HOXB4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HOXB4
Entrez Gene ID	3214
Full Name	homeobox B4
Synonyms	HOX-2.6,HOX2,HOX2F
General protein information	Preferred Names homeobox B4 Names homeobox protein Hox-B4 homeo box 2F homeo box B4 homeobox protein Hox-2.6 homeobox protein Hox-2F
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.32
Summary	This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. [provided by RefSeq, Jul 2008].
Disorder MIM:	142965

mRNA and Protein(s)

mRNA	Protein	Name
NM_024015.4	NP_076920.1	homeobox protein Hox-B4
NM_024015.5	NP_076920.1	homeobox protein Hox-B4

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	HOXB4	NP_990624.1
Danio rerio (zebrafish)	hoxb4a	NP_571193.1
Homo sapiens (human)	HOXB4	NP_076920.1
Mus musculus (house mouse)	Hoxb4	NP_034589.3
Xenopus tropicalis (tropical clawed frog)	hoxb4	NP_001116487.1
Pan troglodytes (chimpanzee)	HOXB4	XP_001173043.1
Canis lupus familiaris (dog)	HOXB4	XP_003639319.1
Bos taurus (cattle)	HOXB4	NP_001071582.1
Rattus norvegicus (Norway rat)	Hoxb4	NP_001094257.1

Gene Ontology
Bibliography

Related articles in PubMed

Functional analysis of HOXA10 and HOXB4 in human medulloblastoma cell lines.
Bonfim-Silva R, Ferreira Melo FU, Thom? CH, Abraham KJ, De Souza FAL, Ramalho FS, Machado HR, De Oliveira RS, Cardoso AA, Covas DT, Fontes AM
International journal of oncology51(6)1929-1940(2017 Dec)

HOXB4 Immunoreactivity in Endometrial Tissues From Women With or Without Endometriosis.
AlKusayer GM, Pon JR, Peng B, Klausen C, Lisonkova S, Kinloch M, Yong P, Muhammad EMS, Leung PCK, Bedaiwy MA
Reproductive sciences (Thousand Oaks, Calif.)1933719117732164(2017 Jan)

HOXB4 knockdown reverses multidrug resistance of human myelogenous leukemia K562/ADM cells by downregulating P-gp, MRP1 and BCRP expression via PI3K/Akt signaling pathway.
Wang H, Jia XH, Chen JR, Yi YJ, Wang JY, Li YJ, Xie SY
International journal of oncology49(6)2529-2537(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HOXB4 knockout led to downregulation of P-glycoprotein, multidrug resistance-associated protein 1 and breast cancer resistance protein expression and PI3K/Akt signaling activity, suggesting that repression of HOXB4 might be a key point to reverse Multidrug resistance of K562/ADM cells.
Title: HOXB4 knockdown reverses multidrug resistance of human myelogenous leukemia K562/ADM cells by downregulating P-gp, MRP1 and BCRP expression via PI3K/Akt signaling pathway.

This study provides novel evidences of the mechanisms integrating Notch and TNF-alpha signaling in the transcriptional induction of GATA3 and HOXB4.
Title: TNF-alpha and Notch signaling regulates the expression of HOXB4 and GATA3 during early T lymphopoiesis.

Increased expression of HOXB4 in human embryonic stem cells enhances the production of hematopoietic Progenitors but does not effect the maturation of red blood cells.
Title: Enforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells.

The analysis of HOX expression in primary mesothelioma tumors indicated that these cells could also be sensitive to the disruption of HOX activity by HXR9, and that the expression of HOXB4 is strongly associated with overall survival
Title: HOX transcription factors are potential targets and markers in malignant mesothelioma.

showed that OAC1 treatment led to OCT4-mediated upregulation of HOXB4
Title: Activation of OCT4 enhances ex vivo expansion of human cord blood hematopoietic stem and progenitor cells by regulating HOXB4 expression.

The following HOXB4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HOXB4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29112	NM_024015.5 Latest version!	Homo sapiens homeobox B4 (HOXB4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29112	NM_024015.4	Homo sapiens homeobox B4 (HOXB4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HOXB4 ( NM_024015.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_076920.1 Homo sapiens homeobox B4 (HOXB4), mRNA.

