HPX cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HPX
Entrez Gene ID	3263
Full Name	hemopexin
Synonyms	HX
General protein information	Preferred Names hemopexin Names hemopexin beta-1B-glycoprotein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.4
Summary	This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009].
Disorder MIM:	142290

mRNA and Protein(s)

mRNA	Protein	Name
XM_005252883.1	XP_005252940.1	hemopexin isoform X1
NM_000613.3	NP_000604.1	hemopexin precursor
NM_000613.2	NP_000604.1	hemopexin precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	HPX	XP_417267.3
Pan troglodytes (chimpanzee)	HPX	XP_508255.1
Canis lupus familiaris (dog)	HPX	XP_853676.1
Xenopus tropicalis (tropical clawed frog)	LOC100495728	XP_002944396.2
	HPX	XP_001109797.1
Mus musculus (house mouse)	Hpx	NP_059067.2
Rattus norvegicus (Norway rat)	Hpx	NP_445770.1
Danio rerio (zebrafish)	hpx	NP_001104617.1
Homo sapiens (human)	HPX	NP_000604.1
Bos taurus (cattle)	HPX	NP_001029784.1

Gene Ontology
Bibliography

Related articles in PubMed

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
Naba A, Pearce OMT, Del Rosario A, Ma D, Ding H, Rajeeve V, Cutillas PR, Balkwill FR, Hynes RO
Journal of proteome research16(8)3083-3091(2017 Aug)

Identification of oxidative modifications of hemopexin and their predicted physiological relevance.
Hahl P, Hunt R, Bjes ES, Skaff A, Keightley A, Smith A
The Journal of biological chemistry292(33)13658-13671(2017 08)

Fetal hemoglobin, ?1-microglobulin and hemopexin are potential predictive first trimester biomarkers for preeclampsia.
Anderson UD, Gram M, Ranstam J, Thilaganathan B, Kerstr?m B, Hansson SR
Pregnancy hypertension6(2)103-9(2016 Apr)

Identification of GlcNAcylated alpha-1-antichymotrypsin as an early biomarker in human non-small-cell lung cancer by quantitative proteomic analysis with two lectins.
Jin Y, Wang J, Ye X, Su Y, Yu G, Yang Q, Liu W, Yu W, Cai J, Chen X, Liang Y, Chen Y, Wong BH, Fu X, Sun H
British journal of cancer114(5)532-44(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that apo-hemopexin isolated from plasma exchibits low endogenous levels of tyrosine nitration in the peptide YYCFQGNQFLR in the heme-binding site of human hemopexin, which was similarly nitrated in rabbit and rat hemopexins; heme binding by hemopexin declined as tyrosine nitration proceeded in vitro.
Title: Identification of oxidative modifications of hemopexin and their predicted physiological relevance.

There were significantly higher serum concentrations of fetal hemoglobin and alpha1-microglobulin and significantly lower first trimester serum concentrations of hemopexin in patients who later developed preeclampsia.
Title: Fetal hemoglobin, ?1-microglobulin and hemopexin are potential predictive first trimester biomarkers for preeclampsia.

HPX is upregulated in non-small cell lung cancer patients compared to those with benign lung disease or no lung disease.
Title: Identification of GlcNAcylated alpha-1-antichymotrypsin as an early biomarker in human non-small-cell lung cancer by quantitative proteomic analysis with two lectins.

Heme scavenging is a major mechanism by which Hx defends against oxidative stress and related inflammatory disorders. [Review]
Title: Role of hemoglobin/heme scavenger protein hemopexin in atherosclerosis and inflammatory diseases.

Plasma hemopexin levels were decreased or markedly decreased in patients with burns or sepsis and in premature infants.
Title: Hemopexin in severe inflammation and infection: mouse models and human diseases.

The following HPX gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HPX cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22890	NM_000613.3 Latest version!	Homo sapiens hemopexin (HPX), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu22890	XM_005252883.1 Latest version!	Homo sapiens hemopexin (HPX), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu22890	NM_000613.2	Homo sapiens hemopexin (HPX), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HPX ( NM_000613.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000604.1 Homo sapiens hemopexin (HPX), mRNA.

