HSPA1L cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HSPA1L
Entrez Gene ID	3305
Full Name	heat shock protein family A (Hsp70) member 1 like
Synonyms	HSP70-1L,HSP70-HOM,HSP70T,hum70t
General protein information	Preferred Names heat shock protein family A (Hsp70) member 1 like Names heat shock 70 kDa protein 1-like heat shock 10kDa protein 1-like heat shock 70 kDa protein 1-Hom heat shock 70 kDa protein 1L heat shock 70kD protein-like 1 heat shock 70kDa protein 1-like
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.33
Summary	This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008].
Disorder MIM:	140559

mRNA and Protein(s)

mRNA	Protein	Name
NM_005527.3	NP_005518.3	heat shock 70 kDa protein 1-like
NM_005527.4	NP_005518.3	heat shock 70 kDa protein 1-like

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	zgc:174006	XP_005163979.1
Saccharomyces cerevisiae (baker's yeast)	SSA2	NP_013076.1
Neurospora crassa	NCU09602	XP_963366.1
Canis lupus familiaris (dog)	HSPA1L	XP_005627220.1
Mus musculus (house mouse)	Hspa1l	NP_038586.2
Eremothecium gossypii	AGOS_AFR114W	NP_985661.1
Danio rerio (zebrafish)	si:ch211-199o1.2	NP_001093532.1
Danio rerio (zebrafish)	hsp70	NP_571472.1
Arabidopsis thaliana (thale cress)	Hsp70b	NP_173055.1
Pan troglodytes (chimpanzee)	HSPA1L	XP_001160137.2
Rattus norvegicus (Norway rat)	Hspa1l	NP_997711.1
Saccharomyces cerevisiae (baker's yeast)	SSA1	NP_009396.2
Magnaporthe oryzae (rice blast fungus)	MGG_06958	XP_003709704.1
Homo sapiens (human)	HSPA1L	NP_005518.3
	LOC716633	XP_002803717.1
Bos taurus (cattle)	HSPA1L	NP_001161367.1
Danio rerio (zebrafish)	hsp70.2	XP_003198158.1
Danio rerio (zebrafish)	hsp70l	NP_001107061.1
Kluyveromyces lactis	KLLA0D04224g	XP_453252.1
Schizosaccharomyces pombe (fission yeast)	ssa1	NP_593704.1
Schizosaccharomyces pombe (fission yeast)	ssa2	NP_588421.1

Gene Ontology
Bibliography

Related articles in PubMed

Role of HSPA1L as a cellular prion protein stabilizer in tumor progression via HIF-1?/GP78 axis.
Lee JH, Han YS, Yoon YM, Yun CW, Yun SP, Kim SM, Kwon HY, Jeong D, Baek MJ, Lee HJ, Lee SJ, Han HJ, Lee SH
Oncogene36(47)6555-6567(2017 Nov)

Integrated transcriptome and methylome analysis in youth at high risk for bipolar disorder: a preliminary analysis.
Fries GR, Quevedo J, Zeni CP, Kazimi IF, Zunta-Soares G, Spiker DE, Bowden CL, Walss-Bass C, Soares JC
Translational psychiatry7(3)e1059(2017 03)

[The genetic aspects of occupational hearing impairment].
Krasitskaya VV, Bashmakova EE, Dobretsov KG, Orlova NV, Frank LA
Vestnik otorinolaringologii82(5)71-76(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This is the first study to show that HSPA1L mediated HIF-1alpha stabilization. In addition, this is the first study to show that GP78 inactivation promotes cancer cell proliferation, migration and eventual tumor growth both in vivo and in vitro by increasing cellular prion protein.
Title: Role of HSPA1L as a cellular prion protein stabilizer in tumor progression via HIF-1?/GP78 axis.

In a cohort of youth at risk for bipolar disorder, pathway analysis showed an enrichment of the glucocorticoid receptor (GR) pathway with the genes MED1, HSPA1L, GTF2A1 and TAF15, which might underlie the previously reported role of stress response in the risk for bipolar disorder in vulnerable populations.
Title: Integrated transcriptome and methylome analysis in youth at high risk for bipolar disorder: a preliminary analysis.

