HOXC12 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HOXC12
Entrez Gene ID	3228
Full Name	homeobox C12
Synonyms	HOC3F,HOX3,HOX3F
General protein information	Preferred Names homeobox C12 Names homeobox protein Hox-C12 homeo box 3F homeo box C12 homeobox protein Hox-3F
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.13
Summary	This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. [provided by RefSeq, Jul 2008].
Disorder MIM:	142975

mRNA and Protein(s)

mRNA	Protein	Name
NM_173860.3	NP_776272.1	homeobox protein Hox-C12
NM_173860.2	NP_776272.1	homeobox protein Hox-C12

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	HOXC12	XP_522409.2
Rattus norvegicus (Norway rat)	Hoxc12	NP_001100266.1
Xenopus tropicalis (tropical clawed frog)	hoxc12	XP_002936693.1
Danio rerio (zebrafish)	hoxc12a	NP_001104229.1
Homo sapiens (human)	HOXC12	NP_776272.1
Bos taurus (cattle)	HOXC12	NP_001180150.1
	LOC704201	XP_001108042.1
Canis lupus familiaris (dog)	HOXC12	XP_543628.2
Mus musculus (house mouse)	Hoxc12	NP_034593.1
Gallus gallus (chicken)	HOXC12	XP_426957.3

Gene Ontology
Bibliography

Related articles in PubMed

Deletions of 5' HOXC genes are associated with lower extremity malformations, including clubfoot and vertical talus.
Alvarado DM, McCall K, Hecht JT, Dobbs MB, Gurnett CA
Journal of medical genetics53(4)250-5(2016 Apr)

A census of human transcription factors: function, expression and evolution.
Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM
Nature reviews. Genetics10(4)252-63(2009 04)

Complete mutation analysis panel of the 39 human HOX genes.
Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N
Teratology65(2)50-62(2002 Feb)

Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines.
Flagiello D, Gibaud A, Dutrillaux B, Poupon MF, Malfoy B
FEBS letters415(3)263-7(1997 Oct)

The human HOX gene family.
Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E
Nucleic acids research17(24)10385-402(1989 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The microdeletions share a minimal non-coding region overlap upstream of HOXC13, with variable phenotypes depending upon HOXC13, HOXC12 or the HOTAIR lncRNA inclusion. Identification of 5' HOXC microdeletions highlights the importance of transcriptional regulators in the aetiology of severe lower limb malformations and will improve their diagnosis and management
Title: Deletions of 5' HOXC genes are associated with lower extremity malformations, including clubfoot and vertical talus.

The following HOXC12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HOXC12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30459	NM_173860.3 Latest version!	Homo sapiens homeobox C12 (HOXC12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
View Old Accession Versions >>
OHu30459	NM_173860.2	Homo sapiens homeobox C12 (HOXC12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HOXC12 ( NM_173860.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_776272.1 Homo sapiens homeobox C12 (HOXC12), mRNA.

Price & Availability↑

CloneID	OHu30459
Clone ID Related Accession (Same CDS sequence)	NM_173860.3 , NM_173860.2
Accession Version	NM_173860.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	homeobox protein Hox-C12
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AH010514.2 and AC012531.11. On Nov 22, 2018 this sequence version replaced NM_173860.2. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000243103.4/ ENSP00000243103.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCGAGC ATAATCTCCT GAATCCCGGG TTTGTGGGGC CGCTGGTAAA CATCCACACG 
GGAGACACCT TCTACTTCCC CAACTTCCGC GCGTCCGGGG CGCAGCTTCC CGGGCTGCCT 
TCGCTGTCCT ACCCACGCCG CGACAACGTG TGCTCCCTGT CCTGGCCGTC GGCGGAGCCG 
TGCAATGGCT ACCCGCAGCC CTACCTCGGC AGCCCAGTGT CTCTCAACCC TCCCTTCGGC 
CGCACGTGCG AGCTGGCGCG CGTGGAGGAC GGCAAGGGTT ACTACCGCGA GCCGTGCGCC 
GAGGGTGGCG GCGGGGGCCT GAAGCGTGAG GAGCGCGGGC GCGACCCGGG AGCCGGGCCC 
GGGGCAGCGC TGCTCCCGCT GGAGCCGTCG GGGCCGCCTG CGCTCGGCTT CAAGTACGAC 
TACGCGGCGG GCGGCGGCGG TGGCGACGGC GGCGGCGGCG CAGGACCTCC GCACGACCCG 
CCCTCCTGCC AGTCGCTGGA ATCCGACTCC AGTTCGTCCC TGCTCAACGA GGGCAACAAG 
GGCGCCGGCG CAGGCGACCC CGGCAGCTTG GTATCGCCGT TGAACCCCGG CGGCGGGCTC 
TCGGCCAGCG GCGCGCCCTG GTACCCGATC AACAGCCGCT CTCGGAAGAA GCGCAAGCCC 
TATTCGAAGT TGCAACTGGC AGAGCTGGAG GGCGAGTTTC TGGTCAACGA GTTCATCACA 
CGCCAGCGCC GGAGGGAACT CTCAGACCGC TTGAATCTTA GTGACCAGCA GGTCAAGATC 
TGGTTTCAGA ACCGGAGAAT GAAAAAGAAA AGACTTCTGT TGAGGGAGCA AGCTCTCTCC 
TTCTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776272.1
CDS	28..876
Translation	MGEHNLLNPGFVGPLVNIHTGDTFYFPNFRASGAQLPGLPSLSYPRRDNVCSLSWPSAEPCNGYPQPYLGSPVSLNPPFGRTCELARVEDGKGYYREPCAEGGGGGLKREERGRDPGAGPGAALLPLEPSGPPALGFKYDYAAGGGGGDGGGGAGPPHDPPSCQSLESDSSSSLLNEGNKGAGAGDPGSLVSPLNPGGGLSASGAPWYPINSRSRKKRKPYSKLQLAELEGEFLVNEFITRQRRRELSDRLNLSDQQVKIWFQNRRMKKKRLLLREQALSFF

