HOXC11 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HOXC11
Entrez Gene ID	3227
Full Name	homeobox C11
Synonyms	HOX3H
General protein information	Preferred Names homeobox C11 Names homeobox protein Hox-C11 homeo box C11 homeobox protein Hox-3H
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.13
Summary	This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined. [provided by RefSeq, Jul 2008].
Disorder MIM:	605559

mRNA and Protein(s)

mRNA	Protein	Name
NM_014212.3	NP_055027.1	homeobox protein Hox-C11
NM_014212.4	NP_055027.1	homeobox protein Hox-C11

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	HOXC11	XP_003433544.2
Bos taurus (cattle)	HOXC11	NP_001179802.1
Homo sapiens (human)	HOXC11	NP_055027.1
Rattus norvegicus (Norway rat)	LOC100911859	XP_003750461.1
Danio rerio (zebrafish)	hoxc11a	NP_571240.1
Xenopus tropicalis (tropical clawed frog)	LOC100487406	XP_002936692.1
Mus musculus (house mouse)	Hoxc11	NP_001020013.1
Gallus gallus (chicken)	HOXC11	XP_428250.2
Pan troglodytes (chimpanzee)	HOXC11	XP_509104.2
	HOXC11	XP_001090607.2

Gene Ontology
Bibliography

Related articles in PubMed

Overexpression of HOXC11 homeobox gene in clear cell renal cell carcinoma induces cellular proliferation and is associated with poor prognosis.
Liu YJ, Zhu Y, Yuan HX, Zhang JP, Guo JM, Lin ZM
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine36(4)2821-9(2015 Apr)

Interaction of developmental transcription factor HOXC11 with steroid receptor coactivator SRC-1 mediates resistance to endocrine therapy in breast cancer [corrected].
McIlroy M, McCartan D, Early S, O Gaora P, Pennington S, Hill AD, Young LS
Cancer research70(4)1585-94(2010 Feb)

A census of human transcription factors: function, expression and evolution.
Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM
Nature reviews. Genetics10(4)252-63(2009 04)

HOXC6 and HOXC11 increase transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwannian cells.
Zhang X, Hamada J, Nishimoto A, Takahashi Y, Murai T, Tada M, Moriuchi T
Journal of cellular and molecular medicine11(2)299-306(2007 Mar-Apr)

Complete mutation analysis panel of the 39 human HOX genes.
Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N
Teratology65(2)50-62(2002 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our data suggest that HOXC11 may contribute to RCC carcinogenesis by increasing tumor cell proliferation and imply that HOXC11 may be an important determinant of RCC patient prognosis
Title: Overexpression of HOXC11 homeobox gene in clear cell renal cell carcinoma induces cellular proliferation and is associated with poor prognosis.

HOXC11 and SRC-1 cooperate to regulate expression of the calcium-binding protein S100beta in resistant breast cancer cells.
Title: Interaction of developmental transcription factor HOXC11 with steroid receptor coactivator SRC-1 mediates resistance to endocrine therapy in breast cancer [corrected].

HOXC11 increases transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwann cells.
Title: HOXC6 and HOXC11 increase transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwannian cells.

The following HOXC11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HOXC11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30240	NM_014212.4 Latest version!	Homo sapiens homeobox C11 (HOXC11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
View Old Accession Versions >>
OHu30240	NM_014212.3	Homo sapiens homeobox C11 (HOXC11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HOXC11 ( NM_014212.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055027.1 Homo sapiens homeobox C11 (HOXC11), mRNA.

