HOXD8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HOXD8
Entrez Gene ID	3234
Full Name	homeobox D8
Synonyms	HOX4,HOX4E,HOX5.4
General protein information	Preferred Names homeobox D8 Names homeobox protein Hox-D8 Hox-4.5 homeo box 4E homeo box D8 homeobox protein 5.4 homeobox protein Hox-4E homeobox protein Hox-5.4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q31.1
Summary	This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010].
Disorder MIM:	142985

mRNA and Protein(s)

mRNA	Protein	Name
NM_001199747.1	NP_001186676.1	homeobox protein Hox-D8 isoform 3
NM_019558.4	NP_062458.1	homeobox protein Hox-D8 isoform 1
NM_001199746.2	NP_001186675.1	homeobox protein Hox-D8 isoform 2
NM_001199746.1	NP_001186675.1	homeobox protein Hox-D8 isoform 2
NM_019558.3	NP_062458.1	homeobox protein Hox-D8 isoform 1
NM_001199747.2	NP_001186676.1	homeobox protein Hox-D8 isoform 3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	HOXD8	NP_001074950.1
Canis lupus familiaris (dog)	HOXD8	XP_005640466.1
Mus musculus (house mouse)	Hoxd8	NP_032302.2
Homo sapiens (human)	HOXD8	NP_001186675.1
Bos taurus (cattle)	HOXD8	XP_005202440.1
Gallus gallus (chicken)	HOXD8	NP_997060.1
Xenopus tropicalis (tropical clawed frog)	hoxd8	NP_001135589.1

Gene Ontology
Bibliography

Related articles in PubMed

HOXD8 exerts a tumor-suppressing role in colorectal cancer as an apoptotic inducer.
Mansour MA, Senga T
The international journal of biochemistry & cell biology881-13(2017 07)

microRNA-520a-3p inhibits proliferation and cancer stem cell phenotype by targeting HOXD8 in non-small cell lung cancer.
Liu Y, Miao L, Ni R, Zhang H, Li L, Wang X, Li X, Wang J
Oncology reports36(6)3529-3535(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HOXD8 exerts a tumor-suppressing role in colorectal cancer as an apoptotic inducer
Title: HOXD8 exerts a tumor-suppressing role in colorectal cancer as an apoptotic inducer.

microRNA-520a-3p inhibits proliferation and cancer stem cell phenotype by targeting HOXD8 in non small cell lung cancer cells and restoration of microRNA-520a-3p might be a therapeutic strategy to reverse gefitinib resistance.
Title: microRNA-520a-3p inhibits proliferation and cancer stem cell phenotype by targeting HOXD8 in non-small cell lung cancer.

Observational study of gene-disease association. (HuGE Navigator)
Title: High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot.

Prox1 and HoxD8 play important roles in the maturation and maintenance of lymphatic vessels.
Title: Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis.

