ID2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ID2
Entrez Gene ID	3398
Full Name	inhibitor of DNA binding 2
Synonyms	GIG8,ID2A,ID2H,bHLHb26
General protein information	Preferred Names inhibitor of DNA binding 2 Names DNA-binding protein inhibitor ID-2 DNA-binding protein inhibitor ID2 cell growth-inhibiting gene 8 class B basic helix-loop-helix protein 26 helix-loop-helix protein ID2 inhibitor of DNA binding 2, HLH protein inhibitor of DNA binding 2, dominant negative helix-loop-helix protein inhibitor of differentiation 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p25.1
Summary	The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011].
Disorder MIM:	600386

mRNA and Protein(s)

mRNA	Protein	Name
NM_002166.4	NP_002157.2	DNA-binding protein inhibitor ID-2
NM_002166.5	NP_002157.2	DNA-binding protein inhibitor ID-2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	id2a	NP_958448.1
Pan troglodytes (chimpanzee)	ID2	XP_003308921.1
Mus musculus (house mouse)	Id2	NP_034626.1
Xenopus tropicalis (tropical clawed frog)	id2	NP_988885.1
Homo sapiens (human)	ID2	NP_002157.2
	ID2	XP_001081982.2
Gallus gallus (chicken)	ID2	NP_990333.1
Bos taurus (cattle)	ID2	NP_001029403.1
Rattus norvegicus (Norway rat)	Id2	NP_037192.1

Gene Ontology
Bibliography

Related articles in PubMed

Increased expression of ID2, PRELP and SMOC2 genes in patients with endometriosis.
Araujo FM, Meola J, Rosa-E-Silva JC, Paz CCP, Ferriani RA, Nogueira AA
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas50(7)e5782(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

cell invasion drastically increased with increased expression and activity of MMP2. Immunoprecipitation revealed a direct interaction between ID2 and zinc finger transcription factor, snail family transcriptional repressor 1 (SNAIL1)
Title: Introduction of ID2 Enhances Invasiveness in ID2-null Oral Squamous Cell Carcinoma Cells via the SNAIL Axis.

Results show that ID2 signaling was involved in BMP4-induced hepatocellular carcinoma proliferation and that Id2 was directly upregulated by BMP4, resulting in the mediated expression of cell cycle regulatory protein of CDKN1B.
Title: BMP4 enhances hepatocellular carcinoma proliferation by promoting cell cycle progression via ID2/CDKN1B signaling.

The ID2 gene expression was increased in the most advanced stage of endometriosis and in ovarian endometriomas. Considering that the genes studied participate either directly or indirectly in cellular processes that can lead to cell migration, angiogenesis, and inappropriate invasion, it is possible that the deregulation of these genes caused the development and maintenance of ectopic tissue.
Title: Increased expression of ID2, PRELP and SMOC2 genes in patients with endometriosis.

Data indicate that the expression level of ID2 in GBM cells can predict the sensitivity of GBM-derived tumor cells to decreased glucose levels.
Title: ID2 promotes survival of glioblastoma cells during metabolic stress by regulating mitochondrial function.

EYA4 functions as tumor suppressor gene in pancreatic ductal adenocarcinoma via repressing beta-catenin/ID2 activation, and was an independent prognostic factor in PDAC.
Title: EYA4 functions as tumor suppressor gene and prognostic marker in pancreatic ductal adenocarcinoma through ?-catenin/ID2 pathway.

The following ID2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ID2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24024	NM_002166.5 Latest version!	Homo sapiens inhibitor of DNA binding 2 (ID2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu24024	NM_002166.4	Homo sapiens inhibitor of DNA binding 2 (ID2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ID2 ( NM_002166.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002157.2 Homo sapiens inhibitor of DNA binding 2 (ID2), mRNA.

Price & Availability↑

CloneID	OHu24024
Clone ID Related Accession (Same CDS sequence)	NM_002166.4 , NM_002166.5
Accession Version	NM_002166.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	DNA-binding protein inhibitor ID-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC030639.2 and BE222494.1. On Aug 20, 2003 this sequence version replaced NM_002166.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC030639.2, SRR1163655.392569.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAAGCCT TCAGTCCCGT GAGGTCCGTT AGGAAAAACA GCCTGTCGGA CCACAGCCTG 
GGCATCTCCC GGAGCAAAAC CCCTGTGGAC GACCCGATGA GCCTGCTATA CAACATGAAC 
GACTGCTACT CCAAGCTCAA GGAGCTGGTG CCCAGCATCC CCCAGAACAA GAAGGTGAGC 
AAGATGGAAA TCCTGCAGCA CGTCATCGAC TACATCTTGG ACCTGCAGAT CGCCCTGGAC 
TCGCATCCCA CTATTGTCAG CCTGCATCAC CAGAGACCCG GGCAGAACCA GGCGTCCAGG 
ACGCCGCTGA CCACCCTCAA CACGGATATC AGCATCCTGT CCTTGCAGGC TTCTGAATTC 
CCTTCTGAGT TAATGTCAAA TGACAGCAAA GCACTGTGTG GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002157.2
CDS	184..588
Translation	MKAFSPVRSVRKNSLSDHSLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVSKMEILQHVIDYILDLQIALDSHPTIVSLHHQRPGQNQASRTPLTTLNTDISILSLQASEFPSELMSNDSKALCG