Price & Availability↑

CloneID	OHu22890
Clone ID Related Accession (Same CDS sequence)	XM_005252883.1 , NM_000613.3 , NM_000613.2
Accession Version	NM_000613.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1389bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	hemopexin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC005395.1, AK313648.1 and AV655383.1. On Nov 23, 2018 this sequence version replaced NM_000613.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189658.81928.1, SRR5189658.89065.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMEA2155590 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000265983.8/ ENSP00000265983.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTAGGG TACTGGGAGC ACCCGTTGCA CTGGGGTTGT GGAGCCTATG CTGGTCTCTG 
GCCATTGCCA CCCCTCTTCC TCCGACTAGT GCCCATGGGA ATGTTGCTGA AGGCGAGACC 
AAGCCAGACC CAGACGTGAC TGAACGCTGC TCAGATGGCT GGAGCTTTGA TGCTACCACC 
CTGGATGACA ATGGAACCAT GCTGTTTTTT AAAGGGGAGT TTGTGTGGAA GAGTCACAAA 
TGGGACCGGG AGTTAATCTC AGAGAGATGG AAGAATTTCC CCAGCCCTGT GGATGCTGCA 
TTCCGTCAAG GTCACAACAG TGTCTTTCTG ATCAAGGGGG ACAAAGTCTG GGTATACCCT 
CCTGAAAAGA AGGAGAAAGG ATACCCAAAG TTGCTCCAAG ATGAATTTCC TGGAATCCCA 
TCCCCACTGG ATGCAGCTGT GGAATGTCAC CGTGGAGAAT GTCAAGCTGA AGGCGTCCTC 
TTCTTCCAAG GTGACCGCGA GTGGTTCTGG GACTTGGCTA CGGGAACCAT GAAGGAGCGT 
TCCTGGCCAG CTGTTGGGAA CTGCTCCTCT GCCCTGAGAT GGCTGGGCCG CTACTACTGC 
TTCCAGGGTA ACCAATTCCT GCGCTTCGAC CCTGTCAGGG GAGAGGTGCC TCCCAGGTAC 
CCGCGGGATG TCCGAGACTA CTTCATGCCC TGCCCTGGCA GAGGCCATGG ACACAGGAAT 
GGGACTGGCC ATGGGAACAG TACCCACCAT GGCCCTGAGT ATATGCGCTG TAGCCCACAT 
CTAGTCTTGT CTGCACTGAC GTCTGACAAC CATGGTGCCA CCTATGCCTT CAGTGGGACC 
CACTACTGGC GTCTGGACAC CAGCCGGGAT GGCTGGCATA GCTGGCCCAT TGCTCATCAG 
TGGCCCCAGG GTCCTTCAGC AGTGGATGCT GCCTTTTCCT GGGAAGAAAA ACTCTATCTG 
GTCCAGGGCA CCCAGGTATA TGTCTTCCTG ACAAAGGGAG GCTATACCCT AGTAAGCGGT 
TATCCGAAGC GGCTGGAGAA GGAAGTCGGG ACCCCTCATG GGATTATCCT GGACTCTGTG 
GATGCGGCCT TTATCTGCCC TGGGTCTTCT CGGCTCCATA TCATGGCAGG ACGGCGGCTG 
TGGTGGCTGG ACCTGAAGTC AGGAGCCCAA GCCACGTGGA CAGAGCTTCC TTGGCCCCAT 
GAGAAGGTAG ACGGAGCCTT GTGTATGGAA AAGTCCCTTG GCCCTAACTC ATGTTCCGCC 
AATGGTCCCG GCTTGTACCT CATCCATGGT CCCAATTTGT ACTGCTACAG TGATGTGGAG 
AAACTGAATG CAGCCAAGGC CCTTCCGCAA CCCCAGAATG TGACCAGTCT CCTGGGCTGC 
ACTCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000604.1
CDS	25..1413
Translation	MARVLGAPVALGLWSLCWSLAIATPLPPTSAHGNVAEGETKPDPDVTERCSDGWSFDATTLDDNGTMLFFKGEFVWKSHKWDRELISERWKNFPSPVDAAFRQGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQDEFPGIPSPLDAAVECHRGECQAEGVLFFQGDREWFWDLATGTMKERSWPAVGNCSSALRWLGRYYCFQGNQFLRFDPVRGEVPPRYPRDVRDYFMPCPGRGHGHRNGTGHGNSTHHGPEYMRCSPHLVLSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPIAHQWPQGPSAVDAAFSWEEKLYLVQGTQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSVDAAFICPGSSRLHIMAGRRLWWLDLKSGAQATWTELPWPHEKVDGALCMEKSLGPNSCSANGPGLYLIHGPNLYCYSDVEKLNAAKALPQPQNVTSLLGCTH

