HPN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HPN
Entrez Gene ID	3249
Full Name	hepsin
Synonyms	TMPRSS1
General protein information	Preferred Names hepsin Names serine protease hepsin testicular tissue protein Li 85 transmembrane protease serine 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.11
Summary	This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013].
Disorder MIM:	142440

mRNA and Protein(s)

mRNA	Protein	Name
NM_002151.2	NP_002142.1	serine protease hepsin precursor
XM_006723181.3	XP_006723244.2	serine protease hepsin isoform X1
XM_017026731.1	XP_016882220.1	serine protease hepsin isoform X1
XM_005258838.4	XP_005258895.2	serine protease hepsin isoform X1
NM_001375441.1	NP_001362370.1	serine protease hepsin precursor
XM_017026732.1	XP_016882221.1	serine protease hepsin isoform X2
NM_182983.2	NP_892028.1	serine protease hepsin precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	HPN	XP_001157575.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004552	XP_313850.5
Canis lupus familiaris (dog)	HPN	XP_541697.2
Bos taurus (cattle)	HPN	NP_001073710.1
Danio rerio (zebrafish)	si:dkey-33i11.3	NP_001091657.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008649	XP_314746.4
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004568	XP_313873.5
Homo sapiens (human)	HPN	NP_892028.1
Rattus norvegicus (Norway rat)	Hpn	NP_058808.1
Danio rerio (zebrafish)	LOC100536154	XP_003200307.1
	HPN	XP_001093699.2
Mus musculus (house mouse)	Hpn	NP_032307.2

Gene Ontology
Bibliography

Related articles in PubMed

Exploring hepsin functional genetic variation association with disease specific protein expression in bipolar disorder: Applications of a proteomic informed genomic approach.
Nassan M, Jia YF, Jenkins G, Colby C, Feeder S, Choi DS, Veldic M, McElroy SL, Bond DJ, Weinshilboum R, Biernacka JM, Frye MA
Journal of psychiatric research95208-212(2017 Dec)

High Hepsin expression predicts poor prognosis in Gastric Cancer.
Zhang M, Zhao J, Tang W, Wang Y, Peng P, Li L, Song S, Wu H, Li C, Yang C, Wang X, Zhang C, Gu J
Scientific reports636902(2016 Nov)

Identification and characterization of hepsin/-TM, a non-transmembrane hepsin isoform.
Li Y, Yu Z, Zhao X, Shen SH
Biochimica et biophysica acta1681(2-3)157-65(2005 Jan)

The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain.
Somoza JR, Ho JD, Luong C, Ghate M, Sprengeler PA, Mortara K, Shrader WD, Sperandio D, Chan H, McGrath ME, Katz BA
Structure (London, England : 1993)11(9)1123-31(2003 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The findings suggest that the oncogenic activity of hepsin arises not only from elevated expression level but also from depletion of HAI-1, events which together trigger gain-of-function activity impacting HGF/MET signalling and epithelial cohesion
Title: Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion.

These data demonstrate that the membrane-bound serine protease hepsin is the enzyme responsible for the physiological cleavage of uromodulin.
Title: The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin.

The Hepsin pathway acts in concert with Wnt pathway to promote prostate cancer progression.
Title: Concurrent Hepsin overexpression and adenomatous polyposis coli deletion causes invasive prostate carcinoma in mice.

Low expression levels of hepsin and TMPRSS3 are associated with poor breast cancer survival
Title: Low expression levels of hepsin and TMPRSS3 are associated with poor breast cancer survival.

Hepsin suppressed CDK11p58 internal ribosome entry site activity in prostate cancer cells by modulating UNR expression and eIF-2alpha phosphorylation.
Title: Hepsin inhibits CDK11p58 IRES activity by suppressing unr expression and eIF-2? phosphorylation in prostate cancer.

The following HPN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HPN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08465	NM_002151.2 Latest version!	Homo sapiens hepsin (HPN), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu08465	NM_182983.2 Latest version!	Homo sapiens hepsin (HPN), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu08465	XM_005258838.4 Latest version!	Homo sapiens hepsin (HPN), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu08465	XM_006723181.3 Latest version!	Homo sapiens hepsin (HPN), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu08465	XM_017026731.1 Latest version!	Homo sapiens hepsin (HPN), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu52218	XM_017026732.1 Latest version!	Homo sapiens hepsin (HPN), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu08465	NM_001375441.1 Latest version!	Homo sapiens hepsin (HPN), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HPN ( NM_002151.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002142.1 Homo sapiens hepsin (HPN), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu08465
Clone ID Related Accession (Same CDS sequence)	NM_002151.2 , XM_006723181.3 , XM_017026731.1 , XM_005258838.4 , NM_001375441.1 , NM_182983.2
Accession Version	NM_002151.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1254bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Homo sapiens(human)
Product	serine protease hepsin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M18930.1, AK091988.1 and BC025716.1. On or before Aug 31, 2013 this sequence version replaced XM_005258839.1, NM_002151.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M18930.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCAGA AGGAGGGTGG CCGGACTGTG CCATGCTGCT CCAGACCCAA GGTGGCAGCT 
CTCACTGCGG GGACCCTGCT ACTTCTGACA GCCATCGGGG CGGCATCCTG GGCCATTGTG 
GCTGTTCTCC TCAGGAGTGA CCAGGAGCCG CTGTACCCAG TGCAGGTCAG CTCTGCGGAC 
GCTCGGCTCA TGGTCTTTGA CAAGACGGAA GGGACGTGGC GGCTGCTGTG CTCCTCGCGC 
TCCAACGCCA GGGTAGCCGG ACTCAGCTGC GAGGAGATGG GCTTCCTCAG GGCACTGACC 
CACTCCGAGC TGGACGTGCG AACGGCGGGC GCCAATGGCA CGTCGGGCTT CTTCTGTGTG 
GACGAGGGGA GGCTGCCCCA CACCCAGAGG CTGCTGGAGG TCATCTCCGT GTGTGATTGC 
CCCAGAGGCC GTTTCTTGGC CGCCATCTGC CAAGACTGTG GCCGCAGGAA GCTGCCCGTG 
GACCGCATCG TGGGAGGCCG GGACACCAGC TTGGGCCGGT GGCCGTGGCA AGTCAGCCTT 
CGCTATGATG GAGCACACCT CTGTGGGGGA TCCCTGCTCT CCGGGGACTG GGTGCTGACA 
GCCGCCCACT GCTTCCCGGA GCGGAACCGG GTCCTGTCCC GATGGCGAGT GTTTGCCGGT 
GCCGTGGCCC AGGCCTCTCC CCACGGTCTG CAGCTGGGGG TGCAGGCTGT GGTCTACCAC 
GGGGGCTATC TTCCCTTTCG GGACCCCAAC AGCGAGGAGA ACAGCAACGA TATTGCCCTG 
GTCCACCTCT CCAGTCCCCT GCCCCTCACA GAATACATCC AGCCTGTGTG CCTCCCAGCT 
GCCGGCCAGG CCCTGGTGGA TGGCAAGATC TGTACCGTGA CGGGCTGGGG CAACACGCAG 
TACTATGGCC AACAGGCCGG GGTACTCCAG GAGGCTCGAG TCCCCATAAT CAGCAATGAT 
GTCTGCAATG GCGCTGACTT CTATGGAAAC CAGATCAAGC CCAAGATGTT CTGTGCTGGC 
TACCCCGAGG GTGGCATTGA TGCCTGCCAG GGCGACAGCG GTGGTCCCTT TGTGTGTGAG 
GACAGCATCT CTCGGACGCC ACGTTGGCGG CTGTGTGGCA TTGTGAGTTG GGGCACTGGC 
TGTGCCCTGG CCCAGAAGCC AGGCGTCTAC ACCAAAGTCA GTGACTTCCG GGAGTGGATC 
TTCCAGGCCA TAAAGACTCA CTCCGAAGCC AGCGGCATGG TGACCCAGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002142.1
CDS	246..1499
Translation	MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL

