HTN3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HTN3
Entrez Gene ID	3347
Full Name	histatin 3
Synonyms	HIS2,HTN2,HTN5
General protein information	Preferred Names histatin 3 Names histatin-3 PB basic histidine-rich protein histatin-4 histatin-5 histatin-6 histatin-7 histatin-8 histatin-9 histidine-rich protein 3 hst
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q13.3
Summary	This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Sep 2014].
Disorder MIM:	142702

mRNA and Protein(s)

mRNA	Protein	Name
NM_000200.2	NP_000191.1	histatin-3 precursor
NM_000200.3	NP_000191.1	histatin-3 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	HTN3	NP_000191.1
Pan troglodytes (chimpanzee)	HTN3	XP_003950382.1

Gene Ontology
Bibliography

Related articles in PubMed

Histatin-5 induces the reversal of Pdr5p mediated fluconazole resistance in Saccharomyces?cerevisae.
da Rocha Curvelo JA, Reis de S? LF, Moraes DC, Soares RM, Ferreira-Pereira A
Journal de mycologie medicale(2017 Dec)

Specific Histidine Residues Confer Histatin Peptides with Copper-Dependent Activity against Candida albicans.
Conklin SE, Bridgman EC, Su Q, Riggs-Gelasco P, Haas KL, Franz KJ
Biochemistry56(32)4244-4255(2017 08)

Danger-recognizing proteins, ?-defensin-128 and histatin-3, as potential biomarkers of recurrent coronary events.
Ghatge M, Sharma A, Maity S, Kakkar VV, Vangala RK
International journal of molecular medicine40(2)531-538(2017 Aug)

Coarse-grained modeling of the intrinsically disordered protein Histatin 5 in solution: Monte Carlo simulations in combination with SAXS.
Cragnell C, Durand D, Cabane B, Skep? M
Proteins84(6)777-91(2016 06)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the availability of Cu during exposure of Candida albicans to histatin-5 (Hist-5) modulates its antifungal activity.
Title: Specific Histidine Residues Confer Histatin Peptides with Copper-Dependent Activity against Candida albicans.

The aim of this study was to achieve a molecular understanding and a physico-chemical insight of the obtained small angle X-ray scattering and to gain information of the conformational changes of Histatin 5 due to altering salt content, charge distribution, and net charge.
Title: Coarse-grained modeling of the intrinsically disordered protein Histatin 5 in solution: Monte Carlo simulations in combination with SAXS.

These findings provide further evidence that histatin 3 may be involved in the regulation of cell proliferation, particularly during G1/S transition, via the ubiquitin-proteasome system of p27(Kip1) and HSC70.
Title: Salivary protein histatin 3 regulates cell proliferation by enhancing p27(Kip1) and heat shock cognate protein 70 ubiquitination.

Histatin 5 Salivary Complexes
Title: In Vitro Identification of Histatin 5 Salivary Complexes.

High intensity of caries is associated with increased levels of some salivary components - sIgA, histatin-5 and lactoperoxidase.
Title: The assessment of sIgA, histatin-5, and lactoperoxidase levels in saliva of adolescents with dental caries.

The following HTN3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HTN3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19101	NM_000200.3 Latest version!	Homo sapiens histatin 3 (HTN3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu19101	NM_000200.2	Homo sapiens histatin 3 (HTN3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HTN3 ( NM_000200.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000191.1 Homo sapiens histatin 3 (HTN3), mRNA.

Price & Availability↑

CloneID	OHu19101
Clone ID Related Accession (Same CDS sequence)	NM_000200.2 , NM_000200.3
Accession Version	NM_000200.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 156bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-02
Organism	Homo sapiens(human)
Product	histatin-3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB957931.1, BC095438.1 and BP332860.1. This sequence is a reference standard in the RefSeqGene project. On May 28, 2009 this sequence version replaced NM_000200.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB957931.1, CB958532.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 2303595 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGAAGTTTT TTGTTTTTGC TTTAATCTTG GCTCTCATGC TTTCCATGAC TGGAGCTGAT 
TCACATGCAA AGAGACATCA TGGGTATAAA AGAAAATTCC ATGAAAAGCA TCATTCACAT 
CGAGGCTATA GATCAAATTA TCTGTATGAC AATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000191.1
CDS	118..273
Translation	MKFFVFALILALMLSMTGADSHAKRHHGYKRKFHEKHHSHRGYRSNYLYDN

Target ORF information:

RefSeq Version	NM_000200.2
Organism	Homo sapiens(human)
Definition	Homo sapiens histatin 3 (HTN3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000200.2

ORF Insert Sequence:

1
61
121

ATGAAGTTTT TTGTTTTTGC TTTAATCTTG GCTCTCATGC TTTCCATGAC TGGAGCTGAT 
TCACATGCAA AGAGACATCA TGGGTATAAA AGAAAATTCC ATGAAAAGCA TCATTCACAT 
CGAGGCTATA GATCAAATTA TCTGTATGAC AATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTN3 ( NM_000200.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000191.1 Homo sapiens histatin 3 (HTN3), mRNA.

Price & Availability↑

CloneID	OHu19101
Clone ID Related Accession (Same CDS sequence)	NM_000200.2 , NM_000200.3
Accession Version	NM_000200.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 156bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	histatin-3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC063956.7. This sequence is a reference standard in the RefSeqGene project. On Mar 12, 2019 this sequence version replaced NM_000200.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP332860.1, BP333327.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000673563.1/ ENSP00000500623.1 Protein has antimicrobial activity :: PMID: 2303595 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGAAGTTTT TTGTTTTTGC TTTAATCTTG GCTCTCATGC TTTCCATGAC TGGAGCTGAT 
TCACATGCAA AGAGACATCA TGGGTATAAA AGAAAATTCC ATGAAAAGCA TCATTCACAT 
CGAGGCTATA GATCAAATTA TCTGTATGAC AATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000191.1
CDS	72..227
Translation	MKFFVFALILALMLSMTGADSHAKRHHGYKRKFHEKHHSHRGYRSNYLYDN

Target ORF information:

RefSeq Version	NM_000200.3
Organism	Homo sapiens(human)
Definition	Homo sapiens histatin 3 (HTN3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000200.3

ORF Insert Sequence:

1
61
121

ATGAAGTTTT TTGTTTTTGC TTTAATCTTG GCTCTCATGC TTTCCATGAC TGGAGCTGAT 
TCACATGCAA AGAGACATCA TGGGTATAAA AGAAAATTCC ATGAAAAGCA TCATTCACAT 
CGAGGCTATA GATCAAATTA TCTGTATGAC AATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Histatin-5 induces the reversal of Pdr5p mediated fluconazole resistance in Saccharomyces?cerevisae.
Journal de mycologie medicale(2017 Dec)
da Rocha Curvelo JA,Reis de S? LF,Moraes DC,Soares RM,Ferreira-Pereira A

Specific Histidine Residues Confer Histatin Peptides with Copper-Dependent Activity against Candida albicans.
Biochemistry56(32)4244-4255(2017 08)
Conklin SE,Bridgman EC,Su Q,Riggs-Gelasco P,Haas KL,Franz KJ

Danger-recognizing proteins, ?-defensin-128 and histatin-3, as potential biomarkers of recurrent coronary events.
International journal of molecular medicine40(2)531-538(2017 Aug)
Ghatge M,Sharma A,Maity S,Kakkar VV,Vangala RK

Coarse-grained modeling of the intrinsically disordered protein Histatin 5 in solution: Monte Carlo simulations in combination with SAXS.
Proteins84(6)777-91(2016 06)
Cragnell C,Durand D,Cabane B,Skep? M

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HTN3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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