RXFP4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RXFP4
Entrez Gene ID	339403
Full Name	relaxin/insulin like family peptide receptor 4
Synonyms	GPCR142,GPR100,RLN3R2,RXFPR4
General protein information	Preferred Names relaxin/insulin like family peptide receptor 4 Names relaxin-3 receptor 2 G protein-coupled receptor 100 G-protein coupled receptor GPCR142 RLN3 receptor 2 insulin-like peptide INSL5 receptor relaxin family peptide receptor 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q22
Summary	GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008].
Disorder MIM:	609043

mRNA and Protein(s)

mRNA	Protein	Name
NM_181885.2	NP_871001.1	relaxin-3 receptor 2
NM_181885.3	NP_871001.1	relaxin-3 receptor 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	RXFP4	NP_871001.1
	RXFP4	XP_001116309.1
Bos taurus (cattle)	RXFP4	NP_001007077.1
Xenopus tropicalis (tropical clawed frog)	LOC100486614	XP_002945102.2
Pan troglodytes (chimpanzee)	RXFP4	XP_001162688.1
Mus musculus (house mouse)	Rxfp4	NP_861538.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression and localization of relaxin family peptide receptor 4 in human spermatozoa and impact of insulin-like peptide 5 on sperm functions.
Yeganeh IS, Taromchi AH, Fathabadi FF, Nejatbakhsh R, Novin MG, Shokri S
Reproductive biology17(4)327-332(2017 Dec)

Interaction mechanism of insulin-like peptide 5 with relaxin family peptide receptor 4.
Hu MJ, Wei D, Shao XX, Wang JH, Liu YL, Xu ZG, Guo ZY
Archives of biochemistry and biophysics61927-34(2017 Apr)

The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4.
Ang SY, Hutchinson DS, Evans BA, Hossain MA, Patil N, Bathgate RA, Kocan M, Summers RJ
Naunyn-Schmiedeberg's archives of pharmacology390(1)105-111(2017 Jan)

Mechanism for insulin-like peptide 5 distinguishing the homologous relaxin family peptide receptor 3 and 4.
Hu MJ, Shao XX, Wang JH, Wei D, Guo YQ, Liu YL, Xu ZG, Guo ZY
Scientific reports629648(2016 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

analysis of the interaction mechanism of INSL5 with its receptor RXFP4
Title: Interaction mechanism of insulin-like peptide 5 with relaxin family peptide receptor 4.

Relaxin-3 is a high-efficacy agonist at RXFP4 with a comparable signal transduction profile to INSL5.
Title: The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4.

The C-terminus of the B-chain of human INSL5 is critical for cognate RXFP4 receptor activity.
Title: The C-terminus of the B-chain of human insulin-like peptide 5 is critical for cognate RXFP4 receptor activity.

electrostatic interactions between INSL5 and RXFP4
Title: Identification of important residues of insulin-like peptide 5 and its receptor RXFP4 for ligand-receptor interactions.

Mutant relaxin-3 shows a significant decrease in receptor-activation potency towards RXFP4.
Title: The electrostatic interactions of relaxin-3 with receptor RXFP4 and the influence of its B-chain C-terminal conformation.

The following RXFP4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RXFP4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30387	NM_181885.3 Latest version!	Homo sapiens relaxin family peptide/INSL5 receptor 4 (RXFP4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OHu30387	NM_181885.2	Homo sapiens relaxin family peptide/INSL5 receptor 4 (RXFP4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RXFP4 ( NM_181885.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_871001.1 Homo sapiens relaxin family peptide/INSL5 receptor 4 (RXFP4), mRNA.

