TMEM240 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TMEM240
Entrez Gene ID	339453
Full Name	transmembrane protein 240
Synonyms	C1orf70,SCA21
General protein information	Preferred Names transmembrane protein 240 Names transmembrane protein 240 transmembrane protein C1orf70
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.33
Summary	This gene encodes a transmembrane-domain containing protein found in the brain and cerebellum. Mutations in this gene result in spinocerebellar ataxia 21. [provided by RefSeq, Dec 2014].
Disorder MIM:	616101
Disorder Html:	Spinocerebellar ataxia 21, 607454 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001114748.1	NP_001108220.1	transmembrane protein 240
NM_001114748.2	NP_001108220.1	transmembrane protein 240

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	C1ORF70	XP_429659.2
Danio rerio (zebrafish)	LOC568378	XP_706440.3
	LOC708041	XP_001096486.1
Bos taurus (cattle)	C16H1orf70	NP_001193892.1
Mus musculus (house mouse)	Tmem240	NP_001094976.1
Homo sapiens (human)	TMEM240	NP_001108220.1
Canis lupus familiaris (dog)	TMEM240	XP_003434720.2
Rattus norvegicus (Norway rat)	Tmem240	XP_002729628.2

Gene Ontology
Bibliography

Related articles in PubMed

TMEM240 mutations cause spinocerebellar ataxia 21 with mental retardation and severe cognitive impairment.
Delplanque J, Devos D, Huin V, Genet A, Sand O, Moreau C, Goizet C, Charles P, Anheim M, Monin ML, Bu?e L, Dest?e A, Grolez G, Delmaire C, Dujardin K, Dellacherie D, Brice A, Stevanin G, Strubi-Vuillaume I, D?rr A, Sablonni?re B
Brain : a journal of neurology137(Pt 10)2657-63(2014 Oct)

Molecular genetics of hereditary spinocerebellar ataxia: mutation analysis of spinocerebellar ataxia genes and CAG/CTG repeat expansion detection in 225 Italian families.
Brusco A, Gellera C, Cagnoli C, Saluto A, Castucci A, Michielotto C, Fetoni V, Mariotti C, Migone N, Di Donato S, Taroni F
Archives of neurology61(5)727-33(2004 May)

A new locus for spinocerebellar ataxia (SCA21) maps to chromosome 7p21.3-p15.1.
Vuillaume I, Devos D, Schraen-Maschke S, Dina C, Lemainque A, Vasseur F, Bocquillon G, Devos P, Kocinski C, Marzys C, Dest?e A, Sablonni?re B
Annals of neurology52(5)666-70(2002 Nov)

Clinical features and genetic analysis of a new form of spinocerebellar ataxia.
Devos D, Schraen-Maschke S, Vuillaume I, Dujardin K, Naz? P, Willoteaux C, Dest?e A, Sablonni?re B
Neurology56(2)234-8(2001 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The causative mutation of spinocerebellar ataxia 21 is the transmembrane protein gene TMEM240
Title: TMEM240 mutations cause spinocerebellar ataxia 21 with mental retardation and severe cognitive impairment.

Observational study of genotype prevalence. (HuGE Navigator)
Title: Molecular genetics of hereditary spinocerebellar ataxia: mutation analysis of spinocerebellar ataxia genes and CAG/CTG repeat expansion detection in 225 Italian families.

A new locus for spinocerebellar ataxia (SCA21) maps to chromosome 7p21.3-p15.1.
Title: A new locus for spinocerebellar ataxia (SCA21) maps to chromosome 7p21.3-p15.1.

The following TMEM240 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMEM240 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24294	NM_001114748.2 Latest version!	Homo sapiens transmembrane protein 240 (TMEM240), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu24294	NM_001114748.1	Homo sapiens transmembrane protein 240 (TMEM240), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TMEM240 ( NM_001114748.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001108220.1 Homo sapiens transmembrane protein 240 (TMEM240), mRNA.

