ZAR1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ZAR1
Entrez Gene ID	326340
Full Name	zygote arrest 1
Synonyms	Z3CXXC6
General protein information	Preferred Names zygote arrest 1 Names zygote arrest protein 1 oocyte-specific maternal effect factor zinc finger, 3CxxC-type 6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4p11
Summary	This maternal effect gene is oocyte-specific and encodes a protein that is thought to function in the initiation of embryogenesis. A similar protein in mouse is required for female fertility. [provided by RefSeq, Jul 2013].
Disorder MIM:	607520

mRNA and Protein(s)

mRNA	Protein	Name
NM_175619.2	NP_783318.1	zygote arrest protein 1
NM_175619.3	NP_783318.1	zygote arrest protein 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	ZAR1	NP_783318.1
	ZAR1	XP_001103446.1
Rattus norvegicus (Norway rat)	Zar1	NP_852050.1
Gallus gallus (chicken)	ZAR1	XP_003641256.2
Mus musculus (house mouse)	Zar1	NP_777366.1
Pan troglodytes (chimpanzee)	ZAR1	XP_001151745.1
Canis lupus familiaris (dog)	ZAR1	XP_003431884.1
Bos taurus (cattle)	ZAR1	NP_001069671.1
Danio rerio (zebrafish)	zar1	NP_919362.2
Xenopus tropicalis (tropical clawed frog)	zar1	NP_001016947.2

Gene Ontology
Bibliography

Related articles in PubMed

ZAR1 knockdown promotes the differentiation of human neuroblastoma cells by suppression of MYCN expression.
Watanabe Y, Ishizuka Y, Hirano T, Nagasaki-Maeoka E, Hoshi R, Yoshizawa S, Uekusa S, Kawashima H, Sugito K, Shinohara K, Fukuda N, Nagase H, Soma M, Koshinaga T, Fujiwara K
Medical oncology (Northwood, London, England)34(9)158(2017 Aug)

ZAR1 is a novel epigenetically inactivated tumour suppressor in lung cancer.
Richter AM, Kiehl S, K?ger N, Breuer J, Stiewe T, Dammann RH
Clinical epigenetics960(2017)

Identification of frequent differentially methylated region in sporadic bladder cancers.
Hasegawa R, Fujiwara K, Obinata D, Kawashima H, Shinojima Y, Igarashi J, Wang X, Ghosh S, Nagase H, Takahashi S
Urologia internationalis94(4)479-84(2015)

Evaluation of ZAR1 and SFRP4 methylation status as potentials biomarkers for diagnosis in cervical cancer: exploratory study phase I.
Brebi P, Hoffstetter R, Andana A, Ili CG, Saavedra K, Viscarra T, Retamal J, Sanchez R, Roa JC
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals19(3)181-8(2014 May)

Non-promoter DNA hypermethylation of Zygote Arrest 1 (ZAR1) in neuroblastomas.
Sugito K, Kawashima H, Yoshizawa S, Uekusa S, Hoshi R, Furuya T, Kaneda H, Hosoda T, Konuma N, Masuko T, Ohashi K, Ikeda T, Koshinaga T, Tomita R, Shinojima Y, Fujiwara K, Watanabe T, Held WA, Nagase H
Journal of pediatric surgery48(4)782-8(2013 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A decreased methylation level at CpG sites of ZAR1 exon 1/intron 1. CpGi could serve as a biomarker for invasive bladder cancer.
Title: Identification of frequent differentially methylated region in sporadic bladder cancers.

ZAR1 and SFRP4 qMSP could be used as potential biomarker for CC diagnosis
Title: Evaluation of ZAR1 and SFRP4 methylation status as potentials biomarkers for diagnosis in cervical cancer: exploratory study phase I.