Target ORF information:

RefSeq Version	NM_000613.3
Organism	Homo sapiens(human)
Definition	Homo sapiens hemopexin (HPX), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000613.3

ORF Insert Sequence:

ATGGCTAGGG TACTGGGAGC ACCCGTTGCA CTGGGGTTGT GGAGCCTATG CTGGTCTCTG 
GCCATTGCCA CCCCTCTTCC TCCGACTAGT GCCCATGGGA ATGTTGCTGA AGGCGAGACC 
AAGCCAGACC CAGACGTGAC TGAACGCTGC TCAGATGGCT GGAGCTTTGA TGCTACCACC 
CTGGATGACA ATGGAACCAT GCTGTTTTTT AAAGGGGAGT TTGTGTGGAA GAGTCACAAA 
TGGGACCGGG AGTTAATCTC AGAGAGATGG AAGAATTTCC CCAGCCCTGT GGATGCTGCA 
TTCCGTCAAG GTCACAACAG TGTCTTTCTG ATCAAGGGGG ACAAAGTCTG GGTATACCCT 
CCTGAAAAGA AGGAGAAAGG ATACCCAAAG TTGCTCCAAG ATGAATTTCC TGGAATCCCA 
TCCCCACTGG ATGCAGCTGT GGAATGTCAC CGTGGAGAAT GTCAAGCTGA AGGCGTCCTC 
TTCTTCCAAG GTGACCGCGA GTGGTTCTGG GACTTGGCTA CGGGAACCAT GAAGGAGCGT 
TCCTGGCCAG CTGTTGGGAA CTGCTCCTCT GCCCTGAGAT GGCTGGGCCG CTACTACTGC 
TTCCAGGGTA ACCAATTCCT GCGCTTCGAC CCTGTCAGGG GAGAGGTGCC TCCCAGGTAC 
CCGCGGGATG TCCGAGACTA CTTCATGCCC TGCCCTGGCA GAGGCCATGG ACACAGGAAT 
GGGACTGGCC ATGGGAACAG TACCCACCAT GGCCCTGAGT ATATGCGCTG TAGCCCACAT 
CTAGTCTTGT CTGCACTGAC GTCTGACAAC CATGGTGCCA CCTATGCCTT CAGTGGGACC 
CACTACTGGC GTCTGGACAC CAGCCGGGAT GGCTGGCATA GCTGGCCCAT TGCTCATCAG 
TGGCCCCAGG GTCCTTCAGC AGTGGATGCT GCCTTTTCCT GGGAAGAAAA ACTCTATCTG 
GTCCAGGGCA CCCAGGTATA TGTCTTCCTG ACAAAGGGAG GCTATACCCT AGTAAGCGGT 
TATCCGAAGC GGCTGGAGAA GGAAGTCGGG ACCCCTCATG GGATTATCCT GGACTCTGTG 
GATGCGGCCT TTATCTGCCC TGGGTCTTCT CGGCTCCATA TCATGGCAGG ACGGCGGCTG 
TGGTGGCTGG ACCTGAAGTC AGGAGCCCAA GCCACGTGGA CAGAGCTTCC TTGGCCCCAT 
GAGAAGGTAG ACGGAGCCTT GTGTATGGAA AAGTCCCTTG GCCCTAACTC ATGTTCCGCC 
AATGGTCCCG GCTTGTACCT CATCCATGGT CCCAATTTGT ACTGCTACAG TGATGTGGAG 
AAACTGAATG CAGCCAAGGC CCTTCCGCAA CCCCAGAATG TGACCAGTCT CCTGGGCTGC 
ACTCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HPX ( NM_000613.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000604.1 Homo sapiens hemopexin (HPX), mRNA.