Target ORF information:

RefSeq Version	NM_002166.4
Organism	Homo sapiens(human)
Definition	Homo sapiens inhibitor of DNA binding 2 (ID2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002166.4

ORF Insert Sequence:

ATGAAAGCCT TCAGTCCCGT GAGGTCCGTT AGGAAAAACA GCCTGTCGGA CCACAGCCTG 
GGCATCTCCC GGAGCAAAAC CCCTGTGGAC GACCCGATGA GCCTGCTATA CAACATGAAC 
GACTGCTACT CCAAGCTCAA GGAGCTGGTG CCCAGCATCC CCCAGAACAA GAAGGTGAGC 
AAGATGGAAA TCCTGCAGCA CGTCATCGAC TACATCTTGG ACCTGCAGAT CGCCCTGGAC 
TCGCATCCCA CTATTGTCAG CCTGCATCAC CAGAGACCCG GGCAGAACCA GGCGTCCAGG 
ACGCCGCTGA CCACCCTCAA CACGGATATC AGCATCCTGT CCTTGCAGGC TTCTGAATTC 
CCTTCTGAGT TAATGTCAAA TGACAGCAAA GCACTGTGTG GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ID2 ( NM_002166.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002157.2 Homo sapiens inhibitor of DNA binding 2 (ID2), mRNA.

Price & Availability↑

CloneID	OHu24024
Clone ID Related Accession (Same CDS sequence)	NM_002166.4 , NM_002166.5
Accession Version	NM_002166.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-26
Organism	Homo sapiens(human)
Product	DNA-binding protein inhibitor ID-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC011747.8. On Nov 26, 2018 this sequence version replaced NM_002166.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189664.165011.1, SRR3476690.248816.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000396290.2/ ENSP00000379585.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAAGCCT TCAGTCCCGT GAGGTCCGTT AGGAAAAACA GCCTGTCGGA CCACAGCCTG 
GGCATCTCCC GGAGCAAAAC CCCTGTGGAC GACCCGATGA GCCTGCTATA CAACATGAAC 
GACTGCTACT CCAAGCTCAA GGAGCTGGTG CCCAGCATCC CCCAGAACAA GAAGGTGAGC 
AAGATGGAAA TCCTGCAGCA CGTCATCGAC TACATCTTGG ACCTGCAGAT CGCCCTGGAC 
TCGCATCCCA CTATTGTCAG CCTGCATCAC CAGAGACCCG GGCAGAACCA GGCGTCCAGG 
ACGCCGCTGA CCACCCTCAA CACGGATATC AGCATCCTGT CCTTGCAGGC TTCTGAATTC 
CCTTCTGAGT TAATGTCAAA TGACAGCAAA GCACTGTGTG GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002157.2
CDS	111..515
Translation	MKAFSPVRSVRKNSLSDHSLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVSKMEILQHVIDYILDLQIALDSHPTIVSLHHQRPGQNQASRTPLTTLNTDISILSLQASEFPSELMSNDSKALCG

Target ORF information:

RefSeq Version	NM_002166.5
Organism	Homo sapiens(human)
Definition	Homo sapiens inhibitor of DNA binding 2 (ID2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002166.5

ORF Insert Sequence:

ATGAAAGCCT TCAGTCCCGT GAGGTCCGTT AGGAAAAACA GCCTGTCGGA CCACAGCCTG 
GGCATCTCCC GGAGCAAAAC CCCTGTGGAC GACCCGATGA GCCTGCTATA CAACATGAAC 
GACTGCTACT CCAAGCTCAA GGAGCTGGTG CCCAGCATCC CCCAGAACAA GAAGGTGAGC 
AAGATGGAAA TCCTGCAGCA CGTCATCGAC TACATCTTGG ACCTGCAGAT CGCCCTGGAC 
TCGCATCCCA CTATTGTCAG CCTGCATCAC CAGAGACCCG GGCAGAACCA GGCGTCCAGG 
ACGCCGCTGA CCACCCTCAA CACGGATATC AGCATCCTGT CCTTGCAGGC TTCTGAATTC 
CCTTCTGAGT TAATGTCAAA TGACAGCAAA GCACTGTGTG GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Increased expression of ID2, PRELP and SMOC2 genes in patients with endometriosis.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas50(7)e5782(2017 Jul)
Araujo FM,Meola J,Rosa-E-Silva JC,Paz CCP,Ferriani RA,Nogueira AA

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ID2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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