AIRE cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	AIRE
Entrez Gene ID	326
Full Name	autoimmune regulator
Synonyms	AIRE1,APECED,APS1,APSI,PGA1
General protein information	Preferred Names autoimmune regulator Names autoimmune regulator autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 21 Map Location: 21q22.3
Summary	This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012].
Disorder MIM:	607358
Disorder Html:	Autoimmune polyendocrinopathy syndrome , type I, with or without reversible metaphyseal dysplasia, 240300 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000383.3	NP_000374.1	autoimmune regulator
NM_000383.4	NP_000374.1	autoimmune regulator

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	AIRE	XP_531580.1
Bos taurus (cattle)	AIRE	XP_002685182.2
Rattus norvegicus (Norway rat)	Aire	NP_001099849.1
	AIRE	XP_001103602.2
Canis lupus familiaris (dog)	AIRE	XP_544921.3
Homo sapiens (human)	AIRE	NP_000374.1
Mus musculus (house mouse)	Aire	NP_001258478.1
Danio rerio (zebrafish)	aire	NP_001103484.1

Gene Ontology
Bibliography

Related articles in PubMed

Exome Sequencing Reveals Mutations in AIRE as a Cause of Isolated Hypoparathyroidism.
Li D, Streeten EA, Chan A, Lwin W, Tian L, Pellegrino da Silva R, Kim CE, Anderson MS, Hakonarson H, Levine MA
The Journal of clinical endocrinology and metabolism102(5)1726-1733(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rs3761389 variant is associated with the susceptibility of myasthenia gravis in Chinese patients.
Title: Rs3761389 polymorphism in autoimmune regulator (AIRE) gene is associated with susceptibility of myasthenia gravis in Chinese patients.

Whole exome sequencing followed by Sanger sequencing revealed that all three subjects affected by hypoparathyroidism were compound heterozygous for two previously reported mutations, c.967_979delCTGTCCCCTCCGC:p.(L323SfsX51) and c.995+(3_5)delGAGinsTAT, in AIRE, which encodes the autoimmune regulator protein that is defective in autoimmune polyglandular syndrome type 1 (APS-1).
Title: Exome Sequencing Reveals Mutations in AIRE as a Cause of Isolated Hypoparathyroidism.

the presence of AIRE can trigger molecular events leading to an altered chromatin landscape and the enhanced transcription of low-expressed genes
Title: DNA breaks and chromatin structural changes enhance the transcription of autoimmune regulator target genes.

Homozygote Mutation in the AIRE gene is associated with APECED syndrome.
Title: Unexplained cyanosis caused by hepatopulmonary syndrome in a girl with APECED syndrome.

Estrogen induces decreased thymic AIRE expression by epigenetic modifications through increased number of methylation sites within the AIRE promoter.[review]
Title: [Autoimmune disease predisposition: Aire ??protects?? men].

The following AIRE gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AIRE cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20021	NM_000383.4 Latest version!	Homo sapiens autoimmune regulator (AIRE), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$229.50-$321.30 $459.00
View Old Accession Versions >>
OHu20021	NM_000383.3	Homo sapiens autoimmune regulator (AIRE), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$229.50-$321.30 $459.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AIRE ( NM_000383.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000374.1 Homo sapiens autoimmune regulator (AIRE), mRNA.