Price & Availability↑

CloneID	OHu22890
Clone ID Related Accession (Same CDS sequence)	XM_005252883.1 , NM_000613.3 , NM_000613.2
Accession Version	NM_000613.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1389bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-10
Organism	Homo sapiens(human)
Product	hemopexin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC005395.1, AK313648.1, AV655383.1 and AC084337.7. On Apr 23, 2009 this sequence version replaced NM_000613.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC005395.1, ERR279874.429.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMEA2155590 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTAGGG TACTGGGAGC ACCCGTTGCA CTGGGGTTGT GGAGCCTATG CTGGTCTCTG 
GCCATTGCCA CCCCTCTTCC TCCGACTAGT GCCCATGGGA ATGTTGCTGA AGGCGAGACC 
AAGCCAGACC CAGACGTGAC TGAACGCTGC TCAGATGGCT GGAGCTTTGA TGCTACCACC 
CTGGATGACA ATGGAACCAT GCTGTTTTTT AAAGGGGAGT TTGTGTGGAA GAGTCACAAA 
TGGGACCGGG AGTTAATCTC AGAGAGATGG AAGAATTTCC CCAGCCCTGT GGATGCTGCA 
TTCCGTCAAG GTCACAACAG TGTCTTTCTG ATCAAGGGGG ACAAAGTCTG GGTATACCCT 
CCTGAAAAGA AGGAGAAAGG ATACCCAAAG TTGCTCCAAG ATGAATTTCC TGGAATCCCA 
TCCCCACTGG ATGCAGCTGT GGAATGTCAC CGTGGAGAAT GTCAAGCTGA AGGCGTCCTC 
TTCTTCCAAG GTGACCGCGA GTGGTTCTGG GACTTGGCTA CGGGAACCAT GAAGGAGCGT 
TCCTGGCCAG CTGTTGGGAA CTGCTCCTCT GCCCTGAGAT GGCTGGGCCG CTACTACTGC 
TTCCAGGGTA ACCAATTCCT GCGCTTCGAC CCTGTCAGGG GAGAGGTGCC TCCCAGGTAC 
CCGCGGGATG TCCGAGACTA CTTCATGCCC TGCCCTGGCA GAGGCCATGG ACACAGGAAT 
GGGACTGGCC ATGGGAACAG TACCCACCAT GGCCCTGAGT ATATGCGCTG TAGCCCACAT 
CTAGTCTTGT CTGCACTGAC GTCTGACAAC CATGGTGCCA CCTATGCCTT CAGTGGGACC 
CACTACTGGC GTCTGGACAC CAGCCGGGAT GGCTGGCATA GCTGGCCCAT TGCTCATCAG 
TGGCCCCAGG GTCCTTCAGC AGTGGATGCT GCCTTTTCCT GGGAAGAAAA ACTCTATCTG 
GTCCAGGGCA CCCAGGTATA TGTCTTCCTG ACAAAGGGAG GCTATACCCT AGTAAGCGGT 
TATCCGAAGC GGCTGGAGAA GGAAGTCGGG ACCCCTCATG GGATTATCCT GGACTCTGTG 
GATGCGGCCT TTATCTGCCC TGGGTCTTCT CGGCTCCATA TCATGGCAGG ACGGCGGCTG 
TGGTGGCTGG ACCTGAAGTC AGGAGCCCAA GCCACGTGGA CAGAGCTTCC TTGGCCCCAT 
GAGAAGGTAG ACGGAGCCTT GTGTATGGAA AAGTCCCTTG GCCCTAACTC ATGTTCCGCC 
AATGGTCCCG GCTTGTACCT CATCCATGGT CCCAATTTGT ACTGCTACAG TGATGTGGAG 
AAACTGAATG CAGCCAAGGC CCTTCCGCAA CCCCAGAATG TGACCAGTCT CCTGGGCTGC 
ACTCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000604.1
CDS	62..1450
Translation	MARVLGAPVALGLWSLCWSLAIATPLPPTSAHGNVAEGETKPDPDVTERCSDGWSFDATTLDDNGTMLFFKGEFVWKSHKWDRELISERWKNFPSPVDAAFRQGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQDEFPGIPSPLDAAVECHRGECQAEGVLFFQGDREWFWDLATGTMKERSWPAVGNCSSALRWLGRYYCFQGNQFLRFDPVRGEVPPRYPRDVRDYFMPCPGRGHGHRNGTGHGNSTHHGPEYMRCSPHLVLSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPIAHQWPQGPSAVDAAFSWEEKLYLVQGTQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSVDAAFICPGSSRLHIMAGRRLWWLDLKSGAQATWTELPWPHEKVDGALCMEKSLGPNSCSANGPGLYLIHGPNLYCYSDVEKLNAAKALPQPQNVTSLLGCTH