Hypermethylation of ZAR1 regions is extremely frequent in neuroblastomas and correlates with established markers of progressive disease and outcome.
Title: Non-promoter DNA hypermethylation of Zygote Arrest 1 (ZAR1) in neuroblastomas.

we identified a frequently aberrant methylated region within the Zygote arrest 1 (ZAR1) gene in melanoma and demonstrated a distinct methylation pattern between melanoma and nevus.The involvement of ZAR1 in the carcinogenesis of melanoma remains unclear.
Title: Identification and analysis of an early diagnostic marker for malignant melanoma: ZAR1 intra-genic differential methylation.

Findings indicate that non-promoter hypermethylation of ZAR1 is extremely frequent in diffuse gliomas and pituitary adenomas, but methylation-related aberrant ZAR1 expression is far less likely to be related to glioma tumorigenesis.
Title: Aberrant hypermethylation of non-promoter zygote arrest 1 (ZAR1) in human brain tumors.

The following ZAR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ZAR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02039	NM_175619.3 Latest version!	Homo sapiens zygote arrest 1 (ZAR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$251.30 $359.00
View Old Accession Versions >>
OHu02039	NM_175619.2	Homo sapiens zygote arrest 1 (ZAR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$251.30 $359.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ZAR1 ( NM_175619.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_783318.1 Homo sapiens zygote arrest 1 (ZAR1), mRNA.

Price & Availability↑

CloneID	OHu02039
Clone ID Related Accession (Same CDS sequence)	NM_175619.2 , NM_175619.3
Accession Version	NM_175619.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1275bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-29
Organism	Homo sapiens(human)
Product	zygote arrest protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC136265.1, AY191416.1, AI217763.1 and AC096952.5. On Jul 31, 2013 this sequence version replaced NM_175619.1. ##Evidence-Data-START## Transcript exon combination :: BC136265.1, AY191416.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCCC TGGGGGACGA GGTGCTGGAC GGTTACGTGT TCCCGGCGTG CCCCCCCTGC 