The rs2763979 locus of the HSP70 genes may be associated with susceptibility to noise-induced hearing loss (NIHL) in Chinese individuals, and other HSP70 genes may also be susceptibility genes for NIHL, but the results must be further replicated in additional independent sample sets.
Title: Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study.

A heterozygous de novo mutation (c.830C > T; p.Ser277Leu) in HSPA1L in ulcerative colitis patient. Five additional rare HSPA1L mutations (p.Gly77Ser, p.Leu172del, p.Thr267Ile, p.Ala268Thr, p.Glu558Asp) were found in six other patients. All six rare HSPA1L variant proteins showed decreased chaperone activity in vitro. Moreover, three variants demonstrated dominant negative effects on HSPA1L and HSPA1A protein activity.
Title: De novo and rare mutations in the HSPA1L heat shock gene associated with inflammatory bowel disease.

Polymorphism of HSPA1L gene is associated with the development of esophageal Carcinoma.
Title: Polymorphisms in Heat Shock Proteins A1B and A1L (HOM) as Risk Factors for Oesophageal Carcinoma in Northeast India.

The following HSPA1L gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HSPA1L cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26022	NM_005527.4 Latest version!	Homo sapiens heat shock protein family A (Hsp70) member 1 like (HSPA1L), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu26022	NM_005527.3	Homo sapiens heat shock protein family A (Hsp70) member 1 like (HSPA1L), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HSPA1L ( NM_005527.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005518.3 Homo sapiens heat shock protein family A (Hsp70) member 1 like (HSPA1L), mRNA.