Target ORF information:

RefSeq Version	NM_000613.2
Organism	Homo sapiens(human)
Definition	Homo sapiens hemopexin (HPX), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000613.2

ORF Insert Sequence:

ATGGCTAGGG TACTGGGAGC ACCCGTTGCA CTGGGGTTGT GGAGCCTATG CTGGTCTCTG 
GCCATTGCCA CCCCTCTTCC TCCGACTAGT GCCCATGGGA ATGTTGCTGA AGGCGAGACC 
AAGCCAGACC CAGACGTGAC TGAACGCTGC TCAGATGGCT GGAGCTTTGA TGCTACCACC 
CTGGATGACA ATGGAACCAT GCTGTTTTTT AAAGGGGAGT TTGTGTGGAA GAGTCACAAA 
TGGGACCGGG AGTTAATCTC AGAGAGATGG AAGAATTTCC CCAGCCCTGT GGATGCTGCA 
TTCCGTCAAG GTCACAACAG TGTCTTTCTG ATCAAGGGGG ACAAAGTCTG GGTATACCCT 
CCTGAAAAGA AGGAGAAAGG ATACCCAAAG TTGCTCCAAG ATGAATTTCC TGGAATCCCA 
TCCCCACTGG ATGCAGCTGT GGAATGTCAC CGTGGAGAAT GTCAAGCTGA AGGCGTCCTC 
TTCTTCCAAG GTGACCGCGA GTGGTTCTGG GACTTGGCTA CGGGAACCAT GAAGGAGCGT 
TCCTGGCCAG CTGTTGGGAA CTGCTCCTCT GCCCTGAGAT GGCTGGGCCG CTACTACTGC 
TTCCAGGGTA ACCAATTCCT GCGCTTCGAC CCTGTCAGGG GAGAGGTGCC TCCCAGGTAC 
CCGCGGGATG TCCGAGACTA CTTCATGCCC TGCCCTGGCA GAGGCCATGG ACACAGGAAT 
GGGACTGGCC ATGGGAACAG TACCCACCAT GGCCCTGAGT ATATGCGCTG TAGCCCACAT 
CTAGTCTTGT CTGCACTGAC GTCTGACAAC CATGGTGCCA CCTATGCCTT CAGTGGGACC 
CACTACTGGC GTCTGGACAC CAGCCGGGAT GGCTGGCATA GCTGGCCCAT TGCTCATCAG 
TGGCCCCAGG GTCCTTCAGC AGTGGATGCT GCCTTTTCCT GGGAAGAAAA ACTCTATCTG 
GTCCAGGGCA CCCAGGTATA TGTCTTCCTG ACAAAGGGAG GCTATACCCT AGTAAGCGGT 
TATCCGAAGC GGCTGGAGAA GGAAGTCGGG ACCCCTCATG GGATTATCCT GGACTCTGTG 
GATGCGGCCT TTATCTGCCC TGGGTCTTCT CGGCTCCATA TCATGGCAGG ACGGCGGCTG 
TGGTGGCTGG ACCTGAAGTC AGGAGCCCAA GCCACGTGGA CAGAGCTTCC TTGGCCCCAT 
GAGAAGGTAG ACGGAGCCTT GTGTATGGAA AAGTCCCTTG GCCCTAACTC ATGTTCCGCC 
AATGGTCCCG GCTTGTACCT CATCCATGGT CCCAATTTGT ACTGCTACAG TGATGTGGAG 
AAACTGAATG CAGCCAAGGC CCTTCCGCAA CCCCAGAATG TGACCAGTCT CCTGGGCTGC 
ACTCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HPX ( XM_005252883.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_005252940.1 Homo sapiens hemopexin (HPX), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu22890
Clone ID Related Accession (Same CDS sequence)	XM_005252883.1 , NM_000613.3 , NM_000613.2
Accession Version	XM_005252883.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1389bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	hemopexin isoform X1
Comment

