APOA2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	APOA2
Entrez Gene ID	336
Full Name	apolipoprotein A2
Synonyms	Apo-AII,ApoA-II,apoAII
General protein information	Preferred Names apolipoprotein A2 Names apolipoprotein A-II
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q23.3
Summary	This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008].
Disorder MIM:	107670
Disorder Html:	Apolipoprotein A-II deficiency (3); {Hypercholesterolemia, familial, modifier of}, 143890 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001643.2	NP_001634.1	apolipoprotein A-II preproprotein
NM_001643.1	NP_001634.1	apolipoprotein A-II preproprotein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Apoa2	NP_038502.2
Homo sapiens (human)	APOA2	NP_001634.1
Pan troglodytes (chimpanzee)	APOA2	NP_001008976.1
	APOA2	XP_001117975.1
Canis lupus familiaris (dog)	APOA2	XP_536139.3
Bos taurus (cattle)	APOA2	NP_001039381.1
Rattus norvegicus (Norway rat)	Apoa2	NP_037244.1

Gene Ontology
Bibliography

Related articles in PubMed

The effect of weight loss on HDL subfractions and LCAT activity in two genotypes of APOA-II -265T>C polymorphism.
Moradi M, Mahmoudi M, Saedisomeolia A, Zahirihashemi R, Koohdani F
Nutrition journal16(1)34(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In type 2 diabetes mellitus patients, the dietary intake of antiinflammatory fatty acids, such as omega-3 PUFAs and MUFAs, could reduce the inflammatory effects associated with the Apolipoprotein A2 CC genotype. In addition, proinflammatory fatty acids, such as SFAs, could overcome the antiinflammatory effect of the T-allele.
Title: Apolipoprotein A2 -265?T>C polymorphism interacts with dietary fatty acids intake to modulate inflammation in type?2?diabetes mellitus patients.

data support an SR-B1 nibbling mechanism that is similar to that of streptococcal serum opacity factor, which also selectively removes CE and releases apoAI, leaving an apoAII-rich remnant.
Title: Scavenger receptor B1 (SR-B1) profoundly excludes high density lipoprotein (HDL) apolipoprotein AII as it nibbles HDL-cholesteryl ester.

A new missense mutation in an ian population has a significant association with high-density lipoprotein cholesterol levels.
Title: Identification of Sequence Variation in the Apolipoprotein A2 Gene and Their Relationship with Serum High-Density Lipoprotein Cholesterol Levels.

ApoAII-ATQ/AT not only distinguished the early stages of pancreatic cancer from healthy controls but also identified patients at high risk for pancreatic malignancy.
Title: Plasma biomarker for detection of early stage pancreatic cancer and risk factors for pancreatic malignancy using antibodies for apolipoprotein-AII isoforms.

ApoA1 and ApoA2 were independently associated with cognitive impairment.
Title: Serum Levels of ApoA1 and ApoA2 Are Associated with Cognitive Status in Older Men.

The following APOA2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the APOA2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18112	NM_001643.2 Latest version!	Homo sapiens apolipoprotein A2 (APOA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18112	NM_001643.1	Homo sapiens apolipoprotein A2 (APOA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

APOA2 ( NM_001643.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001634.1 Homo sapiens apolipoprotein A2 (APOA2), mRNA.

Price & Availability↑

CloneID	OHu18112
Clone ID Related Accession (Same CDS sequence)	NM_001643.2 , NM_001643.1
Accession Version	NM_001643.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 303bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-07
Organism	Homo sapiens(human)
Product	apolipoprotein A-II preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL590714.27. This sequence is a reference standard in the RefSeqGene project. On Nov 26, 2018 this sequence version replaced NM_001643.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AV681656.1, AV682018.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2145122 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000367990.7/ ENSP00000356969.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGCTGC TCGCAGCAAC TGTGCTACTC CTCACCATCT GCAGCCTTGA AGGAGCTTTG 
GTTCGGAGAC AGGCAAAGGA GCCATGTGTG GAGAGCCTGG TTTCTCAGTA CTTCCAGACC 
GTGACTGACT ATGGCAAGGA CCTGATGGAG AAGGTCAAGA GCCCAGAGCT TCAGGCCGAG 
GCCAAGTCTT ACTTTGAAAA GTCAAAGGAG CAGCTGACAC CCCTGATCAA GAAGGCTGGA 
ACGGAACTGG TTAACTTCTT GAGCTATTTC GTGGAACTTG GAACACAGCC TGCCACCCAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001634.1
CDS	59..361
Translation	MKLLAATVLLLTICSLEGALVRRQAKEPCVESLVSQYFQTVTDYGKDLMEKVKSPELQAEAKSYFEKSKEQLTPLIKKAGTELVNFLSYFVELGTQPATQ

