HOXB5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HOXB5
Entrez Gene ID	3215
Full Name	homeobox B5
Synonyms	HHO.C10,HOX2,HOX2A,HU-1,Hox2.1
General protein information	Preferred Names homeobox B5 Names homeobox protein Hox-B5 homeo box 2A homeo box B5 homeobox protein HHO.C10 homeobox protein Hox-2A homeobox protein Hu-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.32
Summary	This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. [provided by RefSeq, Jul 2008].
Disorder MIM:	142960

mRNA and Protein(s)

mRNA	Protein	Name
NM_002147.3	NP_002138.1	homeobox protein Hox-B5

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	hoxb5	NP_001094494.1
Rattus norvegicus (Norway rat)	Hoxb5	NP_001178854.1
Gallus gallus (chicken)	HOXB5	NP_001020526.1
	HOXB5	XP_001088160.1
Homo sapiens (human)	HOXB5	NP_002138.1
Mus musculus (house mouse)	Hoxb5	NP_032294.2
Pan troglodytes (chimpanzee)	HOXB5	XP_001173004.1
Canis lupus familiaris (dog)	HOXB5	XP_003435305.1

Gene Ontology
Bibliography

Related articles in PubMed

miR-455-3p serves as prognostic factor and regulates the proliferation and migration of non-small cell lung cancer through targeting HOXB5.
Gao X, Zhao H, Diao C, Wang X, Xie Y, Liu Y, Han J, Zhang M
Biochemical and biophysical research communications495(1)1074-1080(2018 01)

Knockdown of Homeobox B5 (HOXB5) Inhibits Cell Proliferation, Migration, and Invasion in Non-Small Cell Lung Cancer Cells Through Inactivation of the Wnt/?-Catenin Pathway.
Zhang B, Li N, Zhang H
Oncology research26(1)37-44(2018 Jan)

HOXB5 induces invasion and migration through direct transcriptional up-regulation of ?-catenin in human gastric carcinoma.
Hong CS, Jeong O, Piao Z, Guo C, Jung MR, Choi C, Park YK
The Biochemical journal472(3)393-403(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Taken together, our results for the first time suggested that miR-455-3p was downregulated in NSCLC and was correlated with the poor prognosis of NSCLC patients. Also, miR-455-3p functions as tumor suppressor by directly targeting HOXB5 in NSCLC progression and may be used as a potential target for NSCLC treatment.
Title: miR-455-3p serves as prognostic factor and regulates the proliferation and migration of non-small cell lung cancer through targeting HOXB5.

HOXB5 may be an important regulator of the Wnt/beta-catenin signalling pathway, thereby contributing to gastric cancer progression and metastasis.
Title: HOXB5 induces invasion and migration through direct transcriptional up-regulation of ?-catenin in human gastric carcinoma.

Roles of Hoxb5 in the development of vagal and trunk neural crest cells.
Title: Roles of Hoxb5 in the development of vagal and trunk neural crest cells.

HOXB5 acts as a positive modulator by promoting cell proliferative response and invasiveness in ER-positive breast cancer.
Title: HOXB5 Promotes the Proliferation and Invasion of Breast Cancer Cells.

Overexpression of HoxB5 enhances blood vessel perfusion in vivo by up-regulation of MCP-1 and IL-6 as well as in enhanced leucocyte infiltration and blood vessel remodelling.
Title: The transcription factor HoxB5 stimulates vascular remodelling in a cytokine-dependent manner.

The following HOXB5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HOXB5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu03853	NM_002147.3 Latest version!	Homo sapiens homeobox B5 (HOXB5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HOXB5 ( NM_002147.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002138.1 Homo sapiens homeobox B5 (HOXB5), mRNA.

