HTR2B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HTR2B
Entrez Gene ID	3357
Full Name	5-hydroxytryptamine receptor 2B
Synonyms	5-HT(2B),5-HT-2B,5-HT2B
General protein information	Preferred Names 5-hydroxytryptamine receptor 2B Names 5-hydroxytryptamine receptor 2B 5-HT 2B receptor 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 5-hydroxytryptamine 2B receptor 5-hydroxytryptamine receptor 2B variant b serotonin receptor 2B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q37.1
Summary	This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016].
Disorder MIM:	601122

mRNA and Protein(s)

mRNA	Protein	Name
XM_005246520.3	XP_005246577.1	5-hydroxytryptamine receptor 2B isoform X2
NM_000867.5	NP_000858.3	5-hydroxytryptamine receptor 2B isoform 1
NM_001320758.2	NP_001307687.1	5-hydroxytryptamine receptor 2B isoform 2
XM_006712482.3	XP_006712545.1	5-hydroxytryptamine receptor 2B isoform X1
XM_005246520.4	XP_005246577.1	5-hydroxytryptamine receptor 2B isoform X2
NM_000867.4	NP_000858.3	5-hydroxytryptamine receptor 2B isoform 1
NM_001320758.1	NP_001307687.1	5-hydroxytryptamine receptor 2B isoform 2
XM_006712482.2	XP_006712545.1	5-hydroxytryptamine receptor 2B isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	HTR2B	NP_001019804.1
Gallus gallus (chicken)	HTR2B	XP_004943419.1
Homo sapiens (human)	HTR2B	NP_000858.3
Pan troglodytes (chimpanzee)	HTR2B	XP_001144172.1
Bos taurus (cattle)	HTR2B	NP_001192377.1
Mus musculus (house mouse)	Htr2b	NP_032337.2
Rattus norvegicus (Norway rat)	Htr2b	NP_058946.1
Danio rerio (zebrafish)	htr2b	NP_001038208.1
Xenopus tropicalis (tropical clawed frog)	htr2b	XP_004914439.1
	HTR2B	XP_001113095.1

Gene Ontology
Bibliography

Related articles in PubMed

Serotonin receptor 2B signaling with interstitial cell activation and leaflet remodeling in degenerative mitral regurgitation.
Driesbaugh KH, Branchetti E, Grau JB, Keeney SJ, Glass K, Oyama MA, Rioux N, Ayoub S, Sacks MS, Quackenbush J, Levy RJ, Ferrari G
Journal of molecular and cellular cardiology11594-103(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

heterodimerization with 5-HT2C receptors does not alter 5-HT2C Galphaq-dependent inositol phosphate signaling, 5-HT2A or 5-HT2B receptor-mediated signaling was totally blunted. This feature can be explained by a dominance of 5-HT2C on 5-HT2A and 5-HT2B receptor binding; in 5-HT2C-containing heterodimers, ligands bind and activate the 5-HT2C protomer exclusively.
Title: Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT

These findings suggest that 5-HT promotes CCN2 production through the 5-HT2AR in growth plates, and that it represses CCN2 production through the 5-HT2BR in articular cartilage for harmonized development of long bones
Title: Regulatory mechanism of CCN2 production by serotonin (5-HT) via 5-HT2A and 5-HT2B receptors in chondrocytes.

Study describes the crystal structure of Lysergic acid diethylamide (LSD) in complex with the human serotonin receptor 5-HT2B. The complex reveals conformational rearrangements to accommodate LSD, providing a structural explanation for the conformational selectivity of LSD's key diethylamide moiety.
Title: Crystal Structure of an LSD-Bound Human Serotonin Receptor.

The 5-HT2B receptor may contribute to the regulation of human glucagon and glucose homeostasis and the interplay between glucagon and insulin secretion.
Title: Influence of a HTR2B Stop Codon on Glucagon Homeostasis and Glucose Excursion in Non-Diabetic Men.

The HTR2B Q20* allele and testosterone predicted lower BMI independently, but an interaction between HTR2B Q20* and testosterone lead to increased insulin sensitivity among HTR2B Q20* carriers with low testosterone levels.
Title: The effects of a HTR2B stop codon and testosterone on energy metabolism and beta cell function among antisocial Finnish males.

The following HTR2B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HTR2B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24847	NM_000867.5 Latest version!	Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu58336	NM_001320758.2 Latest version!	Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OHu36183	XM_005246520.4 Latest version!	Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OHu36182	XM_006712482.3 Latest version!	Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu36183	XM_005246520.3	Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OHu24847	NM_000867.4	Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu58336	NM_001320758.1	Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OHu36182	XM_006712482.2	Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HTR2B ( NM_000867.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000858.3 Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24847
Clone ID Related Accession (Same CDS sequence)	NM_000867.5 , NM_000867.4
Accession Version	NM_000867.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	5-hydroxytryptamine receptor 2B isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC063123.1, X77307.1 and AC009407.8. On Nov 22, 2018 this sequence version replaced NM_000867.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK313741.1, BC063123.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000258400.4/ ENSP00000258400.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTCTCT CTTACAGAGT GTCTGAACTT CAAAGCACAA TTCCTGAGCA CATTTTGCAG 
AGCACCTTTG TTCACGTTAT CTCTTCTAAC TGGTCTGGAT TACAGACAGA ATCAATACCA 
GAGGAAATGA AACAGATTGT TGAGGAACAG GGAAATAAAC TGCACTGGGC AGCTCTTCTG 
ATACTCATGG TGATAATACC CACAATTGGT GGAAATACCC TTGTTATTCT GGCTGTTTCA 
CTGGAGAAGA AGCTGCAGTA TGCTACTAAT TACTTTCTAA TGTCCTTGGC GGTGGCTGAT 
TTGCTGGTTG GATTGTTTGT GATGCCAATT GCCCTCTTGA CAATAATGTT TGAGGCTATG 
TGGCCCCTCC CACTTGTTCT ATGTCCTGCC TGGTTATTTC TTGACGTTCT CTTTTCAACC 
GCATCCATCA TGCATCTCTG TGCCATTTCA GTGGATCGTT ACATAGCCAT CAAAAAGCCA 
ATCCAGGCCA ATCAATATAA CTCACGGGCT ACAGCATTCA TCAAGATTAC AGTGGTGTGG 
TTAATTTCAA TAGGCATTGC CATTCCAGTC CCTATTAAAG GGATAGAGAC TGATGTGGAC 
AACCCAAACA ATATCACTTG TGTGCTGACA AAGGAACGTT TTGGCGATTT CATGCTCTTT 
GGCTCACTGG CTGCCTTCTT CACACCTCTT GCAATTATGA TTGTCACCTA CTTTCTCACT 
ATCCATGCTT TACAGAAGAA GGCTTACTTA GTCAAAAACA AGCCACCTCA ACGCCTAACA 
TGGTTGACTG TGTCTACAGT TTTCCAAAGG GATGAAACAC CTTGCTCGTC ACCGGAAAAG 
GTGGCAATGC TGGATGGTTC TCGAAAGGAC AAGGCTCTGC CCAACTCAGG TGATGAAACA 
CTTATGCGAA GAACATCCAC AATTGGGAAA AAGTCAGTGC AGACCATTTC CAACGAACAG 
AGAGCCTCAA AGGTCCTAGG GATTGTGTTT TTCCTCTTTT TGCTTATGTG GTGTCCCTTC 
TTTATTACAA ATATAACTTT AGTTTTATGT GATTCCTGTA ACCAAACTAC TCTCCAAATG 
CTCCTGGAGA TATTTGTGTG GATAGGCTAT GTTTCCTCAG GAGTGAATCC TTTGGTCTAC 
ACCCTCTTCA ATAAGACATT TCGGGATGCA TTTGGCCGAT ATATCACCTG CAATTACCGG 
GCCACAAAGT CAGTAAAAAC TCTCAGAAAA CGCTCCAGTA AGATCTACTT CCGGAATCCA 
ATGGCAGAGA ACTCTAAGTT TTTCAAGAAA CATGGAATTC GAAATGGGAT TAACCCTGCC 
ATGTACCAGA GTCCAATGAG GCTCCGAAGT TCAACCATTC AGTCTTCATC AATCATTCTA 
CTAGATACGC TTCTCCTCAC TGAAAATGAA GGTGACAAAA CTGAAGAGCA AGTTAGTTAT 
GTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000858.3
CDS	438..1883
Translation	MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV

Target ORF information:

RefSeq Version	NM_000867.5
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000867.5

ORF Insert Sequence:

ATGGCTCTCT CTTACAGAGT GTCTGAACTT CAAAGCACAA TTCCTGAGCA CATTTTGCAG 
AGCACCTTTG TTCACGTTAT CTCTTCTAAC TGGTCTGGAT TACAGACAGA ATCAATACCA 
GAGGAAATGA AACAGATTGT TGAGGAACAG GGAAATAAAC TGCACTGGGC AGCTCTTCTG 
ATACTCATGG TGATAATACC CACAATTGGT GGAAATACCC TTGTTATTCT GGCTGTTTCA 
CTGGAGAAGA AGCTGCAGTA TGCTACTAAT TACTTTCTAA TGTCCTTGGC GGTGGCTGAT 
TTGCTGGTTG GATTGTTTGT GATGCCAATT GCCCTCTTGA CAATAATGTT TGAGGCTATG 
TGGCCCCTCC CACTTGTTCT ATGTCCTGCC TGGTTATTTC TTGACGTTCT CTTTTCAACC 
GCATCCATCA TGCATCTCTG TGCCATTTCA GTGGATCGTT ACATAGCCAT CAAAAAGCCA 
ATCCAGGCCA ATCAATATAA CTCACGGGCT ACAGCATTCA TCAAGATTAC AGTGGTGTGG 
TTAATTTCAA TAGGCATTGC CATTCCAGTC CCTATTAAAG GGATAGAGAC TGATGTGGAC 
AACCCAAACA ATATCACTTG TGTGCTGACA AAGGAACGTT TTGGCGATTT CATGCTCTTT 
GGCTCACTGG CTGCCTTCTT CACACCTCTT GCAATTATGA TTGTCACCTA CTTTCTCACT 
ATCCATGCTT TACAGAAGAA GGCTTACTTA GTCAAAAACA AGCCACCTCA ACGCCTAACA 
TGGTTGACTG TGTCTACAGT TTTCCAAAGG GATGAAACAC CTTGCTCGTC ACCGGAAAAG 
GTGGCAATGC TGGATGGTTC TCGAAAGGAC AAGGCTCTGC CCAACTCAGG TGATGAAACA 
CTTATGCGAA GAACATCCAC AATTGGGAAA AAGTCAGTGC AGACCATTTC CAACGAACAG 
AGAGCCTCAA AGGTCCTAGG GATTGTGTTT TTCCTCTTTT TGCTTATGTG GTGTCCCTTC 
TTTATTACAA ATATAACTTT AGTTTTATGT GATTCCTGTA ACCAAACTAC TCTCCAAATG 
CTCCTGGAGA TATTTGTGTG GATAGGCTAT GTTTCCTCAG GAGTGAATCC TTTGGTCTAC 
ACCCTCTTCA ATAAGACATT TCGGGATGCA TTTGGCCGAT ATATCACCTG CAATTACCGG 
GCCACAAAGT CAGTAAAAAC TCTCAGAAAA CGCTCCAGTA AGATCTACTT CCGGAATCCA 
ATGGCAGAGA ACTCTAAGTT TTTCAAGAAA CATGGAATTC GAAATGGGAT TAACCCTGCC 
ATGTACCAGA GTCCAATGAG GCTCCGAAGT TCAACCATTC AGTCTTCATC AATCATTCTA 
CTAGATACGC TTCTCCTCAC TGAAAATGAA GGTGACAAAA CTGAAGAGCA AGTTAGTTAT 
GTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTR2B ( NM_000867.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000858.3 Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24847
Clone ID Related Accession (Same CDS sequence)	NM_000867.5 , NM_000867.4
Accession Version	NM_000867.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Homo sapiens(human)
Product	5-hydroxytryptamine receptor 2B isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC063123.1 and X77307.1. On Jan 28, 2009 this sequence version replaced NM_000867.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC063123.1, SRR1803613.138655.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCTCT CTTACAGAGT GTCTGAACTT CAAAGCACAA TTCCTGAGCA CATTTTGCAG 
AGCACCTTTG TTCACGTTAT CTCTTCTAAC TGGTCTGGAT TACAGACAGA ATCAATACCA 
GAGGAAATGA AACAGATTGT TGAGGAACAG GGAAATAAAC TGCACTGGGC AGCTCTTCTG 
ATACTCATGG TGATAATACC CACAATTGGT GGAAATACCC TTGTTATTCT GGCTGTTTCA 
CTGGAGAAGA AGCTGCAGTA TGCTACTAAT TACTTTCTAA TGTCCTTGGC GGTGGCTGAT 
TTGCTGGTTG GATTGTTTGT GATGCCAATT GCCCTCTTGA CAATAATGTT TGAGGCTATG 
TGGCCCCTCC CACTTGTTCT ATGTCCTGCC TGGTTATTTC TTGACGTTCT CTTTTCAACC 
GCATCCATCA TGCATCTCTG TGCCATTTCA GTGGATCGTT ACATAGCCAT CAAAAAGCCA 
ATCCAGGCCA ATCAATATAA CTCACGGGCT ACAGCATTCA TCAAGATTAC AGTGGTGTGG 
TTAATTTCAA TAGGCATTGC CATTCCAGTC CCTATTAAAG GGATAGAGAC TGATGTGGAC 
AACCCAAACA ATATCACTTG TGTGCTGACA AAGGAACGTT TTGGCGATTT CATGCTCTTT 
GGCTCACTGG CTGCCTTCTT CACACCTCTT GCAATTATGA TTGTCACCTA CTTTCTCACT 
ATCCATGCTT TACAGAAGAA GGCTTACTTA GTCAAAAACA AGCCACCTCA ACGCCTAACA 
TGGTTGACTG TGTCTACAGT TTTCCAAAGG GATGAAACAC CTTGCTCGTC ACCGGAAAAG 
GTGGCAATGC TGGATGGTTC TCGAAAGGAC AAGGCTCTGC CCAACTCAGG TGATGAAACA 
CTTATGCGAA GAACATCCAC AATTGGGAAA AAGTCAGTGC AGACCATTTC CAACGAACAG 
AGAGCCTCAA AGGTCCTAGG GATTGTGTTT TTCCTCTTTT TGCTTATGTG GTGTCCCTTC 
TTTATTACAA ATATAACTTT AGTTTTATGT GATTCCTGTA ACCAAACTAC TCTCCAAATG 
CTCCTGGAGA TATTTGTGTG GATAGGCTAT GTTTCCTCAG GAGTGAATCC TTTGGTCTAC 
ACCCTCTTCA ATAAGACATT TCGGGATGCA TTTGGCCGAT ATATCACCTG CAATTACCGG 
GCCACAAAGT CAGTAAAAAC TCTCAGAAAA CGCTCCAGTA AGATCTACTT CCGGAATCCA 
ATGGCAGAGA ACTCTAAGTT TTTCAAGAAA CATGGAATTC GAAATGGGAT TAACCCTGCC 
ATGTACCAGA GTCCAATGAG GCTCCGAAGT TCAACCATTC AGTCTTCATC AATCATTCTA 
CTAGATACGC TTCTCCTCAC TGAAAATGAA GGTGACAAAA CTGAAGAGCA AGTTAGTTAT 
GTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000858.3
CDS	506..1951
Translation	MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV

Target ORF information:

RefSeq Version	NM_000867.4
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000867.4

ORF Insert Sequence:

ATGGCTCTCT CTTACAGAGT GTCTGAACTT CAAAGCACAA TTCCTGAGCA CATTTTGCAG 
AGCACCTTTG TTCACGTTAT CTCTTCTAAC TGGTCTGGAT TACAGACAGA ATCAATACCA 
GAGGAAATGA AACAGATTGT TGAGGAACAG GGAAATAAAC TGCACTGGGC AGCTCTTCTG 
ATACTCATGG TGATAATACC CACAATTGGT GGAAATACCC TTGTTATTCT GGCTGTTTCA 
CTGGAGAAGA AGCTGCAGTA TGCTACTAAT TACTTTCTAA TGTCCTTGGC GGTGGCTGAT 
TTGCTGGTTG GATTGTTTGT GATGCCAATT GCCCTCTTGA CAATAATGTT TGAGGCTATG 
TGGCCCCTCC CACTTGTTCT ATGTCCTGCC TGGTTATTTC TTGACGTTCT CTTTTCAACC 
GCATCCATCA TGCATCTCTG TGCCATTTCA GTGGATCGTT ACATAGCCAT CAAAAAGCCA 
ATCCAGGCCA ATCAATATAA CTCACGGGCT ACAGCATTCA TCAAGATTAC AGTGGTGTGG 
TTAATTTCAA TAGGCATTGC CATTCCAGTC CCTATTAAAG GGATAGAGAC TGATGTGGAC 
AACCCAAACA ATATCACTTG TGTGCTGACA AAGGAACGTT TTGGCGATTT CATGCTCTTT 
GGCTCACTGG CTGCCTTCTT CACACCTCTT GCAATTATGA TTGTCACCTA CTTTCTCACT 
ATCCATGCTT TACAGAAGAA GGCTTACTTA GTCAAAAACA AGCCACCTCA ACGCCTAACA 
TGGTTGACTG TGTCTACAGT TTTCCAAAGG GATGAAACAC CTTGCTCGTC ACCGGAAAAG 
GTGGCAATGC TGGATGGTTC TCGAAAGGAC AAGGCTCTGC CCAACTCAGG TGATGAAACA 
CTTATGCGAA GAACATCCAC AATTGGGAAA AAGTCAGTGC AGACCATTTC CAACGAACAG 
AGAGCCTCAA AGGTCCTAGG GATTGTGTTT TTCCTCTTTT TGCTTATGTG GTGTCCCTTC 
TTTATTACAA ATATAACTTT AGTTTTATGT GATTCCTGTA ACCAAACTAC TCTCCAAATG 
CTCCTGGAGA TATTTGTGTG GATAGGCTAT GTTTCCTCAG GAGTGAATCC TTTGGTCTAC 
ACCCTCTTCA ATAAGACATT TCGGGATGCA TTTGGCCGAT ATATCACCTG CAATTACCGG 
GCCACAAAGT CAGTAAAAAC TCTCAGAAAA CGCTCCAGTA AGATCTACTT CCGGAATCCA 
ATGGCAGAGA ACTCTAAGTT TTTCAAGAAA CATGGAATTC GAAATGGGAT TAACCCTGCC 
ATGTACCAGA GTCCAATGAG GCTCCGAAGT TCAACCATTC AGTCTTCATC AATCATTCTA 
CTAGATACGC TTCTCCTCAC TGAAAATGAA GGTGACAAAA CTGAAGAGCA AGTTAGTTAT 
GTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTR2B ( NM_001320758.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001307687.1 Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu58336
Clone ID Related Accession (Same CDS sequence)	NM_001320758.2 , NM_001320758.1
Accession Version	NM_001320758.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1320bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	5-hydroxytryptamine receptor 2B isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC063123.1, AC009407.8 and X77307.1. On May 31, 2019 this sequence version replaced NM_001320758.1. Transcript Variant: This variant (2) uses an alternate splice junction in the 5' end compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.226808.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAACAGA TTGTTGAGGA ACAGGGAAAT AAACTGCACT GGGCAGCTCT TCTGATACTC 
ATGGTGATAA TACCCACAAT TGGTGGAAAT ACCCTTGTTA TTCTGGCTGT TTCACTGGAG 
AAGAAGCTGC AGTATGCTAC TAATTACTTT CTAATGTCCT TGGCGGTGGC TGATTTGCTG 
GTTGGATTGT TTGTGATGCC AATTGCCCTC TTGACAATAA TGTTTGAGGC TATGTGGCCC 
CTCCCACTTG TTCTATGTCC TGCCTGGTTA TTTCTTGACG TTCTCTTTTC AACCGCATCC 
ATCATGCATC TCTGTGCCAT TTCAGTGGAT CGTTACATAG CCATCAAAAA GCCAATCCAG 
GCCAATCAAT ATAACTCACG GGCTACAGCA TTCATCAAGA TTACAGTGGT GTGGTTAATT 
TCAATAGGCA TTGCCATTCC AGTCCCTATT AAAGGGATAG AGACTGATGT GGACAACCCA 
AACAATATCA CTTGTGTGCT GACAAAGGAA CGTTTTGGCG ATTTCATGCT CTTTGGCTCA 
CTGGCTGCCT TCTTCACACC TCTTGCAATT ATGATTGTCA CCTACTTTCT CACTATCCAT 
GCTTTACAGA AGAAGGCTTA CTTAGTCAAA AACAAGCCAC CTCAACGCCT AACATGGTTG 
ACTGTGTCTA CAGTTTTCCA AAGGGATGAA ACACCTTGCT CGTCACCGGA AAAGGTGGCA 
ATGCTGGATG GTTCTCGAAA GGACAAGGCT CTGCCCAACT CAGGTGATGA AACACTTATG 
CGAAGAACAT CCACAATTGG GAAAAAGTCA GTGCAGACCA TTTCCAACGA ACAGAGAGCC 
TCAAAGGTCC TAGGGATTGT GTTTTTCCTC TTTTTGCTTA TGTGGTGTCC CTTCTTTATT 
ACAAATATAA CTTTAGTTTT ATGTGATTCC TGTAACCAAA CTACTCTCCA AATGCTCCTG 
GAGATATTTG TGTGGATAGG CTATGTTTCC TCAGGAGTGA ATCCTTTGGT CTACACCCTC 
TTCAATAAGA CATTTCGGGA TGCATTTGGC CGATATATCA CCTGCAATTA CCGGGCCACA 
AAGTCAGTAA AAACTCTCAG AAAACGCTCC AGTAAGATCT ACTTCCGGAA TCCAATGGCA 
GAGAACTCTA AGTTTTTCAA GAAACATGGA ATTCGAAATG GGATTAACCC TGCCATGTAC 
CAGAGTCCAA TGAGGCTCCG AAGTTCAACC ATTCAGTCTT CATCAATCAT TCTACTAGAT 
ACGCTTCTCC TCACTGAAAA TGAAGGTGAC AAAACTGAAG AGCAAGTTAG TTATGTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001307687.1
CDS	181..1500
Translation	MKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV

Target ORF information:

RefSeq Version	NM_001320758.2
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001320758.2

ORF Insert Sequence:

ATGAAACAGA TTGTTGAGGA ACAGGGAAAT AAACTGCACT GGGCAGCTCT TCTGATACTC 
ATGGTGATAA TACCCACAAT TGGTGGAAAT ACCCTTGTTA TTCTGGCTGT TTCACTGGAG 
AAGAAGCTGC AGTATGCTAC TAATTACTTT CTAATGTCCT TGGCGGTGGC TGATTTGCTG 
GTTGGATTGT TTGTGATGCC AATTGCCCTC TTGACAATAA TGTTTGAGGC TATGTGGCCC 
CTCCCACTTG TTCTATGTCC TGCCTGGTTA TTTCTTGACG TTCTCTTTTC AACCGCATCC 
ATCATGCATC TCTGTGCCAT TTCAGTGGAT CGTTACATAG CCATCAAAAA GCCAATCCAG 
GCCAATCAAT ATAACTCACG GGCTACAGCA TTCATCAAGA TTACAGTGGT GTGGTTAATT 
TCAATAGGCA TTGCCATTCC AGTCCCTATT AAAGGGATAG AGACTGATGT GGACAACCCA 
AACAATATCA CTTGTGTGCT GACAAAGGAA CGTTTTGGCG ATTTCATGCT CTTTGGCTCA 
CTGGCTGCCT TCTTCACACC TCTTGCAATT ATGATTGTCA CCTACTTTCT CACTATCCAT 
GCTTTACAGA AGAAGGCTTA CTTAGTCAAA AACAAGCCAC CTCAACGCCT AACATGGTTG 
ACTGTGTCTA CAGTTTTCCA AAGGGATGAA ACACCTTGCT CGTCACCGGA AAAGGTGGCA 
ATGCTGGATG GTTCTCGAAA GGACAAGGCT CTGCCCAACT CAGGTGATGA AACACTTATG 
CGAAGAACAT CCACAATTGG GAAAAAGTCA GTGCAGACCA TTTCCAACGA ACAGAGAGCC 
TCAAAGGTCC TAGGGATTGT GTTTTTCCTC TTTTTGCTTA TGTGGTGTCC CTTCTTTATT 
ACAAATATAA CTTTAGTTTT ATGTGATTCC TGTAACCAAA CTACTCTCCA AATGCTCCTG 
GAGATATTTG TGTGGATAGG CTATGTTTCC TCAGGAGTGA ATCCTTTGGT CTACACCCTC 
TTCAATAAGA CATTTCGGGA TGCATTTGGC CGATATATCA CCTGCAATTA CCGGGCCACA 
AAGTCAGTAA AAACTCTCAG AAAACGCTCC AGTAAGATCT ACTTCCGGAA TCCAATGGCA 
GAGAACTCTA AGTTTTTCAA GAAACATGGA ATTCGAAATG GGATTAACCC TGCCATGTAC 
CAGAGTCCAA TGAGGCTCCG AAGTTCAACC ATTCAGTCTT CATCAATCAT TCTACTAGAT 
ACGCTTCTCC TCACTGAAAA TGAAGGTGAC AAAACTGAAG AGCAAGTTAG TTATGTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTR2B ( NM_001320758.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001307687.1 Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu58336
Clone ID Related Accession (Same CDS sequence)	NM_001320758.2 , NM_001320758.1
Accession Version	NM_001320758.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1320bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	5-hydroxytryptamine receptor 2B isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC063123.1, AC009407.8 and X77307.1. On Mar 4, 2016 this sequence version replaced XM_011511073.1. Transcript Variant: This variant (2) uses an alternate splice junction in the 5' end compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.226808.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAACAGA TTGTTGAGGA ACAGGGAAAT AAACTGCACT GGGCAGCTCT TCTGATACTC 
ATGGTGATAA TACCCACAAT TGGTGGAAAT ACCCTTGTTA TTCTGGCTGT TTCACTGGAG 
AAGAAGCTGC AGTATGCTAC TAATTACTTT CTAATGTCCT TGGCGGTGGC TGATTTGCTG 
GTTGGATTGT TTGTGATGCC AATTGCCCTC TTGACAATAA TGTTTGAGGC TATGTGGCCC 
CTCCCACTTG TTCTATGTCC TGCCTGGTTA TTTCTTGACG TTCTCTTTTC AACCGCATCC 
ATCATGCATC TCTGTGCCAT TTCAGTGGAT CGTTACATAG CCATCAAAAA GCCAATCCAG 
GCCAATCAAT ATAACTCACG GGCTACAGCA TTCATCAAGA TTACAGTGGT GTGGTTAATT 
TCAATAGGCA TTGCCATTCC AGTCCCTATT AAAGGGATAG AGACTGATGT GGACAACCCA 
AACAATATCA CTTGTGTGCT GACAAAGGAA CGTTTTGGCG ATTTCATGCT CTTTGGCTCA 
CTGGCTGCCT TCTTCACACC TCTTGCAATT ATGATTGTCA CCTACTTTCT CACTATCCAT 
GCTTTACAGA AGAAGGCTTA CTTAGTCAAA AACAAGCCAC CTCAACGCCT AACATGGTTG 
ACTGTGTCTA CAGTTTTCCA AAGGGATGAA ACACCTTGCT CGTCACCGGA AAAGGTGGCA 
ATGCTGGATG GTTCTCGAAA GGACAAGGCT CTGCCCAACT CAGGTGATGA AACACTTATG 
CGAAGAACAT CCACAATTGG GAAAAAGTCA GTGCAGACCA TTTCCAACGA ACAGAGAGCC 
TCAAAGGTCC TAGGGATTGT GTTTTTCCTC TTTTTGCTTA TGTGGTGTCC CTTCTTTATT 
ACAAATATAA CTTTAGTTTT ATGTGATTCC TGTAACCAAA CTACTCTCCA AATGCTCCTG 
GAGATATTTG TGTGGATAGG CTATGTTTCC TCAGGAGTGA ATCCTTTGGT CTACACCCTC 
TTCAATAAGA CATTTCGGGA TGCATTTGGC CGATATATCA CCTGCAATTA CCGGGCCACA 
AAGTCAGTAA AAACTCTCAG AAAACGCTCC AGTAAGATCT ACTTCCGGAA TCCAATGGCA 
GAGAACTCTA AGTTTTTCAA GAAACATGGA ATTCGAAATG GGATTAACCC TGCCATGTAC 
CAGAGTCCAA TGAGGCTCCG AAGTTCAACC ATTCAGTCTT CATCAATCAT TCTACTAGAT 
ACGCTTCTCC TCACTGAAAA TGAAGGTGAC AAAACTGAAG AGCAAGTTAG TTATGTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001307687.1
CDS	249..1568
Translation	MKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV

Target ORF information:

RefSeq Version	NM_001320758.1
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001320758.1

ORF Insert Sequence:

ATGAAACAGA TTGTTGAGGA ACAGGGAAAT AAACTGCACT GGGCAGCTCT TCTGATACTC 
ATGGTGATAA TACCCACAAT TGGTGGAAAT ACCCTTGTTA TTCTGGCTGT TTCACTGGAG 
AAGAAGCTGC AGTATGCTAC TAATTACTTT CTAATGTCCT TGGCGGTGGC TGATTTGCTG 
GTTGGATTGT TTGTGATGCC AATTGCCCTC TTGACAATAA TGTTTGAGGC TATGTGGCCC 
CTCCCACTTG TTCTATGTCC TGCCTGGTTA TTTCTTGACG TTCTCTTTTC AACCGCATCC 
ATCATGCATC TCTGTGCCAT TTCAGTGGAT CGTTACATAG CCATCAAAAA GCCAATCCAG 
GCCAATCAAT ATAACTCACG GGCTACAGCA TTCATCAAGA TTACAGTGGT GTGGTTAATT 
TCAATAGGCA TTGCCATTCC AGTCCCTATT AAAGGGATAG AGACTGATGT GGACAACCCA 
AACAATATCA CTTGTGTGCT GACAAAGGAA CGTTTTGGCG ATTTCATGCT CTTTGGCTCA 
CTGGCTGCCT TCTTCACACC TCTTGCAATT ATGATTGTCA CCTACTTTCT CACTATCCAT 
GCTTTACAGA AGAAGGCTTA CTTAGTCAAA AACAAGCCAC CTCAACGCCT AACATGGTTG 
ACTGTGTCTA CAGTTTTCCA AAGGGATGAA ACACCTTGCT CGTCACCGGA AAAGGTGGCA 
ATGCTGGATG GTTCTCGAAA GGACAAGGCT CTGCCCAACT CAGGTGATGA AACACTTATG 
CGAAGAACAT CCACAATTGG GAAAAAGTCA GTGCAGACCA TTTCCAACGA ACAGAGAGCC 
TCAAAGGTCC TAGGGATTGT GTTTTTCCTC TTTTTGCTTA TGTGGTGTCC CTTCTTTATT 
ACAAATATAA CTTTAGTTTT ATGTGATTCC TGTAACCAAA CTACTCTCCA AATGCTCCTG 
GAGATATTTG TGTGGATAGG CTATGTTTCC TCAGGAGTGA ATCCTTTGGT CTACACCCTC 
TTCAATAAGA CATTTCGGGA TGCATTTGGC CGATATATCA CCTGCAATTA CCGGGCCACA 
AAGTCAGTAA AAACTCTCAG AAAACGCTCC AGTAAGATCT ACTTCCGGAA TCCAATGGCA 
GAGAACTCTA AGTTTTTCAA GAAACATGGA ATTCGAAATG GGATTAACCC TGCCATGTAC 
CAGAGTCCAA TGAGGCTCCG AAGTTCAACC ATTCAGTCTT CATCAATCAT TCTACTAGAT 
ACGCTTCTCC TCACTGAAAA TGAAGGTGAC AAAACTGAAG AGCAAGTTAG TTATGTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTR2B ( XM_005246520.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005246577.1 Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu36183
Clone ID Related Accession (Same CDS sequence)	XM_005246520.3 , XM_005246520.4
Accession Version	XM_005246520.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1089bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	5-hydroxytryptamine receptor 2B isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005246520.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGCCCC TCCCACTTGT TCTATGTCCT GCCTGGTTAT TTCTTGACGT TCTCTTTTCA 
ACCGCATCCA TCATGCATCT CTGTGCCATT TCAGTGGATC GTTACATAGC CATCAAAAAG 
CCAATCCAGG CCAATCAATA TAACTCACGG GCTACAGCAT TCATCAAGAT TACAGTGGTG 
TGGTTAATTT CAATAGGCAT TGCCATTCCA GTCCCTATTA AAGGGATAGA GACTGATGTG 
GACAACCCAA ACAATATCAC TTGTGTGCTG ACAAAGGAAC GTTTTGGCGA TTTCATGCTC 
TTTGGCTCAC TGGCTGCCTT CTTCACACCT CTTGCAATTA TGATTGTCAC CTACTTTCTC 
ACTATCCATG CTTTACAGAA GAAGGCTTAC TTAGTCAAAA ACAAGCCACC TCAACGCCTA 
ACATGGTTGA CTGTGTCTAC AGTTTTCCAA AGGGATGAAA CACCTTGCTC GTCACCGGAA 
AAGGTGGCAA TGCTGGATGG TTCTCGAAAG GACAAGGCTC TGCCCAACTC AGGTGATGAA 
ACACTTATGC GAAGAACATC CACAATTGGG AAAAAGTCAG TGCAGACCAT TTCCAACGAA 
CAGAGAGCCT CAAAGGTCCT AGGGATTGTG TTTTTCCTCT TTTTGCTTAT GTGGTGTCCC 
TTCTTTATTA CAAATATAAC TTTAGTTTTA TGTGATTCCT GTAACCAAAC TACTCTCCAA 
ATGCTCCTGG AGATATTTGT GTGGATAGGC TATGTTTCCT CAGGAGTGAA TCCTTTGGTC 
TACACCCTCT TCAATAAGAC ATTTCGGGAT GCATTTGGCC GATATATCAC CTGCAATTAC 
CGGGCCACAA AGTCAGTAAA AACTCTCAGA AAACGCTCCA GTAAGATCTA CTTCCGGAAT 
CCAATGGCAG AGAACTCTAA GTTTTTCAAG AAACATGGAA TTCGAAATGG GATTAACCCT 
GCCATGTACC AGAGTCCAAT GAGGCTCCGA AGTTCAACCA TTCAGTCTTC ATCAATCATT 
CTACTAGATA CGCTTCTCCT CACTGAAAAT GAAGGTGACA AAACTGAAGA GCAAGTTAGT 
TATGTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005246577.1
CDS	813..1901
Translation	MWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV

Target ORF information:

RefSeq Version	XM_005246520.3
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005246520.3

ORF Insert Sequence:

ATGTGGCCCC TCCCACTTGT TCTATGTCCT GCCTGGTTAT TTCTTGACGT TCTCTTTTCA 
ACCGCATCCA TCATGCATCT CTGTGCCATT TCAGTGGATC GTTACATAGC CATCAAAAAG 
CCAATCCAGG CCAATCAATA TAACTCACGG GCTACAGCAT TCATCAAGAT TACAGTGGTG 
TGGTTAATTT CAATAGGCAT TGCCATTCCA GTCCCTATTA AAGGGATAGA GACTGATGTG 
GACAACCCAA ACAATATCAC TTGTGTGCTG ACAAAGGAAC GTTTTGGCGA TTTCATGCTC 
TTTGGCTCAC TGGCTGCCTT CTTCACACCT CTTGCAATTA TGATTGTCAC CTACTTTCTC 
ACTATCCATG CTTTACAGAA GAAGGCTTAC TTAGTCAAAA ACAAGCCACC TCAACGCCTA 
ACATGGTTGA CTGTGTCTAC AGTTTTCCAA AGGGATGAAA CACCTTGCTC GTCACCGGAA 
AAGGTGGCAA TGCTGGATGG TTCTCGAAAG GACAAGGCTC TGCCCAACTC AGGTGATGAA 
ACACTTATGC GAAGAACATC CACAATTGGG AAAAAGTCAG TGCAGACCAT TTCCAACGAA 
CAGAGAGCCT CAAAGGTCCT AGGGATTGTG TTTTTCCTCT TTTTGCTTAT GTGGTGTCCC 
TTCTTTATTA CAAATATAAC TTTAGTTTTA TGTGATTCCT GTAACCAAAC TACTCTCCAA 
ATGCTCCTGG AGATATTTGT GTGGATAGGC TATGTTTCCT CAGGAGTGAA TCCTTTGGTC 
TACACCCTCT TCAATAAGAC ATTTCGGGAT GCATTTGGCC GATATATCAC CTGCAATTAC 
CGGGCCACAA AGTCAGTAAA AACTCTCAGA AAACGCTCCA GTAAGATCTA CTTCCGGAAT 
CCAATGGCAG AGAACTCTAA GTTTTTCAAG AAACATGGAA TTCGAAATGG GATTAACCCT 
GCCATGTACC AGAGTCCAAT GAGGCTCCGA AGTTCAACCA TTCAGTCTTC ATCAATCATT 
CTACTAGATA CGCTTCTCCT CACTGAAAAT GAAGGTGACA AAACTGAAGA GCAAGTTAGT 
TATGTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTR2B ( XM_005246520.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005246577.1 Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu36183
Clone ID Related Accession (Same CDS sequence)	XM_005246520.3 , XM_005246520.4
Accession Version	XM_005246520.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1089bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	5-hydroxytryptamine receptor 2B isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005246520.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGCCCC TCCCACTTGT TCTATGTCCT GCCTGGTTAT TTCTTGACGT TCTCTTTTCA 
ACCGCATCCA TCATGCATCT CTGTGCCATT TCAGTGGATC GTTACATAGC CATCAAAAAG 
CCAATCCAGG CCAATCAATA TAACTCACGG GCTACAGCAT TCATCAAGAT TACAGTGGTG 
TGGTTAATTT CAATAGGCAT TGCCATTCCA GTCCCTATTA AAGGGATAGA GACTGATGTG 
GACAACCCAA ACAATATCAC TTGTGTGCTG ACAAAGGAAC GTTTTGGCGA TTTCATGCTC 
TTTGGCTCAC TGGCTGCCTT CTTCACACCT CTTGCAATTA TGATTGTCAC CTACTTTCTC 
ACTATCCATG CTTTACAGAA GAAGGCTTAC TTAGTCAAAA ACAAGCCACC TCAACGCCTA 
ACATGGTTGA CTGTGTCTAC AGTTTTCCAA AGGGATGAAA CACCTTGCTC GTCACCGGAA 
AAGGTGGCAA TGCTGGATGG TTCTCGAAAG GACAAGGCTC TGCCCAACTC AGGTGATGAA 
ACACTTATGC GAAGAACATC CACAATTGGG AAAAAGTCAG TGCAGACCAT TTCCAACGAA 
CAGAGAGCCT CAAAGGTCCT AGGGATTGTG TTTTTCCTCT TTTTGCTTAT GTGGTGTCCC 
TTCTTTATTA CAAATATAAC TTTAGTTTTA TGTGATTCCT GTAACCAAAC TACTCTCCAA 
ATGCTCCTGG AGATATTTGT GTGGATAGGC TATGTTTCCT CAGGAGTGAA TCCTTTGGTC 
TACACCCTCT TCAATAAGAC ATTTCGGGAT GCATTTGGCC GATATATCAC CTGCAATTAC 
CGGGCCACAA AGTCAGTAAA AACTCTCAGA AAACGCTCCA GTAAGATCTA CTTCCGGAAT 
CCAATGGCAG AGAACTCTAA GTTTTTCAAG AAACATGGAA TTCGAAATGG GATTAACCCT 
GCCATGTACC AGAGTCCAAT GAGGCTCCGA AGTTCAACCA TTCAGTCTTC ATCAATCATT 
CTACTAGATA CGCTTCTCCT CACTGAAAAT GAAGGTGACA AAACTGAAGA GCAAGTTAGT 
TATGTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005246577.1
CDS	1207..2295
Translation	MWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV

Target ORF information:

RefSeq Version	XM_005246520.4
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005246520.4

ORF Insert Sequence:

ATGTGGCCCC TCCCACTTGT TCTATGTCCT GCCTGGTTAT TTCTTGACGT TCTCTTTTCA 
ACCGCATCCA TCATGCATCT CTGTGCCATT TCAGTGGATC GTTACATAGC CATCAAAAAG 
CCAATCCAGG CCAATCAATA TAACTCACGG GCTACAGCAT TCATCAAGAT TACAGTGGTG 
TGGTTAATTT CAATAGGCAT TGCCATTCCA GTCCCTATTA AAGGGATAGA GACTGATGTG 
GACAACCCAA ACAATATCAC TTGTGTGCTG ACAAAGGAAC GTTTTGGCGA TTTCATGCTC 
TTTGGCTCAC TGGCTGCCTT CTTCACACCT CTTGCAATTA TGATTGTCAC CTACTTTCTC 
ACTATCCATG CTTTACAGAA GAAGGCTTAC TTAGTCAAAA ACAAGCCACC TCAACGCCTA 
ACATGGTTGA CTGTGTCTAC AGTTTTCCAA AGGGATGAAA CACCTTGCTC GTCACCGGAA 
AAGGTGGCAA TGCTGGATGG TTCTCGAAAG GACAAGGCTC TGCCCAACTC AGGTGATGAA 
ACACTTATGC GAAGAACATC CACAATTGGG AAAAAGTCAG TGCAGACCAT TTCCAACGAA 
CAGAGAGCCT CAAAGGTCCT AGGGATTGTG TTTTTCCTCT TTTTGCTTAT GTGGTGTCCC 
TTCTTTATTA CAAATATAAC TTTAGTTTTA TGTGATTCCT GTAACCAAAC TACTCTCCAA 
ATGCTCCTGG AGATATTTGT GTGGATAGGC TATGTTTCCT CAGGAGTGAA TCCTTTGGTC 
TACACCCTCT TCAATAAGAC ATTTCGGGAT GCATTTGGCC GATATATCAC CTGCAATTAC 
CGGGCCACAA AGTCAGTAAA AACTCTCAGA AAACGCTCCA GTAAGATCTA CTTCCGGAAT 
CCAATGGCAG AGAACTCTAA GTTTTTCAAG AAACATGGAA TTCGAAATGG GATTAACCCT 
GCCATGTACC AGAGTCCAAT GAGGCTCCGA AGTTCAACCA TTCAGTCTTC ATCAATCATT 
CTACTAGATA CGCTTCTCCT CACTGAAAAT GAAGGTGACA AAACTGAAGA GCAAGTTAGT 
TATGTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTR2B ( XM_006712482.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006712545.1 Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu36182
Clone ID Related Accession (Same CDS sequence)	XM_006712482.3 , XM_006712482.2
Accession Version	XM_006712482.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1371bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	5-hydroxytryptamine receptor 2B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_006712482.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCAGCA AAATAACAAC GAAACCAGAG ACAGAATCAA TACCAGAGGA AATGAAACAG 
ATTGTTGAGG AACAGGGAAA TAAACTGCAC TGGGCAGCTC TTCTGATACT CATGGTGATA 
ATACCCACAA TTGGTGGAAA TACCCTTGTT ATTCTGGCTG TTTCACTGGA GAAGAAGCTG 
CAGTATGCTA CTAATTACTT TCTAATGTCC TTGGCGGTGG CTGATTTGCT GGTTGGATTG 
TTTGTGATGC CAATTGCCCT CTTGACAATA ATGTTTGAGG CTATGTGGCC CCTCCCACTT 
GTTCTATGTC CTGCCTGGTT ATTTCTTGAC GTTCTCTTTT CAACCGCATC CATCATGCAT 
CTCTGTGCCA TTTCAGTGGA TCGTTACATA GCCATCAAAA AGCCAATCCA GGCCAATCAA 
TATAACTCAC GGGCTACAGC ATTCATCAAG ATTACAGTGG TGTGGTTAAT TTCAATAGGC 
ATTGCCATTC CAGTCCCTAT TAAAGGGATA GAGACTGATG TGGACAACCC AAACAATATC 
ACTTGTGTGC TGACAAAGGA ACGTTTTGGC GATTTCATGC TCTTTGGCTC ACTGGCTGCC 
TTCTTCACAC CTCTTGCAAT TATGATTGTC ACCTACTTTC TCACTATCCA TGCTTTACAG 
AAGAAGGCTT ACTTAGTCAA AAACAAGCCA CCTCAACGCC TAACATGGTT GACTGTGTCT 
ACAGTTTTCC AAAGGGATGA AACACCTTGC TCGTCACCGG AAAAGGTGGC AATGCTGGAT 
GGTTCTCGAA AGGACAAGGC TCTGCCCAAC TCAGGTGATG AAACACTTAT GCGAAGAACA 
TCCACAATTG GGAAAAAGTC AGTGCAGACC ATTTCCAACG AACAGAGAGC CTCAAAGGTC 
CTAGGGATTG TGTTTTTCCT CTTTTTGCTT ATGTGGTGTC CCTTCTTTAT TACAAATATA 
ACTTTAGTTT TATGTGATTC CTGTAACCAA ACTACTCTCC AAATGCTCCT GGAGATATTT 
GTGTGGATAG GCTATGTTTC CTCAGGAGTG AATCCTTTGG TCTACACCCT CTTCAATAAG 
ACATTTCGGG ATGCATTTGG CCGATATATC ACCTGCAATT ACCGGGCCAC AAAGTCAGTA 
AAAACTCTCA GAAAACGCTC CAGTAAGATC TACTTCCGGA ATCCAATGGC AGAGAACTCT 
AAGTTTTTCA AGAAACATGG AATTCGAAAT GGGATTAACC CTGCCATGTA CCAGAGTCCA 
ATGAGGCTCC GAAGTTCAAC CATTCAGTCT TCATCAATCA TTCTACTAGA TACGCTTCTC 
CTCACTGAAA ATGAAGGTGA CAAAACTGAA GAGCAAGTTA GTTATGTATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006712545.1
CDS	1172..2542
Translation	MLSKITTKPETESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV

Target ORF information:

RefSeq Version	XM_006712482.3
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006712482.3

ORF Insert Sequence:

ATGCTCAGCA AAATAACAAC GAAACCAGAG ACAGAATCAA TACCAGAGGA AATGAAACAG 
ATTGTTGAGG AACAGGGAAA TAAACTGCAC TGGGCAGCTC TTCTGATACT CATGGTGATA 
ATACCCACAA TTGGTGGAAA TACCCTTGTT ATTCTGGCTG TTTCACTGGA GAAGAAGCTG 
CAGTATGCTA CTAATTACTT TCTAATGTCC TTGGCGGTGG CTGATTTGCT GGTTGGATTG 
TTTGTGATGC CAATTGCCCT CTTGACAATA ATGTTTGAGG CTATGTGGCC CCTCCCACTT 
GTTCTATGTC CTGCCTGGTT ATTTCTTGAC GTTCTCTTTT CAACCGCATC CATCATGCAT 
CTCTGTGCCA TTTCAGTGGA TCGTTACATA GCCATCAAAA AGCCAATCCA GGCCAATCAA 
TATAACTCAC GGGCTACAGC ATTCATCAAG ATTACAGTGG TGTGGTTAAT TTCAATAGGC 
ATTGCCATTC CAGTCCCTAT TAAAGGGATA GAGACTGATG TGGACAACCC AAACAATATC 
ACTTGTGTGC TGACAAAGGA ACGTTTTGGC GATTTCATGC TCTTTGGCTC ACTGGCTGCC 
TTCTTCACAC CTCTTGCAAT TATGATTGTC ACCTACTTTC TCACTATCCA TGCTTTACAG 
AAGAAGGCTT ACTTAGTCAA AAACAAGCCA CCTCAACGCC TAACATGGTT GACTGTGTCT 
ACAGTTTTCC AAAGGGATGA AACACCTTGC TCGTCACCGG AAAAGGTGGC AATGCTGGAT 
GGTTCTCGAA AGGACAAGGC TCTGCCCAAC TCAGGTGATG AAACACTTAT GCGAAGAACA 
TCCACAATTG GGAAAAAGTC AGTGCAGACC ATTTCCAACG AACAGAGAGC CTCAAAGGTC 
CTAGGGATTG TGTTTTTCCT CTTTTTGCTT ATGTGGTGTC CCTTCTTTAT TACAAATATA 
ACTTTAGTTT TATGTGATTC CTGTAACCAA ACTACTCTCC AAATGCTCCT GGAGATATTT 
GTGTGGATAG GCTATGTTTC CTCAGGAGTG AATCCTTTGG TCTACACCCT CTTCAATAAG 
ACATTTCGGG ATGCATTTGG CCGATATATC ACCTGCAATT ACCGGGCCAC AAAGTCAGTA 
AAAACTCTCA GAAAACGCTC CAGTAAGATC TACTTCCGGA ATCCAATGGC AGAGAACTCT 
AAGTTTTTCA AGAAACATGG AATTCGAAAT GGGATTAACC CTGCCATGTA CCAGAGTCCA 
ATGAGGCTCC GAAGTTCAAC CATTCAGTCT TCATCAATCA TTCTACTAGA TACGCTTCTC 
CTCACTGAAA ATGAAGGTGA CAAAACTGAA GAGCAAGTTA GTTATGTATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTR2B ( XM_006712482.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_006712545.1 Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant X1, mRNA.