The following HOXD8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HOXD8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12572	NM_019558.4 Latest version!	Homo sapiens homeobox D8 (HOXD8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu12650	NM_001199746.2 Latest version!	Homo sapiens homeobox D8 (HOXD8), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu01861	NM_001199747.2 Latest version!	Homo sapiens homeobox D8 (HOXD8), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu12650	NM_001199746.1	Homo sapiens homeobox D8 (HOXD8), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu12572	NM_019558.3	Homo sapiens homeobox D8 (HOXD8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu01861	NM_001199747.1	Homo sapiens homeobox D8 (HOXD8), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HOXD8 ( NM_019558.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_062458.1 Homo sapiens homeobox D8 (HOXD8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12572
Clone ID Related Accession (Same CDS sequence)	NM_019558.4 , NM_019558.3
Accession Version	NM_019558.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Homo sapiens(human)
Product	homeobox protein Hox-D8 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009336.13 and AW140108.1. On Nov 22, 2018 this sequence version replaced NM_019558.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189667.31639.1, ERR279832.9862.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000313173.6/ ENSP00000315949.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGTTCGT ACTTCGTGAA CCCGCTGTAC TCCAAGTACA AGGCGGCGGC TGCGGCGGCG 
GCGGCGGCGG GCGAGGCCAT CAATCCCACT TACTACGACT GTCACTTCGC GCCCGAGGTC 
GGCGGCCGTC ACGCCGCCGC CGCAGCAGCC CTGCAGCTCT ATGGCAACAG CGCCGCCGGC 
TTCCCGCACG CGCCCCCGCA GGCGCACGCG CACCCGCACC CGTCCCCGCC GCCCTCCGGG 
ACTGGGTGCG GCGGTAGGGA AGGCCGGGGC CAGGAGTACT TCCACCCCGG CGGGGGCAGC 
CCGGCCGCTG CCTACCAGGC CGCCCCCCCT CCTCCTCCGC ATCCTCCGCC TCCGCCGCCA 
CCTCCCCCCT GCGGCGGGAT TGCCTGTCAC GGGGAGCCCG CGAAGTTTTA CGGATACGAT 
AACTTACAGA GACAGCCGAT TTTTACGACC CAGCAAGAGG CCGAGCTGGT ACAATATCCT 
GACTGTAAAT CGTCCAGTGG TAATATTGGC GAGGACCCAG ACCACTTAAA TCAGAGCTCG 
TCTCCTTCTC AAATGTTTCC GTGGATGAGA CCACAAGCAG CTCCTGGTAG ACGAAGAGGA 
AGACAAACCT ACAGTCGCTT CCAAACTCTA GAGTTGGAAA AGGAATTTCT TTTTAACCCC 
TATCTGACCA GGAAAAGAAG AATCGAGGTT TCCCACGCCC TAGCCCTCAC CGAGAGACAG 
GTAAAAATCT GGTTCCAGAA CAGGAGAATG AAATGGAAAA AGGAAAACAA CAAGGACAAA 
TTTCCCGTTT CCCGGCAGGA GGTGAAGGAC GGGGAAACGA AAAAGGAAGC CCAAGAGCTG 
GAGGAAGACA GAGCCGAAGG CCTGACAAAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062458.1
CDS	663..1535
Translation	MSSYFVNPLYSKYKAAAAAAAAAGEAINPTYYDCHFAPEVGGRHAAAAAALQLYGNSAAGFPHAPPQAHAHPHPSPPPSGTGCGGREGRGQEYFHPGGGSPAAAYQAAPPPPPHPPPPPPPPPCGGIACHGEPAKFYGYDNLQRQPIFTTQQEAELVQYPDCKSSSGNIGEDPDHLNQSSSPSQMFPWMRPQAAPGRRRGRQTYSRFQTLELEKEFLFNPYLTRKRRIEVSHALALTERQVKIWFQNRRMKWKKENNKDKFPVSRQEVKDGETKKEAQELEEDRAEGLTN

Target ORF information:

RefSeq Version	NM_019558.4
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox D8 (HOXD8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019558.4

ORF Insert Sequence:

