Gene Symbol | HPGD |
Entrez Gene ID | 3248 |
Full Name | 15-hydroxyprostaglandin dehydrogenase |
Synonyms | 15-PGDH,PGDH,PGDH1,PHOAR1,SDR36C1 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]. |
Disorder MIM: | |
Disorder Html: | Cranioosteoarthropathy, 259100 (3); Hypertrophic osteoarthropathy, primary, autosomal recessive 1, 259100 (3); Digital clubbing, isolated congenital, 119900 (3) |