DNAJA1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DNAJA1
Entrez Gene ID	3301
Full Name	DnaJ heat shock protein family (Hsp40) member A1
Synonyms	DJ-2,DjA1,HDJ2,HSDJ,HSJ-2,HSJ2,HSPF4,NEDD7,hDJ-2
General protein information	Preferred Names DnaJ heat shock protein family (Hsp40) member A1 Names dnaJ homolog subfamily A member 1 DnaJ (Hsp40) homolog, subfamily A, member 1 dnaJ protein homolog 2 heat shock 40 kDa protein 4 heat shock protein J2 heat shock protein, DNAJ-like 2 human DnaJ protein 2 neural precursor cell expressed, developmentally down-regulated 7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p21.1
Summary	This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on other chromosomes. [provided by RefSeq, Sep 2015].
Disorder MIM:	602837

mRNA and Protein(s)

mRNA	Protein	Name
NM_001539.4	NP_001530.1	dnaJ homolog subfamily A member 1 isoform 1
NM_001539.3	NP_001530.1	dnaJ homolog subfamily A member 1 isoform 1
NM_001314039.1	NP_001300968.1	dnaJ homolog subfamily A member 1 isoform 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DNAJA1	NP_001233463.1
Bos taurus (cattle)	DNAJA1	NP_001015637.1
Rattus norvegicus (Norway rat)	Dnaja1	NP_075223.1
Gallus gallus (chicken)	DNAJA1	NP_001012963.1
Danio rerio (zebrafish)	dnaja1	NP_955956.1
Homo sapiens (human)	DNAJA1	NP_001530.1
Canis lupus familiaris (dog)	DNAJA1	NP_001239072.1
Xenopus tropicalis (tropical clawed frog)	dnaja1	NP_001011012.1
	DNAJA1	XP_001101766.2
Mus musculus (house mouse)	Dnaja1	NP_001158143.1

Gene Ontology
Bibliography

Related articles in PubMed

DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway.
Parrales A, Ranjan A, Iyer SV, Padhye S, Weir SJ, Roy A, Iwakuma T
Nature cell biology18(11)1233-1243(2016 Nov)

RING finger protein RNF207, a novel regulator of cardiac excitation.
Roder K, Werdich AA, Li W, Liu M, Kim TY, Organ-Darling LE, Moshal KS, Hwang JM, Lu Y, Choi BR, MacRae CA, Koren G
The Journal of biological chemistry289(49)33730-40(2014 Dec)

DnaJA1/Hsp40 is co-opted by influenza A virus to enhance its viral RNA polymerase activity.
Cao M, Wei C, Zhao L, Wang J, Jia Q, Wang X, Jin Q, Deng T
Journal of virology88(24)14078-89(2014 Dec)

Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer.
Stark JL, Mehla K, Chaika N, Acton TB, Xiao R, Singh PK, Montelione GT, Powers R
Biochemistry53(8)1360-72(2014 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

that DNAJA1 controls the fate of misfolded stabilization of mutant p53
Title: DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway.

Therefore, we propose that DnaJA1 is co-opted by the influenza A virus to enter the nucleus and to enhance its RNA polymerase activity in an Hsp70 cochaperone-independent manner.
Title: DnaJA1/Hsp40 is co-opted by influenza A virus to enhance its viral RNA polymerase activity.

structure and function of human DNAJA1 and its relationship to pancreatic cancer
Title: Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer.

we combined the Hsp70-NEF pairs with cochaperones of the J protein family (DnaJA1, DnaJA2, DnaJB1, and DnaJB4) to generate 16 permutations.
Title: Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.

Moreover, the levels of DnaJA1 and Hsp70 seem to play against each other with regard to tau: as DnaJA1 levels increase, tau levels are reduced, but this can be prevented if Hsp70 levels are simultaneously induced.
Title: DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau.

