HRC cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HRC
Entrez Gene ID	3270
Full Name	histidine rich calcium binding protein
General protein information	Preferred Names histidine rich calcium binding protein Names sarcoplasmic reticulum histidine-rich calcium-binding protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.33
Summary	This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable calcium into the SR. [provided by RefSeq, Sep 2008].
Disorder MIM:	142705

mRNA and Protein(s)

mRNA	Protein	Name
NM_002152.2	NP_002143.1	sarcoplasmic reticulum histidine-rich calcium-binding protein precursor
NM_002152.3	NP_002143.1	sarcoplasmic reticulum histidine-rich calcium-binding protein precursor
XM_017026733.1	XP_016882222.1	sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X1
XM_017026733.2	XP_016882222.2	sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	HRC	NP_002143.1
Pan troglodytes (chimpanzee)	HRC	XP_513008.3
Bos taurus (cattle)	HRC	NP_001095783.1

Gene Ontology
Bibliography

Related articles in PubMed

Phosphorylation of serine96 of histidine-rich calcium-binding protein by the Fam20C kinase functions to prevent cardiac arrhythmia.
Pollak AJ, Haghighi K, Kunduri S, Arvanitis DA, Bidwell PA, Liu GS, Singh VP, Gonzalez DJ, Sanoudou D, Wiley SE, Dixon JE, Kranias EG
Proceedings of the National Academy of Sciences of the United States of America114(34)9098-9103(2017 Aug)

Histidine-rich calcium binding protein promotes growth of hepatocellular carcinoma in vitro and in vivo.
Liu J, Han P, Li M, Yan W, Liu J, He J, Gong J, Wang Y, Tian D
Cancer science106(10)1288-95(2015 Oct)

The histidine-rich calcium binding protein (HRC) promotes tumor metastasis in hepatocellular carcinoma and is upregulated by SATB1.
Liu J, Han P, Li M, Yan W, Liu J, Liu J, He J, Tu W, Xia Y, Zhou Z, Gong J, Liu M, Ding Q, Tian D
Oncotarget6(9)6811-24(2015 Mar)

The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca(2+) release due to an impaired ability to buffer store Ca(2+).
Zhang JZ, McLay JC, Jones PP
Journal of molecular and cellular cardiology7422-31(2014 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study demonstrates a role of HRC in promoting hepatocellular carcinoma (HCC) growth, besides its role in inducing HCC metastasis, and highlights HRC as a promising intervention target for HCC.
Title: Histidine-rich calcium binding protein promotes growth of hepatocellular carcinoma in vitro and in vivo.

Up-regulation of histidine-rich calcium binding protein promotes tumor metastasis in hepatocellular carcinoma and is mediated by SATB1.
Title: The histidine-rich calcium binding protein (HRC) promotes tumor metastasis in hepatocellular carcinoma and is upregulated by SATB1.

The S96A HRC mutation disrupts the Ca2+ -microdomain around the RyR2, as it alters the Ca2+ -dependent association of RyR2 and HRC.
Title: The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca(2+) release due to an impaired ability to buffer store Ca(2+).

findings suggest that aberrant sarcoplasmic reticulum Ca2+ release and increased susceptibility to delayed afterdepolarizations underlie triggered arrhythmic activity in Ala96 HRC carriers
Title: Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein.

Observational study of gene-disease association. (HuGE Navigator)
Title: The Ser96Ala variant in histidine-rich calcium-binding protein is associated with life-threatening ventricular arrhythmias in idiopathic dilated cardiomyopathy.