Target ORF information:

RefSeq Version	NM_173860.3
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox C12 (HOXC12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173860.3

ORF Insert Sequence:

ATGGGCGAGC ATAATCTCCT GAATCCCGGG TTTGTGGGGC CGCTGGTAAA CATCCACACG 
GGAGACACCT TCTACTTCCC CAACTTCCGC GCGTCCGGGG CGCAGCTTCC CGGGCTGCCT 
TCGCTGTCCT ACCCACGCCG CGACAACGTG TGCTCCCTGT CCTGGCCGTC GGCGGAGCCG 
TGCAATGGCT ACCCGCAGCC CTACCTCGGC AGCCCAGTGT CTCTCAACCC TCCCTTCGGC 
CGCACGTGCG AGCTGGCGCG CGTGGAGGAC GGCAAGGGTT ACTACCGCGA GCCGTGCGCC 
GAGGGTGGCG GCGGGGGCCT GAAGCGTGAG GAGCGCGGGC GCGACCCGGG AGCCGGGCCC 
GGGGCAGCGC TGCTCCCGCT GGAGCCGTCG GGGCCGCCTG CGCTCGGCTT CAAGTACGAC 
TACGCGGCGG GCGGCGGCGG TGGCGACGGC GGCGGCGGCG CAGGACCTCC GCACGACCCG 
CCCTCCTGCC AGTCGCTGGA ATCCGACTCC AGTTCGTCCC TGCTCAACGA GGGCAACAAG 
GGCGCCGGCG CAGGCGACCC CGGCAGCTTG GTATCGCCGT TGAACCCCGG CGGCGGGCTC 
TCGGCCAGCG GCGCGCCCTG GTACCCGATC AACAGCCGCT CTCGGAAGAA GCGCAAGCCC 
TATTCGAAGT TGCAACTGGC AGAGCTGGAG GGCGAGTTTC TGGTCAACGA GTTCATCACA 
CGCCAGCGCC GGAGGGAACT CTCAGACCGC TTGAATCTTA GTGACCAGCA GGTCAAGATC 
TGGTTTCAGA ACCGGAGAAT GAAAAAGAAA AGACTTCTGT TGAGGGAGCA AGCTCTCTCC 
TTCTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOXC12 ( NM_173860.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_776272.1 Homo sapiens homeobox C12 (HOXC12), mRNA.

Price & Availability↑

CloneID	OHu30459
Clone ID Related Accession (Same CDS sequence)	NM_173860.3 , NM_173860.2
Accession Version	NM_173860.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	homeobox protein Hox-C12
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AH010514.2. On Jul 8, 2016 this sequence version replaced NM_173860.1. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2467146 [ECO:0000348] ##Evidence-Data-END##

