Gene Symbol | XIAP |
Entrez Gene ID | 331 |
Full Name | X-linked inhibitor of apoptosis |
Synonyms | API3,BIRC4,IAP-3,ILP1,MIHA,XLP2,hIAP-3,hIAP3 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]. |
Disorder MIM: | |
Disorder Html: | Lymphoproliferative syndrome, X-linked, 2, 300635 (3) |