Price & Availability↑

CloneID	OHu24294
Clone ID Related Accession (Same CDS sequence)	NM_001114748.1 , NM_001114748.2
Accession Version	NM_001114748.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 522bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	transmembrane protein 240
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EG328560.1, BU929336.1, AL645728.31 and BF446167.1. This sequence is a reference standard in the RefSeqGene project. On or before Mar 29, 2008 this sequence version replaced XM_001714132.1, XM_001714140.1, XM_294960.5. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BU929336.1, HY140463.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCATGA GCGCGAACAC CATGATCTTC ATGATTCTGG GGGCGTCGGT CGTGATGGCC 
ATCGCGTGCT TGATGGACAT GAACGCGCTG CTGGACCGAT TCCACAACTA CATCCTCCCG 
CACCTGCGGG GCGAGGACCG CGTCTGCCAC TGCAACTGTG GCCGGCACCA TATCCACTAC 
GTGATCCCGT ACGACGGGGA CCAGTCGGTG GTGGACGCCT CCGAGAACTA CTTTGTGACG 
GACAGTGTGA CCAAGCAGGA GATCGACCTC ATGCTGGGGC TGCTGCTGGG CTTTTGCATC 
AGCTGGTTCC TGGTGTGGAT GGACGGCGTC CTGCACTGCG CCGTGCGCGC CTGGAGAGCC 
GGACGGCGCT ACGATGGCTC GTGGACCTGG CTGCCCAAGC TGTGCAGCCT GCGGGAGCTG 
GGCCGGCGGC CGCACAGGCC CTTCGAGGAG GCCGCCGGGA ACATGGTACA CGTGAAGCAG 
AAACTCTACC ACAATGGCCA CCCCAGCCCG CGGCACCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001108220.1
CDS	15..536
Translation	MSMSANTMIFMILGASVVMAIACLMDMNALLDRFHNYILPHLRGEDRVCHCNCGRHHIHYVIPYDGDQSVVDASENYFVTDSVTKQEIDLMLGLLLGFCISWFLVWMDGVLHCAVRAWRAGRRYDGSWTWLPKLCSLRELGRRPHRPFEEAAGNMVHVKQKLYHNGHPSPRHL

Target ORF information:

RefSeq Version	NM_001114748.1
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 240 (TMEM240), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001114748.1

ORF Insert Sequence:

ATGTCCATGA GCGCGAACAC CATGATCTTC ATGATTCTGG GGGCGTCGGT CGTGATGGCC 
ATCGCGTGCT TGATGGACAT GAACGCGCTG CTGGACCGAT TCCACAACTA CATCCTCCCG 
CACCTGCGGG GCGAGGACCG CGTCTGCCAC TGCAACTGTG GCCGGCACCA TATCCACTAC 
GTGATCCCGT ACGACGGGGA CCAGTCGGTG GTGGACGCCT CCGAGAACTA CTTTGTGACG 
GACAGTGTGA CCAAGCAGGA GATCGACCTC ATGCTGGGGC TGCTGCTGGG CTTTTGCATC 
AGCTGGTTCC TGGTGTGGAT GGACGGCGTC CTGCACTGCG CCGTGCGCGC CTGGAGAGCC 
GGACGGCGCT ACGATGGCTC GTGGACCTGG CTGCCCAAGC TGTGCAGCCT GCGGGAGCTG 
GGCCGGCGGC CGCACAGGCC CTTCGAGGAG GCCGCCGGGA ACATGGTACA CGTGAAGCAG 
AAACTCTACC ACAATGGCCA CCCCAGCCCG CGGCACCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM240 ( NM_001114748.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001108220.1 Homo sapiens transmembrane protein 240 (TMEM240), mRNA.