Price & Availability↑

CloneID	OHu20021
Clone ID Related Accession (Same CDS sequence)	NM_000383.3 , NM_000383.4
Accession Version	NM_000383.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1638bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	autoimmune regulator
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC142608.1 and AB006682.1. On Jun 8, 2012 this sequence version replaced NM_000383.2. Sequence Note:. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Z97990.1, AB006682.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGCGACGG ACGCGGCGCT ACGCCGGCTT CTGAGGCTGC ACCGCACGGA GATCGCGGTG 
GCCGTGGACA GCGCCTTCCC ACTGCTGCAC GCGCTGGCTG ACCACGACGT GGTCCCCGAG 
GACAAGTTTC AGGAGACGCT TCATCTGAAG GAAAAGGAGG GCTGCCCCCA GGCCTTCCAC 
GCCCTCCTGT CCTGGCTGCT GACCCAGGAC TCCACAGCCA TCCTGGACTT CTGGAGGGTG 
CTGTTCAAGG ACTACAACCT GGAGCGCTAT GGCCGGCTGC AGCCCATCCT GGACAGCTTC 
CCCAAAGATG TGGACCTCAG CCAGCCCCGG AAGGGGAGGA AGCCCCCGGC CGTCCCCAAG 
GCTTTGGTAC CGCCACCCAG ACTCCCCACC AAGAGGAAGG CCTCAGAAGA GGCTCGAGCT 
GCCGCGCCAG CAGCCCTGAC TCCAAGGGGC ACCGCCAGCC CAGGCTCTCA ACTGAAGGCC 
AAGCCCCCCA AGAAGCCGGA GAGCAGCGCA GAGCAGCAGC GCCTTCCACT CGGGAACGGG 
ATTCAGACCA TGTCAGCTTC AGTCCAGAGA GCTGTGGCCA TGTCCTCCGG GGACGTCCCG 
GGAGCCCGAG GGGCCGTGGA GGGGATCCTC ATCCAGCAGG TGTTTGAGTC AGGCGGCTCC 
AAGAAGTGCA TCCAGGTTGG CGGGGAGTTC TACACTCCCA GCAAGTTCGA AGACTCCGGC 
AGTGGGAAGA ACAAGGCCCG CAGCAGCAGT GGCCCGAAGC CTCTGGTTCG AGCCAAGGGA 
GCCCAGGGCG CTGCCCCCGG TGGAGGTGAG GCTAGGCTGG GCCAGCAGGG CAGCGTTCCC 
GCCCCTCTGG CCCTCCCCAG TGACCCCCAG CTCCACCAGA AGAATGAGGA CGAGTGTGCC 
GTGTGTCGGG ACGGCGGGGA GCTCATCTGC TGTGACGGCT GCCCTCGGGC CTTCCACCTG 
GCCTGCCTGT CCCCTCCGCT CCGGGAGATC CCCAGTGGGA CCTGGAGGTG CTCCAGCTGC 
CTGCAGGCAA CAGTCCAGGA GGTGCAGCCC CGGGCAGAGG AGCCCCGGCC CCAGGAGCCA 
CCCGTGGAGA CCCCGCTCCC CCCGGGGCTT AGGTCGGCGG GAGAGGAGGT AAGAGGTCCA 
CCTGGGGAAC CCCTAGCCGG CATGGACACG ACTCTTGTCT ACAAGCACCT GCCGGCTCCG 
CCTTCTGCAG CCCCGCTGCC AGGGCTGGAC TCCTCGGCCC TGCACCCCCT ACTGTGTGTG 
GGTCCTGAGG GTCAGCAGAA CCTGGCTCCT GGTGCGCGTT GCGGGGTGTG CGGAGATGGT 
ACGGACGTGC TGCGGTGTAC TCACTGCGCC GCTGCCTTCC ACTGGCGCTG CCACTTCCCA 
GCCGGCACCT CCCGGCCCGG GACGGGCCTG CGCTGCAGAT CCTGCTCAGG AGACGTGACC 
CCAGCCCCTG TGGAGGGGGT GCTGGCCCCC AGCCCCGCCC GCCTGGCCCC TGGGCCTGCC 
AAGGATGACA CTGCCAGTCA CGAGCCCGCT CTGCACAGGG ATGACCTGGA GTCCCTTCTG 
AGCGAGCACA CCTTCGATGG CATCCTGCAG TGGGCCATCC AGAGCATGGC CCGTCCGGCG 
GCCCCCTTCC CCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000374.1
CDS	170..1807
Translation	MATDAALRRLLRLHRTEIAVAVDSAFPLLHALADHDVVPEDKFQETLHLKEKEGCPQAFHALLSWLLTQDSTAILDFWRVLFKDYNLERYGRLQPILDSFPKDVDLSQPRKGRKPPAVPKALVPPPRLPTKRKASEEARAAAPAALTPRGTASPGSQLKAKPPKKPESSAEQQRLPLGNGIQTMSASVQRAVAMSSGDVPGARGAVEGILIQQVFESGGSKKCIQVGGEFYTPSKFEDSGSGKNKARSSSGPKPLVRAKGAQGAAPGGGEARLGQQGSVPAPLALPSDPQLHQKNEDECAVCRDGGELICCDGCPRAFHLACLSPPLREIPSGTWRCSSCLQATVQEVQPRAEEPRPQEPPVETPLPPGLRSAGEEVRGPPGEPLAGMDTTLVYKHLPAPPSAAPLPGLDSSALHPLLCVGPEGQQNLAPGARCGVCGDGTDVLRCTHCAAAFHWRCHFPAGTSRPGTGLRCRSCSGDVTPAPVEGVLAPSPARLAPGPAKDDTASHEPALHRDDLESLLSEHTFDGILQWAIQSMARPAAPFPS

