTCCTTCTCC 
CTGGCCTTCG GGGGCCTCAT CTCCTTCTCC AGCTACAACT CTGTGCACAA CAACTGCGAG 
AAGGACTCGG TGATTGTGTC CATCATCAAC GGCTTCACAT CGGTGTATGT GGCCATCGTG 
GTCTACTCCG TCATTGGGTT CCGCGCCACA CAGCGCTACG ACGACTGCTT CAGCACGAAC 
ATCCTGACCC TCATCAACGG GTTCGACCTG CCTGAAGGCA ACGTGACCCA GGAGAACTTT 
GTGGACATGC AGCAGCGGTG CAACGCCTCC GACCCCGCGG CCTACGCGCA GCTGGTGTTC 
CAGACCTGCG ACATCAACGC CTTCCTCTCA GAGGCCGTGG AGGGCACAGG CCTGGCCTTC 
ATCGTCTTCA CCGAGGCCAT CACCAAGATG CCGTTGTCCC CACTGTGGTC TGTGCTCTTC 
TTCATTATGC TCTTCTGCCT GGGGCTGTCA TCTATGTTTG GGAACATGGA GGGCGTCGTT 
GTGCCCCTGC AGGACCTCAG AGTCATCCCC CCGAAGTGGC CCAAGGAGGT GCTCACAGGC 
CTCATCTGCC TGGGGACATT CCTCATTGGC TTCATCTTCA CGCTGAACTC CGGCCAGTAC 
TGGCTCTCCC TGCTGGACAG CTATGCCGGC TCCATTCCCC TGCTCATCAT CGCCTTCTGC 
GAGATGTTCT CTGTGGTCTA CGTGTACGGT GTGGACAGGT TCAATAAGGA CATCGAGTTC 
ATGATCGGCC ACAAGCCCAA CATCTTCTGG CAAGTCACGT GGCGCGTGGT CAGCCCCCTG 
CTCATGCTGA TCATCTTCCT CTTCTTCTTC GTGGTAGAGG TCAGTCAGGA GCTGACCTAC 
AGCATCTGGG ACCCTGGCTA CGAGGAATTT CCCAAATCCC AGAAGATCTC CTACCCGAAC 
TGGGTGTATG TGGTGGTGGT GATTGTGGCT GGAGTGCCCT CCCTCACCAT CCCTGGCTAT 
GCCATCTACA AGCTCATCAG GAACCACTGC CAGAAGCCAG GGGACCATCA GGGGCTGGTG 
AGCACACTGT CCACAGCCTC CATGAACGGG GACCTGAAGT ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003841.1
CDS	57..1961
Translation	MVRLVLPNPGLDARIPSLAELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQKPGDHQGLVSTLSTASMNGDLKY

Target ORF information:

RefSeq Version	NM_001003841.2
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 6 member 19 (SLC6A19), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003841.2

ORF Insert Sequence:

ATGGTGAGGC TCGTGCTGCC CAACCCCGGC CTAGACGCCC GGATCCCGTC CCTGGCTGAG 
CTGGAGACCA TCGAGCAGGA GGAGGCCAGC TCCCGGCCGA AGTGGGACAA CAAGGCGCAG 
TACATGCTCA CCTGCCTGGG CTTCTGCGTG GGCCTCGGCA ACGTGTGGCG CTTCCCCTAC 
CTGTGTCAGA GCCACGGAGG AGGAGCCTTC ATGATCCCGT TCCTCATCCT GCTGGTCCTG 
GAGGGCATCC CCCTGCTGTA CCTGGAGTTC GCCATCGGGC AGCGGCTGCG GCGGGGCAGC 
CTGGGTGTGT GGAGCTCCAT CCACCCGGCC CTGAAGGGCC TAGGCCTGGC CTCCATGCTC 
ACGTCCTTCA TGGTGGGACT GTATTACAAC ACCATCATCT CCTGGATCAT GTGGTACTTA 
TTCAACTCCT TCCAGGAGCC TCTGCCCTGG AGCGACTGCC CGCTCAACGA GAACCAGACA 
GGGTATGTGG ACGAGTGCGC CAGGAGCTCC CCTGTGGACT ACTTCTGGTA CCGAGAGACG 
CTCAACATCT CCACGTCCAT CAGCGACTCG GGCTCCATCC AGTGGTGGAT GCTGCTGTGC 
CTGGCCTGCG CATGGAGCGT CCTGTACATG TGCACCATCC GCGGCATCGA GACCACCGGG 
AAGGCCGTGT ACATCACCTC CACGCTGCCC TATGTCGTCC TGACCATCTT CCTCATCCGA 
GGCCTGACGC TGAAGGGCGC CACCAATGGC ATCGTCTTCC TCTTCACGCC CAACGTCACG 
GAGCTGGCCC AGCCGGACAC CTGGCTGGAC GCGGGCGCAC AGGTCTTCTT CTCCTTCTCC 
CTGGCCTTCG GGGGCCTCAT CTCCTTCTCC AGCTACAACT CTGTGCACAA CAACTGCGAG 
AAGGACTCGG TGATTGTGTC CATCATCAAC GGCTTCACAT CGGTGTATGT GGCCATCGTG 
GTCTACTCCG TCATTGGGTT CCGCGCCACA CAGCGCTACG ACGACTGCTT CAGCACGAAC 
ATCCTGACCC TCATCAACGG GTTCGACCTG CCTGAAGGCA ACGTGACCCA GGAGAACTTT 
GTGGACATGC AGCAGCGGTG CAACGCCTCC GACCCCGCGG CCTACGCGCA GCTGGTGTTC 
CAGACCTGCG ACATCAACGC CTTCCTCTCA GAGGCCGTGG AGGGCACAGG CCTGGCCTTC 
ATCGTCTTCA CCGAGGCCAT CACCAAGATG CCGTTGTCCC CACTGTGGTC TGTGCTCTTC 
TTCATTATGC TCTTCTGCCT GGGGCTGTCA TCTATGTTTG GGAACATGGA GGGCGTCGTT 
GTGCCCCTGC AGGACCTCAG AGTCATCCCC CCGAAGTGGC CCAAGGAGGT GCTCACAGGC 
CTCATCTGCC TGGGGACATT CCTCATTGGC TTCATCTTCA CGCTGAACTC CGGCCAGTAC 
TGGCTCTCCC TGCTGGACAG CTATGCCGGC TCCATTCCCC TGCTCATCAT CGCCTTCTGC 
GAGATGTTCT CTGTGGTCTA CGTGTACGGT GTGGACAGGT TCAATAAGGA CATCGAGTTC 
ATGATCGGCC ACAAGCCCAA CATCTTCTGG CAAGTCACGT GGCGCGTGGT CAGCCCCCTG 
CTCATGCTGA TCATCTTCCT CTTCTTCTTC GTGGTAGAGG TCAGTCAGGA GCTGACCTAC 
AGCATCTGGG ACCCTGGCTA CGAGGAATTT CCCAAATCCC AGAAGATCTC CTACCCGAAC 
TGGGTGTATG TGGTGGTGGT GATTGTGGCT GGAGTGCCCT CCCTCACCAT CCCTGGCTAT 
GCCATCTACA AGCTCATCAG GAACCACTGC CAGAAGCCAG GGGACCATCA GGGGCTGGTG 
AGCACACTGT CCACAGCCTC CATGAACGGG GACCTGAAGT ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human intestine luminal ACE2 and amino acid transporter expression increased by ACE-inhibitors.
Amino acids47(4)693-705(2015 Apr)
Vuille-dit-Bille RN,Camargo SM,Emmenegger L,Sasse T,Kummer E,Jando J,Hamie QM,Meier CF,Hunziker S,Forras-Kaufmann Z,Kuyumcu S,Fox M,Schwizer W,Fried M,Lindenmeyer M,G?tze O,Verrey F