ATGGGCGAGC ATAATCTCCT GAATCCCGGG TTTGTGGGGC CGCTGGTAAA CATCCACACG 
GGAGACACCT TCTACTTCCC CAACTTCCGC GCGTCCGGGG CGCAGCTTCC CGGGCTGCCT 
TCGCTGTCCT ACCCACGCCG CGACAACGTG TGCTCCCTGT CCTGGCCGTC GGCGGAGCCG 
TGCAATGGCT ACCCGCAGCC CTACCTCGGC AGCCCAGTGT CTCTCAACCC TCCCTTCGGC 
CGCACGTGCG AGCTGGCGCG CGTGGAGGAC GGCAAGGGTT ACTACCGCGA GCCGTGCGCC 
GAGGGTGGCG GCGGGGGCCT GAAGCGTGAG GAGCGCGGGC GCGACCCGGG AGCCGGGCCC 
GGGGCAGCGC TGCTCCCGCT GGAGCCGTCG GGGCCGCCTG CGCTCGGCTT CAAGTACGAC 
TACGCGGCGG GCGGCGGCGG TGGCGACGGC GGCGGCGGCG CAGGACCTCC GCACGACCCG 
CCCTCCTGCC AGTCGCTGGA ATCCGACTCC AGTTCGTCCC TGCTCAACGA GGGCAACAAG 
GGCGCCGGCG CAGGCGACCC CGGCAGCTTG GTATCGCCGT TGAACCCCGG CGGCGGGCTC 
TCGGCCAGCG GCGCGCCCTG GTACCCGATC AACAGCCGCT CTCGGAAGAA GCGCAAGCCC 
TATTCGAAGT TGCAACTGGC AGAGCTGGAG GGCGAGTTTC TGGTCAACGA GTTCATCACA 
CGCCAGCGCC GGAGGGAACT CTCAGACCGC TTGAATCTTA GTGACCAGCA GGTCAAGATC 
TGGTTTCAGA ACCGGAGAAT GAAAAAGAAA AGACTTCTGT TGAGGGAGCA AGCTCTCTCC 
TTCTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776272.1
CDS	63..911
Translation	MGEHNLLNPGFVGPLVNIHTGDTFYFPNFRASGAQLPGLPSLSYPRRDNVCSLSWPSAEPCNGYPQPYLGSPVSLNPPFGRTCELARVEDGKGYYREPCAEGGGGGLKREERGRDPGAGPGAALLPLEPSGPPALGFKYDYAAGGGGGDGGGGAGPPHDPPSCQSLESDSSSSLLNEGNKGAGAGDPGSLVSPLNPGGGLSASGAPWYPINSRSRKKRKPYSKLQLAELEGEFLVNEFITRQRRRELSDRLNLSDQQVKIWFQNRRMKKKRLLLREQALSFF

Target ORF information:

RefSeq Version	NM_173860.2
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox C12 (HOXC12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173860.2

ORF Insert Sequence:

ATGGGCGAGC ATAATCTCCT GAATCCCGGG TTTGTGGGGC CGCTGGTAAA CATCCACACG 
GGAGACACCT TCTACTTCCC CAACTTCCGC GCGTCCGGGG CGCAGCTTCC CGGGCTGCCT 
TCGCTGTCCT ACCCACGCCG CGACAACGTG TGCTCCCTGT CCTGGCCGTC GGCGGAGCCG 
TGCAATGGCT ACCCGCAGCC CTACCTCGGC AGCCCAGTGT CTCTCAACCC TCCCTTCGGC 
CGCACGTGCG AGCTGGCGCG CGTGGAGGAC GGCAAGGGTT ACTACCGCGA GCCGTGCGCC 
GAGGGTGGCG GCGGGGGCCT GAAGCGTGAG GAGCGCGGGC GCGACCCGGG AGCCGGGCCC 
GGGGCAGCGC TGCTCCCGCT GGAGCCGTCG GGGCCGCCTG CGCTCGGCTT CAAGTACGAC 
TACGCGGCGG GCGGCGGCGG TGGCGACGGC GGCGGCGGCG CAGGACCTCC GCACGACCCG 
CCCTCCTGCC AGTCGCTGGA ATCCGACTCC AGTTCGTCCC TGCTCAACGA GGGCAACAAG 
GGCGCCGGCG CAGGCGACCC CGGCAGCTTG GTATCGCCGT TGAACCCCGG CGGCGGGCTC 
TCGGCCAGCG GCGCGCCCTG GTACCCGATC AACAGCCGCT CTCGGAAGAA GCGCAAGCCC 
TATTCGAAGT TGCAACTGGC AGAGCTGGAG GGCGAGTTTC TGGTCAACGA GTTCATCACA 
CGCCAGCGCC GGAGGGAACT CTCAGACCGC TTGAATCTTA GTGACCAGCA GGTCAAGATC 
TGGTTTCAGA ACCGGAGAAT GAAAAAGAAA AGACTTCTGT TGAGGGAGCA AGCTCTCTCC 
TTCTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Deletions of 5' HOXC genes are associated with lower extremity malformations, including clubfoot and vertical talus.
Journal of medical genetics53(4)250-5(2016 Apr)
Alvarado DM,McCall K,Hecht JT,Dobbs MB,Gurnett CA

A census of human transcription factors: function, expression and evolution.
Nature reviews. Genetics10(4)252-63(2009 04)
Vaquerizas JM,Kummerfeld SK,Teichmann SA,Luscombe NM

Complete mutation analysis panel of the 39 human HOX genes.
Teratology65(2)50-62(2002 Feb)
Kosaki K,Kosaki R,Suzuki T,Yoshihashi H,Takahashi T,Sasaki K,Tomita M,McGinnis W,Matsuo N

Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines.
FEBS letters415(3)263-7(1997 Oct)
Flagiello D,Gibaud A,Dutrillaux B,Poupon MF,Malfoy B

The human HOX gene family.
Nucleic acids research17(24)10385-402(1989 Dec)
Acampora D,D'Esposito M,Faiella A,Pannese M,Migliaccio E,Morelli F,Stornaiuolo A,Nigro V,Simeone A,Boncinelli E

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HOXC12 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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