Target ORF information:

RefSeq Version	NM_000383.3
Organism	Homo sapiens(human)
Definition	Homo sapiens autoimmune regulator (AIRE), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000383.3

ORF Insert Sequence:

ATGGCGACGG ACGCGGCGCT ACGCCGGCTT CTGAGGCTGC ACCGCACGGA GATCGCGGTG 
GCCGTGGACA GCGCCTTCCC ACTGCTGCAC GCGCTGGCTG ACCACGACGT GGTCCCCGAG 
GACAAGTTTC AGGAGACGCT TCATCTGAAG GAAAAGGAGG GCTGCCCCCA GGCCTTCCAC 
GCCCTCCTGT CCTGGCTGCT GACCCAGGAC TCCACAGCCA TCCTGGACTT CTGGAGGGTG 
CTGTTCAAGG ACTACAACCT GGAGCGCTAT GGCCGGCTGC AGCCCATCCT GGACAGCTTC 
CCCAAAGATG TGGACCTCAG CCAGCCCCGG AAGGGGAGGA AGCCCCCGGC CGTCCCCAAG 
GCTTTGGTAC CGCCACCCAG ACTCCCCACC AAGAGGAAGG CCTCAGAAGA GGCTCGAGCT 
GCCGCGCCAG CAGCCCTGAC TCCAAGGGGC ACCGCCAGCC CAGGCTCTCA ACTGAAGGCC 
AAGCCCCCCA AGAAGCCGGA GAGCAGCGCA GAGCAGCAGC GCCTTCCACT CGGGAACGGG 
ATTCAGACCA TGTCAGCTTC AGTCCAGAGA GCTGTGGCCA TGTCCTCCGG GGACGTCCCG 
GGAGCCCGAG GGGCCGTGGA GGGGATCCTC ATCCAGCAGG TGTTTGAGTC AGGCGGCTCC 
AAGAAGTGCA TCCAGGTTGG CGGGGAGTTC TACACTCCCA GCAAGTTCGA AGACTCCGGC 
AGTGGGAAGA ACAAGGCCCG CAGCAGCAGT GGCCCGAAGC CTCTGGTTCG AGCCAAGGGA 
GCCCAGGGCG CTGCCCCCGG TGGAGGTGAG GCTAGGCTGG GCCAGCAGGG CAGCGTTCCC 
GCCCCTCTGG CCCTCCCCAG TGACCCCCAG CTCCACCAGA AGAATGAGGA CGAGTGTGCC 
GTGTGTCGGG ACGGCGGGGA GCTCATCTGC TGTGACGGCT GCCCTCGGGC CTTCCACCTG 
GCCTGCCTGT CCCCTCCGCT CCGGGAGATC CCCAGTGGGA CCTGGAGGTG CTCCAGCTGC 
CTGCAGGCAA CAGTCCAGGA GGTGCAGCCC CGGGCAGAGG AGCCCCGGCC CCAGGAGCCA 
CCCGTGGAGA CCCCGCTCCC CCCGGGGCTT AGGTCGGCGG GAGAGGAGGT AAGAGGTCCA 
CCTGGGGAAC CCCTAGCCGG CATGGACACG ACTCTTGTCT ACAAGCACCT GCCGGCTCCG 
CCTTCTGCAG CCCCGCTGCC AGGGCTGGAC TCCTCGGCCC TGCACCCCCT ACTGTGTGTG 
GGTCCTGAGG GTCAGCAGAA CCTGGCTCCT GGTGCGCGTT GCGGGGTGTG CGGAGATGGT 
ACGGACGTGC TGCGGTGTAC TCACTGCGCC GCTGCCTTCC ACTGGCGCTG CCACTTCCCA 
GCCGGCACCT CCCGGCCCGG GACGGGCCTG CGCTGCAGAT CCTGCTCAGG AGACGTGACC 
CCAGCCCCTG TGGAGGGGGT GCTGGCCCCC AGCCCCGCCC GCCTGGCCCC TGGGCCTGCC 
AAGGATGACA CTGCCAGTCA CGAGCCCGCT CTGCACAGGG ATGACCTGGA GTCCCTTCTG 
AGCGAGCACA CCTTCGATGG CATCCTGCAG TGGGCCATCC AGAGCATGGC CCGTCCGGCG 
GCCCCCTTCC CCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AIRE ( NM_000383.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000374.1 Homo sapiens autoimmune regulator (AIRE), mRNA.