ATGAGTTCGT ACTTCGTGAA CCCGCTGTAC TCCAAGTACA AGGCGGCGGC TGCGGCGGCG 
GCGGCGGCGG GCGAGGCCAT CAATCCCACT TACTACGACT GTCACTTCGC GCCCGAGGTC 
GGCGGCCGTC ACGCCGCCGC CGCAGCAGCC CTGCAGCTCT ATGGCAACAG CGCCGCCGGC 
TTCCCGCACG CGCCCCCGCA GGCGCACGCG CACCCGCACC CGTCCCCGCC GCCCTCCGGG 
ACTGGGTGCG GCGGTAGGGA AGGCCGGGGC CAGGAGTACT TCCACCCCGG CGGGGGCAGC 
CCGGCCGCTG CCTACCAGGC CGCCCCCCCT CCTCCTCCGC ATCCTCCGCC TCCGCCGCCA 
CCTCCCCCCT GCGGCGGGAT TGCCTGTCAC GGGGAGCCCG CGAAGTTTTA CGGATACGAT 
AACTTACAGA GACAGCCGAT TTTTACGACC CAGCAAGAGG CCGAGCTGGT ACAATATCCT 
GACTGTAAAT CGTCCAGTGG TAATATTGGC GAGGACCCAG ACCACTTAAA TCAGAGCTCG 
TCTCCTTCTC AAATGTTTCC GTGGATGAGA CCACAAGCAG CTCCTGGTAG ACGAAGAGGA 
AGACAAACCT ACAGTCGCTT CCAAACTCTA GAGTTGGAAA AGGAATTTCT TTTTAACCCC 
TATCTGACCA GGAAAAGAAG AATCGAGGTT TCCCACGCCC TAGCCCTCAC CGAGAGACAG 
GTAAAAATCT GGTTCCAGAA CAGGAGAATG AAATGGAAAA AGGAAAACAA CAAGGACAAA 
TTTCCCGTTT CCCGGCAGGA GGTGAAGGAC GGGGAAACGA AAAAGGAAGC CCAAGAGCTG 
GAGGAAGACA GAGCCGAAGG CCTGACAAAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOXD8 ( NM_019558.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_062458.1 Homo sapiens homeobox D8 (HOXD8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12572
Clone ID Related Accession (Same CDS sequence)	NM_019558.4 , NM_019558.3
Accession Version	NM_019558.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	homeobox protein Hox-D8 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009336.13 and AW140108.1. On Dec 15, 2010 this sequence version replaced NM_019558.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279832.9862.1, AL530924.3 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTTCGT ACTTCGTGAA CCCGCTGTAC TCCAAGTACA AGGCGGCGGC TGCGGCGGCG 
GCGGCGGCGG GCGAGGCCAT CAATCCCACT TACTACGACT GTCACTTCGC GCCCGAGGTC 
GGCGGCCGTC ACGCCGCCGC CGCAGCAGCC CTGCAGCTCT ATGGCAACAG CGCCGCCGGC 
TTCCCGCACG CGCCCCCGCA GGCGCACGCG CACCCGCACC CGTCCCCGCC GCCCTCCGGG 
ACTGGGTGCG GCGGTAGGGA AGGCCGGGGC CAGGAGTACT TCCACCCCGG CGGGGGCAGC 
CCGGCCGCTG CCTACCAGGC CGCCCCCCCT CCTCCTCCGC ATCCTCCGCC TCCGCCGCCA 
CCTCCCCCCT GCGGCGGGAT TGCCTGTCAC GGGGAGCCCG CGAAGTTTTA CGGATACGAT 
AACTTACAGA GACAGCCGAT TTTTACGACC CAGCAAGAGG CCGAGCTGGT ACAATATCCT 
GACTGTAAAT CGTCCAGTGG TAATATTGGC GAGGACCCAG ACCACTTAAA TCAGAGCTCG 
TCTCCTTCTC AAATGTTTCC GTGGATGAGA CCACAAGCAG CTCCTGGTAG ACGAAGAGGA 
AGACAAACCT ACAGTCGCTT CCAAACTCTA GAGTTGGAAA AGGAATTTCT TTTTAACCCC 
TATCTGACCA GGAAAAGAAG AATCGAGGTT TCCCACGCCC TAGCCCTCAC CGAGAGACAG 
GTAAAAATCT GGTTCCAGAA CAGGAGAATG AAATGGAAAA AGGAAAACAA CAAGGACAAA 
TTTCCCGTTT CCCGGCAGGA GGTGAAGGAC GGGGAAACGA AAAAGGAAGC CCAAGAGCTG 
GAGGAAGACA GAGCCGAAGG CCTGACAAAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062458.1
CDS	628..1500
Translation	MSSYFVNPLYSKYKAAAAAAAAAGEAINPTYYDCHFAPEVGGRHAAAAAALQLYGNSAAGFPHAPPQAHAHPHPSPPPSGTGCGGREGRGQEYFHPGGGSPAAAYQAAPPPPPHPPPPPPPPPCGGIACHGEPAKFYGYDNLQRQPIFTTQQEAELVQYPDCKSSSGNIGEDPDHLNQSSSPSQMFPWMRPQAAPGRRRGRQTYSRFQTLELEKEFLFNPYLTRKRRIEVSHALALTERQVKIWFQNRRMKWKKENNKDKFPVSRQEVKDGETKKEAQELEEDRAEGLTN