Price & Availability↑

CloneID	OHu26022
Clone ID Related Accession (Same CDS sequence)	NM_005527.3 , NM_005527.4
Accession Version	NM_005527.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1926bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	heat shock 70 kDa protein 1-like
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG717447.1, D85730.1, BC034483.1, M59829.1, CA443193.1 and BX115051.1. This sequence is a reference standard in the RefSeqGene project. On Jan 29, 2007 this sequence version replaced NM_005527.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.268463.1, BC034483.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTACTG CCAAGGGAAT CGCCATAGGC ATCGACCTGG GCACCACCTA CTCCTGTGTG 
GGGGTGTTCC AGCACGGCAA GGTGGAGATC ATCGCCAACG ACCAGGGCAA CCGCACCACC 
CCCAGCTACG TGGCCTTCAC AGACACCGAG CGGCTCATTG GGGATGCGGC CAAGAACCAG 
GTAGCAATGA ATCCCCAGAA CACTGTTTTT GATGCTAAAC GTCTGATCGG CAGGAAATTT 
AATGATCCTG TTGTACAAGC AGATATGAAA CTTTGGCCTT TTCAAGTGAT TAATGAAGGA 
GGCAAGCCCA AAGTCCTTGT GTCCTACAAA GGGGAGAATA AAGCTTTCTA CCCTGAGGAA 
ATCTCTTCGA TGGTATTGAC TAAGTTGAAG GAGACTGCTG AGGCCTTTTT GGGCCACCCT 
GTCACCAATG CAGTGATTAC CGTGCCAGCC TATTTCAATG ACTCTCAACG TCAGGCTACT 
AAGGATGCAG GTGTGATTGC TGGACTTAAT GTGCTAAGAA TCATCAATGA GCCCACGGCT 
GCTGCCATTG CCTATGGTTT AGATAAAGGA GGTCAAGGAG AACGACATGT CCTGATTTTT 
GATCTGGGTG GAGGCACATT TGATGTGTCA ATTCTGACCA TAGATGATGG GATTTTTGAG 
GTAAAGGCCA CTGCTGGGGA CACTCACCTG GGTGGGGAGG ACTTTGACAA CAGGCTTGTG 
AGCCACTTCG TGGAGGAGTT CAAGAGGAAA CACAAAAAGG ACATCAGCCA GAACAAGCGA 
GCCGTGAGGC GGCTGCGCAC CGCCTGCGAG AGGGCCAAGA GGACCCTGTC GTCCAGCACC 
CAGGCCAACC TAGAAATTGA TTCACTTTAT GAAGGCATTG ACTTCTATAC ATCCATCACC 
AGAGCTCGAT TTGAAGAGTT GTGTGCAGAC CTGTTTAGGG GTACCCTGGA GCCTGTAGAA 
AAAGCGCTTC GGGATGCCAA GATGGATAAG GCTAAAATCC ATGACATTGT TTTAGTAGGG 
GGCTCCACCC GCATCCCCAA GGTGCAGCGG CTGCTTCAGG ACTACTTCAA TGGACGTGAT 