Price & Availability↑

CloneID	OHu20021
Clone ID Related Accession (Same CDS sequence)	NM_000383.3 , NM_000383.4
Accession Version	NM_000383.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1638bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	autoimmune regulator
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC142608.1, AB006682.1 and AP001060.1. On Nov 23, 2018 this sequence version replaced NM_000383.3. Sequence Note:. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Z97990.1, AB006682.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000291582.6/ ENSP00000291582.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGACGG ACGCGGCGCT ACGCCGGCTT CTGAGGCTGC ACCGCACGGA GATCGCGGTG 
GCCGTGGACA GCGCCTTCCC ACTGCTGCAC GCGCTGGCTG ACCACGACGT GGTCCCCGAG 
GACAAGTTTC AGGAGACGCT TCATCTGAAG GAAAAGGAGG GCTGCCCCCA GGCCTTCCAC 
GCCCTCCTGT CCTGGCTGCT GACCCAGGAC TCCACAGCCA TCCTGGACTT CTGGAGGGTG 
CTGTTCAAGG ACTACAACCT GGAGCGCTAT GGCCGGCTGC AGCCCATCCT GGACAGCTTC 
CCCAAAGATG TGGACCTCAG CCAGCCCCGG AAGGGGAGGA AGCCCCCGGC CGTCCCCAAG 
GCTTTGGTAC CGCCACCCAG ACTCCCCACC AAGAGGAAGG CCTCAGAAGA GGCTCGAGCT 
GCCGCGCCAG CAGCCCTGAC TCCAAGGGGC ACCGCCAGCC CAGGCTCTCA ACTGAAGGCC 
AAGCCCCCCA AGAAGCCGGA GAGCAGCGCA GAGCAGCAGC GCCTTCCACT CGGGAACGGG 
ATTCAGACCA TGTCAGCTTC AGTCCAGAGA GCTGTGGCCA TGTCCTCCGG GGACGTCCCG 
GGAGCCCGAG GGGCCGTGGA GGGGATCCTC ATCCAGCAGG TGTTTGAGTC AGGCGGCTCC 
AAGAAGTGCA TCCAGGTTGG CGGGGAGTTC TACACTCCCA GCAAGTTCGA AGACTCCGGC 
AGTGGGAAGA ACAAGGCCCG CAGCAGCAGT GGCCCGAAGC CTCTGGTTCG AGCCAAGGGA 
GCCCAGGGCG CTGCCCCCGG TGGAGGTGAG GCTAGGCTGG GCCAGCAGGG CAGCGTTCCC 
GCCCCTCTGG CCCTCCCCAG TGACCCCCAG CTCCACCAGA AGAATGAGGA CGAGTGTGCC 
