HOXC8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HOXC8
Entrez Gene ID	3224
Full Name	homeobox C8
Synonyms	HOX3,HOX3A
General protein information	Preferred Names homeobox C8 Names homeobox protein Hox-C8 Hox-3.1, mouse, homolog of homeo box 3A homeo box C8 homeobox protein Hox-3A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.13
Summary	This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders. [provided by RefSeq, Jul 2008].
Disorder MIM:	142970

mRNA and Protein(s)

mRNA	Protein	Name
NM_022658.3	NP_073149.1	homeobox protein Hox-C8
NM_022658.4	NP_073149.1	homeobox protein Hox-C8

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LOC607625	XP_005637464.1
Xenopus tropicalis (tropical clawed frog)	hoxc8	NP_001006787.1
Bos taurus (cattle)	HOXC8	XP_002687278.1
Homo sapiens (human)	HOXC8	NP_073149.1
Pan troglodytes (chimpanzee)	HOXC8	XP_003313690.1
Mus musculus (house mouse)	Hoxc8	NP_034596.1
Rattus norvegicus (Norway rat)	Hoxc8	NP_001170797.2
Gallus gallus (chicken)	HOXC8	NP_990224.1
Danio rerio (zebrafish)	hoxc8a	NP_001005771.1

Gene Ontology
Bibliography

Related articles in PubMed

HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells.
Shah M, Cardenas R, Wang B, Persson J, Mongan NP, Grabowska A, Allegrucci C
Molecular cancer16(1)38(2017 Feb)

HOX genes: potential candidates for the progression of laryngeal squamous cell carcinoma.
de Barros E Lima Bueno R, Ram?o A, Pinheiro DG, Alves CP, Kannen V, Jungbluth AA, de Ara?jo LF, Muys BR, Fonseca AS, Pla?a JR, Panepucci RA, Neder L, Saggioro FP, Mamede RC, Figueiredo DL, Silva WA Jr
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(11)15087-15096(2016 Nov)

The predictive potential and oncogenic effects of HOXC8 expression on osteosarcoma.
Cheng L, Wei X, Zhao K, Wu F, Lu W, Tong S, Yu G
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(11)14961-14967(2016 Nov)

Overexpression of HOXC8 is Associated With Poor Prognosis in Epithelial Ovarian Cancer.
Lu S, Liu R, Su M, Wei Y, Yang S, He S, Wang X, Qiang F, Chen C, Zhao S, Qian L, Shao M, Mao G
Reproductive sciences (Thousand Oaks, Calif.)23(7)944-54(2016 07)

Upregulated HOXC8 Expression Is Associated with Poor Prognosis and Oxaliplatin Resistance in Hepatocellular Carcinoma.
Xu P, Zhang X, Ni W, Fan H, Xu J, Chen Y, Zhu J, Gu X, Yang L, Ni R, Chen B, Shi W
Digestive diseases and sciences60(11)3351-63(2015 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

High expression of HOXC8 is associated with laryngeal squamous cell carcinoma.
Title: HOX genes: potential candidates for the progression of laryngeal squamous cell carcinoma.

HOXC8 knockdown led to inhibition of tumor cell proliferation and migration in vitro by inhibiting MMP-9 expression and tumor growth in vivo. The results strongly suggest that HOXC8 is involved in the tumorigenesis of osteosarcoma and might serve as a novel predictor for patients' outcome.
Title: The predictive potential and oncogenic effects of HOXC8 expression on osteosarcoma.

Owing to the overexpression of Homeobox C8 (HOXC8), findings implied that HOXC8 is involved in the progression of epithelial ovarian cancer (EOC) and could be a potential therapeutical approach of EOC.
Title: Overexpression of HOXC8 is Associated With Poor Prognosis in Epithelial Ovarian Cancer.

Upregulated HOXC8 expression was associated with oxaliplatin resistance in hepatocellular carcinoma.
Title: Upregulated HOXC8 Expression Is Associated with Poor Prognosis and Oxaliplatin Resistance in Hepatocellular Carcinoma.

embigin is regulated by HOXC8 and its loss plays an important role in the progression of breast tumors
Title: Embigin, regulated by HOXC8, plays a suppressive role in breast tumorigenesis.

The following HOXC8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HOXC8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29638	NM_022658.4 Latest version!	Homo sapiens homeobox C8 (HOXC8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29638	NM_022658.3	Homo sapiens homeobox C8 (HOXC8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HOXC8 ( NM_022658.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_073149.1 Homo sapiens homeobox C8 (HOXC8), mRNA.