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
Nature genetics46(9)994-1000(2014 Sep)
Wolpin BM,Rizzato C,Kraft P,Kooperberg C,Petersen GM,Wang Z,Arslan AA,Beane-Freeman L,Bracci PM,Buring J,Canzian F,Duell EJ,Gallinger S,Giles GG,Goodman GE,Goodman PJ,Jacobs EJ,Kamineni A,Klein AP,Kolonel LN,Kulke MH,Li D,Malats N,Olson SH,Risch HA,Sesso HD,Visvanathan K,White E,Zheng W,Abnet CC,Albanes D,Andreotti G,Austin MA,Barfield R,Basso D,Berndt SI,Boutron-Ruault MC,Brotzman M,B?chler MW,Bueno-de-Mesquita HB,Bugert P,Burdette L,Campa D,Caporaso NE,Capurso G,Chung C,Cotterchio M,Costello E,Elena J,Funel N,Gaziano JM,Giese NA,Giovannucci EL,Goggins M,Gorman MJ,Gross M,Haiman CA,Hassan M,Helzlsouer KJ,Henderson BE,Holly EA,Hu N,Hunter DJ,Innocenti F,Jenab M,Kaaks R,Key TJ,Khaw KT,Klein EA,Kogevinas M,Krogh V,Kupcinskas J,Kurtz RC,LaCroix A,Landi MT,Landi S,Le Marchand L,Mambrini A,Mannisto S,Milne RL,Nakamura Y,Oberg AL,Owzar K,Patel AV,Peeters PH,Peters U,Pezzilli R,Piepoli A,Porta M,Real FX,Riboli E,Rothman N,Scarpa A,Shu XO,Silverman DT,Soucek P,Sund M,Talar-Wojnarowska R,Taylor PR,Theodoropoulos GE,Thornquist M,Tj?nneland A,Tobias GS,Trichopoulos D,Vodicka P,Wactawski-Wende J,Wentzensen N,Wu C,Yu H,Yu K,Zeleniuch-Jacquotte A,Hoover R,Hartge P,Fuchs C,Chanock SJ,Stolzenberg-Solomon RS,Amundadottir LT

Up-regulation of amino acid transporter SLC6A19 activity and surface protein abundance by PKB/Akt and PIKfyve.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology30(6)1538-46(2012)
Bogatikov E,Munoz C,Pakladok T,Alesutan I,Shojaiefard M,Seebohm G,F?ller M,Palmada M,B?hmer C,Br?er S,Lang F

Stimulation of the amino acid transporter SLC6A19 by JAK2.
Biochemical and biophysical research communications414(3)456-61(2011 Oct)
Bhavsar SK,Hosseinzadeh Z,Merches K,Gu S,Br?er S,Lang F

Loss of solute carriers in T cell-mediated rejection in mouse and human kidneys: an active epithelial injury-repair response.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons10(10)2241-51(2010 Oct)
Einecke G,Kayser D,Vanslambrouck JM,Sis B,Reeve J,Mengel M,Famulski KS,Bailey CG,Rasko JE,Halloran PF

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SLC6A19 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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