GTGTGTCGGG ACGGCGGGGA GCTCATCTGC TGTGACGGCT GCCCTCGGGC CTTCCACCTG 
GCCTGCCTGT CCCCTCCGCT CCGGGAGATC CCCAGTGGGA CCTGGAGGTG CTCCAGCTGC 
CTGCAGGCAA CAGTCCAGGA GGTGCAGCCC CGGGCAGAGG AGCCCCGGCC CCAGGAGCCA 
CCCGTGGAGA CCCCGCTCCC CCCGGGGCTT AGGTCGGCGG GAGAGGAGGT AAGAGGTCCA 
CCTGGGGAAC CCCTAGCCGG CATGGACACG ACTCTTGTCT ACAAGCACCT GCCGGCTCCG 
CCTTCTGCAG CCCCGCTGCC AGGGCTGGAC TCCTCGGCCC TGCACCCCCT ACTGTGTGTG 
GGTCCTGAGG GTCAGCAGAA CCTGGCTCCT GGTGCGCGTT GCGGGGTGTG CGGAGATGGT 
ACGGACGTGC TGCGGTGTAC TCACTGCGCC GCTGCCTTCC ACTGGCGCTG CCACTTCCCA 
GCCGGCACCT CCCGGCCCGG GACGGGCCTG CGCTGCAGAT CCTGCTCAGG AGACGTGACC 
CCAGCCCCTG TGGAGGGGGT GCTGGCCCCC AGCCCCGCCC GCCTGGCCCC TGGGCCTGCC 
AAGGATGACA CTGCCAGTCA CGAGCCCGCT CTGCACAGGG ATGACCTGGA GTCCCTTCTG 
AGCGAGCACA CCTTCGATGG CATCCTGCAG TGGGCCATCC AGAGCATGGC CCGTCCGGCG 
GCCCCCTTCC CCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000374.1
CDS	132..1769
Translation	MATDAALRRLLRLHRTEIAVAVDSAFPLLHALADHDVVPEDKFQETLHLKEKEGCPQAFHALLSWLLTQDSTAILDFWRVLFKDYNLERYGRLQPILDSFPKDVDLSQPRKGRKPPAVPKALVPPPRLPTKRKASEEARAAAPAALTPRGTASPGSQLKAKPPKKPESSAEQQRLPLGNGIQTMSASVQRAVAMSSGDVPGARGAVEGILIQQVFESGGSKKCIQVGGEFYTPSKFEDSGSGKNKARSSSGPKPLVRAKGAQGAAPGGGEARLGQQGSVPAPLALPSDPQLHQKNEDECAVCRDGGELICCDGCPRAFHLACLSPPLREIPSGTWRCSSCLQATVQEVQPRAEEPRPQEPPVETPLPPGLRSAGEEVRGPPGEPLAGMDTTLVYKHLPAPPSAAPLPGLDSSALHPLLCVGPEGQQNLAPGARCGVCGDGTDVLRCTHCAAAFHWRCHFPAGTSRPGTGLRCRSCSGDVTPAPVEGVLAPSPARLAPGPAKDDTASHEPALHRDDLESLLSEHTFDGILQWAIQSMARPAAPFPS

Target ORF information:

RefSeq Version	NM_000383.4
Organism	Homo sapiens(human)
Definition	Homo sapiens autoimmune regulator (AIRE), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000383.4

ORF Insert Sequence:

ATGGCGACGG ACGCGGCGCT ACGCCGGCTT CTGAGGCTGC ACCGCACGGA GATCGCGGTG 
GCCGTGGACA GCGCCTTCCC ACTGCTGCAC GCGCTGGCTG ACCACGACGT GGTCCCCGAG 
GACAAGTTTC AGGAGACGCT TCATCTGAAG GAAAAGGAGG GCTGCCCCCA GGCCTTCCAC 
GCCCTCCTGT CCTGGCTGCT GACCCAGGAC TCCACAGCCA TCCTGGACTT CTGGAGGGTG 
CTGTTCAAGG ACTACAACCT GGAGCGCTAT GGCCGGCTGC AGCCCATCCT GGACAGCTTC 
CCCAAAGATG TGGACCTCAG CCAGCCCCGG AAGGGGAGGA AGCCCCCGGC CGTCCCCAAG 
GCTTTGGTAC CGCCACCCAG ACTCCCCACC AAGAGGAAGG CCTCAGAAGA GGCTCGAGCT 
GCCGCGCCAG CAGCCCTGAC TCCAAGGGGC ACCGCCAGCC CAGGCTCTCA ACTGAAGGCC 
AAGCCCCCCA AGAAGCCGGA GAGCAGCGCA GAGCAGCAGC GCCTTCCACT CGGGAACGGG 
ATTCAGACCA TGTCAGCTTC AGTCCAGAGA GCTGTGGCCA TGTCCTCCGG GGACGTCCCG 
GGAGCCCGAG GGGCCGTGGA GGGGATCCTC ATCCAGCAGG TGTTTGAGTC AGGCGGCTCC 
AAGAAGTGCA TCCAGGTTGG CGGGGAGTTC TACACTCCCA GCAAGTTCGA AGACTCCGGC 
AGTGGGAAGA ACAAGGCCCG CAGCAGCAGT GGCCCGAAGC CTCTGGTTCG AGCCAAGGGA 
GCCCAGGGCG CTGCCCCCGG TGGAGGTGAG GCTAGGCTGG GCCAGCAGGG CAGCGTTCCC 
GCCCCTCTGG CCCTCCCCAG TGACCCCCAG CTCCACCAGA AGAATGAGGA CGAGTGTGCC 
GTGTGTCGGG ACGGCGGGGA GCTCATCTGC TGTGACGGCT GCCCTCGGGC CTTCCACCTG 
GCCTGCCTGT CCCCTCCGCT CCGGGAGATC CCCAGTGGGA CCTGGAGGTG CTCCAGCTGC 
CTGCAGGCAA CAGTCCAGGA GGTGCAGCCC CGGGCAGAGG AGCCCCGGCC CCAGGAGCCA 
CCCGTGGAGA CCCCGCTCCC CCCGGGGCTT AGGTCGGCGG GAGAGGAGGT AAGAGGTCCA 
CCTGGGGAAC CCCTAGCCGG CATGGACACG ACTCTTGTCT ACAAGCACCT GCCGGCTCCG 
CCTTCTGCAG CCCCGCTGCC AGGGCTGGAC TCCTCGGCCC TGCACCCCCT ACTGTGTGTG 
GGTCCTGAGG GTCAGCAGAA CCTGGCTCCT GGTGCGCGTT GCGGGGTGTG CGGAGATGGT 
ACGGACGTGC TGCGGTGTAC TCACTGCGCC GCTGCCTTCC ACTGGCGCTG CCACTTCCCA 
GCCGGCACCT CCCGGCCCGG GACGGGCCTG CGCTGCAGAT CCTGCTCAGG AGACGTGACC 
CCAGCCCCTG TGGAGGGGGT GCTGGCCCCC AGCCCCGCCC GCCTGGCCCC TGGGCCTGCC 
AAGGATGACA CTGCCAGTCA CGAGCCCGCT CTGCACAGGG ATGACCTGGA GTCCCTTCTG 
AGCGAGCACA CCTTCGATGG CATCCTGCAG TGGGCCATCC AGAGCATGGC CCGTCCGGCG 
GCCCCCTTCC CCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Exome Sequencing Reveals Mutations in AIRE as a Cause of Isolated Hypoparathyroidism.
The Journal of clinical endocrinology and metabolism102(5)1726-1733(2017 May)
Li D,Streeten EA,Chan A,Lwin W,Tian L,Pellegrino da Silva R,Kim CE,Anderson MS,Hakonarson H,Levine MA

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AIRE cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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