Price & Availability↑

CloneID	OHu30240
Clone ID Related Accession (Same CDS sequence)	NM_014212.3 , NM_014212.4
Accession Version	NM_014212.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	homeobox protein Hox-C11
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC012531.11, AJ000041.1 and BC001543.1. On Dec 29, 2005 this sequence version replaced NM_014212.2. ##Evidence-Data-START## Transcript exon combination :: BC001543.1, AK291946.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145774, SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTTAACT CGGTCAACCT GGGCAACTTC TGCTCTCCGT CGCGCAAGGA GAGGGGCGCA 
GATTTCGGCG AGCGAGGGAG CTGCGCCTCC AACCTCTATC TGCCCAGTTG CACTTACTAC 
ATGCCCGAGT TCTCCACGGT CTCCTCCTTC CTGCCCCAGG CCCCCTCTCG TCAGATCTCC 
TATCCCTACT CGGCCCAAGT GCCCCCGGTC CGGGAGGTCT CCTACGGCCT GGAGCCATCC 
GGCAAGTGGC ACCATCGGAA CAGCTACTCC TCCTGCTATG CGGCGGCCGA CGAGCTTATG 
CACCGGGAGT GCCTGCCTCC TTCCACCGTC ACCGAGATCC TCATGAAAAA CGAAGGCTCC 
TACGGCGGCC ACCACCACCC CAGCGCCCCG CACGCAACCC CCGCCGGCTT CTACTCCTCA 
GTCAACAAGA ACAGCGTCCT GCCTCAAGCC TTCGACCGTT TCTTCGACAA CGCCTACTGC 
GGTGGCGGCG ACCCGCCCGC CGAGCCCCCC TGCTCCGGCA AGGGCGAGGC CAAGGGGGAG 
CCCGAGGCAC CCCCGGCCTC GGGACTGGCG TCCCGGGCTG AGGCGGGTGC CGAGGCGGAG 
GCTGAGGAGG AGAACACAAA TCCCAGCTCG TCCGGTTCAG CCCACTCCGT GGCCAAGGAG 
CCGGCCAAAG GAGCCGCCCC CAACGCCCCC CGCACCCGCA AGAAGCGCTG CCCTTATTCG 
AAATTCCAGA TCCGGGAACT GGAGCGAGAG TTTTTCTTCA ACGTGTATAT CAACAAAGAG 
AAGCGGCTGC AGCTGTCCCG GATGCTGAAC CTGACGGACC GACAAGTGAA AATTTGGTTT 
CAGAACAGAA GGATGAAAGA AAAGAAACTG AGCAGAGACC GGCTGCAGTA TTTCTCGGGA 
AATCCTCTGC TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055027.1
CDS	117..1031
Translation	MFNSVNLGNFCSPSRKERGADFGERGSCASNLYLPSCTYYMPEFSTVSSFLPQAPSRQISYPYSAQVPPVREVSYGLEPSGKWHHRNSYSSCYAAADELMHRECLPPSTVTEILMKNEGSYGGHHHPSAPHATPAGFYSSVNKNSVLPQAFDRFFDNAYCGGGDPPAEPPCSGKGEAKGEPEAPPASGLASRAEAGAEAEAEEENTNPSSSGSAHSVAKEPAKGAAPNAPRTRKKRCPYSKFQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKLSRDRLQYFSGNPLL

Target ORF information:

RefSeq Version	NM_014212.3
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox C11 (HOXC11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014212.3

ORF Insert Sequence:

ATGTTTAACT CGGTCAACCT GGGCAACTTC TGCTCTCCGT CGCGCAAGGA GAGGGGCGCA 
GATTTCGGCG AGCGAGGGAG CTGCGCCTCC AACCTCTATC TGCCCAGTTG CACTTACTAC 
ATGCCCGAGT TCTCCACGGT CTCCTCCTTC CTGCCCCAGG CCCCCTCTCG TCAGATCTCC 
TATCCCTACT CGGCCCAAGT GCCCCCGGTC CGGGAGGTCT CCTACGGCCT GGAGCCATCC 
GGCAAGTGGC ACCATCGGAA CAGCTACTCC TCCTGCTATG CGGCGGCCGA CGAGCTTATG 
CACCGGGAGT GCCTGCCTCC TTCCACCGTC ACCGAGATCC TCATGAAAAA CGAAGGCTCC 
TACGGCGGCC ACCACCACCC CAGCGCCCCG CACGCAACCC CCGCCGGCTT CTACTCCTCA 
GTCAACAAGA ACAGCGTCCT GCCTCAAGCC TTCGACCGTT TCTTCGACAA CGCCTACTGC 
GGTGGCGGCG ACCCGCCCGC CGAGCCCCCC TGCTCCGGCA AGGGCGAGGC CAAGGGGGAG 
CCCGAGGCAC CCCCGGCCTC GGGACTGGCG TCCCGGGCTG AGGCGGGTGC CGAGGCGGAG 
GCTGAGGAGG AGAACACAAA TCCCAGCTCG TCCGGTTCAG CCCACTCCGT GGCCAAGGAG 
CCGGCCAAAG GAGCCGCCCC CAACGCCCCC CGCACCCGCA AGAAGCGCTG CCCTTATTCG 
AAATTCCAGA TCCGGGAACT GGAGCGAGAG TTTTTCTTCA ACGTGTATAT CAACAAAGAG 
AAGCGGCTGC AGCTGTCCCG GATGCTGAAC CTGACGGACC GACAAGTGAA AATTTGGTTT 
CAGAACAGAA GGATGAAAGA AAAGAAACTG AGCAGAGACC GGCTGCAGTA TTTCTCGGGA 
AATCCTCTGC TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOXC11 ( NM_014212.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055027.1 Homo sapiens homeobox C11 (HOXC11), mRNA.