The following DNAJA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DNAJA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17230	NM_001539.4 Latest version!	Homo sapiens DnaJ heat shock protein family (Hsp40) member A1 (DNAJA1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$265.30 $379.00
OHu100530	NM_001314039.1 Latest version!	Homo sapiens DnaJ heat shock protein family (Hsp40) member A1 (DNAJA1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu17230	NM_001539.3	Homo sapiens DnaJ heat shock protein family (Hsp40) member A1 (DNAJA1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DNAJA1 ( NM_001539.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001530.1 Homo sapiens DnaJ heat shock protein family (Hsp40) member A1 (DNAJA1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17230
Clone ID Related Accession (Same CDS sequence)	NM_001539.4 , NM_001539.3
Accession Version	NM_001539.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1194bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	dnaJ homolog subfamily A member 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI462555.1, BC008182.1, DB575768.1, BU508753.1 and AK095541.1. On Nov 23, 2018 this sequence version replaced NM_001539.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.264389.1, SRR1803616.30216.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000330899.5/ ENSP00000369127.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGAAAG AAACAACTTA CTACGATGTT TTGGGGGTCA AACCCAATGC TACTCAGGAA 
GAATTGAAAA AGGCTTATAG GAAACTGGCT TTGAAGTACC ATCCTGATAA GAACCCAAAT 
GAAGGAGAGA AGTTTAAACA GATTTCTCAA GCTTACGAAG TTCTCTCTGA TGCAAAGAAA 
AGGGAATTAT ATGACAAAGG AGGAGAACAG GCAATTAAAG AGGGTGGAGC AGGTGGCGGT 
TTTGGCTCCC CCATGGACAT CTTTGATATG TTTTTTGGAG GAGGAGGAAG GATGCAGAGA 
GAAAGGAGAG GTAAAAATGT TGTACATCAG CTCTCAGTAA CCCTAGAAGA CTTATATAAT 
GGTGCAACAA GAAAACTGGC TCTGCAAAAG AATGTGATTT GTGACAAATG TGAAGGTAGA 
GGAGGTAAGA AAGGAGCAGT AGAGTGCTGT CCCAATTGCC GAGGTACTGG AATGCAAATA 
AGAATTCATC AGATAGGACC TGGAATGGTT CAGCAAATTC AGTCTGTGTG CATGGAGTGC 
CAGGGCCATG GGGAGCGGAT CAGTCCTAAA GATAGATGTA AAAGCTGCAA CGGAAGGAAG 
ATAGTTCGAG AGAAGAAAAT TTTAGAAGTT CATATTGACA AAGGCATGAA AGATGGCCAG 
AAGATAACAT TCCATGGTGA AGGAGACCAA GAACCAGGAC TGGAGCCAGG CGATATTATC 
ATTGTGTTAG ATCAGAAGGA CCATGCTGTT TTTACTCGAC GAGGAGAAGA CCTTTTCATG 
TGTATGGACA TACAGCTCGT TGAAGCACTG TGTGGCTTCC AGAAGCCAAT ATCTACTCTT 
GACAACCGAA CCATCGTCAT CACCTCTCAT CCAGGTCAGA TTGTCAAGCA TGGAGATATC 
AAGTGTGTAC TAAATGAAGG CATGCCAATT TATCGTAGAC CATATGAAAA GGGTCGCCTA 
ATCATCGAAT TTAAGGTAAA CTTTCCTGAG AATGGCTTTC TCTCTCCTGA TAAACTGTCT 
TTGCTGGAAA AACTCCTACC CGAGAGGAAG GAAGTGGAAG AGACTGATGA GATGGACCAA 
GTAGAACTGG TGGACTTTGA TCCAAATCAG GAAAGACGGC GCCACTACAA TGGAGAAGCA 
TATGAGGATG ATGAACATCA TCCCAGAGGT GGTGTTCAGT GTCAGACCTC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001530.1
CDS	122..1315
Translation	MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLSDAKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQCQTS

Target ORF information:

RefSeq Version	NM_001539.4
Organism	Homo sapiens(human)
Definition	Homo sapiens DnaJ heat shock protein family (Hsp40) member A1 (DNAJA1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001539.4

ORF Insert Sequence:

ATGGTGAAAG AAACAACTTA CTACGATGTT TTGGGGGTCA AACCCAATGC TACTCAGGAA 
GAATTGAAAA AGGCTTATAG GAAACTGGCT TTGAAGTACC ATCCTGATAA GAACCCAAAT 
GAAGGAGAGA AGTTTAAACA GATTTCTCAA GCTTACGAAG TTCTCTCTGA TGCAAAGAAA 
AGGGAATTAT ATGACAAAGG AGGAGAACAG GCAATTAAAG AGGGTGGAGC AGGTGGCGGT 
TTTGGCTCCC CCATGGACAT CTTTGATATG TTTTTTGGAG GAGGAGGAAG GATGCAGAGA 
GAAAGGAGAG GTAAAAATGT TGTACATCAG CTCTCAGTAA CCCTAGAAGA CTTATATAAT 
GGTGCAACAA GAAAACTGGC TCTGCAAAAG AATGTGATTT GTGACAAATG TGAAGGTAGA 
GGAGGTAAGA AAGGAGCAGT AGAGTGCTGT CCCAATTGCC GAGGTACTGG AATGCAAATA 
AGAATTCATC AGATAGGACC TGGAATGGTT CAGCAAATTC AGTCTGTGTG CATGGAGTGC 
CAGGGCCATG GGGAGCGGAT CAGTCCTAAA GATAGATGTA AAAGCTGCAA CGGAAGGAAG 
ATAGTTCGAG AGAAGAAAAT TTTAGAAGTT CATATTGACA AAGGCATGAA AGATGGCCAG 
AAGATAACAT TCCATGGTGA AGGAGACCAA GAACCAGGAC TGGAGCCAGG CGATATTATC 
ATTGTGTTAG ATCAGAAGGA CCATGCTGTT TTTACTCGAC GAGGAGAAGA CCTTTTCATG 
TGTATGGACA TACAGCTCGT TGAAGCACTG TGTGGCTTCC AGAAGCCAAT ATCTACTCTT 
GACAACCGAA CCATCGTCAT CACCTCTCAT CCAGGTCAGA TTGTCAAGCA TGGAGATATC 
AAGTGTGTAC TAAATGAAGG CATGCCAATT TATCGTAGAC CATATGAAAA GGGTCGCCTA 
ATCATCGAAT TTAAGGTAAA CTTTCCTGAG AATGGCTTTC TCTCTCCTGA TAAACTGTCT 
TTGCTGGAAA AACTCCTACC CGAGAGGAAG GAAGTGGAAG AGACTGATGA GATGGACCAA 
GTAGAACTGG TGGACTTTGA TCCAAATCAG GAAAGACGGC GCCACTACAA TGGAGAAGCA 
TATGAGGATG ATGAACATCA TCCCAGAGGT GGTGTTCAGT GTCAGACCTC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNAJA1 ( NM_001539.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001530.1 Homo sapiens DnaJ heat shock protein family (Hsp40) member A1 (DNAJA1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17230
Clone ID Related Accession (Same CDS sequence)	NM_001539.4 , NM_001539.3
Accession Version	NM_001539.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1194bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	dnaJ homolog subfamily A member 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA003255.1, BI462555.1, BC008182.1, DB575768.1, BU508753.1 and AK095541.1. On Sep 26, 2015 this sequence version replaced NM_001539.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.139255.1, SRR1803616.152730.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGAAAG AAACAACTTA CTACGATGTT TTGGGGGTCA AACCCAATGC TACTCAGGAA 
GAATTGAAAA AGGCTTATAG GAAACTGGCT TTGAAGTACC ATCCTGATAA GAACCCAAAT 
GAAGGAGAGA AGTTTAAACA GATTTCTCAA GCTTACGAAG TTCTCTCTGA TGCAAAGAAA 
AGGGAATTAT ATGACAAAGG AGGAGAACAG GCAATTAAAG AGGGTGGAGC AGGTGGCGGT 
TTTGGCTCCC CCATGGACAT CTTTGATATG TTTTTTGGAG GAGGAGGAAG GATGCAGAGA 
GAAAGGAGAG GTAAAAATGT TGTACATCAG CTCTCAGTAA CCCTAGAAGA CTTATATAAT 
GGTGCAACAA GAAAACTGGC TCTGCAAAAG AATGTGATTT GTGACAAATG TGAAGGTAGA 
GGAGGTAAGA AAGGAGCAGT AGAGTGCTGT CCCAATTGCC GAGGTACTGG AATGCAAATA 
AGAATTCATC AGATAGGACC TGGAATGGTT CAGCAAATTC AGTCTGTGTG CATGGAGTGC 
CAGGGCCATG GGGAGCGGAT CAGTCCTAAA GATAGATGTA AAAGCTGCAA CGGAAGGAAG 
ATAGTTCGAG AGAAGAAAAT TTTAGAAGTT CATATTGACA AAGGCATGAA AGATGGCCAG 
AAGATAACAT TCCATGGTGA AGGAGACCAA GAACCAGGAC TGGAGCCAGG CGATATTATC 
ATTGTGTTAG ATCAGAAGGA CCATGCTGTT TTTACTCGAC GAGGAGAAGA CCTTTTCATG 
TGTATGGACA TACAGCTCGT TGAAGCACTG TGTGGCTTCC AGAAGCCAAT ATCTACTCTT 
GACAACCGAA CCATCGTCAT CACCTCTCAT CCAGGTCAGA TTGTCAAGCA TGGAGATATC 
AAGTGTGTAC TAAATGAAGG CATGCCAATT TATCGTAGAC CATATGAAAA GGGTCGCCTA 
ATCATCGAAT TTAAGGTAAA CTTTCCTGAG AATGGCTTTC TCTCTCCTGA TAAACTGTCT 
TTGCTGGAAA AACTCCTACC CGAGAGGAAG GAAGTGGAAG AGACTGATGA GATGGACCAA 
GTAGAACTGG TGGACTTTGA TCCAAATCAG GAAAGACGGC GCCACTACAA TGGAGAAGCA 
TATGAGGATG ATGAACATCA TCCCAGAGGT GGTGTTCAGT GTCAGACCTC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001530.1
CDS	192..1385
Translation	MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLSDAKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQCQTS

Target ORF information:

RefSeq Version	NM_001539.3
Organism	Homo sapiens(human)
Definition	Homo sapiens DnaJ heat shock protein family (Hsp40) member A1 (DNAJA1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001539.3

ORF Insert Sequence:

ATGGTGAAAG AAACAACTTA CTACGATGTT TTGGGGGTCA AACCCAATGC TACTCAGGAA 
GAATTGAAAA AGGCTTATAG GAAACTGGCT TTGAAGTACC ATCCTGATAA GAACCCAAAT 
GAAGGAGAGA AGTTTAAACA GATTTCTCAA GCTTACGAAG TTCTCTCTGA TGCAAAGAAA 
AGGGAATTAT ATGACAAAGG AGGAGAACAG GCAATTAAAG AGGGTGGAGC AGGTGGCGGT 
TTTGGCTCCC CCATGGACAT CTTTGATATG TTTTTTGGAG GAGGAGGAAG GATGCAGAGA 
GAAAGGAGAG GTAAAAATGT TGTACATCAG CTCTCAGTAA CCCTAGAAGA CTTATATAAT 
GGTGCAACAA GAAAACTGGC TCTGCAAAAG AATGTGATTT GTGACAAATG TGAAGGTAGA 
GGAGGTAAGA AAGGAGCAGT AGAGTGCTGT CCCAATTGCC GAGGTACTGG AATGCAAATA 
AGAATTCATC AGATAGGACC TGGAATGGTT CAGCAAATTC AGTCTGTGTG CATGGAGTGC 
CAGGGCCATG GGGAGCGGAT CAGTCCTAAA GATAGATGTA AAAGCTGCAA CGGAAGGAAG 
ATAGTTCGAG AGAAGAAAAT TTTAGAAGTT CATATTGACA AAGGCATGAA AGATGGCCAG 
AAGATAACAT TCCATGGTGA AGGAGACCAA GAACCAGGAC TGGAGCCAGG CGATATTATC 
ATTGTGTTAG ATCAGAAGGA CCATGCTGTT TTTACTCGAC GAGGAGAAGA CCTTTTCATG 
TGTATGGACA TACAGCTCGT TGAAGCACTG TGTGGCTTCC AGAAGCCAAT ATCTACTCTT 
GACAACCGAA CCATCGTCAT CACCTCTCAT CCAGGTCAGA TTGTCAAGCA TGGAGATATC 
AAGTGTGTAC TAAATGAAGG CATGCCAATT TATCGTAGAC CATATGAAAA GGGTCGCCTA 
ATCATCGAAT TTAAGGTAAA CTTTCCTGAG AATGGCTTTC TCTCTCCTGA TAAACTGTCT 
TTGCTGGAAA AACTCCTACC CGAGAGGAAG GAAGTGGAAG AGACTGATGA GATGGACCAA 
GTAGAACTGG TGGACTTTGA TCCAAATCAG GAAAGACGGC GCCACTACAA TGGAGAAGCA 
TATGAGGATG ATGAACATCA TCCCAGAGGT GGTGTTCAGT GTCAGACCTC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNAJA1 ( NM_001314039.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001300968.1 Homo sapiens DnaJ heat shock protein family (Hsp40) member A1 (DNAJA1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu100530
Clone ID Related Accession (Same CDS sequence)	NM_001314039.1
Accession Version	NM_001314039.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 723bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Homo sapiens(human)
Product	dnaJ homolog subfamily A member 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA003255.1, AK298725.1, BM469197.1, DB575768.1, BU508753.1 and AK095541.1. Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK298725.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAAATAA GAATTCATCA GATAGGACCT GGAATGGTTC AGCAAATTCA GTCTGTGTGC 
ATGGAGTGCC AGGGCCATGG GGAGCGGATC AGTCCTAAAG ATAGATGTAA AAGCTGCAAC 
GGAAGGAAGA TAGTTCGAGA GAAGAAAATT TTAGAAGTTC ATATTGACAA AGGCATGAAA 
GATGGCCAGA AGATAACATT CCATGGTGAA GGAGACCAAG AACCAGGACT GGAGCCAGGC 
GATATTATCA TTGTGTTAGA TCAGAAGGAC CATGCTGTTT TTACTCGACG AGGAGAAGAC 
CTTTTCATGT GTATGGACAT ACAGCTCGTT GAAGCACTGT GTGGCTTCCA GAAGCCAATA 
TCTACTCTTG ACAACCGAAC CATCGTCATC ACCTCTCATC CAGGTCAGAT TGTCAAGCAT 
GGAGATATCA AGTGTGTACT AAATGAAGGC ATGCCAATTT ATCGTAGACC ATATGAAAAG 
GGTCGCCTAA TCATCGAATT TAAGGTAAAC TTTCCTGAGA ATGGCTTTCT CTCTCCTGAT 
AAACTGTCTT TGCTGGAAAA ACTCCTACCC GAGAGGAAGG AAGTGGAAGA GACTGATGAG 
ATGGACCAAG TAGAACTGGT GGACTTTGAT CCAAATCAGG AAAGACGGCG CCACTACAAT 
GGAGAAGCAT ATGAGGATGA TGAACATCAT CCCAGAGGTG GTGTTCAGTG TCAGACCTCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001300968.1
CDS	485..1207
Translation	MQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQCQTS

Target ORF information:

RefSeq Version	NM_001314039.1
Organism	Homo sapiens(human)
Definition	Homo sapiens DnaJ heat shock protein family (Hsp40) member A1 (DNAJA1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001314039.1

ORF Insert Sequence:

ATGCAAATAA GAATTCATCA GATAGGACCT GGAATGGTTC AGCAAATTCA GTCTGTGTGC 
ATGGAGTGCC AGGGCCATGG GGAGCGGATC AGTCCTAAAG ATAGATGTAA AAGCTGCAAC 
GGAAGGAAGA TAGTTCGAGA GAAGAAAATT TTAGAAGTTC ATATTGACAA AGGCATGAAA 
GATGGCCAGA AGATAACATT CCATGGTGAA GGAGACCAAG AACCAGGACT GGAGCCAGGC 
GATATTATCA TTGTGTTAGA TCAGAAGGAC CATGCTGTTT TTACTCGACG AGGAGAAGAC 
CTTTTCATGT GTATGGACAT ACAGCTCGTT GAAGCACTGT GTGGCTTCCA GAAGCCAATA 
TCTACTCTTG ACAACCGAAC CATCGTCATC ACCTCTCATC CAGGTCAGAT TGTCAAGCAT 
GGAGATATCA AGTGTGTACT AAATGAAGGC ATGCCAATTT ATCGTAGACC ATATGAAAAG 
GGTCGCCTAA TCATCGAATT TAAGGTAAAC TTTCCTGAGA ATGGCTTTCT CTCTCCTGAT 
AAACTGTCTT TGCTGGAAAA ACTCCTACCC GAGAGGAAGG AAGTGGAAGA GACTGATGAG 
ATGGACCAAG TAGAACTGGT GGACTTTGAT CCAAATCAGG AAAGACGGCG CCACTACAAT 
GGAGAAGCAT ATGAGGATGA TGAACATCAT CCCAGAGGTG GTGTTCAGTG TCAGACCTCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway.
Nature cell biology18(11)1233-1243(2016 Nov)
Parrales A,Ranjan A,Iyer SV,Padhye S,Weir SJ,Roy A,Iwakuma T

RING finger protein RNF207, a novel regulator of cardiac excitation.
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DNAJA1 cDNA ORF clone, Homo sapiens(human)

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