Price & Availability↑

CloneID	OHu29638
Clone ID Related Accession (Same CDS sequence)	NM_022658.3 , NM_022658.4
Accession Version	NM_022658.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 729bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-08
Organism	Homo sapiens(human)
Product	homeobox protein Hox-C8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC053898.1 and BU618342.1. On Mar 18, 2004 this sequence version replaced NM_022658.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC053898.1, AK290959.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGAGCTCCT ACTTCGTCAA CCCCCTGTTC TCCAAATACA AAGCCGGCGA GTCCCTGGAA 
CCGGCCTATT ACGACTGCCG GTTCCCTCAG AGCGTGGGCA GGAGCCATGC GCTGGTGTAC 
GGGCCCGGCG GCTCGGCGCC CGGCTTCCAG CACGCTTCGC ACCACGTTCA AGACTTCTTC 
CACCACGGCA CCTCCGGCAT CTCCAACTCA GGCTACCAGC AGAACCCGTG CTCGCTTAGC 
TGCCACGGAG ACGCCTCCAA ATTCTATGGC TACGAGGCGC TCCCCAGACA GTCCCTTTAT 
GGGGCTCAGC AAGAGGCGAG CGTGGTGCAA TATCCCGACT GTAAATCCTC CGCCAACACT 
AACAGTAGCG AAGGACAAGG CCACTTAAAT CAAAACTCGT CTCCCAGCCT CATGTTTCCA 
TGGATGAGAC CCCACGCTCC GGGGAGGCGC AGTGGACGGC AAACTTACAG CCGGTATCAG 
ACCTTGGAAC TAGAAAAGGA GTTTCTCTTT AATCCTTATT TGACACGAAA ACGTCGGATT 
GAAGTCTCTC ATGCCCTGGG ACTGACCGAG AGACAAGTGA AGATCTGGTT CCAGAACCGA 
AGGATGAAGT GGAAAAAGGA GAACAACAAG GATAAACTGC CGGGAGCCCG AGATGAGGAG 
AAGGTGGAGG AAGAAGGAAA TGAGGAAGAG GAGAAAGAAG AGGAGGAAAA GGAAGAAAAC 
AAGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_073149.1
CDS	180..908
Translation	MSSYFVNPLFSKYKAGESLEPAYYDCRFPQSVGRSHALVYGPGGSAPGFQHASHHVQDFFHHGTSGISNSGYQQNPCSLSCHGDASKFYGYEALPRQSLYGAQQEASVVQYPDCKSSANTNSSEGQGHLNQNSSPSLMFPWMRPHAPGRRSGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKLPGARDEEKVEEEGNEEEEKEEEEKEENKD

Target ORF information:

RefSeq Version	NM_022658.3
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox C8 (HOXC8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022658.3

ORF Insert Sequence:

ATGAGCTCCT ACTTCGTCAA CCCCCTGTTC TCCAAATACA AAGCCGGCGA GTCCCTGGAA 
CCGGCCTATT ACGACTGCCG GTTCCCTCAG AGCGTGGGCA GGAGCCATGC GCTGGTGTAC 
GGGCCCGGCG GCTCGGCGCC CGGCTTCCAG CACGCTTCGC ACCACGTTCA AGACTTCTTC 
CACCACGGCA CCTCCGGCAT CTCCAACTCA GGCTACCAGC AGAACCCGTG CTCGCTTAGC 
TGCCACGGAG ACGCCTCCAA ATTCTATGGC TACGAGGCGC TCCCCAGACA GTCCCTTTAT 
GGGGCTCAGC AAGAGGCGAG CGTGGTGCAA TATCCCGACT GTAAATCCTC CGCCAACACT 
AACAGTAGCG AAGGACAAGG CCACTTAAAT CAAAACTCGT CTCCCAGCCT CATGTTTCCA 
TGGATGAGAC CCCACGCTCC GGGGAGGCGC AGTGGACGGC AAACTTACAG CCGGTATCAG 
ACCTTGGAAC TAGAAAAGGA GTTTCTCTTT AATCCTTATT TGACACGAAA ACGTCGGATT 
GAAGTCTCTC ATGCCCTGGG ACTGACCGAG AGACAAGTGA AGATCTGGTT CCAGAACCGA 
AGGATGAAGT GGAAAAAGGA GAACAACAAG GATAAACTGC CGGGAGCCCG AGATGAGGAG 
AAGGTGGAGG AAGAAGGAAA TGAGGAAGAG GAGAAAGAAG AGGAGGAAAA GGAAGAAAAC 
AAGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOXC8 ( NM_022658.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_073149.1 Homo sapiens homeobox C8 (HOXC8), mRNA.