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CloneID	OHu36182
Clone ID Related Accession (Same CDS sequence)	XM_006712482.3 , XM_006712482.2
Accession Version	XM_006712482.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1371bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	5-hydroxytryptamine receptor 2B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_006712482.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCAGCA AAATAACAAC GAAACCAGAG ACAGAATCAA TACCAGAGGA AATGAAACAG 
ATTGTTGAGG AACAGGGAAA TAAACTGCAC TGGGCAGCTC TTCTGATACT CATGGTGATA 
ATACCCACAA TTGGTGGAAA TACCCTTGTT ATTCTGGCTG TTTCACTGGA GAAGAAGCTG 
CAGTATGCTA CTAATTACTT TCTAATGTCC TTGGCGGTGG CTGATTTGCT GGTTGGATTG 
TTTGTGATGC CAATTGCCCT CTTGACAATA ATGTTTGAGG CTATGTGGCC CCTCCCACTT 
GTTCTATGTC CTGCCTGGTT ATTTCTTGAC GTTCTCTTTT CAACCGCATC CATCATGCAT 
CTCTGTGCCA TTTCAGTGGA TCGTTACATA GCCATCAAAA AGCCAATCCA GGCCAATCAA 
TATAACTCAC GGGCTACAGC ATTCATCAAG ATTACAGTGG TGTGGTTAAT TTCAATAGGC 
ATTGCCATTC CAGTCCCTAT TAAAGGGATA GAGACTGATG TGGACAACCC AAACAATATC 
ACTTGTGTGC TGACAAAGGA ACGTTTTGGC GATTTCATGC TCTTTGGCTC ACTGGCTGCC 
TTCTTCACAC CTCTTGCAAT TATGATTGTC ACCTACTTTC TCACTATCCA TGCTTTACAG 
AAGAAGGCTT ACTTAGTCAA AAACAAGCCA CCTCAACGCC TAACATGGTT GACTGTGTCT 
ACAGTTTTCC AAAGGGATGA AACACCTTGC TCGTCACCGG AAAAGGTGGC AATGCTGGAT 
GGTTCTCGAA AGGACAAGGC TCTGCCCAAC TCAGGTGATG AAACACTTAT GCGAAGAACA 
TCCACAATTG GGAAAAAGTC AGTGCAGACC ATTTCCAACG AACAGAGAGC CTCAAAGGTC 
CTAGGGATTG TGTTTTTCCT CTTTTTGCTT ATGTGGTGTC CCTTCTTTAT TACAAATATA 
ACTTTAGTTT TATGTGATTC CTGTAACCAA ACTACTCTCC AAATGCTCCT GGAGATATTT 
GTGTGGATAG GCTATGTTTC CTCAGGAGTG AATCCTTTGG TCTACACCCT CTTCAATAAG 
ACATTTCGGG ATGCATTTGG CCGATATATC ACCTGCAATT ACCGGGCCAC AAAGTCAGTA 
AAAACTCTCA GAAAACGCTC CAGTAAGATC TACTTCCGGA ATCCAATGGC AGAGAACTCT 
AAGTTTTTCA AGAAACATGG AATTCGAAAT GGGATTAACC CTGCCATGTA CCAGAGTCCA 
ATGAGGCTCC GAAGTTCAAC CATTCAGTCT TCATCAATCA TTCTACTAGA TACGCTTCTC 
CTCACTGAAA ATGAAGGTGA CAAAACTGAA GAGCAAGTTA GTTATGTATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006712545.1
CDS	778..2148
Translation	MLSKITTKPETESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV

Target ORF information:

RefSeq Version	XM_006712482.2
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-hydroxytryptamine receptor 2B (HTR2B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006712482.2

ORF Insert Sequence:

ATGCTCAGCA AAATAACAAC GAAACCAGAG ACAGAATCAA TACCAGAGGA AATGAAACAG 
ATTGTTGAGG AACAGGGAAA TAAACTGCAC TGGGCAGCTC TTCTGATACT CATGGTGATA 
ATACCCACAA TTGGTGGAAA TACCCTTGTT ATTCTGGCTG TTTCACTGGA GAAGAAGCTG 
CAGTATGCTA CTAATTACTT TCTAATGTCC TTGGCGGTGG CTGATTTGCT GGTTGGATTG 
TTTGTGATGC CAATTGCCCT CTTGACAATA ATGTTTGAGG CTATGTGGCC CCTCCCACTT 
GTTCTATGTC CTGCCTGGTT ATTTCTTGAC GTTCTCTTTT CAACCGCATC CATCATGCAT 
CTCTGTGCCA TTTCAGTGGA TCGTTACATA GCCATCAAAA AGCCAATCCA GGCCAATCAA 
TATAACTCAC GGGCTACAGC ATTCATCAAG ATTACAGTGG TGTGGTTAAT TTCAATAGGC 
ATTGCCATTC CAGTCCCTAT TAAAGGGATA GAGACTGATG TGGACAACCC AAACAATATC 
ACTTGTGTGC TGACAAAGGA ACGTTTTGGC GATTTCATGC TCTTTGGCTC ACTGGCTGCC 
TTCTTCACAC CTCTTGCAAT TATGATTGTC ACCTACTTTC TCACTATCCA TGCTTTACAG 
AAGAAGGCTT ACTTAGTCAA AAACAAGCCA CCTCAACGCC TAACATGGTT GACTGTGTCT 
ACAGTTTTCC AAAGGGATGA AACACCTTGC TCGTCACCGG AAAAGGTGGC AATGCTGGAT 
GGTTCTCGAA AGGACAAGGC TCTGCCCAAC TCAGGTGATG AAACACTTAT GCGAAGAACA 
TCCACAATTG GGAAAAAGTC AGTGCAGACC ATTTCCAACG AACAGAGAGC CTCAAAGGTC 
CTAGGGATTG TGTTTTTCCT CTTTTTGCTT ATGTGGTGTC CCTTCTTTAT TACAAATATA 
ACTTTAGTTT TATGTGATTC CTGTAACCAA ACTACTCTCC AAATGCTCCT GGAGATATTT 
GTGTGGATAG GCTATGTTTC CTCAGGAGTG AATCCTTTGG TCTACACCCT CTTCAATAAG 
ACATTTCGGG ATGCATTTGG CCGATATATC ACCTGCAATT ACCGGGCCAC AAAGTCAGTA 
AAAACTCTCA GAAAACGCTC CAGTAAGATC TACTTCCGGA ATCCAATGGC AGAGAACTCT 
AAGTTTTTCA AGAAACATGG AATTCGAAAT GGGATTAACC CTGCCATGTA CCAGAGTCCA 
ATGAGGCTCC GAAGTTCAAC CATTCAGTCT TCATCAATCA TTCTACTAGA TACGCTTCTC 
CTCACTGAAA ATGAAGGTGA CAAAACTGAA GAGCAAGTTA GTTATGTATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Serotonin receptor 2B signaling with interstitial cell activation and leaflet remodeling in degenerative mitral regurgitation.
Journal of molecular and cellular cardiology11594-103(2017 Dec)
Driesbaugh KH,Branchetti E,Grau JB,Keeney SJ,Glass K,Oyama MA,Rioux N,Ayoub S,Sacks MS,Quackenbush J,Levy RJ,Ferrari G

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HTR2B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

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Target ORF information:

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Target ORF information:

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