Price & Availability↑

CloneID	OHu03853
Clone ID Related Accession (Same CDS sequence)	NM_002147.3
Accession Version	NM_002147.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Homo sapiens(human)
Product	homeobox protein Hox-B5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M92299.1, BE621135.1, BQ073272.1, M86726.1, BC004454.1 and BQ001097.1. On Jan 19, 2006 this sequence version replaced NM_002147.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI766494.1, M92299.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCTCGT ACTTTGTAAA CTCCTTCTCG GGGCGTTATC CAAATGGCCC GGACTATCAG 
TTGCTAAATT ATGGCAGTGG CAGCTCTCTG AGCGGCTCTT ACAGGGATCC CGCTGCCATG 
CACACCGGCT CTTACGGCTA CAATTACAAT GGGATGGACC TCAGCGTCAA CCGCTCCTCG 
GCCTCCTCCA GCCACTTTGG GGCGGTGGGC GAGAGCTCGC GCGCCTTCCC CGCGCCCGCC 
CAGGAGCCCC GCTTCAGGCA AGCGGCTTCG AGCTGCTCCC TGTCCTCGCC CGAGTCCCTG 
CCCTGCACCA ACGGCGACAG CCACGGCGCC AAGCCCTCTG CTTCGTCCCC CTCCGACCAG 
GCGACCTCAG CCAGCTCCAG CGCCAATTTC ACCGAAATAG ACGAGGCCAG CGCGTCCTCG 
GAGCCTGAGG AAGCGGCAAG CCAGCTAAGC AGCCCCAGCC TAGCTCGGGC GCAGCCAGAG 
CCCATGGCCA CCTCCACAGC CGCGCCCGAG GGGCAGACTC CGCAAATATT CCCCTGGATG 
AGGAAGCTTC ACATCAGCCA TGATATGACC GGGCCGGACG GGAAAAGGGC CCGGACCGCG 
TATACCCGCT ACCAGACCCT GGAGCTGGAA AAGGAGTTCC ACTTCAACCG CTACCTGACC 
CGGCGACGGC GCATCGAGAT CGCCCACGCA CTCTGCCTGT CCGAGCGCCA GATCAAGATC 
TGGTTCCAGA ACCGGCGCAT GAAGTGGAAG AAGGACAACA AATTGAAAAG TATGAGCCTG 
GCTACAGCTG GCAGCGCCTT CCAGCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002138.1
CDS	60..869
Translation	MSSYFVNSFSGRYPNGPDYQLLNYGSGSSLSGSYRDPAAMHTGSYGYNYNGMDLSVNRSSASSSHFGAVGESSRAFPAPAQEPRFRQAASSCSLSSPESLPCTNGDSHGAKPSASSPSDQATSASSSANFTEIDEASASSEPEEAASQLSSPSLARAQPEPMATSTAAPEGQTPQIFPWMRKLHISHDMTGPDGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSLATAGSAFQP

Target ORF information:

RefSeq Version	NM_002147.3
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox B5 (HOXB5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002147.3

ORF Insert Sequence:

ATGAGCTCGT ACTTTGTAAA CTCCTTCTCG GGGCGTTATC CAAATGGCCC GGACTATCAG 
TTGCTAAATT ATGGCAGTGG CAGCTCTCTG AGCGGCTCTT ACAGGGATCC CGCTGCCATG 
CACACCGGCT CTTACGGCTA CAATTACAAT GGGATGGACC TCAGCGTCAA CCGCTCCTCG 
GCCTCCTCCA GCCACTTTGG GGCGGTGGGC GAGAGCTCGC GCGCCTTCCC CGCGCCCGCC 
CAGGAGCCCC GCTTCAGGCA AGCGGCTTCG AGCTGCTCCC TGTCCTCGCC CGAGTCCCTG 
CCCTGCACCA ACGGCGACAG CCACGGCGCC AAGCCCTCTG CTTCGTCCCC CTCCGACCAG 
GCGACCTCAG CCAGCTCCAG CGCCAATTTC ACCGAAATAG ACGAGGCCAG CGCGTCCTCG 
GAGCCTGAGG AAGCGGCAAG CCAGCTAAGC AGCCCCAGCC TAGCTCGGGC GCAGCCAGAG 
CCCATGGCCA CCTCCACAGC CGCGCCCGAG GGGCAGACTC CGCAAATATT CCCCTGGATG 
AGGAAGCTTC ACATCAGCCA TGATATGACC GGGCCGGACG GGAAAAGGGC CCGGACCGCG 
TATACCCGCT ACCAGACCCT GGAGCTGGAA AAGGAGTTCC ACTTCAACCG CTACCTGACC 
CGGCGACGGC GCATCGAGAT CGCCCACGCA CTCTGCCTGT CCGAGCGCCA GATCAAGATC 
TGGTTCCAGA ACCGGCGCAT GAAGTGGAAG AAGGACAACA AATTGAAAAG TATGAGCCTG 
GCTACAGCTG GCAGCGCCTT CCAGCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

miR-455-3p serves as prognostic factor and regulates the proliferation and migration of non-small cell lung cancer through targeting HOXB5.
Biochemical and biophysical research communications495(1)1074-1080(2018 01)
Gao X,Zhao H,Diao C,Wang X,Xie Y,Liu Y,Han J,Zhang M

Knockdown of Homeobox B5 (HOXB5) Inhibits Cell Proliferation, Migration, and Invasion in Non-Small Cell Lung Cancer Cells Through Inactivation of the Wnt/?-Catenin Pathway.
Oncology research26(1)37-44(2018 Jan)
Zhang B,Li N,Zhang H

HOXB5 induces invasion and migration through direct transcriptional up-regulation of ?-catenin in human gastric carcinoma.
The Biochemical journal472(3)393-403(2015 Dec)
Hong CS,Jeong O,Piao Z,Guo C,Jung MR,Choi C,Park YK

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HOXB5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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