Target ORF information:

RefSeq Version	NM_019558.3
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox D8 (HOXD8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019558.3

ORF Insert Sequence:

ATGAGTTCGT ACTTCGTGAA CCCGCTGTAC TCCAAGTACA AGGCGGCGGC TGCGGCGGCG 
GCGGCGGCGG GCGAGGCCAT CAATCCCACT TACTACGACT GTCACTTCGC GCCCGAGGTC 
GGCGGCCGTC ACGCCGCCGC CGCAGCAGCC CTGCAGCTCT ATGGCAACAG CGCCGCCGGC 
TTCCCGCACG CGCCCCCGCA GGCGCACGCG CACCCGCACC CGTCCCCGCC GCCCTCCGGG 
ACTGGGTGCG GCGGTAGGGA AGGCCGGGGC CAGGAGTACT TCCACCCCGG CGGGGGCAGC 
CCGGCCGCTG CCTACCAGGC CGCCCCCCCT CCTCCTCCGC ATCCTCCGCC TCCGCCGCCA 
CCTCCCCCCT GCGGCGGGAT TGCCTGTCAC GGGGAGCCCG CGAAGTTTTA CGGATACGAT 
AACTTACAGA GACAGCCGAT TTTTACGACC CAGCAAGAGG CCGAGCTGGT ACAATATCCT 
GACTGTAAAT CGTCCAGTGG TAATATTGGC GAGGACCCAG ACCACTTAAA TCAGAGCTCG 
TCTCCTTCTC AAATGTTTCC GTGGATGAGA CCACAAGCAG CTCCTGGTAG ACGAAGAGGA 
AGACAAACCT ACAGTCGCTT CCAAACTCTA GAGTTGGAAA AGGAATTTCT TTTTAACCCC 
TATCTGACCA GGAAAAGAAG AATCGAGGTT TCCCACGCCC TAGCCCTCAC CGAGAGACAG 
GTAAAAATCT GGTTCCAGAA CAGGAGAATG AAATGGAAAA AGGAAAACAA CAAGGACAAA 
TTTCCCGTTT CCCGGCAGGA GGTGAAGGAC GGGGAAACGA AAAAGGAAGC CCAAGAGCTG 
GAGGAAGACA GAGCCGAAGG CCTGACAAAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOXD8 ( NM_001199746.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001186675.1 Homo sapiens homeobox D8 (HOXD8), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu12650
Clone ID Related Accession (Same CDS sequence)	NM_001199746.2 , NM_001199746.1
Accession Version	NM_001199746.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 870bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Homo sapiens(human)