CTCAACAAGA GCATCAACCC TGATGAGGCC GTAGCATATG GGGCTGCGGT ACAAGCAGCC 
ATCCTGATGG GGGACAAGTC TGAGAAGGTA CAGGACCTGC TGCTGCTGGA CGTGGCTCCC 
CTGTCCCTGG GGCTGGAGAC GGCTGGGGGC GTGATGACTG CCCTGATAAA GCGCAACTCC 
ACCATCCCCA CCAAGCAGAC ACAGATTTTC ACCACCTACT CTGACAACCA ACCCGGGGTG 
CTGATCCAGG TGTATGAGGG CGAGAGGGCC ATGACAAAGG ACAACAACCT GCTGGGGCGG 
TTTGACCTGA CTGGAATCCC TCCAGCACCC AGGGGAGTTC CTCAGATCGA GGTGACGTTT 
GACATTGATG CCAATGGTAT TCTCAATGTC ACAGCCACGG ACAAGAGCAC CGGCAAGGTG 
AACAAGATCA CCATCACCAA TGACAAGGGC CGCCTGAGCA AGGAGGAGAT TGAGCGCATG 
GTTCTGGATG CTGAGAAATA TAAAGCTGAA GATGAGGTCC AGAGGGAGAA AATTGCTGCA 
AAGAATGCCT TAGAATCCTA TGCTTTTAAC ATGAAGAGTG TTGTGAGTGA TGAAGGTTTG 
AAGGGCAAGA TTAGTGAGTC TGATAAAAAT AAAATATTGG ATAAATGCAA CGAGCTCCTT 
TCGTGGCTGG AGGTCAATCA ACTGGCAGAG AAAGATGAGT TTGATCATAA GAGAAAGGAA 
TTGGAGCAGA TGTGTAACCC TATCATCACA AAACTCTACC AAGGAGGATG CACTGGGCCT 
GCCTGCGGAA CAGGGTATGT GCCTGGAAGG CCTGCCACAG GCCCCACAAT TGAAGAAGTA 
GATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005518.3
CDS	184..2109
Translation	MATAKGIAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPQNTVFDAKRLIGRKFNDPVVQADMKLWPFQVINEGGKPKVLVSYKGENKAFYPEEISSMVLTKLKETAEAFLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGGQGERHVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKALRDAKMDKAKIHDIVLVGGSTRIPKVQRLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFDLTGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKVNKITITNDKGRLSKEEIERMVLDAEKYKAEDEVQREKIAAKNALESYAFNMKSVVSDEGLKGKISESDKNKILDKCNELLSWLEVNQLAEKDEFDHKRKELEQMCNPIITKLYQGGCTGPACGTGYVPGRPATGPTIEEVD

Target ORF information:

RefSeq Version	NM_005527.3
Organism	Homo sapiens(human)
Definition	Homo sapiens heat shock protein family A (Hsp70) member 1 like (HSPA1L), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005527.3

ORF Insert Sequence:

ATGGCTACTG CCAAGGGAAT CGCCATAGGC ATCGACCTGG GCACCACCTA CTCCTGTGTG 
GGGGTGTTCC AGCACGGCAA GGTGGAGATC ATCGCCAACG ACCAGGGCAA CCGCACCACC 
CCCAGCTACG TGGCCTTCAC AGACACCGAG CGGCTCATTG GGGATGCGGC CAAGAACCAG 
GTAGCAATGA ATCCCCAGAA CACTGTTTTT GATGCTAAAC GTCTGATCGG CAGGAAATTT 
AATGATCCTG TTGTACAAGC AGATATGAAA CTTTGGCCTT TTCAAGTGAT TAATGAAGGA 
GGCAAGCCCA AAGTCCTTGT GTCCTACAAA GGGGAGAATA AAGCTTTCTA CCCTGAGGAA 
ATCTCTTCGA TGGTATTGAC TAAGTTGAAG GAGACTGCTG AGGCCTTTTT GGGCCACCCT 
GTCACCAATG CAGTGATTAC CGTGCCAGCC TATTTCAATG ACTCTCAACG TCAGGCTACT 
AAGGATGCAG GTGTGATTGC TGGACTTAAT GTGCTAAGAA TCATCAATGA GCCCACGGCT 
GCTGCCATTG CCTATGGTTT AGATAAAGGA GGTCAAGGAG AACGACATGT CCTGATTTTT 
GATCTGGGTG GAGGCACATT TGATGTGTCA ATTCTGACCA TAGATGATGG GATTTTTGAG 
GTAAAGGCCA CTGCTGGGGA CACTCACCTG GGTGGGGAGG ACTTTGACAA CAGGCTTGTG 
AGCCACTTCG TGGAGGAGTT CAAGAGGAAA CACAAAAAGG ACATCAGCCA GAACAAGCGA 
GCCGTGAGGC GGCTGCGCAC CGCCTGCGAG AGGGCCAAGA GGACCCTGTC GTCCAGCACC 
CAGGCCAACC TAGAAATTGA TTCACTTTAT GAAGGCATTG ACTTCTATAC ATCCATCACC 
AGAGCTCGAT TTGAAGAGTT GTGTGCAGAC CTGTTTAGGG GTACCCTGGA GCCTGTAGAA 
AAAGCGCTTC GGGATGCCAA GATGGATAAG GCTAAAATCC ATGACATTGT TTTAGTAGGG 
GGCTCCACCC GCATCCCCAA GGTGCAGCGG CTGCTTCAGG ACTACTTCAA TGGACGTGAT 
CTCAACAAGA GCATCAACCC TGATGAGGCC GTAGCATATG GGGCTGCGGT ACAAGCAGCC 
ATCCTGATGG GGGACAAGTC TGAGAAGGTA CAGGACCTGC TGCTGCTGGA CGTGGCTCCC 
CTGTCCCTGG GGCTGGAGAC GGCTGGGGGC GTGATGACTG CCCTGATAAA GCGCAACTCC 
ACCATCCCCA CCAAGCAGAC ACAGATTTTC ACCACCTACT CTGACAACCA ACCCGGGGTG 
CTGATCCAGG TGTATGAGGG CGAGAGGGCC ATGACAAAGG ACAACAACCT GCTGGGGCGG 
TTTGACCTGA CTGGAATCCC TCCAGCACCC AGGGGAGTTC CTCAGATCGA GGTGACGTTT 
GACATTGATG CCAATGGTAT TCTCAATGTC ACAGCCACGG ACAAGAGCAC CGGCAAGGTG 
AACAAGATCA CCATCACCAA TGACAAGGGC CGCCTGAGCA AGGAGGAGAT TGAGCGCATG 
GTTCTGGATG CTGAGAAATA TAAAGCTGAA GATGAGGTCC AGAGGGAGAA AATTGCTGCA 
AAGAATGCCT TAGAATCCTA TGCTTTTAAC ATGAAGAGTG TTGTGAGTGA TGAAGGTTTG 
AAGGGCAAGA TTAGTGAGTC TGATAAAAAT AAAATATTGG ATAAATGCAA CGAGCTCCTT 
TCGTGGCTGG AGGTCAATCA ACTGGCAGAG AAAGATGAGT TTGATCATAA GAGAAAGGAA 
TTGGAGCAGA TGTGTAACCC TATCATCACA AAACTCTACC AAGGAGGATG CACTGGGCCT 
GCCTGCGGAA CAGGGTATGT GCCTGGAAGG CCTGCCACAG GCCCCACAAT TGAAGAAGTA 
GATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HSPA1L ( NM_005527.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005518.3 Homo sapiens heat shock protein family A (Hsp70) member 1 like (HSPA1L), mRNA.