The following HRC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HRC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu104669	XM_017026733.2 Latest version!	Homo sapiens histidine rich calcium binding protein (HRC), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OHu08870	NM_002152.3 Latest version!	Homo sapiens histidine rich calcium binding protein (HRC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00
OHu88427	XM_017026733.1 Latest version!	Homo sapiens histidine rich calcium binding protein (HRC), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
View Old Accession Versions >>
OHu08870	NM_002152.2	Homo sapiens histidine rich calcium binding protein (HRC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HRC ( XM_017026733.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016882222.2 Homo sapiens histidine rich calcium binding protein (HRC), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu104669
Clone ID Related Accession (Same CDS sequence)	XM_017026733.2
Accession Version	XM_017026733.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2064bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017026733.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGAGGG AGGGCCCCAG AGGGGGGTCA GGGGGCTCCG GAGACAGCCT CAGAGGGGTG 
TCCAGAGCCA GGCAGCAAGG ACCAGAGGAA GGTGGACAGA GACCGAAAGG ACAAAGGAGA 
GACACAGAGA AAAAAAGAGA CCAACCCCAA AGGGACAAAG ACCCCAACGT TTGTCCACAT 
TGCCGCAGAG GCAGCTGGAG CCAGTGCTGC CTGTCCGTCC CCATGGGCCA CCATAGGCCA 
TGGCTGCACG CTTCTGTCCT CTGGGCTGGG GTGGCCAGCC TGCTCCTCCC CCCGGCCATG 
ACCCAGCAGC TCAGAGGGGA TGGGCTAGGC TTCAGAAACC GGAACAACAG CACTGGAGTC 
GCCGGGCTCT CCGAGGAGGC ATCAGCAGAG CTTCGCCACC ACCTCCACAG CCCTAGAGAC 
CATCCAGATG AGAACAAGGA TGTTTCCACA GAGAATGGGC ATCATTTCTG GAGCCACCCA 
GACCGTGAAA AGGAGGATGA AGATGTCTCC AAGGAATATG GGCACCTACT CCCAGGCCAC 
AGGTCCCAAG ACCACAAAGT CGGAGATGAG GGTGTCTCAG GTGAGGAGGT CTTTGCAGAG 
CATGGTGGGC AGGCCCGTGG GCACAGAGGC CACGGGAGTG AAGACACGGA AGACTCAGCT 
GAGCACAGGC ACCACCTCCC CAGCCACAGG AGCCACAGCC ATCAAGACGA GGATGAGGAT 
GAAGTTGTGT CCAGTGAGCA TCACCATCAT ATCCTCAGGC ATGGACACCG AGGCCATGAT 
GGGGAAGATG ATGAAGGAGA AGAGGAGGAG GAGGAGGAGG AGGAGGAAGA GGAGGCCTCC 
ACTGAGTATG GACACCAGGC CCACAGGCAC CGAGGCCATG GGAGTGAAGA GGATGAGGAT 
GTCTCAGATG GACACCATCA TCATGGCCCC AGCCACAGGC ACCAAGGCCA TGAAGAAGAT 
GACGATGATG ATGATGATGA TGATGATGAT GATGATGATG ATGATGTCTC CATTGAATAT 
AGACACCAGG CTCACAGGCA CCAAGGCCAC GGGATTGAAG AGGATGAAGA TGTCTCAGAT 
GGACACCATC ATCGCGACCC CAGCCACAGG CACCGAAGCC ATGAAGAAGA TGACAATGAT 
GATGATGATG TCTCCACTGA GTATGGACAC CAGGCCCACA GGCACCAAGA CCACAGAAAG 
GAAGAGGTTG AGGCTGTCTC AGGTGAACAC CACCATCATG TCCCTGACCA CAGGCACCAA 
GGCCACAGAG ACGAGGAAGA AGATGAGGAT GTGTCCACTG AACGTTGGCA CCAGGGTCCC 
CAACATGTCC ACCATGGCCT TGTAGATGAG GAAGAGGAAG AAGAGGAGAT CACAGTCCAG 
TTCGGCCACT ATGTTGCAAG CCACCAACCT CGAGGCCACA AGAGTGATGA AGAGGACTTC 
CAAGATGAGT ATAAAACAGA AGTCCCTCAC CATCACCACC ACAGAGTCCC CAGGGAGGAA 
GATGAGGAGG TCTCTGCTGA GCTTGGCCAC CAGGCCCCCA GCCACAGGCA AAGCCACCAA 
GATGAAGAAA CTGGCCATGG TCAAAGAGGG TCCATCAAAG AGATGAGCCA TCACCCCCCA 
GGACACACAG TGGTCAAGGA TAGAAGCCAT TTGAGGAAGG ATGATTCTGA GGAGGAAAAG 
GAGAAGGAAG AGGACCCCGG CTCCCATGAG GAAGACGATG AAAGTTCAGA GCAGGGAGAG 
AAAGGCACCC ATCATGGCAG CCGGGACCAG GAAGATGAGG AGGATGAGGA GGAAGGTCAT 
GGCCTCAGCC TGAACCAGGA GGAGGAAGAA GAGGAAGACA AGGAGGAGGA GGAGGAGGAA 
GAAGACGAGG AGAGGAGGGA AGAGAGGGCT GAGGTTGGGG CCCCACTGAG CCCAGACCAC 
AGCGAGGAGG AAGAGGAGGA GGAGGAGGGG CTGGAGGAAG ATGAGCCCCG CTTCACCATC 
ATCCCCAACC CACTGGACAG GAGAGAGGAG GCTGGAGGTG CCTCCAGCGA GGAGGAAAGC 
GGTGAGGACA CAGCGATGCA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016882222.2
CDS	6..2069
Translation	MGREGPRGGSGGSGDSLRGVSRARQQGPEEGGQRPKGQRRDTEKKRDQPQRDKDPNVCPHCRRGSWSQCCLSVPMGHHRPWLHASVLWAGVASLLLPPAMTQQLRGDGLGFRNRNNSTGVAGLSEEASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTAMH

Target ORF information:

RefSeq Version	XM_017026733.2
Organism	Homo sapiens(human)
Definition	Homo sapiens histidine rich calcium binding protein (HRC), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026733.2

ORF Insert Sequence:

ATGGGGAGGG AGGGCCCCAG AGGGGGGTCA GGGGGCTCCG GAGACAGCCT CAGAGGGGTG 
TCCAGAGCCA GGCAGCAAGG ACCAGAGGAA GGTGGACAGA GACCGAAAGG ACAAAGGAGA 
GACACAGAGA AAAAAAGAGA CCAACCCCAA AGGGACAAAG ACCCCAACGT TTGTCCACAT 
TGCCGCAGAG GCAGCTGGAG CCAGTGCTGC CTGTCCGTCC CCATGGGCCA CCATAGGCCA 
TGGCTGCACG CTTCTGTCCT CTGGGCTGGG GTGGCCAGCC TGCTCCTCCC CCCGGCCATG 
ACCCAGCAGC TCAGAGGGGA TGGGCTAGGC TTCAGAAACC GGAACAACAG CACTGGAGTC 
GCCGGGCTCT CCGAGGAGGC ATCAGCAGAG CTTCGCCACC ACCTCCACAG CCCTAGAGAC 
CATCCAGATG AGAACAAGGA TGTTTCCACA GAGAATGGGC ATCATTTCTG GAGCCACCCA 
GACCGTGAAA AGGAGGATGA AGATGTCTCC AAGGAATATG GGCACCTACT CCCAGGCCAC 
AGGTCCCAAG ACCACAAAGT CGGAGATGAG GGTGTCTCAG GTGAGGAGGT CTTTGCAGAG 
CATGGTGGGC AGGCCCGTGG GCACAGAGGC CACGGGAGTG AAGACACGGA AGACTCAGCT 
GAGCACAGGC ACCACCTCCC CAGCCACAGG AGCCACAGCC ATCAAGACGA GGATGAGGAT 
GAAGTTGTGT CCAGTGAGCA TCACCATCAT ATCCTCAGGC ATGGACACCG AGGCCATGAT 
GGGGAAGATG ATGAAGGAGA AGAGGAGGAG GAGGAGGAGG AGGAGGAAGA GGAGGCCTCC 
ACTGAGTATG GACACCAGGC CCACAGGCAC CGAGGCCATG GGAGTGAAGA GGATGAGGAT 
GTCTCAGATG GACACCATCA TCATGGCCCC AGCCACAGGC ACCAAGGCCA TGAAGAAGAT 
GACGATGATG ATGATGATGA TGATGATGAT GATGATGATG ATGATGTCTC CATTGAATAT 
AGACACCAGG CTCACAGGCA CCAAGGCCAC GGGATTGAAG AGGATGAAGA TGTCTCAGAT 
GGACACCATC ATCGCGACCC CAGCCACAGG CACCGAAGCC ATGAAGAAGA TGACAATGAT 
GATGATGATG TCTCCACTGA GTATGGACAC CAGGCCCACA GGCACCAAGA CCACAGAAAG 
GAAGAGGTTG AGGCTGTCTC AGGTGAACAC CACCATCATG TCCCTGACCA CAGGCACCAA 
GGCCACAGAG ACGAGGAAGA AGATGAGGAT GTGTCCACTG AACGTTGGCA CCAGGGTCCC 
CAACATGTCC ACCATGGCCT TGTAGATGAG GAAGAGGAAG AAGAGGAGAT CACAGTCCAG 
TTCGGCCACT ATGTTGCAAG CCACCAACCT CGAGGCCACA AGAGTGATGA AGAGGACTTC 
CAAGATGAGT ATAAAACAGA AGTCCCTCAC CATCACCACC ACAGAGTCCC CAGGGAGGAA 
GATGAGGAGG TCTCTGCTGA GCTTGGCCAC CAGGCCCCCA GCCACAGGCA AAGCCACCAA 
GATGAAGAAA CTGGCCATGG TCAAAGAGGG TCCATCAAAG AGATGAGCCA TCACCCCCCA 
GGACACACAG TGGTCAAGGA TAGAAGCCAT TTGAGGAAGG ATGATTCTGA GGAGGAAAAG 
GAGAAGGAAG AGGACCCCGG CTCCCATGAG GAAGACGATG AAAGTTCAGA GCAGGGAGAG 
AAAGGCACCC ATCATGGCAG CCGGGACCAG GAAGATGAGG AGGATGAGGA GGAAGGTCAT 
GGCCTCAGCC TGAACCAGGA GGAGGAAGAA GAGGAAGACA AGGAGGAGGA GGAGGAGGAA 
GAAGACGAGG AGAGGAGGGA AGAGAGGGCT GAGGTTGGGG CCCCACTGAG CCCAGACCAC 
AGCGAGGAGG AAGAGGAGGA GGAGGAGGGG CTGGAGGAAG ATGAGCCCCG CTTCACCATC 
ATCCCCAACC CACTGGACAG GAGAGAGGAG GCTGGAGGTG CCTCCAGCGA GGAGGAAAGC 
GGTGAGGACA CAGCGATGCA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HRC ( NM_002152.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002143.1 Homo sapiens histidine rich calcium binding protein (HRC), mRNA.

Price & Availability↑

CloneID	OHu08870
Clone ID Related Accession (Same CDS sequence)	NM_002152.2 , NM_002152.3
Accession Version	NM_002152.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2100bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	sarcoplasmic reticulum histidine-rich calcium-binding protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC094691.1. On Sep 20, 2005 this sequence version replaced NM_002152.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC094691.1, M60052.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCCACC ATAGGCCATG GCTGCACGCT TCTGTCCTCT GGGCTGGGGT GGCCAGCCTG 
CTCCTCCCCC CGGCCATGAC CCAGCAGCTC AGAGGGGATG GGCTAGGCTT CAGAAACCGG 
AACAACAGCA CTGGAGTCGC CGGGCTCTCC GAGGAGGCAT CAGCAGAGCT TCGCCACCAC 
CTCCACAGCC CTAGAGACCA TCCAGATGAG AACAAGGATG TTTCCACAGA GAATGGGCAT 
CATTTCTGGA GCCACCCAGA CCGTGAAAAG GAGGATGAAG ATGTCTCCAA GGAATATGGG 
CACCTACTCC CAGGCCACAG GTCCCAAGAC CACAAAGTCG GAGATGAGGG TGTCTCAGGT 
GAGGAGGTCT TTGCAGAGCA TGGTGGGCAG GCCCGTGGGC ACAGAGGCCA CGGGAGTGAA 
GACACGGAAG ACTCAGCTGA GCACAGGCAC CACCTCCCCA GCCACAGGAG CCACAGCCAT 
CAAGACGAGG ATGAGGATGA AGTTGTGTCC AGTGAGCATC ACCATCATAT CCTCAGGCAT 
GGACACCGAG GCCATGATGG GGAAGATGAT GAAGGAGAAG AGGAGGAGGA GGAGGAGGAG 
GAGGAAGAGG AGGCCTCCAC TGAGTATGGA CACCAGGCCC ACAGGCACCG AGGCCATGGG 
AGTGAAGAGG ATGAGGATGT CTCAGATGGA CACCATCATC ATGGCCCCAG CCACAGGCAC 
CAAGGCCATG AAGAAGATGA CGATGATGAT GATGATGATG ATGATGATGA TGATGATGAT 
GATGTCTCCA TTGAATATAG ACACCAGGCT CACAGGCACC AAGGCCACGG GATTGAAGAG 
GATGAAGATG TCTCAGATGG ACACCATCAT CGCGACCCCA GCCACAGGCA CCGAAGCCAT 
GAAGAAGATG ACAATGATGA TGATGATGTC TCCACTGAGT ATGGACACCA GGCCCACAGG 
CACCAAGACC ACAGAAAGGA AGAGGTTGAG GCTGTCTCAG GTGAACACCA CCATCATGTC 
CCTGACCACA GGCACCAAGG CCACAGAGAC GAGGAAGAAG ATGAGGATGT GTCCACTGAA 
CGTTGGCACC AGGGTCCCCA ACATGTCCAC CATGGCCTTG TAGATGAGGA AGAGGAAGAA 
GAGGAGATCA CAGTCCAGTT CGGCCACTAT GTTGCAAGCC ACCAACCTCG AGGCCACAAG 
AGTGATGAAG AGGACTTCCA AGATGAGTAT AAAACAGAAG TCCCTCACCA TCACCACCAC 
AGAGTCCCCA GGGAGGAAGA TGAGGAGGTC TCTGCTGAGC TTGGCCACCA GGCCCCCAGC 
CACAGGCAAA GCCACCAAGA TGAAGAAACT GGCCATGGTC AAAGAGGGTC CATCAAAGAG 
ATGAGCCATC ACCCCCCAGG ACACACAGTG GTCAAGGATA GAAGCCATTT GAGGAAGGAT 
GATTCTGAGG AGGAAAAGGA GAAGGAAGAG GACCCCGGCT CCCATGAGGA AGACGATGAA 
AGTTCAGAGC AGGGAGAGAA AGGCACCCAT CATGGCAGCC GGGACCAGGA AGATGAGGAG 
GATGAGGAGG AAGGTCATGG CCTCAGCCTG AACCAGGAGG AGGAAGAAGA GGAAGACAAG 
GAGGAGGAGG AGGAGGAAGA AGACGAGGAG AGGAGGGAAG AGAGGGCTGA GGTTGGGGCC 
CCACTGAGCC CAGACCACAG CGAGGAGGAA GAGGAGGAGG AGGAGGGGCT GGAGGAAGAT 
GAGCCCCGCT TCACCATCAT CCCCAACCCA CTGGACAGGA GAGAGGAGGC TGGAGGTGCC 
TCCAGCGAGG AGGAAAGCGG TGAGGACACA GGTCCACAGG ATGCTCAGGA GTATGGGAAC 
TACCAGCCAG GGTCCCTGTG TGGCTACTGC TCCTTCTGCA ATCGATGCAC TGAATGTGAG 
AGCTGTCACT GTGATGAGGA GAACATGGGT GAGCACTGCG ACCAGTGCCA GCACTGTCAG 
TTCTGCTATC TCTGCCCGCT GGTCTGCGAA ACGGTCTGCG CTCCAGGAAG CTACGTTGAC 
TATTTCTCCT CGTCCCTTTA TCAGGCCCTG GCAGACATGC TGGAAACGCC GGAACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002143.1
CDS	188..2287
Translation	MGHHRPWLHASVLWAGVASLLLPPAMTQQLRGDGLGFRNRNNSTGVAGLSEEASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQEYGNYQPGSLCGYCSFCNRCTECESCHCDEENMGEHCDQCQHCQFCYLCPLVCETVCAPGSYVDYFSSSLYQALADMLETPEP