Target ORF information:

RefSeq Version	NM_002151.2
Organism	Homo sapiens(human)
Definition	Homo sapiens hepsin (HPN), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002151.2

ORF Insert Sequence:

ATGGCGCAGA AGGAGGGTGG CCGGACTGTG CCATGCTGCT CCAGACCCAA GGTGGCAGCT 
CTCACTGCGG GGACCCTGCT ACTTCTGACA GCCATCGGGG CGGCATCCTG GGCCATTGTG 
GCTGTTCTCC TCAGGAGTGA CCAGGAGCCG CTGTACCCAG TGCAGGTCAG CTCTGCGGAC 
GCTCGGCTCA TGGTCTTTGA CAAGACGGAA GGGACGTGGC GGCTGCTGTG CTCCTCGCGC 
TCCAACGCCA GGGTAGCCGG ACTCAGCTGC GAGGAGATGG GCTTCCTCAG GGCACTGACC 
CACTCCGAGC TGGACGTGCG AACGGCGGGC GCCAATGGCA CGTCGGGCTT CTTCTGTGTG 
GACGAGGGGA GGCTGCCCCA CACCCAGAGG CTGCTGGAGG TCATCTCCGT GTGTGATTGC 
CCCAGAGGCC GTTTCTTGGC CGCCATCTGC CAAGACTGTG GCCGCAGGAA GCTGCCCGTG 
GACCGCATCG TGGGAGGCCG GGACACCAGC TTGGGCCGGT GGCCGTGGCA AGTCAGCCTT 
CGCTATGATG GAGCACACCT CTGTGGGGGA TCCCTGCTCT CCGGGGACTG GGTGCTGACA 
GCCGCCCACT GCTTCCCGGA GCGGAACCGG GTCCTGTCCC GATGGCGAGT GTTTGCCGGT 
GCCGTGGCCC AGGCCTCTCC CCACGGTCTG CAGCTGGGGG TGCAGGCTGT GGTCTACCAC 
GGGGGCTATC TTCCCTTTCG GGACCCCAAC AGCGAGGAGA ACAGCAACGA TATTGCCCTG 
GTCCACCTCT CCAGTCCCCT GCCCCTCACA GAATACATCC AGCCTGTGTG CCTCCCAGCT 
GCCGGCCAGG CCCTGGTGGA TGGCAAGATC TGTACCGTGA CGGGCTGGGG CAACACGCAG 
TACTATGGCC AACAGGCCGG GGTACTCCAG GAGGCTCGAG TCCCCATAAT CAGCAATGAT 
GTCTGCAATG GCGCTGACTT CTATGGAAAC CAGATCAAGC CCAAGATGTT CTGTGCTGGC 
TACCCCGAGG GTGGCATTGA TGCCTGCCAG GGCGACAGCG GTGGTCCCTT TGTGTGTGAG 
GACAGCATCT CTCGGACGCC ACGTTGGCGG CTGTGTGGCA TTGTGAGTTG GGGCACTGGC 
TGTGCCCTGG CCCAGAAGCC AGGCGTCTAC ACCAAAGTCA GTGACTTCCG GGAGTGGATC 
TTCCAGGCCA TAAAGACTCA CTCCGAAGCC AGCGGCATGG TGACCCAGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HPN ( NM_182983.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_892028.1 Homo sapiens hepsin (HPN), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu08465
Clone ID Related Accession (Same CDS sequence)	NM_002151.2 , XM_006723181.3 , XM_017026731.1 , XM_005258838.4 , NM_001375441.1 , NM_182983.2
Accession Version	NM_182983.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1254bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Homo sapiens(human)
Product	serine protease hepsin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X07732.1, AC020907.6 and BC025716.1. On Apr 23, 2009 this sequence version replaced NM_182983.1. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X07732.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCAGA AGGAGGGTGG CCGGACTGTG CCATGCTGCT CCAGACCCAA GGTGGCAGCT 
CTCACTGCGG GGACCCTGCT ACTTCTGACA GCCATCGGGG CGGCATCCTG GGCCATTGTG 
GCTGTTCTCC TCAGGAGTGA CCAGGAGCCG CTGTACCCAG TGCAGGTCAG CTCTGCGGAC 
GCTCGGCTCA TGGTCTTTGA CAAGACGGAA GGGACGTGGC GGCTGCTGTG CTCCTCGCGC 
TCCAACGCCA GGGTAGCCGG ACTCAGCTGC GAGGAGATGG GCTTCCTCAG GGCACTGACC 
CACTCCGAGC TGGACGTGCG AACGGCGGGC GCCAATGGCA CGTCGGGCTT CTTCTGTGTG 
GACGAGGGGA GGCTGCCCCA CACCCAGAGG CTGCTGGAGG TCATCTCCGT GTGTGATTGC 
CCCAGAGGCC GTTTCTTGGC CGCCATCTGC CAAGACTGTG GCCGCAGGAA GCTGCCCGTG 
GACCGCATCG TGGGAGGCCG GGACACCAGC TTGGGCCGGT GGCCGTGGCA AGTCAGCCTT 
CGCTATGATG GAGCACACCT CTGTGGGGGA TCCCTGCTCT CCGGGGACTG GGTGCTGACA 
GCCGCCCACT GCTTCCCGGA GCGGAACCGG GTCCTGTCCC GATGGCGAGT GTTTGCCGGT 
GCCGTGGCCC AGGCCTCTCC CCACGGTCTG CAGCTGGGGG TGCAGGCTGT GGTCTACCAC 
GGGGGCTATC TTCCCTTTCG GGACCCCAAC AGCGAGGAGA ACAGCAACGA TATTGCCCTG 
GTCCACCTCT CCAGTCCCCT GCCCCTCACA GAATACATCC AGCCTGTGTG CCTCCCAGCT 
GCCGGCCAGG CCCTGGTGGA TGGCAAGATC TGTACCGTGA CGGGCTGGGG CAACACGCAG 
TACTATGGCC AACAGGCCGG GGTACTCCAG GAGGCTCGAG TCCCCATAAT CAGCAATGAT 
GTCTGCAATG GCGCTGACTT CTATGGAAAC CAGATCAAGC CCAAGATGTT CTGTGCTGGC 
TACCCCGAGG GTGGCATTGA TGCCTGCCAG GGCGACAGCG GTGGTCCCTT TGTGTGTGAG 
GACAGCATCT CTCGGACGCC ACGTTGGCGG CTGTGTGGCA TTGTGAGTTG GGGCACTGGC 
TGTGCCCTGG CCCAGAAGCC AGGCGTCTAC ACCAAAGTCA GTGACTTCCG GGAGTGGATC 
TTCCAGGCCA TAAAGACTCA CTCCGAAGCC AGCGGCATGG TGACCCAGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_892028.1
CDS	826..2079
Translation	MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL

Target ORF information:

RefSeq Version	NM_182983.2
Organism	Homo sapiens(human)
Definition	Homo sapiens hepsin (HPN), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_182983.2

ORF Insert Sequence:

ATGGCGCAGA AGGAGGGTGG CCGGACTGTG CCATGCTGCT CCAGACCCAA GGTGGCAGCT 
CTCACTGCGG GGACCCTGCT ACTTCTGACA GCCATCGGGG CGGCATCCTG GGCCATTGTG 
GCTGTTCTCC TCAGGAGTGA CCAGGAGCCG CTGTACCCAG TGCAGGTCAG CTCTGCGGAC 
GCTCGGCTCA TGGTCTTTGA CAAGACGGAA GGGACGTGGC GGCTGCTGTG CTCCTCGCGC 
TCCAACGCCA GGGTAGCCGG ACTCAGCTGC GAGGAGATGG GCTTCCTCAG GGCACTGACC 
CACTCCGAGC TGGACGTGCG AACGGCGGGC GCCAATGGCA CGTCGGGCTT CTTCTGTGTG 
GACGAGGGGA GGCTGCCCCA CACCCAGAGG CTGCTGGAGG TCATCTCCGT GTGTGATTGC 
CCCAGAGGCC GTTTCTTGGC CGCCATCTGC CAAGACTGTG GCCGCAGGAA GCTGCCCGTG 
GACCGCATCG TGGGAGGCCG GGACACCAGC TTGGGCCGGT GGCCGTGGCA AGTCAGCCTT 
CGCTATGATG GAGCACACCT CTGTGGGGGA TCCCTGCTCT CCGGGGACTG GGTGCTGACA 
GCCGCCCACT GCTTCCCGGA GCGGAACCGG GTCCTGTCCC GATGGCGAGT GTTTGCCGGT 
GCCGTGGCCC AGGCCTCTCC CCACGGTCTG CAGCTGGGGG TGCAGGCTGT GGTCTACCAC 
GGGGGCTATC TTCCCTTTCG GGACCCCAAC AGCGAGGAGA ACAGCAACGA TATTGCCCTG 
GTCCACCTCT CCAGTCCCCT GCCCCTCACA GAATACATCC AGCCTGTGTG CCTCCCAGCT 
GCCGGCCAGG CCCTGGTGGA TGGCAAGATC TGTACCGTGA CGGGCTGGGG CAACACGCAG 
TACTATGGCC AACAGGCCGG GGTACTCCAG GAGGCTCGAG TCCCCATAAT CAGCAATGAT 
GTCTGCAATG GCGCTGACTT CTATGGAAAC CAGATCAAGC CCAAGATGTT CTGTGCTGGC 
TACCCCGAGG GTGGCATTGA TGCCTGCCAG GGCGACAGCG GTGGTCCCTT TGTGTGTGAG 
GACAGCATCT CTCGGACGCC ACGTTGGCGG CTGTGTGGCA TTGTGAGTTG GGGCACTGGC 
TGTGCCCTGG CCCAGAAGCC AGGCGTCTAC ACCAAAGTCA GTGACTTCCG GGAGTGGATC 
TTCCAGGCCA TAAAGACTCA CTCCGAAGCC AGCGGCATGG TGACCCAGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HPN ( XM_006723181.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006723244.2 Homo sapiens hepsin (HPN), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu08465
Clone ID Related Accession (Same CDS sequence)	NM_002151.2 , XM_006723181.3 , XM_017026731.1 , XM_005258838.4 , NM_001375441.1 , NM_182983.2
Accession Version	XM_006723181.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1254bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	serine protease hepsin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006723181.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGCAGA AGGAGGGTGG CCGGACTGTG CCATGCTGCT CCAGACCCAA GGTGGCAGCT 
CTCACTGCGG GGACCCTGCT ACTTCTGACA GCCATCGGGG CGGCATCCTG GGCCATTGTG 
GCTGTTCTCC TCAGGAGTGA CCAGGAGCCG CTGTACCCAG TGCAGGTCAG CTCTGCGGAC 
GCTCGGCTCA TGGTCTTTGA CAAGACGGAA GGGACGTGGC GGCTGCTGTG CTCCTCGCGC 
TCCAACGCCA GGGTAGCCGG ACTCAGCTGC GAGGAGATGG GCTTCCTCAG GGCACTGACC 
CACTCCGAGC TGGACGTGCG AACGGCGGGC GCCAATGGCA CGTCGGGCTT CTTCTGTGTG 
GACGAGGGGA GGCTGCCCCA CACCCAGAGG CTGCTGGAGG TCATCTCCGT GTGTGATTGC 
CCCAGAGGCC GTTTCTTGGC CGCCATCTGC CAAGACTGTG GCCGCAGGAA GCTGCCCGTG 
GACCGCATCG TGGGAGGCCG GGACACCAGC TTGGGCCGGT GGCCGTGGCA AGTCAGCCTT 
CGCTATGATG GAGCACACCT CTGTGGGGGA TCCCTGCTCT CCGGGGACTG GGTGCTGACA 
GCCGCCCACT GCTTCCCGGA GCGGAACCGG GTCCTGTCCC GATGGCGAGT GTTTGCCGGT 
GCCGTGGCCC AGGCCTCTCC CCACGGTCTG CAGCTGGGGG TGCAGGCTGT GGTCTACCAC 
GGGGGCTATC TTCCCTTTCG GGACCCCAAC AGCGAGGAGA ACAGCAACGA TATTGCCCTG 
GTCCACCTCT CCAGTCCCCT GCCCCTCACA GAATACATCC AGCCTGTGTG CCTCCCAGCT 
GCCGGCCAGG CCCTGGTGGA TGGCAAGATC TGTACCGTGA CGGGCTGGGG CAACACGCAG 
TACTATGGCC AACAGGCCGG GGTACTCCAG GAGGCTCGAG TCCCCATAAT CAGCAATGAT 
GTCTGCAATG GCGCTGACTT CTATGGAAAC CAGATCAAGC CCAAGATGTT CTGTGCTGGC 
TACCCCGAGG GTGGCATTGA TGCCTGCCAG GGCGACAGCG GTGGTCCCTT TGTGTGTGAG 
GACAGCATCT CTCGGACGCC ACGTTGGCGG CTGTGTGGCA TTGTGAGTTG GGGCACTGGC 
TGTGCCCTGG CCCAGAAGCC AGGCGTCTAC ACCAAAGTCA GTGACTTCCG GGAGTGGATC 
TTCCAGGCCA TAAAGACTCA CTCCGAAGCC AGCGGCATGG TGACCCAGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006723244.2
CDS	200..1453
Translation	MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL

Target ORF information:

RefSeq Version	XM_006723181.3
Organism	Homo sapiens(human)
Definition	Homo sapiens hepsin (HPN), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006723181.3

ORF Insert Sequence:

ATGGCGCAGA AGGAGGGTGG CCGGACTGTG CCATGCTGCT CCAGACCCAA GGTGGCAGCT 
CTCACTGCGG GGACCCTGCT ACTTCTGACA GCCATCGGGG CGGCATCCTG GGCCATTGTG 
GCTGTTCTCC TCAGGAGTGA CCAGGAGCCG CTGTACCCAG TGCAGGTCAG CTCTGCGGAC 
GCTCGGCTCA TGGTCTTTGA CAAGACGGAA GGGACGTGGC GGCTGCTGTG CTCCTCGCGC 
TCCAACGCCA GGGTAGCCGG ACTCAGCTGC GAGGAGATGG GCTTCCTCAG GGCACTGACC 
CACTCCGAGC TGGACGTGCG AACGGCGGGC GCCAATGGCA CGTCGGGCTT CTTCTGTGTG 
GACGAGGGGA GGCTGCCCCA CACCCAGAGG CTGCTGGAGG TCATCTCCGT GTGTGATTGC 
CCCAGAGGCC GTTTCTTGGC CGCCATCTGC CAAGACTGTG GCCGCAGGAA GCTGCCCGTG 
GACCGCATCG TGGGAGGCCG GGACACCAGC TTGGGCCGGT GGCCGTGGCA AGTCAGCCTT 
CGCTATGATG GAGCACACCT CTGTGGGGGA TCCCTGCTCT CCGGGGACTG GGTGCTGACA 
GCCGCCCACT GCTTCCCGGA GCGGAACCGG GTCCTGTCCC GATGGCGAGT GTTTGCCGGT 
GCCGTGGCCC AGGCCTCTCC CCACGGTCTG CAGCTGGGGG TGCAGGCTGT GGTCTACCAC 
GGGGGCTATC TTCCCTTTCG GGACCCCAAC AGCGAGGAGA ACAGCAACGA TATTGCCCTG 
GTCCACCTCT CCAGTCCCCT GCCCCTCACA GAATACATCC AGCCTGTGTG CCTCCCAGCT 
GCCGGCCAGG CCCTGGTGGA TGGCAAGATC TGTACCGTGA CGGGCTGGGG CAACACGCAG 
TACTATGGCC AACAGGCCGG GGTACTCCAG GAGGCTCGAG TCCCCATAAT CAGCAATGAT 
GTCTGCAATG GCGCTGACTT CTATGGAAAC CAGATCAAGC CCAAGATGTT CTGTGCTGGC 
TACCCCGAGG GTGGCATTGA TGCCTGCCAG GGCGACAGCG GTGGTCCCTT TGTGTGTGAG 
GACAGCATCT CTCGGACGCC ACGTTGGCGG CTGTGTGGCA TTGTGAGTTG GGGCACTGGC 
TGTGCCCTGG CCCAGAAGCC AGGCGTCTAC ACCAAAGTCA GTGACTTCCG GGAGTGGATC 
TTCCAGGCCA TAAAGACTCA CTCCGAAGCC AGCGGCATGG TGACCCAGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HPN ( XM_017026731.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016882220.1 Homo sapiens hepsin (HPN), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu08465
Clone ID Related Accession (Same CDS sequence)	NM_002151.2 , XM_006723181.3 , XM_017026731.1 , XM_005258838.4 , NM_001375441.1 , NM_182983.2
Accession Version	XM_017026731.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1254bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	serine protease hepsin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGCAGA AGGAGGGTGG CCGGACTGTG CCATGCTGCT CCAGACCCAA GGTGGCAGCT 
CTCACTGCGG GGACCCTGCT ACTTCTGACA GCCATCGGGG CGGCATCCTG GGCCATTGTG 
GCTGTTCTCC TCAGGAGTGA CCAGGAGCCG CTGTACCCAG TGCAGGTCAG CTCTGCGGAC 
GCTCGGCTCA TGGTCTTTGA CAAGACGGAA GGGACGTGGC GGCTGCTGTG CTCCTCGCGC 
TCCAACGCCA GGGTAGCCGG ACTCAGCTGC GAGGAGATGG GCTTCCTCAG GGCACTGACC 
CACTCCGAGC TGGACGTGCG AACGGCGGGC GCCAATGGCA CGTCGGGCTT CTTCTGTGTG 
GACGAGGGGA GGCTGCCCCA CACCCAGAGG CTGCTGGAGG TCATCTCCGT GTGTGATTGC 
CCCAGAGGCC GTTTCTTGGC CGCCATCTGC CAAGACTGTG GCCGCAGGAA GCTGCCCGTG 
GACCGCATCG TGGGAGGCCG GGACACCAGC TTGGGCCGGT GGCCGTGGCA AGTCAGCCTT 
CGCTATGATG GAGCACACCT CTGTGGGGGA TCCCTGCTCT CCGGGGACTG GGTGCTGACA 
GCCGCCCACT GCTTCCCGGA GCGGAACCGG GTCCTGTCCC GATGGCGAGT GTTTGCCGGT 
GCCGTGGCCC AGGCCTCTCC CCACGGTCTG CAGCTGGGGG TGCAGGCTGT GGTCTACCAC 
GGGGGCTATC TTCCCTTTCG GGACCCCAAC AGCGAGGAGA ACAGCAACGA TATTGCCCTG 
GTCCACCTCT CCAGTCCCCT GCCCCTCACA GAATACATCC AGCCTGTGTG CCTCCCAGCT 
GCCGGCCAGG CCCTGGTGGA TGGCAAGATC TGTACCGTGA CGGGCTGGGG CAACACGCAG 
TACTATGGCC AACAGGCCGG GGTACTCCAG GAGGCTCGAG TCCCCATAAT CAGCAATGAT 
GTCTGCAATG GCGCTGACTT CTATGGAAAC CAGATCAAGC CCAAGATGTT CTGTGCTGGC 
TACCCCGAGG GTGGCATTGA TGCCTGCCAG GGCGACAGCG GTGGTCCCTT TGTGTGTGAG 
GACAGCATCT CTCGGACGCC ACGTTGGCGG CTGTGTGGCA TTGTGAGTTG GGGCACTGGC 
TGTGCCCTGG CCCAGAAGCC AGGCGTCTAC ACCAAAGTCA GTGACTTCCG GGAGTGGATC 
TTCCAGGCCA TAAAGACTCA CTCCGAAGCC AGCGGCATGG TGACCCAGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016882220.1
CDS	499..1752
Translation	MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL

Target ORF information:

RefSeq Version	XM_017026731.1
Organism	Homo sapiens(human)
Definition	Homo sapiens hepsin (HPN), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026731.1

ORF Insert Sequence:

ATGGCGCAGA AGGAGGGTGG CCGGACTGTG CCATGCTGCT CCAGACCCAA GGTGGCAGCT 
CTCACTGCGG GGACCCTGCT ACTTCTGACA GCCATCGGGG CGGCATCCTG GGCCATTGTG 
GCTGTTCTCC TCAGGAGTGA CCAGGAGCCG CTGTACCCAG TGCAGGTCAG CTCTGCGGAC 
GCTCGGCTCA TGGTCTTTGA CAAGACGGAA GGGACGTGGC GGCTGCTGTG CTCCTCGCGC 
TCCAACGCCA GGGTAGCCGG ACTCAGCTGC GAGGAGATGG GCTTCCTCAG GGCACTGACC 
CACTCCGAGC TGGACGTGCG AACGGCGGGC GCCAATGGCA CGTCGGGCTT CTTCTGTGTG 
GACGAGGGGA GGCTGCCCCA CACCCAGAGG CTGCTGGAGG TCATCTCCGT GTGTGATTGC 
CCCAGAGGCC GTTTCTTGGC CGCCATCTGC CAAGACTGTG GCCGCAGGAA GCTGCCCGTG 
GACCGCATCG TGGGAGGCCG GGACACCAGC TTGGGCCGGT GGCCGTGGCA AGTCAGCCTT 
CGCTATGATG GAGCACACCT CTGTGGGGGA TCCCTGCTCT CCGGGGACTG GGTGCTGACA 
GCCGCCCACT GCTTCCCGGA GCGGAACCGG GTCCTGTCCC GATGGCGAGT GTTTGCCGGT 
GCCGTGGCCC AGGCCTCTCC CCACGGTCTG CAGCTGGGGG TGCAGGCTGT GGTCTACCAC 
GGGGGCTATC TTCCCTTTCG GGACCCCAAC AGCGAGGAGA ACAGCAACGA TATTGCCCTG 
GTCCACCTCT CCAGTCCCCT GCCCCTCACA GAATACATCC AGCCTGTGTG CCTCCCAGCT 
GCCGGCCAGG CCCTGGTGGA TGGCAAGATC TGTACCGTGA CGGGCTGGGG CAACACGCAG 
TACTATGGCC AACAGGCCGG GGTACTCCAG GAGGCTCGAG TCCCCATAAT CAGCAATGAT 
GTCTGCAATG GCGCTGACTT CTATGGAAAC CAGATCAAGC CCAAGATGTT CTGTGCTGGC 
TACCCCGAGG GTGGCATTGA TGCCTGCCAG GGCGACAGCG GTGGTCCCTT TGTGTGTGAG 
GACAGCATCT CTCGGACGCC ACGTTGGCGG CTGTGTGGCA TTGTGAGTTG GGGCACTGGC 
TGTGCCCTGG CCCAGAAGCC AGGCGTCTAC ACCAAAGTCA GTGACTTCCG GGAGTGGATC 
TTCCAGGCCA TAAAGACTCA CTCCGAAGCC AGCGGCATGG TGACCCAGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HPN ( XM_005258838.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005258895.2 Homo sapiens hepsin (HPN), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu08465
Clone ID Related Accession (Same CDS sequence)	NM_002151.2 , XM_006723181.3 , XM_017026731.1 , XM_005258838.4 , NM_001375441.1 , NM_182983.2
Accession Version	XM_005258838.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1254bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-12
Organism	Homo sapiens(human)
Product	serine protease hepsin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005258838.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20190607 Annotation Version :: 109.20190607 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Freeze :: 20190607 ##Genome-Annotation-Data-END##