Price & Availability↑

CloneID	OHu29638
Clone ID Related Accession (Same CDS sequence)	NM_022658.3 , NM_022658.4
Accession Version	NM_022658.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 729bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	homeobox protein Hox-C8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC012531.11, BC053898.1 and BU618342.1. On Nov 22, 2018 this sequence version replaced NM_022658.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC053898.1, AK290959.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000040584.6/ ENSP00000040584.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCTCCT ACTTCGTCAA CCCCCTGTTC TCCAAATACA AAGCCGGCGA GTCCCTGGAA 
CCGGCCTATT ACGACTGCCG GTTCCCTCAG AGCGTGGGCA GGAGCCATGC GCTGGTGTAC 
GGGCCCGGCG GCTCGGCGCC CGGCTTCCAG CACGCTTCGC ACCACGTTCA AGACTTCTTC 
CACCACGGCA CCTCCGGCAT CTCCAACTCA GGCTACCAGC AGAACCCGTG CTCGCTTAGC 
TGCCACGGAG ACGCCTCCAA ATTCTATGGC TACGAGGCGC TCCCCAGACA GTCCCTTTAT 
GGGGCTCAGC AAGAGGCGAG CGTGGTGCAA TATCCCGACT GTAAATCCTC CGCCAACACT 
AACAGTAGCG AAGGACAAGG CCACTTAAAT CAAAACTCGT CTCCCAGCCT CATGTTTCCA 
TGGATGAGAC CCCACGCTCC GGGGAGGCGC AGTGGACGGC AAACTTACAG CCGGTATCAG 
ACCTTGGAAC TAGAAAAGGA GTTTCTCTTT AATCCTTATT TGACACGAAA ACGTCGGATT 
GAAGTCTCTC ATGCCCTGGG ACTGACCGAG AGACAAGTGA AGATCTGGTT CCAGAACCGA 
AGGATGAAGT GGAAAAAGGA GAACAACAAG GATAAACTGC CGGGAGCCCG AGATGAGGAG 
AAGGTGGAGG AAGAAGGAAA TGAGGAAGAG GAGAAAGAAG AGGAGGAAAA GGAAGAAAAC 
AAGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_073149.1
CDS	301..1029
Translation	MSSYFVNPLFSKYKAGESLEPAYYDCRFPQSVGRSHALVYGPGGSAPGFQHASHHVQDFFHHGTSGISNSGYQQNPCSLSCHGDASKFYGYEALPRQSLYGAQQEASVVQYPDCKSSANTNSSEGQGHLNQNSSPSLMFPWMRPHAPGRRSGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKLPGARDEEKVEEEGNEEEEKEEEEKEENKD

Target ORF information:

RefSeq Version	NM_022658.4
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox C8 (HOXC8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022658.4

ORF Insert Sequence:

ATGAGCTCCT ACTTCGTCAA CCCCCTGTTC TCCAAATACA AAGCCGGCGA GTCCCTGGAA 
CCGGCCTATT ACGACTGCCG GTTCCCTCAG AGCGTGGGCA GGAGCCATGC GCTGGTGTAC 
GGGCCCGGCG GCTCGGCGCC CGGCTTCCAG CACGCTTCGC ACCACGTTCA AGACTTCTTC 
CACCACGGCA CCTCCGGCAT CTCCAACTCA GGCTACCAGC AGAACCCGTG CTCGCTTAGC 
TGCCACGGAG ACGCCTCCAA ATTCTATGGC TACGAGGCGC TCCCCAGACA GTCCCTTTAT 
GGGGCTCAGC AAGAGGCGAG CGTGGTGCAA TATCCCGACT GTAAATCCTC CGCCAACACT 
AACAGTAGCG AAGGACAAGG CCACTTAAAT CAAAACTCGT CTCCCAGCCT CATGTTTCCA 
TGGATGAGAC CCCACGCTCC GGGGAGGCGC AGTGGACGGC AAACTTACAG CCGGTATCAG 
ACCTTGGAAC TAGAAAAGGA GTTTCTCTTT AATCCTTATT TGACACGAAA ACGTCGGATT 
GAAGTCTCTC ATGCCCTGGG ACTGACCGAG AGACAAGTGA AGATCTGGTT CCAGAACCGA 
AGGATGAAGT GGAAAAAGGA GAACAACAAG GATAAACTGC CGGGAGCCCG AGATGAGGAG 
AAGGTGGAGG AAGAAGGAAA TGAGGAAGAG GAGAAAGAAG AGGAGGAAAA GGAAGAAAAC 
AAGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells.
Molecular cancer16(1)38(2017 Feb)
Shah M,Cardenas R,Wang B,Persson J,Mongan NP,Grabowska A,Allegrucci C

HOX genes: potential candidates for the progression of laryngeal squamous cell carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(11)15087-15096(2016 Nov)
de Barros E Lima Bueno R,Ram?o A,Pinheiro DG,Alves CP,Kannen V,Jungbluth AA,de Ara?jo LF,Muys BR,Fonseca AS,Pla?a JR,Panepucci RA,Neder L,Saggioro FP,Mamede RC,Figueiredo DL,Silva WA Jr

The predictive potential and oncogenic effects of HOXC8 expression on osteosarcoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(11)14961-14967(2016 Nov)
Cheng L,Wei X,Zhao K,Wu F,Lu W,Tong S,Yu G

Overexpression of HOXC8 is Associated With Poor Prognosis in Epithelial Ovarian Cancer.
Reproductive sciences (Thousand Oaks, Calif.)23(7)944-54(2016 07)
Lu S,Liu R,Su M,Wei Y,Yang S,He S,Wang X,Qiang F,Chen C,Zhao S,Qian L,Shao M,Mao G

Upregulated HOXC8 Expression Is Associated with Poor Prognosis and Oxaliplatin Resistance in Hepatocellular Carcinoma.
Digestive diseases and sciences60(11)3351-63(2015 Nov)
Xu P,Zhang X,Ni W,Fan H,Xu J,Chen Y,Zhu J,Gu X,Yang L,Ni R,Chen B,Shi W

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HOXC8 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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