Target ORF information:

RefSeq Version	NM_002152.2
Organism	Homo sapiens(human)
Definition	Homo sapiens histidine rich calcium binding protein (HRC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002152.2

ORF Insert Sequence:

ATGGGCCACC ATAGGCCATG GCTGCACGCT TCTGTCCTCT GGGCTGGGGT GGCCAGCCTG 
CTCCTCCCCC CGGCCATGAC CCAGCAGCTC AGAGGGGATG GGCTAGGCTT CAGAAACCGG 
AACAACAGCA CTGGAGTCGC CGGGCTCTCC GAGGAGGCAT CAGCAGAGCT TCGCCACCAC 
CTCCACAGCC CTAGAGACCA TCCAGATGAG AACAAGGATG TTTCCACAGA GAATGGGCAT 
CATTTCTGGA GCCACCCAGA CCGTGAAAAG GAGGATGAAG ATGTCTCCAA GGAATATGGG 
CACCTACTCC CAGGCCACAG GTCCCAAGAC CACAAAGTCG GAGATGAGGG TGTCTCAGGT 
GAGGAGGTCT TTGCAGAGCA TGGTGGGCAG GCCCGTGGGC ACAGAGGCCA CGGGAGTGAA 
GACACGGAAG ACTCAGCTGA GCACAGGCAC CACCTCCCCA GCCACAGGAG CCACAGCCAT 
CAAGACGAGG ATGAGGATGA AGTTGTGTCC AGTGAGCATC ACCATCATAT CCTCAGGCAT 
GGACACCGAG GCCATGATGG GGAAGATGAT GAAGGAGAAG AGGAGGAGGA GGAGGAGGAG 
GAGGAAGAGG AGGCCTCCAC TGAGTATGGA CACCAGGCCC ACAGGCACCG AGGCCATGGG 
AGTGAAGAGG ATGAGGATGT CTCAGATGGA CACCATCATC ATGGCCCCAG CCACAGGCAC 
CAAGGCCATG AAGAAGATGA CGATGATGAT GATGATGATG ATGATGATGA TGATGATGAT 
GATGTCTCCA TTGAATATAG ACACCAGGCT CACAGGCACC AAGGCCACGG GATTGAAGAG 
GATGAAGATG TCTCAGATGG ACACCATCAT CGCGACCCCA GCCACAGGCA CCGAAGCCAT 
GAAGAAGATG ACAATGATGA TGATGATGTC TCCACTGAGT ATGGACACCA GGCCCACAGG 
CACCAAGACC ACAGAAAGGA AGAGGTTGAG GCTGTCTCAG GTGAACACCA CCATCATGTC 
CCTGACCACA GGCACCAAGG CCACAGAGAC GAGGAAGAAG ATGAGGATGT GTCCACTGAA 
CGTTGGCACC AGGGTCCCCA ACATGTCCAC CATGGCCTTG TAGATGAGGA AGAGGAAGAA 
GAGGAGATCA CAGTCCAGTT CGGCCACTAT GTTGCAAGCC ACCAACCTCG AGGCCACAAG 
AGTGATGAAG AGGACTTCCA AGATGAGTAT AAAACAGAAG TCCCTCACCA TCACCACCAC 
AGAGTCCCCA GGGAGGAAGA TGAGGAGGTC TCTGCTGAGC TTGGCCACCA GGCCCCCAGC 
CACAGGCAAA GCCACCAAGA TGAAGAAACT GGCCATGGTC AAAGAGGGTC CATCAAAGAG 
ATGAGCCATC ACCCCCCAGG ACACACAGTG GTCAAGGATA GAAGCCATTT GAGGAAGGAT 
GATTCTGAGG AGGAAAAGGA GAAGGAAGAG GACCCCGGCT CCCATGAGGA AGACGATGAA 
AGTTCAGAGC AGGGAGAGAA AGGCACCCAT CATGGCAGCC GGGACCAGGA AGATGAGGAG 
GATGAGGAGG AAGGTCATGG CCTCAGCCTG AACCAGGAGG AGGAAGAAGA GGAAGACAAG 
GAGGAGGAGG AGGAGGAAGA AGACGAGGAG AGGAGGGAAG AGAGGGCTGA GGTTGGGGCC 
CCACTGAGCC CAGACCACAG CGAGGAGGAA GAGGAGGAGG AGGAGGGGCT GGAGGAAGAT 
GAGCCCCGCT TCACCATCAT CCCCAACCCA CTGGACAGGA GAGAGGAGGC TGGAGGTGCC 
TCCAGCGAGG AGGAAAGCGG TGAGGACACA GGTCCACAGG ATGCTCAGGA GTATGGGAAC 
TACCAGCCAG GGTCCCTGTG TGGCTACTGC TCCTTCTGCA ATCGATGCAC TGAATGTGAG 
AGCTGTCACT GTGATGAGGA GAACATGGGT GAGCACTGCG ACCAGTGCCA GCACTGTCAG 
TTCTGCTATC TCTGCCCGCT GGTCTGCGAA ACGGTCTGCG CTCCAGGAAG CTACGTTGAC 
TATTTCTCCT CGTCCCTTTA TCAGGCCCTG GCAGACATGC TGGAAACGCC GGAACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HRC ( NM_002152.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002143.1 Homo sapiens histidine rich calcium binding protein (HRC), mRNA.