Product	homeobox protein Hox-D8 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009336.13, BC038709.1 and AW140108.1. On May 31, 2019 this sequence version replaced NM_001199746.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DRR138523.256768.1, BC038709.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTTCGT ACTTCGTGAA CCCGCTGTAC TCCAAGTACA AGGCGGCGGC TGCGGCGGCG 
GCGGCGGCGG GCGAGGCCAT CAATCCCACT TACTACGACT GTCACTTCGC GCCCGAGGTC 
GGCGGCCGTC ACGCCGCCGC CGCAGCAGCC CTGCAGCTCT ATGGCAACAG CGCCGCCGGC 
TTCCCGCACG CGCCCCCGCA GGCGCACGCG CACCCGCACC CGTCCCCGCC GCCCTCCGGG 
ACTGGGTGCG GCGGTAGGGA AGGCCGGGGC CAGGAGTACT TCCACCCCGG CGGGGGCAGC 
CCGGCCGCTG CCTACCAGGC CGCCCCCCCT CCTCCTCCGC ATCCTCCGCC TCCGCCGCCA 
CCTCCCCCCT GCGGCGGGAT TGCCTGTCAC GGGGAGCCCG CGAAGTTTTA CGGATACGAT 
AACTTACAGA GACAGCCGAT TTTTACGACC CAGCAAGAGG CCGAGCTGGT ACAATATCCT 
GACTGTAAAT CGTCCAGTGG TAATATTGGC GAGGACCCAG ACCACTTAAA TCAGAGCTCG 
TCTCCTTCTC AAATGTTTCC GTGGATGAGA CCACAAGCTC CTGGTAGACG AAGAGGAAGA 
CAAACCTACA GTCGCTTCCA AACTCTAGAG TTGGAAAAGG AATTTCTTTT TAACCCCTAT 
CTGACCAGGA AAAGAAGAAT CGAGGTTTCC CACGCCCTAG CCCTCACCGA GAGACAGGTA 
AAAATCTGGT TCCAGAACAG GAGAATGAAA TGGAAAAAGG AAAACAACAA GGACAAATTT 
CCCGTTTCCC GGCAGGAGGT GAAGGACGGG GAAACGAAAA AGGAAGCCCA AGAGCTGGAG 
GAAGACAGAG CCGAAGGCCT GACAAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186675.1
CDS	663..1532
Translation	MSSYFVNPLYSKYKAAAAAAAAAGEAINPTYYDCHFAPEVGGRHAAAAAALQLYGNSAAGFPHAPPQAHAHPHPSPPPSGTGCGGREGRGQEYFHPGGGSPAAAYQAAPPPPPHPPPPPPPPPCGGIACHGEPAKFYGYDNLQRQPIFTTQQEAELVQYPDCKSSSGNIGEDPDHLNQSSSPSQMFPWMRPQAPGRRRGRQTYSRFQTLELEKEFLFNPYLTRKRRIEVSHALALTERQVKIWFQNRRMKWKKENNKDKFPVSRQEVKDGETKKEAQELEEDRAEGLTN

