HOXD11 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HOXD11
Entrez Gene ID	3237
Full Name	homeobox D11
Synonyms	HOX4,HOX4F
General protein information	Preferred Names homeobox D11 Names homeobox protein Hox-D11 Hox-4.6, mouse, homolog of homeo box 4F homeo box D11 homeobox protein Hox-4F
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q31.1
Summary	This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis. [provided by RefSeq, Jul 2008].
Disorder MIM:	142986

mRNA and Protein(s)

mRNA	Protein	Name
NM_021192.2	NP_067015.2	homeobox protein Hox-D11
NM_021192.3	NP_067015.2	homeobox protein Hox-D11

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	HOXD11	NP_989951.1
Xenopus tropicalis (tropical clawed frog)	hoxd11	XP_002935722.1
Pan troglodytes (chimpanzee)	HOXD11	XP_515927.2
Danio rerio (zebrafish)	hoxd11a	NP_571242.1
Homo sapiens (human)	HOXD11	NP_067015.2
Bos taurus (cattle)	HOXD11	NP_001193253.1
Mus musculus (house mouse)	Hoxd11	NP_032299.1

Gene Ontology
Bibliography

Related articles in PubMed

HOX genes: potential candidates for the progression of laryngeal squamous cell carcinoma.
de Barros E Lima Bueno R, Ram?o A, Pinheiro DG, Alves CP, Kannen V, Jungbluth AA, de Ara?jo LF, Muys BR, Fonseca AS, Pla?a JR, Panepucci RA, Neder L, Saggioro FP, Mamede RC, Figueiredo DL, Silva WA Jr
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(11)15087-15096(2016 Nov)

The posterior HOXD locus: Its contribution to phenotype and malignancy of Ewing sarcoma.
von Heyking K, Roth L, Ertl M, Schmidt O, Calzada-Wack J, Neff F, Lawlor ER, Burdach S, Richter GH
Oncotarget7(27)41767-41780(2016 Jul)

POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in head and neck cancer.
Sharpe DJ, Orr KS, Moran M, White SJ, McQuaid S, Lappin TR, Thompson A, James JA
Oncotarget5(18)8803-15(2014 Sep)

A region of the human HOXD cluster that confers polycomb-group responsiveness.
Woo CJ, Kharchenko PV, Daheron L, Park PJ, Kingston RE
Cell140(1)99-110(2010 Jan)

Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot.
Ester AR, Weymouth KS, Burt A, Wise CA, Scott A, Gurnett CA, Dobbs MB, Blanton SH, Hecht JT
American journal of medical genetics. Part A149A(12)2745-52(2009 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

High expression of HOXD11 is associated with laryngeal squamous cell carcinoma.
Title: HOX genes: potential candidates for the progression of laryngeal squamous cell carcinoma.

Knock down of the dickkopf WNT signaling pathway inhibitor 2 (DKK2) resulted in a significant suppression of HOXD10, HOXD11 and HOXD13 while over-expression of DKK2 and stimulation with factors of the WNT signaling pathway.
Title: The posterior HOXD locus: Its contribution to phenotype and malignancy of Ewing sarcoma.

POU2F1 activity regulates HOXD10 and HOXD11 gene expression in head and neck squamous cell carcinoma, promoting a proliferative and invasive phenotype.
Title: POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in head and neck cancer.

In human embryonic stem cell (hESCs)differentiation, a 1.8kb region between HOXD11 and HOXD12 (D11.12) that is associated with PcG proteins was discovered, it shows alteration in nuclease sensitivity as hESCs differentiate.
Title: A region of the human HOXD cluster that confers polycomb-group responsiveness.

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot.

The following HOXD11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HOXD11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29702	NM_021192.3 Latest version!	Homo sapiens homeobox D11 (HOXD11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
View Old Accession Versions >>
OHu29702	NM_021192.2	Homo sapiens homeobox D11 (HOXD11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HOXD11 ( NM_021192.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_067015.2 Homo sapiens homeobox D11 (HOXD11), mRNA.