TCGTACCGGT ACCCATACCC CGCGGCCACC AAGGGCAAGG GCGCGGCGGG CGGCAGCTGG 
CAGCAGCGCG GCAGGGGCTG CCTTCCCGCC TCCTCCCCCT GCTCGGCGGG CGCGGCCTCG 
TTGTCCTTCC CGGGCTGCGG GCGGCTGACG GCCGCCGAGT ACTTCGACAG CTACCAGCGG 
GAGCGGCTCA TGGCTCTCCT GGCGCAGGTG GGGCCGGGTC TCGGGCCGCG CGCCCGCAGG 
GCCGGCAGCT GCGACGTGGC GGTGCAGGTG AGCCCGCGCA TCGACGCCGC GGTACAGTGC 
TCGCTGGGGA GGCGCACGCT GCAGCGCCGG GCCCGCGACC CCGAGTCCCC GGCCGGCCCC 
GGGGCCGAGG GCACCACGGG TGGCGGCTCT TTCTCCCAGC AGCCATCCCG TCGAGGCCTG 
GAGCAGGGCA GCCCCCAGAA CGGCGCCCCG CGGCCCATGC GCTTCCCGCG CACCGTCGCC 
GTGTACTCGC CCCTGGCCTT GCGCCGTCTC ACCGCCTTCC TGGAGGGGCC CGGGCCCGCG 
GCGGGCGAGC AGAGGTCCGG GGCGTCGGAC GGAGAGAGGG GGCCGCCGCC CGCGCGGCTT 
CAAGGCCCAG AGGAGGGGGA GGTGTGGACG AAGAAGGCGC CCCGGCGGCC GCAGTCCGAC 
GACGACGGCG AGGCCCAGGC CGCAGTCCGA GCGAGCTGGG AGCAGCCGGC CGACGGTCCC 
GAGCTGCCGC CGCGAGAGGC CCAGGAGGGC GAGGCGGCTC CGCGGTCGGC GCTAAGGAGC 
CCGGGGCAAC CTCCGTCGGC GGGGAGGGCC CGAGACGGCG GCGACGGACG GGAGGCGGCC 
GTCGCGGGAG AGGGGCCGTC GCCACGGAGC CCGGAGCTGG GCAAGGAGCG GCTGCGCTTC 
CAGTTCTTAG AGCAGAAATA TGGCTATTAC CACTGCAAGG ACTGCAACAT CCGCTGGGAG 
AGTGCTTATG TGTGGTGTGT ACAGGGAACT AACAAGGTTT ACTTCAAACA GTTTTGCAGA 
ACTTGTCAGA AGTCTTATAA CCCTTACCGA GTGGAGGATA TCACCTGTCA AAGTTGTAAA 
CAAACGAGAT GTTCCTGCCC AGTAAAACTT CGCCACGTGG ACCCTAAACG GCCCCACCGT 
CAAGATTTGT GCGGTAGATG CAAAGGCAAA CGCCTGTCCT GTGACAGCAC TTTCAGCTTC 
AAATACATCA TTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_783318.1
CDS	41..1315
Translation	MAALGDEVLDGYVFPACPPCSYRYPYPAATKGKGAAGGSWQQRGRGCLPASSPCSAGAASLSFPGCGRLTAAEYFDSYQRERLMALLAQVGPGLGPRARRAGSCDVAVQVSPRIDAAVQCSLGRRTLQRRARDPESPAGPGAEGTTGGGSFSQQPSRRGLEQGSPQNGAPRPMRFPRTVAVYSPLALRRLTAFLEGPGPAAGEQRSGASDGERGPPPARLQGPEEGEVWTKKAPRRPQSDDDGEAQAAVRASWEQPADGPELPPREAQEGEAAPRSALRSPGQPPSAGRARDGGDGREAAVAGEGPSPRSPELGKERLRFQFLEQKYGYYHCKDCNIRWESAYVWCVQGTNKVYFKQFCRTCQKSYNPYRVEDITCQSCKQTRCSCPVKLRHVDPKRPHRQDLCGRCKGKRLSCDSTFSFKYII