Target ORF information:

RefSeq Version	NM_001199746.2
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox D8 (HOXD8), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199746.2

ORF Insert Sequence:

ATGAGTTCGT ACTTCGTGAA CCCGCTGTAC TCCAAGTACA AGGCGGCGGC TGCGGCGGCG 
GCGGCGGCGG GCGAGGCCAT CAATCCCACT TACTACGACT GTCACTTCGC GCCCGAGGTC 
GGCGGCCGTC ACGCCGCCGC CGCAGCAGCC CTGCAGCTCT ATGGCAACAG CGCCGCCGGC 
TTCCCGCACG CGCCCCCGCA GGCGCACGCG CACCCGCACC CGTCCCCGCC GCCCTCCGGG 
ACTGGGTGCG GCGGTAGGGA AGGCCGGGGC CAGGAGTACT TCCACCCCGG CGGGGGCAGC 
CCGGCCGCTG CCTACCAGGC CGCCCCCCCT CCTCCTCCGC ATCCTCCGCC TCCGCCGCCA 
CCTCCCCCCT GCGGCGGGAT TGCCTGTCAC GGGGAGCCCG CGAAGTTTTA CGGATACGAT 
AACTTACAGA GACAGCCGAT TTTTACGACC CAGCAAGAGG CCGAGCTGGT ACAATATCCT 
GACTGTAAAT CGTCCAGTGG TAATATTGGC GAGGACCCAG ACCACTTAAA TCAGAGCTCG 
TCTCCTTCTC AAATGTTTCC GTGGATGAGA CCACAAGCTC CTGGTAGACG AAGAGGAAGA 
CAAACCTACA GTCGCTTCCA AACTCTAGAG TTGGAAAAGG AATTTCTTTT TAACCCCTAT 
CTGACCAGGA AAAGAAGAAT CGAGGTTTCC CACGCCCTAG CCCTCACCGA GAGACAGGTA 
AAAATCTGGT TCCAGAACAG GAGAATGAAA TGGAAAAAGG AAAACAACAA GGACAAATTT 
CCCGTTTCCC GGCAGGAGGT GAAGGACGGG GAAACGAAAA AGGAAGCCCA AGAGCTGGAG 
GAAGACAGAG CCGAAGGCCT GACAAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOXD8 ( NM_001199746.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001186675.1 Homo sapiens homeobox D8 (HOXD8), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu12650
Clone ID Related Accession (Same CDS sequence)	NM_001199746.2 , NM_001199746.1
Accession Version	NM_001199746.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 870bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-24
Organism	Homo sapiens(human)
Product	homeobox protein Hox-D8 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009336.13, BC038709.1 and AW140108.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC038709.1, ERR279825.166.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTTCGT ACTTCGTGAA CCCGCTGTAC TCCAAGTACA AGGCGGCGGC TGCGGCGGCG 
GCGGCGGCGG GCGAGGCCAT CAATCCCACT TACTACGACT GTCACTTCGC GCCCGAGGTC 
GGCGGCCGTC ACGCCGCCGC CGCAGCAGCC CTGCAGCTCT ATGGCAACAG CGCCGCCGGC 
TTCCCGCACG CGCCCCCGCA GGCGCACGCG CACCCGCACC CGTCCCCGCC GCCCTCCGGG 
ACTGGGTGCG GCGGTAGGGA AGGCCGGGGC CAGGAGTACT TCCACCCCGG CGGGGGCAGC 
CCGGCCGCTG CCTACCAGGC CGCCCCCCCT CCTCCTCCGC ATCCTCCGCC TCCGCCGCCA 
CCTCCCCCCT GCGGCGGGAT TGCCTGTCAC GGGGAGCCCG CGAAGTTTTA CGGATACGAT 
AACTTACAGA GACAGCCGAT TTTTACGACC CAGCAAGAGG CCGAGCTGGT ACAATATCCT 
GACTGTAAAT CGTCCAGTGG TAATATTGGC GAGGACCCAG ACCACTTAAA TCAGAGCTCG 
TCTCCTTCTC AAATGTTTCC GTGGATGAGA CCACAAGCTC CTGGTAGACG AAGAGGAAGA 
CAAACCTACA GTCGCTTCCA AACTCTAGAG TTGGAAAAGG AATTTCTTTT TAACCCCTAT 
CTGACCAGGA AAAGAAGAAT CGAGGTTTCC CACGCCCTAG CCCTCACCGA GAGACAGGTA 
AAAATCTGGT TCCAGAACAG GAGAATGAAA TGGAAAAAGG AAAACAACAA GGACAAATTT 
CCCGTTTCCC GGCAGGAGGT GAAGGACGGG GAAACGAAAA AGGAAGCCCA AGAGCTGGAG 
GAAGACAGAG CCGAAGGCCT GACAAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186675.1
CDS	628..1497
Translation	MSSYFVNPLYSKYKAAAAAAAAAGEAINPTYYDCHFAPEVGGRHAAAAAALQLYGNSAAGFPHAPPQAHAHPHPSPPPSGTGCGGREGRGQEYFHPGGGSPAAAYQAAPPPPPHPPPPPPPPPCGGIACHGEPAKFYGYDNLQRQPIFTTQQEAELVQYPDCKSSSGNIGEDPDHLNQSSSPSQMFPWMRPQAPGRRRGRQTYSRFQTLELEKEFLFNPYLTRKRRIEVSHALALTERQVKIWFQNRRMKWKKENNKDKFPVSRQEVKDGETKKEAQELEEDRAEGLTN