Price & Availability↑

CloneID	OHu30387
Clone ID Related Accession (Same CDS sequence)	NM_181885.2 , NM_181885.3
Accession Version	NM_181885.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1125bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	relaxin-3 receptor 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DN693323.1 and AY288415.1. On Aug 9, 2006 this sequence version replaced NM_181885.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC101507.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCCCACAC TCAATACTTC TGCCTCTCCA CCCACATTCT TCTGGGCCAA TGCCTCCGGA 
GGCAGTGTGC TGAGTGCTGA TGATGCTCCG ATGCCTGTCA AATTCCTAGC CCTGAGGCTC 
ATGGTTGCCC TGGCCTATGG GCTTGTGGGG GCCATTGGCT TGCTGGGAAA TTTGGCGGTG 
CTGTGGGTAC TGAGTAACTG TGCCCGGAGA GCCCCTGGCC CACCTTCAGA CACCTTCGTC 
TTCAACCTGG CTCTGGCGGA CCTGGGACTG GCACTCACTC TCCCCTTTTG GGCAGCCGAG 
TCGGCACTGG ACTTTCACTG GCCCTTCGGA GGTGCCCTCT GCAAGATGGT TCTGACGGCC 
ACTGTCCTCA ACGTCTATGC CAGCATCTTC CTCATCACAG CGCTGAGCGT TGCTCGCTAC 
TGGGTGGTGG CCATGGCTGC GGGGCCAGGC ACCCACCTCT CACTCTTCTG GGCCCGAATA 
GCCACCCTGG CAGTGTGGGC GGCGGCTGCC CTGGTGACGG TGCCCACAGC TGTCTTCGGG 
GTGGAGGGTG AGGTGTGTGG TGTGCGCCTT TGCCTGCTGC GTTTCCCCAG CAGGTACTGG 
CTGGGGGCCT ACCAGCTGCA GAGGGTGGTG CTGGCTTTCA TGGTGCCCTT GGGCGTCATC 
ACCACCAGCT ACCTGCTGCT GCTGGCCTTC CTGCAGCGGC GGCAACGGCG GCGGCAGGAC 
AGCAGGGTCG TGGCCCGCTC TGTCCGCATC CTGGTGGCTT CCTTCTTCCT CTGCTGGTTT 
CCCAACCATG TGGTCACTCT CTGGGGTGTC CTGGTGAAGT TTGACCTGGT GCCCTGGAAC 
AGTACTTTCT ATACTATCCA GACGTATGTC TTCCCTGTCA CTACTTGCTT GGCACACAGC 
AATAGCTGCC TCAACCCTGT GCTGTACTGT CTCCTGAGGC GGGAGCCCCG GCAGGCTCTG 
GCAGGCACCT TCAGGGATCT GCGGTTGAGG CTGTGGCCCC AGGGCGGAGG CTGGGTGCAA 
CAGGTGGCCC TAAAGCAGGT AGGCAGGCGG TGGGTCGCAA GCAACCCCCG GGAGAGCCGC 
CCTTCTACCC TGCTCACCAA CCTGGACAGA GGGACACCCG GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_871001.1
CDS	22..1146
Translation	MPTLNTSASPPTFFWANASGGSVLSADDAPMPVKFLALRLMVALAYGLVGAIGLLGNLAVLWVLSNCARRAPGPPSDTFVFNLALADLGLALTLPFWAAESALDFHWPFGGALCKMVLTATVLNVYASIFLITALSVARYWVVAMAAGPGTHLSLFWARIATLAVWAAAALVTVPTAVFGVEGEVCGVRLCLLRFPSRYWLGAYQLQRVVLAFMVPLGVITTSYLLLLAFLQRRQRRRQDSRVVARSVRILVASFFLCWFPNHVVTLWGVLVKFDLVPWNSTFYTIQTYVFPVTTCLAHSNSCLNPVLYCLLRREPRQALAGTFRDLRLRLWPQGGGWVQQVALKQVGRRWVASNPRESRPSTLLTNLDRGTPG

Target ORF information:

RefSeq Version	NM_181885.2
Organism	Homo sapiens(human)
Definition	Homo sapiens relaxin family peptide/INSL5 receptor 4 (RXFP4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181885.2

ORF Insert Sequence:

ATGCCCACAC TCAATACTTC TGCCTCTCCA CCCACATTCT TCTGGGCCAA TGCCTCCGGA 
GGCAGTGTGC TGAGTGCTGA TGATGCTCCG ATGCCTGTCA AATTCCTAGC CCTGAGGCTC 
ATGGTTGCCC TGGCCTATGG GCTTGTGGGG GCCATTGGCT TGCTGGGAAA TTTGGCGGTG 
CTGTGGGTAC TGAGTAACTG TGCCCGGAGA GCCCCTGGCC CACCTTCAGA CACCTTCGTC 
TTCAACCTGG CTCTGGCGGA CCTGGGACTG GCACTCACTC TCCCCTTTTG GGCAGCCGAG 
TCGGCACTGG ACTTTCACTG GCCCTTCGGA GGTGCCCTCT GCAAGATGGT TCTGACGGCC 
ACTGTCCTCA ACGTCTATGC CAGCATCTTC CTCATCACAG CGCTGAGCGT TGCTCGCTAC 
TGGGTGGTGG CCATGGCTGC GGGGCCAGGC ACCCACCTCT CACTCTTCTG GGCCCGAATA 
GCCACCCTGG CAGTGTGGGC GGCGGCTGCC CTGGTGACGG TGCCCACAGC TGTCTTCGGG 
GTGGAGGGTG AGGTGTGTGG TGTGCGCCTT TGCCTGCTGC GTTTCCCCAG CAGGTACTGG 
CTGGGGGCCT ACCAGCTGCA GAGGGTGGTG CTGGCTTTCA TGGTGCCCTT GGGCGTCATC 
ACCACCAGCT ACCTGCTGCT GCTGGCCTTC CTGCAGCGGC GGCAACGGCG GCGGCAGGAC 
AGCAGGGTCG TGGCCCGCTC TGTCCGCATC CTGGTGGCTT CCTTCTTCCT CTGCTGGTTT 
CCCAACCATG TGGTCACTCT CTGGGGTGTC CTGGTGAAGT TTGACCTGGT GCCCTGGAAC 
AGTACTTTCT ATACTATCCA GACGTATGTC TTCCCTGTCA CTACTTGCTT GGCACACAGC 
AATAGCTGCC TCAACCCTGT GCTGTACTGT CTCCTGAGGC GGGAGCCCCG GCAGGCTCTG 
GCAGGCACCT TCAGGGATCT GCGGTTGAGG CTGTGGCCCC AGGGCGGAGG CTGGGTGCAA 
CAGGTGGCCC TAAAGCAGGT AGGCAGGCGG TGGGTCGCAA GCAACCCCCG GGAGAGCCGC 
CCTTCTACCC TGCTCACCAA CCTGGACAGA GGGACACCCG GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RXFP4 ( NM_181885.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_871001.1 Homo sapiens relaxin family peptide/INSL5 receptor 4 (RXFP4), mRNA.