Target ORF information:

RefSeq Version	NM_001643.2
Organism	Homo sapiens(human)
Definition	Homo sapiens apolipoprotein A2 (APOA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001643.2

ORF Insert Sequence:

ATGAAGCTGC TCGCAGCAAC TGTGCTACTC CTCACCATCT GCAGCCTTGA AGGAGCTTTG 
GTTCGGAGAC AGGCAAAGGA GCCATGTGTG GAGAGCCTGG TTTCTCAGTA CTTCCAGACC 
GTGACTGACT ATGGCAAGGA CCTGATGGAG AAGGTCAAGA GCCCAGAGCT TCAGGCCGAG 
GCCAAGTCTT ACTTTGAAAA GTCAAAGGAG CAGCTGACAC CCCTGATCAA GAAGGCTGGA 
ACGGAACTGG TTAACTTCTT GAGCTATTTC GTGGAACTTG GAACACAGCC TGCCACCCAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

APOA2 ( NM_001643.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001634.1 Homo sapiens apolipoprotein A2 (APOA2), mRNA.

Price & Availability↑

CloneID	OHu18112
Clone ID Related Accession (Same CDS sequence)	NM_001643.2 , NM_001643.1
Accession Version	NM_001643.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 303bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	apolipoprotein A-II preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X02619.1. This sequence is a reference standard in the RefSeqGene project. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BJ996447.1, BJ996463.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2145122 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTGC TCGCAGCAAC TGTGCTACTC CTCACCATCT GCAGCCTTGA AGGAGCTTTG 
GTTCGGAGAC AGGCAAAGGA GCCATGTGTG GAGAGCCTGG TTTCTCAGTA CTTCCAGACC 
GTGACTGACT ATGGCAAGGA CCTGATGGAG AAGGTCAAGA GCCCAGAGCT TCAGGCCGAG 
GCCAAGTCTT ACTTTGAAAA GTCAAAGGAG CAGCTGACAC CCCTGATCAA GAAGGCTGGA 
ACGGAACTGG TTAACTTCTT GAGCTATTTC GTGGAACTTG GAACACAGCC TGCCACCCAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001634.1
CDS	59..361
Translation	MKLLAATVLLLTICSLEGALVRRQAKEPCVESLVSQYFQTVTDYGKDLMEKVKSPELQAEAKSYFEKSKEQLTPLIKKAGTELVNFLSYFVELGTQPATQ

Target ORF information:

RefSeq Version	NM_001643.1
Organism	Homo sapiens(human)
Definition	Homo sapiens apolipoprotein A2 (APOA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001643.1

ORF Insert Sequence:

ATGAAGCTGC TCGCAGCAAC TGTGCTACTC CTCACCATCT GCAGCCTTGA AGGAGCTTTG 
GTTCGGAGAC AGGCAAAGGA GCCATGTGTG GAGAGCCTGG TTTCTCAGTA CTTCCAGACC 
GTGACTGACT ATGGCAAGGA CCTGATGGAG AAGGTCAAGA GCCCAGAGCT TCAGGCCGAG 
GCCAAGTCTT ACTTTGAAAA GTCAAAGGAG CAGCTGACAC CCCTGATCAA GAAGGCTGGA 
ACGGAACTGG TTAACTTCTT GAGCTATTTC GTGGAACTTG GAACACAGCC TGCCACCCAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The effect of weight loss on HDL subfractions and LCAT activity in two genotypes of APOA-II -265T>C polymorphism.
Nutrition journal16(1)34(2017 May)
Moradi M,Mahmoudi M,Saedisomeolia A,Zahirihashemi R,Koohdani F

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APOA2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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