Price & Availability↑

CloneID	OHu08870
Clone ID Related Accession (Same CDS sequence)	NM_002152.2 , NM_002152.3
Accession Version	NM_002152.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2100bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	sarcoplasmic reticulum histidine-rich calcium-binding protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC094691.1. On Nov 23, 2018 this sequence version replaced NM_002152.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC094691.1, M60052.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000252825.9/ ENSP00000252825.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCCACC ATAGGCCATG GCTGCACGCT TCTGTCCTCT GGGCTGGGGT GGCCAGCCTG 
CTCCTCCCCC CGGCCATGAC CCAGCAGCTC AGAGGGGATG GGCTAGGCTT CAGAAACCGG 
AACAACAGCA CTGGAGTCGC CGGGCTCTCC GAGGAGGCAT CAGCAGAGCT TCGCCACCAC 
CTCCACAGCC CTAGAGACCA TCCAGATGAG AACAAGGATG TTTCCACAGA GAATGGGCAT 
CATTTCTGGA GCCACCCAGA CCGTGAAAAG GAGGATGAAG ATGTCTCCAA GGAATATGGG 
CACCTACTCC CAGGCCACAG GTCCCAAGAC CACAAAGTCG GAGATGAGGG TGTCTCAGGT 
GAGGAGGTCT TTGCAGAGCA TGGTGGGCAG GCCCGTGGGC ACAGAGGCCA CGGGAGTGAA 
GACACGGAAG ACTCAGCTGA GCACAGGCAC CACCTCCCCA GCCACAGGAG CCACAGCCAT 
CAAGACGAGG ATGAGGATGA AGTTGTGTCC AGTGAGCATC ACCATCATAT CCTCAGGCAT 
GGACACCGAG GCCATGATGG GGAAGATGAT GAAGGAGAAG AGGAGGAGGA GGAGGAGGAG 
GAGGAAGAGG AGGCCTCCAC TGAGTATGGA CACCAGGCCC ACAGGCACCG AGGCCATGGG 
AGTGAAGAGG ATGAGGATGT CTCAGATGGA CACCATCATC ATGGCCCCAG CCACAGGCAC 
CAAGGCCATG AAGAAGATGA CGATGATGAT GATGATGATG ATGATGATGA TGATGATGAT 
GATGTCTCCA TTGAATATAG ACACCAGGCT CACAGGCACC AAGGCCACGG GATTGAAGAG 
GATGAAGATG TCTCAGATGG ACACCATCAT CGCGACCCCA GCCACAGGCA CCGAAGCCAT 
GAAGAAGATG ACAATGATGA TGATGATGTC TCCACTGAGT ATGGACACCA GGCCCACAGG 
CACCAAGACC ACAGAAAGGA AGAGGTTGAG GCTGTCTCAG GTGAACACCA CCATCATGTC 
CCTGACCACA GGCACCAAGG CCACAGAGAC GAGGAAGAAG ATGAGGATGT GTCCACTGAA 
CGTTGGCACC AGGGTCCCCA ACATGTCCAC CATGGCCTTG TAGATGAGGA AGAGGAAGAA 
GAGGAGATCA CAGTCCAGTT CGGCCACTAT GTTGCAAGCC ACCAACCTCG AGGCCACAAG 
AGTGATGAAG AGGACTTCCA AGATGAGTAT AAAACAGAAG TCCCTCACCA TCACCACCAC 
AGAGTCCCCA GGGAGGAAGA TGAGGAGGTC TCTGCTGAGC TTGGCCACCA GGCCCCCAGC 
CACAGGCAAA GCCACCAAGA TGAAGAAACT GGCCATGGTC AAAGAGGGTC CATCAAAGAG 
ATGAGCCATC ACCCCCCAGG ACACACAGTG GTCAAGGATA GAAGCCATTT GAGGAAGGAT 
GATTCTGAGG AGGAAAAGGA GAAGGAAGAG GACCCCGGCT CCCATGAGGA AGACGATGAA 
AGTTCAGAGC AGGGAGAGAA AGGCACCCAT CATGGCAGCC GGGACCAGGA AGATGAGGAG 
GATGAGGAGG AAGGTCATGG CCTCAGCCTG AACCAGGAGG AGGAAGAAGA GGAAGACAAG 
GAGGAGGAGG AGGAGGAAGA AGACGAGGAG AGGAGGGAAG AGAGGGCTGA GGTTGGGGCC 
CCACTGAGCC CAGACCACAG CGAGGAGGAA GAGGAGGAGG AGGAGGGGCT GGAGGAAGAT 
GAGCCCCGCT TCACCATCAT CCCCAACCCA CTGGACAGGA GAGAGGAGGC TGGAGGTGCC 
TCCAGCGAGG AGGAAAGCGG TGAGGACACA GGTCCACAGG ATGCTCAGGA GTATGGGAAC 
TACCAGCCAG GGTCCCTGTG TGGCTACTGC TCCTTCTGCA ATCGATGCAC TGAATGTGAG 
AGCTGTCACT GTGATGAGGA GAACATGGGT GAGCACTGCG ACCAGTGCCA GCACTGTCAG 
TTCTGCTATC TCTGCCCGCT GGTCTGCGAA ACGGTCTGCG CTCCAGGAAG CTACGTTGAC 
TATTTCTCCT CGTCCCTTTA TCAGGCCCTG GCAGACATGC TGGAAACGCC GGAACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002143.1
CDS	160..2259
Translation	MGHHRPWLHASVLWAGVASLLLPPAMTQQLRGDGLGFRNRNNSTGVAGLSEEASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQEYGNYQPGSLCGYCSFCNRCTECESCHCDEENMGEHCDQCQHCQFCYLCPLVCETVCAPGSYVDYFSSSLYQALADMLETPEP