Target ORF information:

RefSeq Version	NM_175619.2
Organism	Homo sapiens(human)
Definition	Homo sapiens zygote arrest 1 (ZAR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175619.2

ORF Insert Sequence:

ATGGCGGCCC TGGGGGACGA GGTGCTGGAC GGTTACGTGT TCCCGGCGTG CCCCCCCTGC 
TCGTACCGGT ACCCATACCC CGCGGCCACC AAGGGCAAGG GCGCGGCGGG CGGCAGCTGG 
CAGCAGCGCG GCAGGGGCTG CCTTCCCGCC TCCTCCCCCT GCTCGGCGGG CGCGGCCTCG 
TTGTCCTTCC CGGGCTGCGG GCGGCTGACG GCCGCCGAGT ACTTCGACAG CTACCAGCGG 
GAGCGGCTCA TGGCTCTCCT GGCGCAGGTG GGGCCGGGTC TCGGGCCGCG CGCCCGCAGG 
GCCGGCAGCT GCGACGTGGC GGTGCAGGTG AGCCCGCGCA TCGACGCCGC GGTACAGTGC 
TCGCTGGGGA GGCGCACGCT GCAGCGCCGG GCCCGCGACC CCGAGTCCCC GGCCGGCCCC 
GGGGCCGAGG GCACCACGGG TGGCGGCTCT TTCTCCCAGC AGCCATCCCG TCGAGGCCTG 
GAGCAGGGCA GCCCCCAGAA CGGCGCCCCG CGGCCCATGC GCTTCCCGCG CACCGTCGCC 
GTGTACTCGC CCCTGGCCTT GCGCCGTCTC ACCGCCTTCC TGGAGGGGCC CGGGCCCGCG 
GCGGGCGAGC AGAGGTCCGG GGCGTCGGAC GGAGAGAGGG GGCCGCCGCC CGCGCGGCTT 
CAAGGCCCAG AGGAGGGGGA GGTGTGGACG AAGAAGGCGC CCCGGCGGCC GCAGTCCGAC 
GACGACGGCG AGGCCCAGGC CGCAGTCCGA GCGAGCTGGG AGCAGCCGGC CGACGGTCCC 
GAGCTGCCGC CGCGAGAGGC CCAGGAGGGC GAGGCGGCTC CGCGGTCGGC GCTAAGGAGC 
CCGGGGCAAC CTCCGTCGGC GGGGAGGGCC CGAGACGGCG GCGACGGACG GGAGGCGGCC 
GTCGCGGGAG AGGGGCCGTC GCCACGGAGC CCGGAGCTGG GCAAGGAGCG GCTGCGCTTC 
CAGTTCTTAG AGCAGAAATA TGGCTATTAC CACTGCAAGG ACTGCAACAT CCGCTGGGAG 
AGTGCTTATG TGTGGTGTGT ACAGGGAACT AACAAGGTTT ACTTCAAACA GTTTTGCAGA 
ACTTGTCAGA AGTCTTATAA CCCTTACCGA GTGGAGGATA TCACCTGTCA AAGTTGTAAA 
CAAACGAGAT GTTCCTGCCC AGTAAAACTT CGCCACGTGG ACCCTAAACG GCCCCACCGT 
CAAGATTTGT GCGGTAGATG CAAAGGCAAA CGCCTGTCCT GTGACAGCAC TTTCAGCTTC 
AAATACATCA TTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZAR1 ( NM_175619.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_783318.1 Homo sapiens zygote arrest 1 (ZAR1), mRNA.