Price & Availability↑

CloneID	OHu29702
Clone ID Related Accession (Same CDS sequence)	NM_021192.2 , NM_021192.3
Accession Version	NM_021192.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1017bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	homeobox protein Hox-D11
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF154915.1 and BE260674.1. On Oct 7, 2002 this sequence version replaced NM_021192.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AI139039.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END##

ATGAACGACT TTGACGAGTG CGGCCAGAGC GCAGCCAGCA TGTACCTGCC GGGCTGCGCC 
TACTATGTGG CCCCGTCTGA CTTCGCTAGC AAGCCTTCGT TCCTTTCCCA ACCGTCGTCC 
TGCCAGATGA CTTTCCCCTA CTCTTCCAAC CTGGCTCCGC ACGTCCAGCC CGTGCGCGAA 
GTGGCCTTCC GCGACTACGG CCTGGAGCGC GCCAAGTGGC CGTACCGCGG CGGCGGCGGC 
GGCGGCAGCG CGGGGGGCGG CAGCAGCGGG GGCGGCCCCG GCGGGGGCGG CGGCGGCGCG 
GGGGGCTACG CTCCCTACTA CGCGGCGGCG GCGGCGGCGG CTGCGGCGGC CGCGGCGGCC 
GAGGAGGCGG CCATGCAACG CGAGCTTCTC CCGCCCGCGG GCCGCCGGCC GGACGTGCTC 
TTCAAGGCGC CTGAGCCGGT GTGCGCTGCG CCGGGGCCGC CGCACGGCCC CGCGGGCGCC 
GCCTCCAACT TCTACAGCGC GGTGGGCCGC AATGGCATCT TGCCACAGGG CTTCGACCAG 
TTCTACGAGG CAGCGCCCGG GCCCCCGTTC GCCGGGCCGC AGCCCCCGCC GCCACCCGCG 
CCGCCACAGC CCGAGGGCGC AGCCGACAAG GGCGACCCCA GGACCGGGGC TGGTGGCGGC 
GGGGGCAGTC CCTGCACCAA GGCGACCCCT GGCTCGGAGC CCAAGGGGGC AGCAGAAGGC 
AGCGGTGGCG ACGGCGAGGG CCCCCCGGGA GAGGCGGGGG CCGAGAAGAG CAGCAGCGCA 
GTTGCCCCCC AGCGGTCCCG GAAAAAGCGC TGTCCCTATA CCAAGTACCA GATCCGCGAA 
CTGGAACGCG AGTTTTTCTT TAACGTGTAC ATAAACAAAG AGAAAAGACT TCAACTCTCT 
CGGATGCTCA ACCTCACTGA CCGGCAAGTC AAAATCTGGT TCCAGAATCG CAGGATGAAA 
GAAAAGAAAC TGAACAGAGA CCGTCTGCAG TATTTCACTG GAAACCCCTT ATTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067015.2
CDS	1..1017
Translation	MNDFDECGQSAASMYLPGCAYYVAPSDFASKPSFLSQPSSCQMTFPYSSNLAPHVQPVREVAFRDYGLERAKWPYRGGGGGGSAGGGSSGGGPGGGGGGAGGYAPYYAAAAAAAAAAAAAEEAAMQRELLPPAGRRPDVLFKAPEPVCAAPGPPHGPAGAASNFYSAVGRNGILPQGFDQFYEAAPGPPFAGPQPPPPPAPPQPEGAADKGDPRTGAGGGGGSPCTKATPGSEPKGAAEGSGGDGEGPPGEAGAEKSSSAVAPQRSRKKRCPYTKYQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKLNRDRLQYFTGNPLF

Target ORF information:

RefSeq Version	NM_021192.2
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox D11 (HOXD11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021192.2

ORF Insert Sequence:

ATGAACGACT TTGACGAGTG CGGCCAGAGC GCAGCCAGCA TGTACCTGCC GGGCTGCGCC 
TACTATGTGG CCCCGTCTGA CTTCGCTAGC AAGCCTTCGT TCCTTTCCCA ACCGTCGTCC 
TGCCAGATGA CTTTCCCCTA CTCTTCCAAC CTGGCTCCGC ACGTCCAGCC CGTGCGCGAA 
GTGGCCTTCC GCGACTACGG CCTGGAGCGC GCCAAGTGGC CGTACCGCGG CGGCGGCGGC 
GGCGGCAGCG CGGGGGGCGG CAGCAGCGGG GGCGGCCCCG GCGGGGGCGG CGGCGGCGCG 
GGGGGCTACG CTCCCTACTA CGCGGCGGCG GCGGCGGCGG CTGCGGCGGC CGCGGCGGCC 
GAGGAGGCGG CCATGCAACG CGAGCTTCTC CCGCCCGCGG GCCGCCGGCC GGACGTGCTC 
TTCAAGGCGC CTGAGCCGGT GTGCGCTGCG CCGGGGCCGC CGCACGGCCC CGCGGGCGCC 
GCCTCCAACT TCTACAGCGC GGTGGGCCGC AATGGCATCT TGCCACAGGG CTTCGACCAG 
TTCTACGAGG CAGCGCCCGG GCCCCCGTTC GCCGGGCCGC AGCCCCCGCC GCCACCCGCG 
CCGCCACAGC CCGAGGGCGC AGCCGACAAG GGCGACCCCA GGACCGGGGC TGGTGGCGGC 
GGGGGCAGTC CCTGCACCAA GGCGACCCCT GGCTCGGAGC CCAAGGGGGC AGCAGAAGGC 
AGCGGTGGCG ACGGCGAGGG CCCCCCGGGA GAGGCGGGGG CCGAGAAGAG CAGCAGCGCA 
GTTGCCCCCC AGCGGTCCCG GAAAAAGCGC TGTCCCTATA CCAAGTACCA GATCCGCGAA 
CTGGAACGCG AGTTTTTCTT TAACGTGTAC ATAAACAAAG AGAAAAGACT TCAACTCTCT 
CGGATGCTCA ACCTCACTGA CCGGCAAGTC AAAATCTGGT TCCAGAATCG CAGGATGAAA 
GAAAAGAAAC TGAACAGAGA CCGTCTGCAG TATTTCACTG GAAACCCCTT ATTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOXD11 ( NM_021192.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_067015.2 Homo sapiens homeobox D11 (HOXD11), mRNA.

Price & Availability↑

CloneID	OHu29702
Clone ID Related Accession (Same CDS sequence)	NM_021192.2 , NM_021192.3
Accession Version	NM_021192.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1017bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	homeobox protein Hox-D11
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009336.13. On May 17, 2019 this sequence version replaced NM_021192.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AI139039.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000249504.7/ ENSP00000249504.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAACGACT TTGACGAGTG CGGCCAGAGC GCAGCCAGCA TGTACCTGCC GGGCTGCGCC 
TACTATGTGG CCCCGTCTGA CTTCGCTAGC AAGCCTTCGT TCCTTTCCCA ACCGTCGTCC 
TGCCAGATGA CTTTCCCCTA CTCTTCCAAC CTGGCTCCGC ACGTCCAGCC CGTGCGCGAA 
GTGGCCTTCC GCGACTACGG CCTGGAGCGC GCCAAGTGGC CGTACCGCGG CGGCGGCGGC 
GGCGGCAGCG CGGGGGGCGG CAGCAGCGGG GGCGGCCCCG GCGGGGGCGG CGGCGGCGCG 
GGGGGCTACG CTCCCTACTA CGCGGCGGCG GCGGCGGCGG CTGCGGCGGC CGCGGCGGCC 
GAGGAGGCGG CCATGCAACG CGAGCTTCTC CCGCCCGCGG GCCGCCGGCC GGACGTGCTC 
TTCAAGGCGC CTGAGCCGGT GTGCGCTGCG CCGGGGCCGC CGCACGGCCC CGCGGGCGCC 
GCCTCCAACT TCTACAGCGC GGTGGGCCGC AATGGCATCT TGCCACAGGG CTTCGACCAG 
TTCTACGAGG CAGCGCCCGG GCCCCCGTTC GCCGGGCCGC AGCCCCCGCC GCCACCCGCG 
CCGCCACAGC CCGAGGGCGC AGCCGACAAG GGCGACCCCA GGACCGGGGC TGGTGGCGGC 
GGGGGCAGTC CCTGCACCAA GGCGACCCCT GGCTCGGAGC CCAAGGGGGC AGCAGAAGGC 
AGCGGTGGCG ACGGCGAGGG CCCCCCGGGA GAGGCGGGGG CCGAGAAGAG CAGCAGCGCA 
GTTGCCCCCC AGCGGTCCCG GAAAAAGCGC TGTCCCTATA CCAAGTACCA GATCCGCGAA 
CTGGAACGCG AGTTTTTCTT TAACGTGTAC ATAAACAAAG AGAAAAGACT TCAACTCTCT 
CGGATGCTCA ACCTCACTGA CCGGCAAGTC AAAATCTGGT TCCAGAATCG CAGGATGAAA 
GAAAAGAAAC TGAACAGAGA CCGTCTGCAG TATTTCACTG GAAACCCCTT ATTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067015.2
CDS	77..1093
Translation	MNDFDECGQSAASMYLPGCAYYVAPSDFASKPSFLSQPSSCQMTFPYSSNLAPHVQPVREVAFRDYGLERAKWPYRGGGGGGSAGGGSSGGGPGGGGGGAGGYAPYYAAAAAAAAAAAAAEEAAMQRELLPPAGRRPDVLFKAPEPVCAAPGPPHGPAGAASNFYSAVGRNGILPQGFDQFYEAAPGPPFAGPQPPPPPAPPQPEGAADKGDPRTGAGGGGGSPCTKATPGSEPKGAAEGSGGDGEGPPGEAGAEKSSSAVAPQRSRKKRCPYTKYQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKLNRDRLQYFTGNPLF

Target ORF information:

RefSeq Version	NM_021192.3
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox D11 (HOXD11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021192.3

ORF Insert Sequence:

ATGAACGACT TTGACGAGTG CGGCCAGAGC GCAGCCAGCA TGTACCTGCC GGGCTGCGCC 
TACTATGTGG CCCCGTCTGA CTTCGCTAGC AAGCCTTCGT TCCTTTCCCA ACCGTCGTCC 
TGCCAGATGA CTTTCCCCTA CTCTTCCAAC CTGGCTCCGC ACGTCCAGCC CGTGCGCGAA 
GTGGCCTTCC GCGACTACGG CCTGGAGCGC GCCAAGTGGC CGTACCGCGG CGGCGGCGGC 
GGCGGCAGCG CGGGGGGCGG CAGCAGCGGG GGCGGCCCCG GCGGGGGCGG CGGCGGCGCG 
GGGGGCTACG CTCCCTACTA CGCGGCGGCG GCGGCGGCGG CTGCGGCGGC CGCGGCGGCC 
GAGGAGGCGG CCATGCAACG CGAGCTTCTC CCGCCCGCGG GCCGCCGGCC GGACGTGCTC 
TTCAAGGCGC CTGAGCCGGT GTGCGCTGCG CCGGGGCCGC CGCACGGCCC CGCGGGCGCC 
GCCTCCAACT TCTACAGCGC GGTGGGCCGC AATGGCATCT TGCCACAGGG CTTCGACCAG 
TTCTACGAGG CAGCGCCCGG GCCCCCGTTC GCCGGGCCGC AGCCCCCGCC GCCACCCGCG 
CCGCCACAGC CCGAGGGCGC AGCCGACAAG GGCGACCCCA GGACCGGGGC TGGTGGCGGC 
GGGGGCAGTC CCTGCACCAA GGCGACCCCT GGCTCGGAGC CCAAGGGGGC AGCAGAAGGC 
AGCGGTGGCG ACGGCGAGGG CCCCCCGGGA GAGGCGGGGG CCGAGAAGAG CAGCAGCGCA 
GTTGCCCCCC AGCGGTCCCG GAAAAAGCGC TGTCCCTATA CCAAGTACCA GATCCGCGAA 
CTGGAACGCG AGTTTTTCTT TAACGTGTAC ATAAACAAAG AGAAAAGACT TCAACTCTCT 
CGGATGCTCA ACCTCACTGA CCGGCAAGTC AAAATCTGGT TCCAGAATCG CAGGATGAAA 
GAAAAGAAAC TGAACAGAGA CCGTCTGCAG TATTTCACTG GAAACCCCTT ATTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

HOX genes: potential candidates for the progression of laryngeal squamous cell carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(11)15087-15096(2016 Nov)
de Barros E Lima Bueno R,Ram?o A,Pinheiro DG,Alves CP,Kannen V,Jungbluth AA,de Ara?jo LF,Muys BR,Fonseca AS,Pla?a JR,Panepucci RA,Neder L,Saggioro FP,Mamede RC,Figueiredo DL,Silva WA Jr

The posterior HOXD locus: Its contribution to phenotype and malignancy of Ewing sarcoma.
Oncotarget7(27)41767-41780(2016 Jul)
von Heyking K,Roth L,Ertl M,Schmidt O,Calzada-Wack J,Neff F,Lawlor ER,Burdach S,Richter GH

POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in head and neck cancer.
Oncotarget5(18)8803-15(2014 Sep)
Sharpe DJ,Orr KS,Moran M,White SJ,McQuaid S,Lappin TR,Thompson A,James JA

A region of the human HOXD cluster that confers polycomb-group responsiveness.
Cell140(1)99-110(2010 Jan)
Woo CJ,Kharchenko PV,Daheron L,Park PJ,Kingston RE

Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot.
American journal of medical genetics. Part A149A(12)2745-52(2009 Dec)
Ester AR,Weymouth KS,Burt A,Wise CA,Scott A,Gurnett CA,Dobbs MB,Blanton SH,Hecht JT

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HOXD11 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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