Price & Availability↑

CloneID	OHu30240
Clone ID Related Accession (Same CDS sequence)	NM_014212.3 , NM_014212.4
Accession Version	NM_014212.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Homo sapiens(human)
Product	homeobox protein Hox-C11
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC012531.11, AJ000041.1 and BC001543.1. On Nov 28, 2018 this sequence version replaced NM_014212.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC001543.1, AJ000041.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000546378.1/ ENSP00000446680.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTTAACT CGGTCAACCT GGGCAACTTC TGCTCTCCGT CGCGCAAGGA GAGGGGCGCA 
GATTTCGGCG AGCGAGGGAG CTGCGCCTCC AACCTCTATC TGCCCAGTTG CACTTACTAC 
ATGCCCGAGT TCTCCACGGT CTCCTCCTTC CTGCCCCAGG CCCCCTCTCG TCAGATCTCC 
TATCCCTACT CGGCCCAAGT GCCCCCGGTC CGGGAGGTCT CCTACGGCCT GGAGCCATCC 
GGCAAGTGGC ACCATCGGAA CAGCTACTCC TCCTGCTATG CGGCGGCCGA CGAGCTTATG 
CACCGGGAGT GCCTGCCTCC TTCCACCGTC ACCGAGATCC TCATGAAAAA CGAAGGCTCC 
TACGGCGGCC ACCACCACCC CAGCGCCCCG CACGCAACCC CCGCCGGCTT CTACTCCTCA 
GTCAACAAGA ACAGCGTCCT GCCTCAAGCC TTCGACCGTT TCTTCGACAA CGCCTACTGC 
GGTGGCGGCG ACCCGCCCGC CGAGCCCCCC TGCTCCGGCA AGGGCGAGGC CAAGGGGGAG 
CCCGAGGCAC CCCCGGCCTC GGGACTGGCG TCCCGGGCTG AGGCGGGTGC CGAGGCGGAG 
GCTGAGGAGG AGAACACAAA TCCCAGCTCG TCCGGTTCAG CCCACTCCGT GGCCAAGGAG 
CCGGCCAAAG GAGCCGCCCC CAACGCCCCC CGCACCCGCA AGAAGCGCTG CCCTTATTCG 
AAATTCCAGA TCCGGGAACT GGAGCGAGAG TTTTTCTTCA ACGTGTATAT CAACAAAGAG 
AAGCGGCTGC AGCTGTCCCG GATGCTGAAC CTGACGGACC GACAAGTGAA AATTTGGTTT 
CAGAACAGAA GGATGAAAGA AAAGAAACTG AGCAGAGACC GGCTGCAGTA TTTCTCGGGA 
AATCCTCTGC TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055027.1
CDS	117..1031
Translation	MFNSVNLGNFCSPSRKERGADFGERGSCASNLYLPSCTYYMPEFSTVSSFLPQAPSRQISYPYSAQVPPVREVSYGLEPSGKWHHRNSYSSCYAAADELMHRECLPPSTVTEILMKNEGSYGGHHHPSAPHATPAGFYSSVNKNSVLPQAFDRFFDNAYCGGGDPPAEPPCSGKGEAKGEPEAPPASGLASRAEAGAEAEAEEENTNPSSSGSAHSVAKEPAKGAAPNAPRTRKKRCPYSKFQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKLSRDRLQYFSGNPLL

Target ORF information:

RefSeq Version	NM_014212.4
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox C11 (HOXC11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014212.4

ORF Insert Sequence:

ATGTTTAACT CGGTCAACCT GGGCAACTTC TGCTCTCCGT CGCGCAAGGA GAGGGGCGCA 
GATTTCGGCG AGCGAGGGAG CTGCGCCTCC AACCTCTATC TGCCCAGTTG CACTTACTAC 
ATGCCCGAGT TCTCCACGGT CTCCTCCTTC CTGCCCCAGG CCCCCTCTCG TCAGATCTCC 
TATCCCTACT CGGCCCAAGT GCCCCCGGTC CGGGAGGTCT CCTACGGCCT GGAGCCATCC 
GGCAAGTGGC ACCATCGGAA CAGCTACTCC TCCTGCTATG CGGCGGCCGA CGAGCTTATG 
CACCGGGAGT GCCTGCCTCC TTCCACCGTC ACCGAGATCC TCATGAAAAA CGAAGGCTCC 
TACGGCGGCC ACCACCACCC CAGCGCCCCG CACGCAACCC CCGCCGGCTT CTACTCCTCA 
GTCAACAAGA ACAGCGTCCT GCCTCAAGCC TTCGACCGTT TCTTCGACAA CGCCTACTGC 
GGTGGCGGCG ACCCGCCCGC CGAGCCCCCC TGCTCCGGCA AGGGCGAGGC CAAGGGGGAG 
CCCGAGGCAC CCCCGGCCTC GGGACTGGCG TCCCGGGCTG AGGCGGGTGC CGAGGCGGAG 
GCTGAGGAGG AGAACACAAA TCCCAGCTCG TCCGGTTCAG CCCACTCCGT GGCCAAGGAG 
CCGGCCAAAG GAGCCGCCCC CAACGCCCCC CGCACCCGCA AGAAGCGCTG CCCTTATTCG 
AAATTCCAGA TCCGGGAACT GGAGCGAGAG TTTTTCTTCA ACGTGTATAT CAACAAAGAG 
AAGCGGCTGC AGCTGTCCCG GATGCTGAAC CTGACGGACC GACAAGTGAA AATTTGGTTT 
CAGAACAGAA GGATGAAAGA AAAGAAACTG AGCAGAGACC GGCTGCAGTA TTTCTCGGGA 
AATCCTCTGC TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Overexpression of HOXC11 homeobox gene in clear cell renal cell carcinoma induces cellular proliferation and is associated with poor prognosis.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine36(4)2821-9(2015 Apr)
Liu YJ,Zhu Y,Yuan HX,Zhang JP,Guo JM,Lin ZM

Interaction of developmental transcription factor HOXC11 with steroid receptor coactivator SRC-1 mediates resistance to endocrine therapy in breast cancer [corrected].
Cancer research70(4)1585-94(2010 Feb)
McIlroy M,McCartan D,Early S,O Gaora P,Pennington S,Hill AD,Young LS

A census of human transcription factors: function, expression and evolution.
Nature reviews. Genetics10(4)252-63(2009 04)
Vaquerizas JM,Kummerfeld SK,Teichmann SA,Luscombe NM

HOXC6 and HOXC11 increase transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwannian cells.
Journal of cellular and molecular medicine11(2)299-306(2007 Mar-Apr)
Zhang X,Hamada J,Nishimoto A,Takahashi Y,Murai T,Tada M,Moriuchi T

Complete mutation analysis panel of the 39 human HOX genes.
Teratology65(2)50-62(2002 Feb)
Kosaki K,Kosaki R,Suzuki T,Yoshihashi H,Takahashi T,Sasaki K,Tomita M,McGinnis W,Matsuo N

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HOXC11 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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