Target ORF information:

RefSeq Version	NM_001199746.1
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox D8 (HOXD8), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199746.1

ORF Insert Sequence:

ATGAGTTCGT ACTTCGTGAA CCCGCTGTAC TCCAAGTACA AGGCGGCGGC TGCGGCGGCG 
GCGGCGGCGG GCGAGGCCAT CAATCCCACT TACTACGACT GTCACTTCGC GCCCGAGGTC 
GGCGGCCGTC ACGCCGCCGC CGCAGCAGCC CTGCAGCTCT ATGGCAACAG CGCCGCCGGC 
TTCCCGCACG CGCCCCCGCA GGCGCACGCG CACCCGCACC CGTCCCCGCC GCCCTCCGGG 
ACTGGGTGCG GCGGTAGGGA AGGCCGGGGC CAGGAGTACT TCCACCCCGG CGGGGGCAGC 
CCGGCCGCTG CCTACCAGGC CGCCCCCCCT CCTCCTCCGC ATCCTCCGCC TCCGCCGCCA 
CCTCCCCCCT GCGGCGGGAT TGCCTGTCAC GGGGAGCCCG CGAAGTTTTA CGGATACGAT 
AACTTACAGA GACAGCCGAT TTTTACGACC CAGCAAGAGG CCGAGCTGGT ACAATATCCT 
GACTGTAAAT CGTCCAGTGG TAATATTGGC GAGGACCCAG ACCACTTAAA TCAGAGCTCG 
TCTCCTTCTC AAATGTTTCC GTGGATGAGA CCACAAGCTC CTGGTAGACG AAGAGGAAGA 
CAAACCTACA GTCGCTTCCA AACTCTAGAG TTGGAAAAGG AATTTCTTTT TAACCCCTAT 
CTGACCAGGA AAAGAAGAAT CGAGGTTTCC CACGCCCTAG CCCTCACCGA GAGACAGGTA 
AAAATCTGGT TCCAGAACAG GAGAATGAAA TGGAAAAAGG AAAACAACAA GGACAAATTT 
CCCGTTTCCC GGCAGGAGGT GAAGGACGGG GAAACGAAAA AGGAAGCCCA AGAGCTGGAG 
GAAGACAGAG CCGAAGGCCT GACAAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOXD8 ( NM_001199747.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001186676.1 Homo sapiens homeobox D8 (HOXD8), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu01861
Clone ID Related Accession (Same CDS sequence)	NM_001199747.1 , NM_001199747.2
Accession Version	NM_001199747.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 321bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-24
Organism	Homo sapiens(human)
Product	homeobox protein Hox-D8 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009336.13, BQ429720.1 and AW140108.1. Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL520835.3, BQ429720.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTTCCGT GGATGAGACC ACAAGCAGCT CCTGGTAGAC GAAGAGGAAG ACAAACCTAC 
AGTCGCTTCC AAACTCTAGA GTTGGAAAAG GAATTTCTTT TTAACCCCTA TCTGACCAGG 
AAAAGAAGAA TCGAGGTTTC CCACGCCCTA GCCCTCACCG AGAGACAGGT AAAAATCTGG 
TTCCAGAACA GGAGAATGAA ATGGAAAAAG GAAAACAACA AGGACAAATT TCCCGTTTCC 
CGGCAGGAGG TGAAGGACGG GGAAACGAAA AAGGAAGCCC AAGAGCTGGA GGAAGACAGA 
GCCGAAGGCC TGACAAATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186676.1
CDS	205..525
Translation	MFPWMRPQAAPGRRRGRQTYSRFQTLELEKEFLFNPYLTRKRRIEVSHALALTERQVKIWFQNRRMKWKKENNKDKFPVSRQEVKDGETKKEAQELEEDRAEGLTN