Target ORF information:

RefSeq Version	NM_002152.3
Organism	Homo sapiens(human)
Definition	Homo sapiens histidine rich calcium binding protein (HRC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002152.3

ORF Insert Sequence:

ATGGGCCACC ATAGGCCATG GCTGCACGCT TCTGTCCTCT GGGCTGGGGT GGCCAGCCTG 
CTCCTCCCCC CGGCCATGAC CCAGCAGCTC AGAGGGGATG GGCTAGGCTT CAGAAACCGG 
AACAACAGCA CTGGAGTCGC CGGGCTCTCC GAGGAGGCAT CAGCAGAGCT TCGCCACCAC 
CTCCACAGCC CTAGAGACCA TCCAGATGAG AACAAGGATG TTTCCACAGA GAATGGGCAT 
CATTTCTGGA GCCACCCAGA CCGTGAAAAG GAGGATGAAG ATGTCTCCAA GGAATATGGG 
CACCTACTCC CAGGCCACAG GTCCCAAGAC CACAAAGTCG GAGATGAGGG TGTCTCAGGT 
GAGGAGGTCT TTGCAGAGCA TGGTGGGCAG GCCCGTGGGC ACAGAGGCCA CGGGAGTGAA 
GACACGGAAG ACTCAGCTGA GCACAGGCAC CACCTCCCCA GCCACAGGAG CCACAGCCAT 
CAAGACGAGG ATGAGGATGA AGTTGTGTCC AGTGAGCATC ACCATCATAT CCTCAGGCAT 
GGACACCGAG GCCATGATGG GGAAGATGAT GAAGGAGAAG AGGAGGAGGA GGAGGAGGAG 
GAGGAAGAGG AGGCCTCCAC TGAGTATGGA CACCAGGCCC ACAGGCACCG AGGCCATGGG 
AGTGAAGAGG ATGAGGATGT CTCAGATGGA CACCATCATC ATGGCCCCAG CCACAGGCAC 
CAAGGCCATG AAGAAGATGA CGATGATGAT GATGATGATG ATGATGATGA TGATGATGAT 
GATGTCTCCA TTGAATATAG ACACCAGGCT CACAGGCACC AAGGCCACGG GATTGAAGAG 
GATGAAGATG TCTCAGATGG ACACCATCAT CGCGACCCCA GCCACAGGCA CCGAAGCCAT 
GAAGAAGATG ACAATGATGA TGATGATGTC TCCACTGAGT ATGGACACCA GGCCCACAGG 
CACCAAGACC ACAGAAAGGA AGAGGTTGAG GCTGTCTCAG GTGAACACCA CCATCATGTC 
CCTGACCACA GGCACCAAGG CCACAGAGAC GAGGAAGAAG ATGAGGATGT GTCCACTGAA 
CGTTGGCACC AGGGTCCCCA ACATGTCCAC CATGGCCTTG TAGATGAGGA AGAGGAAGAA 
GAGGAGATCA CAGTCCAGTT CGGCCACTAT GTTGCAAGCC ACCAACCTCG AGGCCACAAG 
AGTGATGAAG AGGACTTCCA AGATGAGTAT AAAACAGAAG TCCCTCACCA TCACCACCAC 
AGAGTCCCCA GGGAGGAAGA TGAGGAGGTC TCTGCTGAGC TTGGCCACCA GGCCCCCAGC 
CACAGGCAAA GCCACCAAGA TGAAGAAACT GGCCATGGTC AAAGAGGGTC CATCAAAGAG 
ATGAGCCATC ACCCCCCAGG ACACACAGTG GTCAAGGATA GAAGCCATTT GAGGAAGGAT 
GATTCTGAGG AGGAAAAGGA GAAGGAAGAG GACCCCGGCT CCCATGAGGA AGACGATGAA 
AGTTCAGAGC AGGGAGAGAA AGGCACCCAT CATGGCAGCC GGGACCAGGA AGATGAGGAG 
GATGAGGAGG AAGGTCATGG CCTCAGCCTG AACCAGGAGG AGGAAGAAGA GGAAGACAAG 
GAGGAGGAGG AGGAGGAAGA AGACGAGGAG AGGAGGGAAG AGAGGGCTGA GGTTGGGGCC 
CCACTGAGCC CAGACCACAG CGAGGAGGAA GAGGAGGAGG AGGAGGGGCT GGAGGAAGAT 
GAGCCCCGCT TCACCATCAT CCCCAACCCA CTGGACAGGA GAGAGGAGGC TGGAGGTGCC 
TCCAGCGAGG AGGAAAGCGG TGAGGACACA GGTCCACAGG ATGCTCAGGA GTATGGGAAC 
TACCAGCCAG GGTCCCTGTG TGGCTACTGC TCCTTCTGCA ATCGATGCAC TGAATGTGAG 
AGCTGTCACT GTGATGAGGA GAACATGGGT GAGCACTGCG ACCAGTGCCA GCACTGTCAG 
TTCTGCTATC TCTGCCCGCT GGTCTGCGAA ACGGTCTGCG CTCCAGGAAG CTACGTTGAC 
TATTTCTCCT CGTCCCTTTA TCAGGCCCTG GCAGACATGC TGGAAACGCC GGAACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HRC ( XM_017026733.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016882222.1 Homo sapiens histidine rich calcium binding protein (HRC), transcript variant X1, mRNA.