ATGGCTAGGG TACTGGGAGC ACCCGTTGCA CTGGGGTTGT GGAGCCTATG CTGGTCTCTG 
GCCATTGCCA CCCCTCTTCC TCCGACTAGT GCCCATGGGA ATGTTGCTGA AGGCGAGACC 
AAGCCAGACC CAGACGTGAC TGAACGCTGC TCAGATGGCT GGAGCTTTGA TGCTACCACC 
CTGGATGACA ATGGAACCAT GCTGTTTTTT AAAGGGGAGT TTGTGTGGAA GAGTCACAAA 
TGGGACCGGG AGTTAATCTC AGAGAGATGG AAGAATTTCC CCAGCCCTGT GGATGCTGCA 
TTCCGTCAAG GTCACAACAG TGTCTTTCTG ATCAAGGGGG ACAAAGTCTG GGTATACCCT 
CCTGAAAAGA AGGAGAAAGG ATACCCAAAG TTGCTCCAAG ATGAATTTCC TGGAATCCCA 
TCCCCACTGG ATGCAGCTGT GGAATGTCAC CGTGGAGAAT GTCAAGCTGA AGGCGTCCTC 
TTCTTCCAAG GTGACCGCGA GTGGTTCTGG GACTTGGCTA CGGGAACCAT GAAGGAGCGT 
TCCTGGCCAG CTGTTGGGAA CTGCTCCTCT GCCCTGAGAT GGCTGGGCCG CTACTACTGC 
TTCCAGGGTA ACCAATTCCT GCGCTTCGAC CCTGTCAGGG GAGAGGTGCC TCCCAGGTAC 
CCGCGGGATG TCCGAGACTA CTTCATGCCC TGCCCTGGCA GAGGCCATGG ACACAGGAAT 
GGGACTGGCC ATGGGAACAG TACCCACCAT GGCCCTGAGT ATATGCGCTG TAGCCCACAT 
CTAGTCTTGT CTGCACTGAC GTCTGACAAC CATGGTGCCA CCTATGCCTT CAGTGGGACC 
CACTACTGGC GTCTGGACAC CAGCCGGGAT GGCTGGCATA GCTGGCCCAT TGCTCATCAG 
TGGCCCCAGG GTCCTTCAGC AGTGGATGCT GCCTTTTCCT GGGAAGAAAA ACTCTATCTG 
GTCCAGGGCA CCCAGGTATA TGTCTTCCTG ACAAAGGGAG GCTATACCCT AGTAAGCGGT 
TATCCGAAGC GGCTGGAGAA GGAAGTCGGG ACCCCTCATG GGATTATCCT GGACTCTGTG 
GATGCGGCCT TTATCTGCCC TGGGTCTTCT CGGCTCCATA TCATGGCAGG ACGGCGGCTG 
TGGTGGCTGG ACCTGAAGTC AGGAGCCCAA GCCACGTGGA CAGAGCTTCC TTGGCCCCAT 
GAGAAGGTAG ACGGAGCCTT GTGTATGGAA AAGTCCCTTG GCCCTAACTC ATGTTCCGCC 
AATGGTCCCG GCTTGTACCT CATCCATGGT CCCAATTTGT ACTGCTACAG TGATGTGGAG 
AAACTGAATG CAGCCAAGGC CCTTCCGCAA CCCCAGAATG TGACCAGTCT CCTGGGCTGC 
ACTCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_005252940.1

Translation

MARVLGAPVALGLWSLCWSLAIATPLPPTSAHGNVAEGETKPDPDVTERCSDGWSFDATTLDDNGTMLFFKGEFVWKSHKWDRELISERWKNFPSPVDAAFRQGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQDEFPGIPSPLDAAVECHRGECQAEGVLFFQGDREWFWDLATGTMKERSWPAVGNCSSALRWLGRYYCFQGNQFLRFDPVRGEVPPRYPRDVRDYFMPCPGRGHGHRNGTGHGNSTHHGPEYMRCSPHLVLSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPIAHQWPQGPSAVDAAFSWEEKLYLVQGTQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSVDAAFICPGSSRLHIMAGRRLWWLDLKSGAQATWTELPWPHEKVDGALCMEKSLGPNSCSANGPGLYLIHGPNLYCYSDVEKLNAAKALPQPQNVTSLLGCTH

Target ORF information:

RefSeq Version	XM_005252883.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens hemopexin (HPX), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005252883.1

ORF Insert Sequence:

ATGGCTAGGG TACTGGGAGC ACCCGTTGCA CTGGGGTTGT GGAGCCTATG CTGGTCTCTG 
GCCATTGCCA CCCCTCTTCC TCCGACTAGT GCCCATGGGA ATGTTGCTGA AGGCGAGACC 
AAGCCAGACC CAGACGTGAC TGAACGCTGC TCAGATGGCT GGAGCTTTGA TGCTACCACC 
CTGGATGACA ATGGAACCAT GCTGTTTTTT AAAGGGGAGT TTGTGTGGAA GAGTCACAAA 
TGGGACCGGG AGTTAATCTC AGAGAGATGG AAGAATTTCC CCAGCCCTGT GGATGCTGCA 
TTCCGTCAAG GTCACAACAG TGTCTTTCTG ATCAAGGGGG ACAAAGTCTG GGTATACCCT 
CCTGAAAAGA AGGAGAAAGG ATACCCAAAG TTGCTCCAAG ATGAATTTCC TGGAATCCCA 
TCCCCACTGG ATGCAGCTGT GGAATGTCAC CGTGGAGAAT GTCAAGCTGA AGGCGTCCTC 
TTCTTCCAAG GTGACCGCGA GTGGTTCTGG GACTTGGCTA CGGGAACCAT GAAGGAGCGT 
TCCTGGCCAG CTGTTGGGAA CTGCTCCTCT GCCCTGAGAT GGCTGGGCCG CTACTACTGC 
TTCCAGGGTA ACCAATTCCT GCGCTTCGAC CCTGTCAGGG GAGAGGTGCC TCCCAGGTAC 
CCGCGGGATG TCCGAGACTA CTTCATGCCC TGCCCTGGCA GAGGCCATGG ACACAGGAAT 
GGGACTGGCC ATGGGAACAG TACCCACCAT GGCCCTGAGT ATATGCGCTG TAGCCCACAT 
CTAGTCTTGT CTGCACTGAC GTCTGACAAC CATGGTGCCA CCTATGCCTT CAGTGGGACC 
CACTACTGGC GTCTGGACAC CAGCCGGGAT GGCTGGCATA GCTGGCCCAT TGCTCATCAG 
TGGCCCCAGG GTCCTTCAGC AGTGGATGCT GCCTTTTCCT GGGAAGAAAA ACTCTATCTG 
GTCCAGGGCA CCCAGGTATA TGTCTTCCTG ACAAAGGGAG GCTATACCCT AGTAAGCGGT 
TATCCGAAGC GGCTGGAGAA GGAAGTCGGG ACCCCTCATG GGATTATCCT GGACTCTGTG 
GATGCGGCCT TTATCTGCCC TGGGTCTTCT CGGCTCCATA TCATGGCAGG ACGGCGGCTG 
TGGTGGCTGG ACCTGAAGTC AGGAGCCCAA GCCACGTGGA CAGAGCTTCC TTGGCCCCAT 
GAGAAGGTAG ACGGAGCCTT GTGTATGGAA AAGTCCCTTG GCCCTAACTC ATGTTCCGCC 
AATGGTCCCG GCTTGTACCT CATCCATGGT CCCAATTTGT ACTGCTACAG TGATGTGGAG 
AAACTGAATG CAGCCAAGGC CCTTCCGCAA CCCCAGAATG TGACCAGTCT CCTGGGCTGC 
ACTCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
Journal of proteome research16(8)3083-3091(2017 Aug)
Naba A,Pearce OMT,Del Rosario A,Ma D,Ding H,Rajeeve V,Cutillas PR,Balkwill FR,Hynes RO

Identification of oxidative modifications of hemopexin and their predicted physiological relevance.
The Journal of biological chemistry292(33)13658-13671(2017 08)
Hahl P,Hunt R,Bjes ES,Skaff A,Keightley A,Smith A

Fetal hemoglobin, ?1-microglobulin and hemopexin are potential predictive first trimester biomarkers for preeclampsia.
Pregnancy hypertension6(2)103-9(2016 Apr)
Anderson UD,Gram M,Ranstam J,Thilaganathan B,Kerstr?m B,Hansson SR

Identification of GlcNAcylated alpha-1-antichymotrypsin as an early biomarker in human non-small-cell lung cancer by quantitative proteomic analysis with two lectins.
British journal of cancer114(5)532-44(2016 Mar)
Jin Y,Wang J,Ye X,Su Y,Yu G,Yang Q,Liu W,Yu W,Cai J,Chen X,Liang Y,Chen Y,Wong BH,Fu X,Sun H

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HPX cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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