ATGGCGCAGA AGGAGGGTGG CCGGACTGTG CCATGCTGCT CCAGACCCAA GGTGGCAGCT 
CTCACTGCGG GGACCCTGCT ACTTCTGACA GCCATCGGGG CGGCATCCTG GGCCATTGTG 
GCTGTTCTCC TCAGGAGTGA CCAGGAGCCG CTGTACCCAG TGCAGGTCAG CTCTGCGGAC 
GCTCGGCTCA TGGTCTTTGA CAAGACGGAA GGGACGTGGC GGCTGCTGTG CTCCTCGCGC 
TCCAACGCCA GGGTAGCCGG ACTCAGCTGC GAGGAGATGG GCTTCCTCAG GGCACTGACC 
CACTCCGAGC TGGACGTGCG AACGGCGGGC GCCAATGGCA CGTCGGGCTT CTTCTGTGTG 
GACGAGGGGA GGCTGCCCCA CACCCAGAGG CTGCTGGAGG TCATCTCCGT GTGTGATTGC 
CCCAGAGGCC GTTTCTTGGC CGCCATCTGC CAAGACTGTG GCCGCAGGAA GCTGCCCGTG 
GACCGCATCG TGGGAGGCCG GGACACCAGC TTGGGCCGGT GGCCGTGGCA AGTCAGCCTT 
CGCTATGATG GAGCACACCT CTGTGGGGGA TCCCTGCTCT CCGGGGACTG GGTGCTGACA 
GCCGCCCACT GCTTCCCGGA GCGGAACCGG GTCCTGTCCC GATGGCGAGT GTTTGCCGGT 
GCCGTGGCCC AGGCCTCTCC CCACGGTCTG CAGCTGGGGG TGCAGGCTGT GGTCTACCAC 
GGGGGCTATC TTCCCTTTCG GGACCCCAAC AGCGAGGAGA ACAGCAACGA TATTGCCCTG 
GTCCACCTCT CCAGTCCCCT GCCCCTCACA GAATACATCC AGCCTGTGTG CCTCCCAGCT 
GCCGGCCAGG CCCTGGTGGA TGGCAAGATC TGTACCGTGA CGGGCTGGGG CAACACGCAG 
TACTATGGCC AACAGGCCGG GGTACTCCAG GAGGCTCGAG TCCCCATAAT CAGCAATGAT 
GTCTGCAATG GCGCTGACTT CTATGGAAAC CAGATCAAGC CCAAGATGTT CTGTGCTGGC 
TACCCCGAGG GTGGCATTGA TGCCTGCCAG GGCGACAGCG GTGGTCCCTT TGTGTGTGAG 
GACAGCATCT CTCGGACGCC ACGTTGGCGG CTGTGTGGCA TTGTGAGTTG GGGCACTGGC 
TGTGCCCTGG CCCAGAAGCC AGGCGTCTAC ACCAAAGTCA GTGACTTCCG GGAGTGGATC 
TTCCAGGCCA TAAAGACTCA CTCCGAAGCC AGCGGCATGG TGACCCAGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005258895.2
CDS	324..1577
Translation	MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL

Target ORF information:

RefSeq Version	XM_005258838.4
Organism	Homo sapiens(human)
Definition	Homo sapiens hepsin (HPN), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005258838.4

ORF Insert Sequence:

ATGGCGCAGA AGGAGGGTGG CCGGACTGTG CCATGCTGCT CCAGACCCAA GGTGGCAGCT 
CTCACTGCGG GGACCCTGCT ACTTCTGACA GCCATCGGGG CGGCATCCTG GGCCATTGTG 
GCTGTTCTCC TCAGGAGTGA CCAGGAGCCG CTGTACCCAG TGCAGGTCAG CTCTGCGGAC 
GCTCGGCTCA TGGTCTTTGA CAAGACGGAA GGGACGTGGC GGCTGCTGTG CTCCTCGCGC 
TCCAACGCCA GGGTAGCCGG ACTCAGCTGC GAGGAGATGG GCTTCCTCAG GGCACTGACC 
CACTCCGAGC TGGACGTGCG AACGGCGGGC GCCAATGGCA CGTCGGGCTT CTTCTGTGTG 
GACGAGGGGA GGCTGCCCCA CACCCAGAGG CTGCTGGAGG TCATCTCCGT GTGTGATTGC 
CCCAGAGGCC GTTTCTTGGC CGCCATCTGC CAAGACTGTG GCCGCAGGAA GCTGCCCGTG 
GACCGCATCG TGGGAGGCCG GGACACCAGC TTGGGCCGGT GGCCGTGGCA AGTCAGCCTT 
CGCTATGATG GAGCACACCT CTGTGGGGGA TCCCTGCTCT CCGGGGACTG GGTGCTGACA 
GCCGCCCACT GCTTCCCGGA GCGGAACCGG GTCCTGTCCC GATGGCGAGT GTTTGCCGGT 
GCCGTGGCCC AGGCCTCTCC CCACGGTCTG CAGCTGGGGG TGCAGGCTGT GGTCTACCAC 
GGGGGCTATC TTCCCTTTCG GGACCCCAAC AGCGAGGAGA ACAGCAACGA TATTGCCCTG 
GTCCACCTCT CCAGTCCCCT GCCCCTCACA GAATACATCC AGCCTGTGTG CCTCCCAGCT 
GCCGGCCAGG CCCTGGTGGA TGGCAAGATC TGTACCGTGA CGGGCTGGGG CAACACGCAG 
TACTATGGCC AACAGGCCGG GGTACTCCAG GAGGCTCGAG TCCCCATAAT CAGCAATGAT 
GTCTGCAATG GCGCTGACTT CTATGGAAAC CAGATCAAGC CCAAGATGTT CTGTGCTGGC 
TACCCCGAGG GTGGCATTGA TGCCTGCCAG GGCGACAGCG GTGGTCCCTT TGTGTGTGAG 
GACAGCATCT CTCGGACGCC ACGTTGGCGG CTGTGTGGCA TTGTGAGTTG GGGCACTGGC 
TGTGCCCTGG CCCAGAAGCC AGGCGTCTAC ACCAAAGTCA GTGACTTCCG GGAGTGGATC 
TTCCAGGCCA TAAAGACTCA CTCCGAAGCC AGCGGCATGG TGACCCAGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HPN ( XM_017026732.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016882221.1 Homo sapiens hepsin (HPN), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu52218
Clone ID Related Accession (Same CDS sequence)	XM_017026732.1
Accession Version	XM_017026732.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1182bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	serine protease hepsin isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGCAAAA TGAGGACCAG AGAGGACATG CAGCTGGGGA ACGAGGGGCC AGGAACAGCT 
CTTAGACTTA TCCACTTGCA GGTCAGCTCT GCGGACGCTC GGCTCATGGT CTTTGACAAG 
ACGGAAGGGA CGTGGCGGCT GCTGTGCTCC TCGCGCTCCA ACGCCAGGGT AGCCGGACTC 
AGCTGCGAGG AGATGGGCTT CCTCAGGGCA CTGACCCACT CCGAGCTGGA CGTGCGAACG 
GCGGGCGCCA ATGGCACGTC GGGCTTCTTC TGTGTGGACG AGGGGAGGCT GCCCCACACC 
CAGAGGCTGC TGGAGGTCAT CTCCGTGTGT GATTGCCCCA GAGGCCGTTT CTTGGCCGCC 
ATCTGCCAAG ACTGTGGCCG CAGGAAGCTG CCCGTGGACC GCATCGTGGG AGGCCGGGAC 
ACCAGCTTGG GCCGGTGGCC GTGGCAAGTC AGCCTTCGCT ATGATGGAGC ACACCTCTGT 
GGGGGATCCC TGCTCTCCGG GGACTGGGTG CTGACAGCCG CCCACTGCTT CCCGGAGCGG 
AACCGGGTCC TGTCCCGATG GCGAGTGTTT GCCGGTGCCG TGGCCCAGGC CTCTCCCCAC 
GGTCTGCAGC TGGGGGTGCA GGCTGTGGTC TACCACGGGG GCTATCTTCC CTTTCGGGAC 
CCCAACAGCG AGGAGAACAG CAACGATATT GCCCTGGTCC ACCTCTCCAG TCCCCTGCCC 
CTCACAGAAT ACATCCAGCC TGTGTGCCTC CCAGCTGCCG GCCAGGCCCT GGTGGATGGC 
AAGATCTGTA CCGTGACGGG CTGGGGCAAC ACGCAGTACT ATGGCCAACA GGCCGGGGTA 
CTCCAGGAGG CTCGAGTCCC CATAATCAGC AATGATGTCT GCAATGGCGC TGACTTCTAT 
GGAAACCAGA TCAAGCCCAA GATGTTCTGT GCTGGCTACC CCGAGGGTGG CATTGATGCC 
TGCCAGGGCG ACAGCGGTGG TCCCTTTGTG TGTGAGGACA GCATCTCTCG GACGCCACGT 
TGGCGGCTGT GTGGCATTGT GAGTTGGGGC ACTGGCTGTG CCCTGGCCCA GAAGCCAGGC 
GTCTACACCA AAGTCAGTGA CTTCCGGGAG TGGATCTTCC AGGCCATAAA GGTGAAAGTT 
GGGTCCAGAT GGGAGCCAGG GTGGGGACGT TTGGGTGTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016882221.1
CDS	145..1326
Translation	MCKMRTREDMQLGNEGPGTALRLIHLQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKVKVGSRWEPGWGRLGV

Target ORF information:

RefSeq Version	XM_017026732.1
Organism	Homo sapiens(human)
Definition	Homo sapiens hepsin (HPN), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026732.1

ORF Insert Sequence:

ATGTGCAAAA TGAGGACCAG AGAGGACATG CAGCTGGGGA ACGAGGGGCC AGGAACAGCT 
CTTAGACTTA TCCACTTGCA GGTCAGCTCT GCGGACGCTC GGCTCATGGT CTTTGACAAG 
ACGGAAGGGA CGTGGCGGCT GCTGTGCTCC TCGCGCTCCA ACGCCAGGGT AGCCGGACTC 
AGCTGCGAGG AGATGGGCTT CCTCAGGGCA CTGACCCACT CCGAGCTGGA CGTGCGAACG 
GCGGGCGCCA ATGGCACGTC GGGCTTCTTC TGTGTGGACG AGGGGAGGCT GCCCCACACC 
CAGAGGCTGC TGGAGGTCAT CTCCGTGTGT GATTGCCCCA GAGGCCGTTT CTTGGCCGCC 
ATCTGCCAAG ACTGTGGCCG CAGGAAGCTG CCCGTGGACC GCATCGTGGG AGGCCGGGAC 
ACCAGCTTGG GCCGGTGGCC GTGGCAAGTC AGCCTTCGCT ATGATGGAGC ACACCTCTGT 
GGGGGATCCC TGCTCTCCGG GGACTGGGTG CTGACAGCCG CCCACTGCTT CCCGGAGCGG 
AACCGGGTCC TGTCCCGATG GCGAGTGTTT GCCGGTGCCG TGGCCCAGGC CTCTCCCCAC 
GGTCTGCAGC TGGGGGTGCA GGCTGTGGTC TACCACGGGG GCTATCTTCC CTTTCGGGAC 
CCCAACAGCG AGGAGAACAG CAACGATATT GCCCTGGTCC ACCTCTCCAG TCCCCTGCCC 
CTCACAGAAT ACATCCAGCC TGTGTGCCTC CCAGCTGCCG GCCAGGCCCT GGTGGATGGC 
AAGATCTGTA CCGTGACGGG CTGGGGCAAC ACGCAGTACT ATGGCCAACA GGCCGGGGTA 
CTCCAGGAGG CTCGAGTCCC CATAATCAGC AATGATGTCT GCAATGGCGC TGACTTCTAT 
GGAAACCAGA TCAAGCCCAA GATGTTCTGT GCTGGCTACC CCGAGGGTGG CATTGATGCC 
TGCCAGGGCG ACAGCGGTGG TCCCTTTGTG TGTGAGGACA GCATCTCTCG GACGCCACGT 
TGGCGGCTGT GTGGCATTGT GAGTTGGGGC ACTGGCTGTG CCCTGGCCCA GAAGCCAGGC 
GTCTACACCA AAGTCAGTGA CTTCCGGGAG TGGATCTTCC AGGCCATAAA GGTGAAAGTT 
GGGTCCAGAT GGGAGCCAGG GTGGGGACGT TTGGGTGTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HPN ( NM_001375441.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001362370.1 Homo sapiens hepsin (HPN), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu08465
Clone ID Related Accession (Same CDS sequence)	NM_002151.2 , XM_006723181.3 , XM_017026731.1 , XM_005258838.4 , NM_001375441.1 , NM_182983.2
Accession Version	NM_001375441.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1254bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Homo sapiens(human)
Product	serine protease hepsin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC020907.6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGCAGA AGGAGGGTGG CCGGACTGTG CCATGCTGCT CCAGACCCAA GGTGGCAGCT 
CTCACTGCGG GGACCCTGCT ACTTCTGACA GCCATCGGGG CGGCATCCTG GGCCATTGTG 
GCTGTTCTCC TCAGGAGTGA CCAGGAGCCG CTGTACCCAG TGCAGGTCAG CTCTGCGGAC 
GCTCGGCTCA TGGTCTTTGA CAAGACGGAA GGGACGTGGC GGCTGCTGTG CTCCTCGCGC 
TCCAACGCCA GGGTAGCCGG ACTCAGCTGC GAGGAGATGG GCTTCCTCAG GGCACTGACC 
CACTCCGAGC TGGACGTGCG AACGGCGGGC GCCAATGGCA CGTCGGGCTT CTTCTGTGTG 
GACGAGGGGA GGCTGCCCCA CACCCAGAGG CTGCTGGAGG TCATCTCCGT GTGTGATTGC 
CCCAGAGGCC GTTTCTTGGC CGCCATCTGC CAAGACTGTG GCCGCAGGAA GCTGCCCGTG 
GACCGCATCG TGGGAGGCCG GGACACCAGC TTGGGCCGGT GGCCGTGGCA AGTCAGCCTT 
CGCTATGATG GAGCACACCT CTGTGGGGGA TCCCTGCTCT CCGGGGACTG GGTGCTGACA 
GCCGCCCACT GCTTCCCGGA GCGGAACCGG GTCCTGTCCC GATGGCGAGT GTTTGCCGGT 
GCCGTGGCCC AGGCCTCTCC CCACGGTCTG CAGCTGGGGG TGCAGGCTGT GGTCTACCAC 
GGGGGCTATC TTCCCTTTCG GGACCCCAAC AGCGAGGAGA ACAGCAACGA TATTGCCCTG 
GTCCACCTCT CCAGTCCCCT GCCCCTCACA GAATACATCC AGCCTGTGTG CCTCCCAGCT 
GCCGGCCAGG CCCTGGTGGA TGGCAAGATC TGTACCGTGA CGGGCTGGGG CAACACGCAG 
TACTATGGCC AACAGGCCGG GGTACTCCAG GAGGCTCGAG TCCCCATAAT CAGCAATGAT 
GTCTGCAATG GCGCTGACTT CTATGGAAAC CAGATCAAGC CCAAGATGTT CTGTGCTGGC 
TACCCCGAGG GTGGCATTGA TGCCTGCCAG GGCGACAGCG GTGGTCCCTT TGTGTGTGAG 
GACAGCATCT CTCGGACGCC ACGTTGGCGG CTGTGTGGCA TTGTGAGTTG GGGCACTGGC 
TGTGCCCTGG CCCAGAAGCC AGGCGTCTAC ACCAAAGTCA GTGACTTCCG GGAGTGGATC 
TTCCAGGCCA TAAAGACTCA CTCCGAAGCC AGCGGCATGG TGACCCAGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001362370.1
CDS	352..1605
Translation	MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL

Target ORF information:

RefSeq Version	NM_001375441.1
Organism	Homo sapiens(human)
Definition	Homo sapiens hepsin (HPN), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001375441.1

ORF Insert Sequence:

ATGGCGCAGA AGGAGGGTGG CCGGACTGTG CCATGCTGCT CCAGACCCAA GGTGGCAGCT 
CTCACTGCGG GGACCCTGCT ACTTCTGACA GCCATCGGGG CGGCATCCTG GGCCATTGTG 
GCTGTTCTCC TCAGGAGTGA CCAGGAGCCG CTGTACCCAG TGCAGGTCAG CTCTGCGGAC 
GCTCGGCTCA TGGTCTTTGA CAAGACGGAA GGGACGTGGC GGCTGCTGTG CTCCTCGCGC 
TCCAACGCCA GGGTAGCCGG ACTCAGCTGC GAGGAGATGG GCTTCCTCAG GGCACTGACC 
CACTCCGAGC TGGACGTGCG AACGGCGGGC GCCAATGGCA CGTCGGGCTT CTTCTGTGTG 
GACGAGGGGA GGCTGCCCCA CACCCAGAGG CTGCTGGAGG TCATCTCCGT GTGTGATTGC 
CCCAGAGGCC GTTTCTTGGC CGCCATCTGC CAAGACTGTG GCCGCAGGAA GCTGCCCGTG 
GACCGCATCG TGGGAGGCCG GGACACCAGC TTGGGCCGGT GGCCGTGGCA AGTCAGCCTT 
CGCTATGATG GAGCACACCT CTGTGGGGGA TCCCTGCTCT CCGGGGACTG GGTGCTGACA 
GCCGCCCACT GCTTCCCGGA GCGGAACCGG GTCCTGTCCC GATGGCGAGT GTTTGCCGGT 
GCCGTGGCCC AGGCCTCTCC CCACGGTCTG CAGCTGGGGG TGCAGGCTGT GGTCTACCAC 
GGGGGCTATC TTCCCTTTCG GGACCCCAAC AGCGAGGAGA ACAGCAACGA TATTGCCCTG 
GTCCACCTCT CCAGTCCCCT GCCCCTCACA GAATACATCC AGCCTGTGTG CCTCCCAGCT 
GCCGGCCAGG CCCTGGTGGA TGGCAAGATC TGTACCGTGA CGGGCTGGGG CAACACGCAG 
TACTATGGCC AACAGGCCGG GGTACTCCAG GAGGCTCGAG TCCCCATAAT CAGCAATGAT 
GTCTGCAATG GCGCTGACTT CTATGGAAAC CAGATCAAGC CCAAGATGTT CTGTGCTGGC 
TACCCCGAGG GTGGCATTGA TGCCTGCCAG GGCGACAGCG GTGGTCCCTT TGTGTGTGAG 
GACAGCATCT CTCGGACGCC ACGTTGGCGG CTGTGTGGCA TTGTGAGTTG GGGCACTGGC 
TGTGCCCTGG CCCAGAAGCC AGGCGTCTAC ACCAAAGTCA GTGACTTCCG GGAGTGGATC 
TTCCAGGCCA TAAAGACTCA CTCCGAAGCC AGCGGCATGG TGACCCAGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Exploring hepsin functional genetic variation association with disease specific protein expression in bipolar disorder: Applications of a proteomic informed genomic approach.
Journal of psychiatric research95208-212(2017 Dec)
Nassan M,Jia YF,Jenkins G,Colby C,Feeder S,Choi DS,Veldic M,McElroy SL,Bond DJ,Weinshilboum R,Biernacka JM,Frye MA

High Hepsin expression predicts poor prognosis in Gastric Cancer.
Scientific reports636902(2016 Nov)
Zhang M,Zhao J,Tang W,Wang Y,Peng P,Li L,Song S,Wu H,Li C,Yang C,Wang X,Zhang C,Gu J

Identification and characterization of hepsin/-TM, a non-transmembrane hepsin isoform.
Biochimica et biophysica acta1681(2-3)157-65(2005 Jan)
Li Y,Yu Z,Zhao X,Shen SH

The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain.
Structure (London, England : 1993)11(9)1123-31(2003 Sep)
Somoza JR,Ho JD,Luong C,Ghate M,Sprengeler PA,Mortara K,Shrader WD,Sperandio D,Chan H,McGrath ME,Katz BA

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

HPN cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報