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CloneID	OHu88427
Clone ID Related Accession (Same CDS sequence)	XM_017026733.1
Accession Version	XM_017026733.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1842bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCCACC ATAGGCCATG GCTGCACGCT TCTGTCCTCT GGGCTGGGGT GGCCAGCCTG 
CTCCTCCCCC CGGCCATGAC CCAGCAGCTC AGAGGGGATG GGCTAGGCTT CAGAAACCGG 
AACAACAGCA CTGGAGTCGC CGGGCTCTCC GAGGAGGCAT CAGCAGAGCT TCGCCACCAC 
CTCCACAGCC CTAGAGACCA TCCAGATGAG AACAAGGATG TTTCCACAGA GAATGGGCAT 
CATTTCTGGA GCCACCCAGA CCGTGAAAAG GAGGATGAAG ATGTCTCCAA GGAATATGGG 
CACCTACTCC CAGGCCACAG GTCCCAAGAC CACAAAGTCG GAGATGAGGG TGTCTCAGGT 
GAGGAGGTCT TTGCAGAGCA TGGTGGGCAG GCCCGTGGGC ACAGAGGCCA CGGGAGTGAA 
GACACGGAAG ACTCAGCTGA GCACAGGCAC CACCTCCCCA GCCACAGGAG CCACAGCCAT 
CAAGACGAGG ATGAGGATGA AGTTGTGTCC AGTGAGCATC ACCATCATAT CCTCAGGCAT 
GGACACCGAG GCCATGATGG GGAAGATGAT GAAGGAGAAG AGGAGGAGGA GGAGGAGGAG 
GAGGAAGAGG AGGCCTCCAC TGAGTATGGA CACCAGGCCC ACAGGCACCG AGGCCATGGG 
AGTGAAGAGG ATGAGGATGT CTCAGATGGA CACCATCATC ATGGCCCCAG CCACAGGCAC 
CAAGGCCATG AAGAAGATGA CGATGATGAT GATGATGATG ATGATGATGA TGATGATGAT 
GATGTCTCCA TTGAATATAG ACACCAGGCT CACAGGCACC AAGGCCACGG GATTGAAGAG 
GATGAAGATG TCTCAGATGG ACACCATCAT CGCGACCCCA GCCACAGGCA CCGAAGCCAT 
GAAGAAGATG ACAATGATGA TGATGATGTC TCCACTGAGT ATGGACACCA GGCCCACAGG 
CACCAAGACC ACAGAAAGGA AGAGGTTGAG GCTGTCTCAG GTGAACACCA CCATCATGTC 
CCTGACCACA GGCACCAAGG CCACAGAGAC GAGGAAGAAG ATGAGGATGT GTCCACTGAA 
CGTTGGCACC AGGGTCCCCA ACATGTCCAC CATGGCCTTG TAGATGAGGA AGAGGAAGAA 
GAGGAGATCA CAGTCCAGTT CGGCCACTAT GTTGCAAGCC ACCAACCTCG AGGCCACAAG 
AGTGATGAAG AGGACTTCCA AGATGAGTAT AAAACAGAAG TCCCTCACCA TCACCACCAC 
AGAGTCCCCA GGGAGGAAGA TGAGGAGGTC TCTGCTGAGC TTGGCCACCA GGCCCCCAGC 
CACAGGCAAA GCCACCAAGA TGAAGAAACT GGCCATGGTC AAAGAGGGTC CATCAAAGAG 
ATGAGCCATC ACCCCCCAGG ACACACAGTG GTCAAGGATA GAAGCCATTT GAGGAAGGAT 
GATTCTGAGG AGGAAAAGGA GAAGGAAGAG GACCCCGGCT CCCATGAGGA AGACGATGAA 
AGTTCAGAGC AGGGAGAGAA AGGCACCCAT CATGGCAGCC GGGACCAGGA AGATGAGGAG 
GATGAGGAGG AAGGTCATGG CCTCAGCCTG AACCAGGAGG AGGAAGAAGA GGAAGACAAG 
GAGGAGGAGG AGGAGGAAGA AGACGAGGAG AGGAGGGAAG AGAGGGCTGA GGTTGGGGCC 
CCACTGAGCC CAGACCACAG CGAGGAGGAA GAGGAGGAGG AGGAGGGGCT GGAGGAAGAT 
GAGCCCCGCT TCACCATCAT CCCCAACCCA CTGGACAGGA GAGAGGAGGC TGGAGGTGCC 
TCCAGCGAGG AGGAAAGCGG TGAGGACACA GCGATGCACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016882222.1
CDS	207..2048
Translation	MGHHRPWLHASVLWAGVASLLLPPAMTQQLRGDGLGFRNRNNSTGVAGLSEEASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTAMH

Target ORF information:

RefSeq Version	XM_017026733.1
Organism	Homo sapiens(human)
Definition	Homo sapiens histidine rich calcium binding protein (HRC), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026733.1

ORF Insert Sequence:

ATGGGCCACC ATAGGCCATG GCTGCACGCT TCTGTCCTCT GGGCTGGGGT GGCCAGCCTG 
CTCCTCCCCC CGGCCATGAC CCAGCAGCTC AGAGGGGATG GGCTAGGCTT CAGAAACCGG 
AACAACAGCA CTGGAGTCGC CGGGCTCTCC GAGGAGGCAT CAGCAGAGCT TCGCCACCAC 
CTCCACAGCC CTAGAGACCA TCCAGATGAG AACAAGGATG TTTCCACAGA GAATGGGCAT 
CATTTCTGGA GCCACCCAGA CCGTGAAAAG GAGGATGAAG ATGTCTCCAA GGAATATGGG 
CACCTACTCC CAGGCCACAG GTCCCAAGAC CACAAAGTCG GAGATGAGGG TGTCTCAGGT 
GAGGAGGTCT TTGCAGAGCA TGGTGGGCAG GCCCGTGGGC ACAGAGGCCA CGGGAGTGAA 
GACACGGAAG ACTCAGCTGA GCACAGGCAC CACCTCCCCA GCCACAGGAG CCACAGCCAT 
CAAGACGAGG ATGAGGATGA AGTTGTGTCC AGTGAGCATC ACCATCATAT CCTCAGGCAT 
GGACACCGAG GCCATGATGG GGAAGATGAT GAAGGAGAAG AGGAGGAGGA GGAGGAGGAG 
GAGGAAGAGG AGGCCTCCAC TGAGTATGGA CACCAGGCCC ACAGGCACCG AGGCCATGGG 
AGTGAAGAGG ATGAGGATGT CTCAGATGGA CACCATCATC ATGGCCCCAG CCACAGGCAC 
CAAGGCCATG AAGAAGATGA CGATGATGAT GATGATGATG ATGATGATGA TGATGATGAT 
GATGTCTCCA TTGAATATAG ACACCAGGCT CACAGGCACC AAGGCCACGG GATTGAAGAG 
GATGAAGATG TCTCAGATGG ACACCATCAT CGCGACCCCA GCCACAGGCA CCGAAGCCAT 
GAAGAAGATG ACAATGATGA TGATGATGTC TCCACTGAGT ATGGACACCA GGCCCACAGG 
CACCAAGACC ACAGAAAGGA AGAGGTTGAG GCTGTCTCAG GTGAACACCA CCATCATGTC 
CCTGACCACA GGCACCAAGG CCACAGAGAC GAGGAAGAAG ATGAGGATGT GTCCACTGAA 
CGTTGGCACC AGGGTCCCCA ACATGTCCAC CATGGCCTTG TAGATGAGGA AGAGGAAGAA 
GAGGAGATCA CAGTCCAGTT CGGCCACTAT GTTGCAAGCC ACCAACCTCG AGGCCACAAG 
AGTGATGAAG AGGACTTCCA AGATGAGTAT AAAACAGAAG TCCCTCACCA TCACCACCAC 
AGAGTCCCCA GGGAGGAAGA TGAGGAGGTC TCTGCTGAGC TTGGCCACCA GGCCCCCAGC 
CACAGGCAAA GCCACCAAGA TGAAGAAACT GGCCATGGTC AAAGAGGGTC CATCAAAGAG 
ATGAGCCATC ACCCCCCAGG ACACACAGTG GTCAAGGATA GAAGCCATTT GAGGAAGGAT 
GATTCTGAGG AGGAAAAGGA GAAGGAAGAG GACCCCGGCT CCCATGAGGA AGACGATGAA 
AGTTCAGAGC AGGGAGAGAA AGGCACCCAT CATGGCAGCC GGGACCAGGA AGATGAGGAG 
GATGAGGAGG AAGGTCATGG CCTCAGCCTG AACCAGGAGG AGGAAGAAGA GGAAGACAAG 
GAGGAGGAGG AGGAGGAAGA AGACGAGGAG AGGAGGGAAG AGAGGGCTGA GGTTGGGGCC 
CCACTGAGCC CAGACCACAG CGAGGAGGAA GAGGAGGAGG AGGAGGGGCT GGAGGAAGAT 
GAGCCCCGCT TCACCATCAT CCCCAACCCA CTGGACAGGA GAGAGGAGGC TGGAGGTGCC 
TCCAGCGAGG AGGAAAGCGG TGAGGACACA GCGATGCACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Phosphorylation of serine96 of histidine-rich calcium-binding protein by the Fam20C kinase functions to prevent cardiac arrhythmia.
Proceedings of the National Academy of Sciences of the United States of America114(34)9098-9103(2017 Aug)
Pollak AJ,Haghighi K,Kunduri S,Arvanitis DA,Bidwell PA,Liu GS,Singh VP,Gonzalez DJ,Sanoudou D,Wiley SE,Dixon JE,Kranias EG

Histidine-rich calcium binding protein promotes growth of hepatocellular carcinoma in vitro and in vivo.
Cancer science106(10)1288-95(2015 Oct)
Liu J,Han P,Li M,Yan W,Liu J,He J,Gong J,Wang Y,Tian D

The histidine-rich calcium binding protein (HRC) promotes tumor metastasis in hepatocellular carcinoma and is upregulated by SATB1.
Oncotarget6(9)6811-24(2015 Mar)
Liu J,Han P,Li M,Yan W,Liu J,Liu J,He J,Tu W,Xia Y,Zhou Z,Gong J,Liu M,Ding Q,Tian D

The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca(2+) release due to an impaired ability to buffer store Ca(2+).
Journal of molecular and cellular cardiology7422-31(2014 Sep)
Zhang JZ,McLay JC,Jones PP

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HRC cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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