Price & Availability↑

CloneID	OHu30387
Clone ID Related Accession (Same CDS sequence)	NM_181885.2 , NM_181885.3
Accession Version	NM_181885.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1125bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	relaxin-3 receptor 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL355388.30. On Nov 27, 2019 this sequence version replaced NM_181885.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC101509.1, AY170824.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCCACAC TCAATACTTC TGCCTCTCCA CCCACATTCT TCTGGGCCAA TGCCTCCGGA 
GGCAGTGTGC TGAGTGCTGA TGATGCTCCG ATGCCTGTCA AATTCCTAGC CCTGAGGCTC 
ATGGTTGCCC TGGCCTATGG GCTTGTGGGG GCCATTGGCT TGCTGGGAAA TTTGGCGGTG 
CTGTGGGTAC TGAGTAACTG TGCCCGGAGA GCCCCTGGCC CACCTTCAGA CACCTTCGTC 
TTCAACCTGG CTCTGGCGGA CCTGGGACTG GCACTCACTC TCCCCTTTTG GGCAGCCGAG 
TCGGCACTGG ACTTTCACTG GCCCTTCGGA GGTGCCCTCT GCAAGATGGT TCTGACGGCC 
ACTGTCCTCA ACGTCTATGC CAGCATCTTC CTCATCACAG CGCTGAGCGT TGCTCGCTAC 
TGGGTGGTGG CCATGGCTGC GGGGCCAGGC ACCCACCTCT CACTCTTCTG GGCCCGAATA 
GCCACCCTGG CAGTGTGGGC GGCGGCTGCC CTGGTGACGG TGCCCACAGC TGTCTTCGGG 
GTGGAGGGTG AGGTGTGTGG TGTGCGCCTT TGCCTGCTGC GTTTCCCCAG CAGGTACTGG 
CTGGGGGCCT ACCAGCTGCA GAGGGTGGTG CTGGCTTTCA TGGTGCCCTT GGGCGTCATC 
ACCACCAGCT ACCTGCTGCT GCTGGCCTTC CTGCAGCGGC GGCAACGGCG GCGGCAGGAC 
AGCAGGGTCG TGGCCCGCTC TGTCCGCATC CTGGTGGCTT CCTTCTTCCT CTGCTGGTTT 
CCCAACCATG TGGTCACTCT CTGGGGTGTC CTGGTGAAGT TTGACCTGGT GCCCTGGAAC 
AGTACTTTCT ATACTATCCA GACGTATGTC TTCCCTGTCA CTACTTGCTT GGCACACAGC 
AATAGCTGCC TCAACCCTGT GCTGTACTGT CTCCTGAGGC GGGAGCCCCG GCAGGCTCTG 
GCAGGCACCT TCAGGGATCT GCGGTTGAGG CTGTGGCCCC AGGGCGGAGG CTGGGTGCAA 
CAGGTGGCCC TAAAGCAGGT AGGCAGGCGG TGGGTCGCAA GCAACCCCCG GGAGAGCCGC 
CCTTCTACCC TGCTCACCAA CCTGGACAGA GGGACACCCG GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_871001.1
CDS	73..1197
Translation	MPTLNTSASPPTFFWANASGGSVLSADDAPMPVKFLALRLMVALAYGLVGAIGLLGNLAVLWVLSNCARRAPGPPSDTFVFNLALADLGLALTLPFWAAESALDFHWPFGGALCKMVLTATVLNVYASIFLITALSVARYWVVAMAAGPGTHLSLFWARIATLAVWAAAALVTVPTAVFGVEGEVCGVRLCLLRFPSRYWLGAYQLQRVVLAFMVPLGVITTSYLLLLAFLQRRQRRRQDSRVVARSVRILVASFFLCWFPNHVVTLWGVLVKFDLVPWNSTFYTIQTYVFPVTTCLAHSNSCLNPVLYCLLRREPRQALAGTFRDLRLRLWPQGGGWVQQVALKQVGRRWVASNPRESRPSTLLTNLDRGTPG