Price & Availability↑

CloneID	OHu24294
Clone ID Related Accession (Same CDS sequence)	NM_001114748.1 , NM_001114748.2
Accession Version	NM_001114748.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 522bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	transmembrane protein 240
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL645728.31, EG328560.1, BU929336.1 and BF446167.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001114748.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BU929336.1, HY140463.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000378733.9/ ENSP00000368007.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCATGA GCGCGAACAC CATGATCTTC ATGATTCTGG GGGCGTCGGT CGTGATGGCC 
ATCGCGTGCT TGATGGACAT GAACGCGCTG CTGGACCGAT TCCACAACTA CATCCTCCCG 
CACCTGCGGG GCGAGGACCG CGTCTGCCAC TGCAACTGTG GCCGGCACCA TATCCACTAC 
GTGATCCCGT ACGACGGGGA CCAGTCGGTG GTGGACGCCT CCGAGAACTA CTTTGTGACG 
GACAGTGTGA CCAAGCAGGA GATCGACCTC ATGCTGGGGC TGCTGCTGGG CTTTTGCATC 
AGCTGGTTCC TGGTGTGGAT GGACGGCGTC CTGCACTGCG CCGTGCGCGC CTGGAGAGCC 
GGACGGCGCT ACGATGGCTC GTGGACCTGG CTGCCCAAGC TGTGCAGCCT GCGGGAGCTG 
GGCCGGCGGC CGCACAGGCC CTTCGAGGAG GCCGCCGGGA ACATGGTACA CGTGAAGCAG 
AAACTCTACC ACAATGGCCA CCCCAGCCCG CGGCACCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001108220.1
CDS	279..800
Translation	MSMSANTMIFMILGASVVMAIACLMDMNALLDRFHNYILPHLRGEDRVCHCNCGRHHIHYVIPYDGDQSVVDASENYFVTDSVTKQEIDLMLGLLLGFCISWFLVWMDGVLHCAVRAWRAGRRYDGSWTWLPKLCSLRELGRRPHRPFEEAAGNMVHVKQKLYHNGHPSPRHL

Target ORF information:

RefSeq Version	NM_001114748.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 240 (TMEM240), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001114748.2

ORF Insert Sequence:

ATGTCCATGA GCGCGAACAC CATGATCTTC ATGATTCTGG GGGCGTCGGT CGTGATGGCC 
ATCGCGTGCT TGATGGACAT GAACGCGCTG CTGGACCGAT TCCACAACTA CATCCTCCCG 
CACCTGCGGG GCGAGGACCG CGTCTGCCAC TGCAACTGTG GCCGGCACCA TATCCACTAC 
GTGATCCCGT ACGACGGGGA CCAGTCGGTG GTGGACGCCT CCGAGAACTA CTTTGTGACG 
GACAGTGTGA CCAAGCAGGA GATCGACCTC ATGCTGGGGC TGCTGCTGGG CTTTTGCATC 
AGCTGGTTCC TGGTGTGGAT GGACGGCGTC CTGCACTGCG CCGTGCGCGC CTGGAGAGCC 
GGACGGCGCT ACGATGGCTC GTGGACCTGG CTGCCCAAGC TGTGCAGCCT GCGGGAGCTG 
GGCCGGCGGC CGCACAGGCC CTTCGAGGAG GCCGCCGGGA ACATGGTACA CGTGAAGCAG 
AAACTCTACC ACAATGGCCA CCCCAGCCCG CGGCACCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TMEM240 mutations cause spinocerebellar ataxia 21 with mental retardation and severe cognitive impairment.
Brain : a journal of neurology137(Pt 10)2657-63(2014 Oct)
Delplanque J,Devos D,Huin V,Genet A,Sand O,Moreau C,Goizet C,Charles P,Anheim M,Monin ML,Bu?e L,Dest?e A,Grolez G,Delmaire C,Dujardin K,Dellacherie D,Brice A,Stevanin G,Strubi-Vuillaume I,D?rr A,Sablonni?re B

Molecular genetics of hereditary spinocerebellar ataxia: mutation analysis of spinocerebellar ataxia genes and CAG/CTG repeat expansion detection in 225 Italian families.
Archives of neurology61(5)727-33(2004 May)
Brusco A,Gellera C,Cagnoli C,Saluto A,Castucci A,Michielotto C,Fetoni V,Mariotti C,Migone N,Di Donato S,Taroni F

A new locus for spinocerebellar ataxia (SCA21) maps to chromosome 7p21.3-p15.1.
Annals of neurology52(5)666-70(2002 Nov)
Vuillaume I,Devos D,Schraen-Maschke S,Dina C,Lemainque A,Vasseur F,Bocquillon G,Devos P,Kocinski C,Marzys C,Dest?e A,Sablonni?re B

Clinical features and genetic analysis of a new form of spinocerebellar ataxia.
Neurology56(2)234-8(2001 Jan)
Devos D,Schraen-Maschke S,Vuillaume I,Dujardin K,Naz? P,Willoteaux C,Dest?e A,Sablonni?re B

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TMEM240 cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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