Price & Availability↑

CloneID	OHu26022
Clone ID Related Accession (Same CDS sequence)	NM_005527.3 , NM_005527.4
Accession Version	NM_005527.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1926bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	heat shock 70 kDa protein 1-like
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL671762.10, BG717447.1, D85730.1, BC034483.1, M59829.1, CA443193.1 and BX115051.1. This sequence is a reference standard in the RefSeqGene project. On Nov 28, 2018 this sequence version replaced NM_005527.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK295416.1, SRR1803615.268463.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved MANE Ensembl match :: ENST00000375654.5/ ENSP00000364805.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTACTG CCAAGGGAAT CGCCATAGGC ATCGACCTGG GCACCACCTA CTCCTGTGTG 
GGGGTGTTCC AGCACGGCAA GGTGGAGATC ATCGCCAACG ACCAGGGCAA CCGCACCACC 
CCCAGCTACG TGGCCTTCAC AGACACCGAG CGGCTCATTG GGGATGCGGC CAAGAACCAG 
GTAGCAATGA ATCCCCAGAA CACTGTTTTT GATGCTAAAC GTCTGATCGG CAGGAAATTT 
AATGATCCTG TTGTACAAGC AGATATGAAA CTTTGGCCTT TTCAAGTGAT TAATGAAGGA 
GGCAAGCCCA AAGTCCTTGT GTCCTACAAA GGGGAGAATA AAGCTTTCTA CCCTGAGGAA 
ATCTCTTCGA TGGTATTGAC TAAGTTGAAG GAGACTGCTG AGGCCTTTTT GGGCCACCCT 
GTCACCAATG CAGTGATTAC CGTGCCAGCC TATTTCAATG ACTCTCAACG TCAGGCTACT 
AAGGATGCAG GTGTGATTGC TGGACTTAAT GTGCTAAGAA TCATCAATGA GCCCACGGCT 
GCTGCCATTG CCTATGGTTT AGATAAAGGA GGTCAAGGAG AACGACATGT CCTGATTTTT 
GATCTGGGTG GAGGCACATT TGATGTGTCA ATTCTGACCA TAGATGATGG GATTTTTGAG 
GTAAAGGCCA CTGCTGGGGA CACTCACCTG GGTGGGGAGG ACTTTGACAA CAGGCTTGTG 
AGCCACTTCG TGGAGGAGTT CAAGAGGAAA CACAAAAAGG ACATCAGCCA GAACAAGCGA 
GCCGTGAGGC GGCTGCGCAC CGCCTGCGAG AGGGCCAAGA GGACCCTGTC GTCCAGCACC 
CAGGCCAACC TAGAAATTGA TTCACTTTAT GAAGGCATTG ACTTCTATAC ATCCATCACC 
AGAGCTCGAT TTGAAGAGTT GTGTGCAGAC CTGTTTAGGG GTACCCTGGA GCCTGTAGAA 
AAAGCGCTTC GGGATGCCAA GATGGATAAG GCTAAAATCC ATGACATTGT TTTAGTAGGG 
GGCTCCACCC GCATCCCCAA GGTGCAGCGG CTGCTTCAGG ACTACTTCAA TGGACGTGAT 
CTCAACAAGA GCATCAACCC TGATGAGGCC GTAGCATATG GGGCTGCGGT ACAAGCAGCC 
ATCCTGATGG GGGACAAGTC TGAGAAGGTA CAGGACCTGC TGCTGCTGGA CGTGGCTCCC 
CTGTCCCTGG GGCTGGAGAC GGCTGGGGGC GTGATGACTG CCCTGATAAA GCGCAACTCC 
ACCATCCCCA CCAAGCAGAC ACAGATTTTC ACCACCTACT CTGACAACCA ACCCGGGGTG 
CTGATCCAGG TGTATGAGGG CGAGAGGGCC ATGACAAAGG ACAACAACCT GCTGGGGCGG 
TTTGACCTGA CTGGAATCCC TCCAGCACCC AGGGGAGTTC CTCAGATCGA GGTGACGTTT 
GACATTGATG CCAATGGTAT TCTCAATGTC ACAGCCACGG ACAAGAGCAC CGGCAAGGTG 
AACAAGATCA CCATCACCAA TGACAAGGGC CGCCTGAGCA AGGAGGAGAT TGAGCGCATG 
GTTCTGGATG CTGAGAAATA TAAAGCTGAA GATGAGGTCC AGAGGGAGAA AATTGCTGCA 
AAGAATGCCT TAGAATCCTA TGCTTTTAAC ATGAAGAGTG TTGTGAGTGA TGAAGGTTTG 
AAGGGCAAGA TTAGTGAGTC TGATAAAAAT AAAATATTGG ATAAATGCAA CGAGCTCCTT 
TCGTGGCTGG AGGTCAATCA ACTGGCAGAG AAAGATGAGT TTGATCATAA GAGAAAGGAA 
TTGGAGCAGA TGTGTAACCC TATCATCACA AAACTCTACC AAGGAGGATG CACTGGGCCT 
GCCTGCGGAA CAGGGTATGT GCCTGGAAGG CCTGCCACAG GCCCCACAAT TGAAGAAGTA 
GATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005518.3
CDS	409..2334
Translation	MATAKGIAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPQNTVFDAKRLIGRKFNDPVVQADMKLWPFQVINEGGKPKVLVSYKGENKAFYPEEISSMVLTKLKETAEAFLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGGQGERHVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKALRDAKMDKAKIHDIVLVGGSTRIPKVQRLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFDLTGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKVNKITITNDKGRLSKEEIERMVLDAEKYKAEDEVQREKIAAKNALESYAFNMKSVVSDEGLKGKISESDKNKILDKCNELLSWLEVNQLAEKDEFDHKRKELEQMCNPIITKLYQGGCTGPACGTGYVPGRPATGPTIEEVD