Target ORF information:

RefSeq Version	NM_001199747.1
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox D8 (HOXD8), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199747.1

ORF Insert Sequence:

ATGTTTCCGT GGATGAGACC ACAAGCAGCT CCTGGTAGAC GAAGAGGAAG ACAAACCTAC 
AGTCGCTTCC AAACTCTAGA GTTGGAAAAG GAATTTCTTT TTAACCCCTA TCTGACCAGG 
AAAAGAAGAA TCGAGGTTTC CCACGCCCTA GCCCTCACCG AGAGACAGGT AAAAATCTGG 
TTCCAGAACA GGAGAATGAA ATGGAAAAAG GAAAACAACA AGGACAAATT TCCCGTTTCC 
CGGCAGGAGG TGAAGGACGG GGAAACGAAA AAGGAAGCCC AAGAGCTGGA GGAAGACAGA 
GCCGAAGGCC TGACAAATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOXD8 ( NM_001199747.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001186676.1 Homo sapiens homeobox D8 (HOXD8), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu01861
Clone ID Related Accession (Same CDS sequence)	NM_001199747.1 , NM_001199747.2
Accession Version	NM_001199747.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 321bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Homo sapiens(human)
Product	homeobox protein Hox-D8 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009336.13, BQ429720.1 and AW140108.1. On May 31, 2019 this sequence version replaced NM_001199747.1. Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189667.287870.1, AL520835.3 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTTCCGT GGATGAGACC ACAAGCAGCT CCTGGTAGAC GAAGAGGAAG ACAAACCTAC 
AGTCGCTTCC AAACTCTAGA GTTGGAAAAG GAATTTCTTT TTAACCCCTA TCTGACCAGG 
AAAAGAAGAA TCGAGGTTTC CCACGCCCTA GCCCTCACCG AGAGACAGGT AAAAATCTGG 
TTCCAGAACA GGAGAATGAA ATGGAAAAAG GAAAACAACA AGGACAAATT TCCCGTTTCC 
CGGCAGGAGG TGAAGGACGG GGAAACGAAA AAGGAAGCCC AAGAGCTGGA GGAAGACAGA 
GCCGAAGGCC TGACAAATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186676.1
CDS	194..514
Translation	MFPWMRPQAAPGRRRGRQTYSRFQTLELEKEFLFNPYLTRKRRIEVSHALALTERQVKIWFQNRRMKWKKENNKDKFPVSRQEVKDGETKKEAQELEEDRAEGLTN

Target ORF information:

RefSeq Version	NM_001199747.2
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox D8 (HOXD8), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199747.2

ORF Insert Sequence:

ATGTTTCCGT GGATGAGACC ACAAGCAGCT CCTGGTAGAC GAAGAGGAAG ACAAACCTAC 
AGTCGCTTCC AAACTCTAGA GTTGGAAAAG GAATTTCTTT TTAACCCCTA TCTGACCAGG 
AAAAGAAGAA TCGAGGTTTC CCACGCCCTA GCCCTCACCG AGAGACAGGT AAAAATCTGG 
TTCCAGAACA GGAGAATGAA ATGGAAAAAG GAAAACAACA AGGACAAATT TCCCGTTTCC 
CGGCAGGAGG TGAAGGACGG GGAAACGAAA AAGGAAGCCC AAGAGCTGGA GGAAGACAGA 
GCCGAAGGCC TGACAAATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

HOXD8 exerts a tumor-suppressing role in colorectal cancer as an apoptotic inducer.
The international journal of biochemistry & cell biology881-13(2017 07)
Mansour MA,Senga T

microRNA-520a-3p inhibits proliferation and cancer stem cell phenotype by targeting HOXD8 in non-small cell lung cancer.
Oncology reports36(6)3529-3535(2016 Dec)
Liu Y,Miao L,Ni R,Zhang H,Li L,Wang X,Li X,Wang J

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HOXD8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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