Price & Availability↑

CloneID	OHu02039
Clone ID Related Accession (Same CDS sequence)	NM_175619.2 , NM_175619.3
Accession Version	NM_175619.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1275bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-29
Organism	Homo sapiens(human)
Product	zygote arrest protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC136265.1, AY191416.1, AI217763.1 and AC096952.5. On May 17, 2019 this sequence version replaced NM_175619.2. ##Evidence-Data-START## Transcript exon combination :: BC136265.1, AY191416.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000327939.4/ ENSP00000329803.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCCC TGGGGGACGA GGTGCTGGAC GGTTACGTGT TCCCGGCGTG CCCCCCCTGC 
TCGTACCGGT ACCCATACCC CGCGGCCACC AAGGGCAAGG GCGCGGCGGG CGGCAGCTGG 
CAGCAGCGCG GCAGGGGCTG CCTTCCCGCC TCCTCCCCCT GCTCGGCGGG CGCGGCCTCG 
TTGTCCTTCC CGGGCTGCGG GCGGCTGACG GCCGCCGAGT ACTTCGACAG CTACCAGCGG 
GAGCGGCTCA TGGCTCTCCT GGCGCAGGTG GGGCCGGGTC TCGGGCCGCG CGCCCGCAGG 
GCCGGCAGCT GCGACGTGGC GGTGCAGGTG AGCCCGCGCA TCGACGCCGC GGTACAGTGC 
TCGCTGGGGA GGCGCACGCT GCAGCGCCGG GCCCGCGACC CCGAGTCCCC GGCCGGCCCC 
GGGGCCGAGG GCACCACGGG TGGCGGCTCT TTCTCCCAGC AGCCATCCCG TCGAGGCCTG 
GAGCAGGGCA GCCCCCAGAA CGGCGCCCCG CGGCCCATGC GCTTCCCGCG CACCGTCGCC 
GTGTACTCGC CCCTGGCCTT GCGCCGTCTC ACCGCCTTCC TGGAGGGGCC CGGGCCCGCG 
GCGGGCGAGC AGAGGTCCGG GGCGTCGGAC GGAGAGAGGG GGCCGCCGCC CGCGCGGCTT 
CAAGGCCCAG AGGAGGGGGA GGTGTGGACG AAGAAGGCGC CCCGGCGGCC GCAGTCCGAC 
GACGACGGCG AGGCCCAGGC CGCAGTCCGA GCGAGCTGGG AGCAGCCGGC CGACGGTCCC 
GAGCTGCCGC CGCGAGAGGC CCAGGAGGGC GAGGCGGCTC CGCGGTCGGC GCTAAGGAGC 
CCGGGGCAAC CTCCGTCGGC GGGGAGGGCC CGAGACGGCG GCGACGGACG GGAGGCGGCC 
GTCGCGGGAG AGGGGCCGTC GCCACGGAGC CCGGAGCTGG GCAAGGAGCG GCTGCGCTTC 
CAGTTCTTAG AGCAGAAATA TGGCTATTAC CACTGCAAGG ACTGCAACAT CCGCTGGGAG 
AGTGCTTATG TGTGGTGTGT ACAGGGAACT AACAAGGTTT ACTTCAAACA GTTTTGCAGA 
ACTTGTCAGA AGTCTTATAA CCCTTACCGA GTGGAGGATA TCACCTGTCA AAGTTGTAAA 
CAAACGAGAT GTTCCTGCCC AGTAAAACTT CGCCACGTGG ACCCTAAACG GCCCCACCGT 
CAAGATTTGT GCGGTAGATG CAAAGGCAAA CGCCTGTCCT GTGACAGCAC TTTCAGCTTC 
AAATACATCA TTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_783318.1
CDS	41..1315
Translation	MAALGDEVLDGYVFPACPPCSYRYPYPAATKGKGAAGGSWQQRGRGCLPASSPCSAGAASLSFPGCGRLTAAEYFDSYQRERLMALLAQVGPGLGPRARRAGSCDVAVQVSPRIDAAVQCSLGRRTLQRRARDPESPAGPGAEGTTGGGSFSQQPSRRGLEQGSPQNGAPRPMRFPRTVAVYSPLALRRLTAFLEGPGPAAGEQRSGASDGERGPPPARLQGPEEGEVWTKKAPRRPQSDDDGEAQAAVRASWEQPADGPELPPREAQEGEAAPRSALRSPGQPPSAGRARDGGDGREAAVAGEGPSPRSPELGKERLRFQFLEQKYGYYHCKDCNIRWESAYVWCVQGTNKVYFKQFCRTCQKSYNPYRVEDITCQSCKQTRCSCPVKLRHVDPKRPHRQDLCGRCKGKRLSCDSTFSFKYII

Target ORF information:

RefSeq Version	NM_175619.3
Organism	Homo sapiens(human)
Definition	Homo sapiens zygote arrest 1 (ZAR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175619.3

ORF Insert Sequence:

ATGGCGGCCC TGGGGGACGA GGTGCTGGAC GGTTACGTGT TCCCGGCGTG CCCCCCCTGC 
TCGTACCGGT ACCCATACCC CGCGGCCACC AAGGGCAAGG GCGCGGCGGG CGGCAGCTGG 
CAGCAGCGCG GCAGGGGCTG CCTTCCCGCC TCCTCCCCCT GCTCGGCGGG CGCGGCCTCG 
TTGTCCTTCC CGGGCTGCGG GCGGCTGACG GCCGCCGAGT ACTTCGACAG CTACCAGCGG 
GAGCGGCTCA TGGCTCTCCT GGCGCAGGTG GGGCCGGGTC TCGGGCCGCG CGCCCGCAGG 
GCCGGCAGCT GCGACGTGGC GGTGCAGGTG AGCCCGCGCA TCGACGCCGC GGTACAGTGC 
TCGCTGGGGA GGCGCACGCT GCAGCGCCGG GCCCGCGACC CCGAGTCCCC GGCCGGCCCC 
GGGGCCGAGG GCACCACGGG TGGCGGCTCT TTCTCCCAGC AGCCATCCCG TCGAGGCCTG 
GAGCAGGGCA GCCCCCAGAA CGGCGCCCCG CGGCCCATGC GCTTCCCGCG CACCGTCGCC 
GTGTACTCGC CCCTGGCCTT GCGCCGTCTC ACCGCCTTCC TGGAGGGGCC CGGGCCCGCG 
GCGGGCGAGC AGAGGTCCGG GGCGTCGGAC GGAGAGAGGG GGCCGCCGCC CGCGCGGCTT 
CAAGGCCCAG AGGAGGGGGA GGTGTGGACG AAGAAGGCGC CCCGGCGGCC GCAGTCCGAC 
GACGACGGCG AGGCCCAGGC CGCAGTCCGA GCGAGCTGGG AGCAGCCGGC CGACGGTCCC 
GAGCTGCCGC CGCGAGAGGC CCAGGAGGGC GAGGCGGCTC CGCGGTCGGC GCTAAGGAGC 
CCGGGGCAAC CTCCGTCGGC GGGGAGGGCC CGAGACGGCG GCGACGGACG GGAGGCGGCC 
GTCGCGGGAG AGGGGCCGTC GCCACGGAGC CCGGAGCTGG GCAAGGAGCG GCTGCGCTTC 
CAGTTCTTAG AGCAGAAATA TGGCTATTAC CACTGCAAGG ACTGCAACAT CCGCTGGGAG 
AGTGCTTATG TGTGGTGTGT ACAGGGAACT AACAAGGTTT ACTTCAAACA GTTTTGCAGA 
ACTTGTCAGA AGTCTTATAA CCCTTACCGA GTGGAGGATA TCACCTGTCA AAGTTGTAAA 
CAAACGAGAT GTTCCTGCCC AGTAAAACTT CGCCACGTGG ACCCTAAACG GCCCCACCGT 
CAAGATTTGT GCGGTAGATG CAAAGGCAAA CGCCTGTCCT GTGACAGCAC TTTCAGCTTC 
AAATACATCA TTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ZAR1 knockdown promotes the differentiation of human neuroblastoma cells by suppression of MYCN expression.
Medical oncology (Northwood, London, England)34(9)158(2017 Aug)
Watanabe Y,Ishizuka Y,Hirano T,Nagasaki-Maeoka E,Hoshi R,Yoshizawa S,Uekusa S,Kawashima H,Sugito K,Shinohara K,Fukuda N,Nagase H,Soma M,Koshinaga T,Fujiwara K

ZAR1 is a novel epigenetically inactivated tumour suppressor in lung cancer.
Clinical epigenetics960(2017)
Richter AM,Kiehl S,K?ger N,Breuer J,Stiewe T,Dammann RH

Identification of frequent differentially methylated region in sporadic bladder cancers.
Urologia internationalis94(4)479-84(2015)
Hasegawa R,Fujiwara K,Obinata D,Kawashima H,Shinojima Y,Igarashi J,Wang X,Ghosh S,Nagase H,Takahashi S

Evaluation of ZAR1 and SFRP4 methylation status as potentials biomarkers for diagnosis in cervical cancer: exploratory study phase I.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals19(3)181-8(2014 May)
Brebi P,Hoffstetter R,Andana A,Ili CG,Saavedra K,Viscarra T,Retamal J,Sanchez R,Roa JC

Non-promoter DNA hypermethylation of Zygote Arrest 1 (ZAR1) in neuroblastomas.
Journal of pediatric surgery48(4)782-8(2013 Apr)
Sugito K,Kawashima H,Yoshizawa S,Uekusa S,Hoshi R,Furuya T,Kaneda H,Hosoda T,Konuma N,Masuko T,Ohashi K,Ikeda T,Koshinaga T,Tomita R,Shinojima Y,Fujiwara K,Watanabe T,Held WA,Nagase H

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ZAR1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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