Target ORF information:

RefSeq Version	NM_005527.4
Organism	Homo sapiens(human)
Definition	Homo sapiens heat shock protein family A (Hsp70) member 1 like (HSPA1L), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005527.4

ORF Insert Sequence:

ATGGCTACTG CCAAGGGAAT CGCCATAGGC ATCGACCTGG GCACCACCTA CTCCTGTGTG 
GGGGTGTTCC AGCACGGCAA GGTGGAGATC ATCGCCAACG ACCAGGGCAA CCGCACCACC 
CCCAGCTACG TGGCCTTCAC AGACACCGAG CGGCTCATTG GGGATGCGGC CAAGAACCAG 
GTAGCAATGA ATCCCCAGAA CACTGTTTTT GATGCTAAAC GTCTGATCGG CAGGAAATTT 
AATGATCCTG TTGTACAAGC AGATATGAAA CTTTGGCCTT TTCAAGTGAT TAATGAAGGA 
GGCAAGCCCA AAGTCCTTGT GTCCTACAAA GGGGAGAATA AAGCTTTCTA CCCTGAGGAA 
ATCTCTTCGA TGGTATTGAC TAAGTTGAAG GAGACTGCTG AGGCCTTTTT GGGCCACCCT 
GTCACCAATG CAGTGATTAC CGTGCCAGCC TATTTCAATG ACTCTCAACG TCAGGCTACT 
AAGGATGCAG GTGTGATTGC TGGACTTAAT GTGCTAAGAA TCATCAATGA GCCCACGGCT 
GCTGCCATTG CCTATGGTTT AGATAAAGGA GGTCAAGGAG AACGACATGT CCTGATTTTT 
GATCTGGGTG GAGGCACATT TGATGTGTCA ATTCTGACCA TAGATGATGG GATTTTTGAG 
GTAAAGGCCA CTGCTGGGGA CACTCACCTG GGTGGGGAGG ACTTTGACAA CAGGCTTGTG 
AGCCACTTCG TGGAGGAGTT CAAGAGGAAA CACAAAAAGG ACATCAGCCA GAACAAGCGA 
GCCGTGAGGC GGCTGCGCAC CGCCTGCGAG AGGGCCAAGA GGACCCTGTC GTCCAGCACC 
CAGGCCAACC TAGAAATTGA TTCACTTTAT GAAGGCATTG ACTTCTATAC ATCCATCACC 
AGAGCTCGAT TTGAAGAGTT GTGTGCAGAC CTGTTTAGGG GTACCCTGGA GCCTGTAGAA 
AAAGCGCTTC GGGATGCCAA GATGGATAAG GCTAAAATCC ATGACATTGT TTTAGTAGGG 
GGCTCCACCC GCATCCCCAA GGTGCAGCGG CTGCTTCAGG ACTACTTCAA TGGACGTGAT 
CTCAACAAGA GCATCAACCC TGATGAGGCC GTAGCATATG GGGCTGCGGT ACAAGCAGCC 
ATCCTGATGG GGGACAAGTC TGAGAAGGTA CAGGACCTGC TGCTGCTGGA CGTGGCTCCC 
CTGTCCCTGG GGCTGGAGAC GGCTGGGGGC GTGATGACTG CCCTGATAAA GCGCAACTCC 
ACCATCCCCA CCAAGCAGAC ACAGATTTTC ACCACCTACT CTGACAACCA ACCCGGGGTG 
CTGATCCAGG TGTATGAGGG CGAGAGGGCC ATGACAAAGG ACAACAACCT GCTGGGGCGG 
TTTGACCTGA CTGGAATCCC TCCAGCACCC AGGGGAGTTC CTCAGATCGA GGTGACGTTT 
GACATTGATG CCAATGGTAT TCTCAATGTC ACAGCCACGG ACAAGAGCAC CGGCAAGGTG 
AACAAGATCA CCATCACCAA TGACAAGGGC CGCCTGAGCA AGGAGGAGAT TGAGCGCATG 
GTTCTGGATG CTGAGAAATA TAAAGCTGAA GATGAGGTCC AGAGGGAGAA AATTGCTGCA 
AAGAATGCCT TAGAATCCTA TGCTTTTAAC ATGAAGAGTG TTGTGAGTGA TGAAGGTTTG 
AAGGGCAAGA TTAGTGAGTC TGATAAAAAT AAAATATTGG ATAAATGCAA CGAGCTCCTT 
TCGTGGCTGG AGGTCAATCA ACTGGCAGAG AAAGATGAGT TTGATCATAA GAGAAAGGAA 
TTGGAGCAGA TGTGTAACCC TATCATCACA AAACTCTACC AAGGAGGATG CACTGGGCCT 
GCCTGCGGAA CAGGGTATGT GCCTGGAAGG CCTGCCACAG GCCCCACAAT TGAAGAAGTA 
GATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of HSPA1L as a cellular prion protein stabilizer in tumor progression via HIF-1?/GP78 axis.
Oncogene36(47)6555-6567(2017 Nov)
Lee JH,Han YS,Yoon YM,Yun CW,Yun SP,Kim SM,Kwon HY,Jeong D,Baek MJ,Lee HJ,Lee SJ,Han HJ,Lee SH

Integrated transcriptome and methylome analysis in youth at high risk for bipolar disorder: a preliminary analysis.
Translational psychiatry7(3)e1059(2017 03)
Fries GR,Quevedo J,Zeni CP,Kazimi IF,Zunta-Soares G,Spiker DE,Bowden CL,Walss-Bass C,Soares JC

[The genetic aspects of occupational hearing impairment].
Vestnik otorinolaringologii82(5)71-76(2017)
Krasitskaya VV,Bashmakova EE,Dobretsov KG,Orlova NV,Frank LA

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HSPA1L cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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