Target ORF information:

RefSeq Version	NM_181885.3
Organism	Homo sapiens(human)
Definition	Homo sapiens relaxin family peptide/INSL5 receptor 4 (RXFP4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181885.3

ORF Insert Sequence:

ATGCCCACAC TCAATACTTC TGCCTCTCCA CCCACATTCT TCTGGGCCAA TGCCTCCGGA 
GGCAGTGTGC TGAGTGCTGA TGATGCTCCG ATGCCTGTCA AATTCCTAGC CCTGAGGCTC 
ATGGTTGCCC TGGCCTATGG GCTTGTGGGG GCCATTGGCT TGCTGGGAAA TTTGGCGGTG 
CTGTGGGTAC TGAGTAACTG TGCCCGGAGA GCCCCTGGCC CACCTTCAGA CACCTTCGTC 
TTCAACCTGG CTCTGGCGGA CCTGGGACTG GCACTCACTC TCCCCTTTTG GGCAGCCGAG 
TCGGCACTGG ACTTTCACTG GCCCTTCGGA GGTGCCCTCT GCAAGATGGT TCTGACGGCC 
ACTGTCCTCA ACGTCTATGC CAGCATCTTC CTCATCACAG CGCTGAGCGT TGCTCGCTAC 
TGGGTGGTGG CCATGGCTGC GGGGCCAGGC ACCCACCTCT CACTCTTCTG GGCCCGAATA 
GCCACCCTGG CAGTGTGGGC GGCGGCTGCC CTGGTGACGG TGCCCACAGC TGTCTTCGGG 
GTGGAGGGTG AGGTGTGTGG TGTGCGCCTT TGCCTGCTGC GTTTCCCCAG CAGGTACTGG 
CTGGGGGCCT ACCAGCTGCA GAGGGTGGTG CTGGCTTTCA TGGTGCCCTT GGGCGTCATC 
ACCACCAGCT ACCTGCTGCT GCTGGCCTTC CTGCAGCGGC GGCAACGGCG GCGGCAGGAC 
AGCAGGGTCG TGGCCCGCTC TGTCCGCATC CTGGTGGCTT CCTTCTTCCT CTGCTGGTTT 
CCCAACCATG TGGTCACTCT CTGGGGTGTC CTGGTGAAGT TTGACCTGGT GCCCTGGAAC 
AGTACTTTCT ATACTATCCA GACGTATGTC TTCCCTGTCA CTACTTGCTT GGCACACAGC 
AATAGCTGCC TCAACCCTGT GCTGTACTGT CTCCTGAGGC GGGAGCCCCG GCAGGCTCTG 
GCAGGCACCT TCAGGGATCT GCGGTTGAGG CTGTGGCCCC AGGGCGGAGG CTGGGTGCAA 
CAGGTGGCCC TAAAGCAGGT AGGCAGGCGG TGGGTCGCAA GCAACCCCCG GGAGAGCCGC 
CCTTCTACCC TGCTCACCAA CCTGGACAGA GGGACACCCG GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression and localization of relaxin family peptide receptor 4 in human spermatozoa and impact of insulin-like peptide 5 on sperm functions.
Reproductive biology17(4)327-332(2017 Dec)
Yeganeh IS,Taromchi AH,Fathabadi FF,Nejatbakhsh R,Novin MG,Shokri S

Interaction mechanism of insulin-like peptide 5 with relaxin family peptide receptor 4.
Archives of biochemistry and biophysics61927-34(2017 Apr)
Hu MJ,Wei D,Shao XX,Wang JH,Liu YL,Xu ZG,Guo ZY

The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4.
Naunyn-Schmiedeberg's archives of pharmacology390(1)105-111(2017 Jan)
Ang SY,Hutchinson DS,Evans BA,Hossain MA,Patil N,Bathgate RA,Kocan M,Summers RJ

Mechanism for insulin-like peptide 5 distinguishing the homologous relaxin family peptide receptor 3 and 4.
Scientific reports629648(2016 Jul)
Hu MJ,Shao XX,Wang JH,Wei D,Guo YQ,Liu YL,Xu ZG,Guo ZY

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RXFP4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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