Price & Availability↑

CloneID	OHu29112
Clone ID Related Accession (Same CDS sequence)	NM_024015.4 , NM_024015.5
Accession Version	NM_024015.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 756bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	homeobox protein Hox-B4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC049204.1, AC103702.3 and AL137449.1. On Jan 19, 2006 this sequence version replaced NM_024015.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC049204.1, SRR1163655.352277.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMN03267773 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCTATGA GTTCTTTTTT GATCAACTCA AACTATGTCG ACCCCAAGTT CCCTCCATGC 
GAGGAATATT CACAGAGCGA TTACCTACCC AGCGACCACT CGCCCGGGTA CTACGCCGGC 
GGCCAGAGGC GAGAGAGCAG CTTCCAGCCG GAGGCGGGCT TCGGGCGGCG CGCGGCGTGC 
ACCGTGCAGC GCTACGCGGC CTGCCGGGAC CCTGGGCCCC CGCCGCCTCC GCCACCACCC 
CCGCCGCCCC CGCCACCGCC CGGTCTGTCC CCTCGGGCTC CTGCGCCGCC ACCCGCCGGG 
GCCCTCCTCC CGGAGCCCGG CCAGCGCTGC GAGGCGGTCA GCAGCAGCCC CCCGCCGCCT 
CCCTGCGCCC AGAACCCCCT GCACCCCAGC CCGTCCCACT CCGCGTGCAA AGAGCCCGTC 
GTCTACCCCT GGATGCGCAA AGTTCACGTG AGCACGGTAA ACCCCAATTA CGCCGGCGGG 
GAGCCCAAGC GCTCTCGGAC CGCCTACACG CGCCAGCAGG TCTTGGAGCT GGAGAAGGAA 
TTTCACTACA ACCGCTACCT GACACGGCGC CGGAGGGTGG AGATCGCCCA CGCGCTCTGC 
CTCTCCGAGC GCCAGATCAA GATCTGGTTC CAGAACCGGC GCATGAAGTG GAAAAAAGAC 
CACAAGTTGC CCAACACCAA GATCCGCTCG GGTGGTGCGG CAGGCTCAGC CGGAGGGCCC 
CCTGGCCGGC CCAATGGAGG CCCCCGCGCG CTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076920.1
CDS	63..818
Translation	MAMSSFLINSNYVDPKFPPCEEYSQSDYLPSDHSPGYYAGGQRRESSFQPEAGFGRRAACTVQRYAACRDPGPPPPPPPPPPPPPPPGLSPRAPAPPPAGALLPEPGQRCEAVSSSPPPPPCAQNPLHPSPSHSACKEPVVYPWMRKVHVSTVNPNYAGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRVEIAHALCLSERQIKIWFQNRRMKWKKDHKLPNTKIRSGGAAGSAGGPPGRPNGGPRAL

Target ORF information:

RefSeq Version	NM_024015.4
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox B4 (HOXB4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024015.4

ORF Insert Sequence:

ATGGCTATGA GTTCTTTTTT GATCAACTCA AACTATGTCG ACCCCAAGTT CCCTCCATGC 
GAGGAATATT CACAGAGCGA TTACCTACCC AGCGACCACT CGCCCGGGTA CTACGCCGGC 
GGCCAGAGGC GAGAGAGCAG CTTCCAGCCG GAGGCGGGCT TCGGGCGGCG CGCGGCGTGC 
ACCGTGCAGC GCTACGCGGC CTGCCGGGAC CCTGGGCCCC CGCCGCCTCC GCCACCACCC 
CCGCCGCCCC CGCCACCGCC CGGTCTGTCC CCTCGGGCTC CTGCGCCGCC ACCCGCCGGG 
GCCCTCCTCC CGGAGCCCGG CCAGCGCTGC GAGGCGGTCA GCAGCAGCCC CCCGCCGCCT 
CCCTGCGCCC AGAACCCCCT GCACCCCAGC CCGTCCCACT CCGCGTGCAA AGAGCCCGTC 
GTCTACCCCT GGATGCGCAA AGTTCACGTG AGCACGGTAA ACCCCAATTA CGCCGGCGGG 
GAGCCCAAGC GCTCTCGGAC CGCCTACACG CGCCAGCAGG TCTTGGAGCT GGAGAAGGAA 
TTTCACTACA ACCGCTACCT GACACGGCGC CGGAGGGTGG AGATCGCCCA CGCGCTCTGC 
CTCTCCGAGC GCCAGATCAA GATCTGGTTC CAGAACCGGC GCATGAAGTG GAAAAAAGAC 
CACAAGTTGC CCAACACCAA GATCCGCTCG GGTGGTGCGG CAGGCTCAGC CGGAGGGCCC 
CCTGGCCGGC CCAATGGAGG CCCCCGCGCG CTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOXB4 ( NM_024015.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_076920.1 Homo sapiens homeobox B4 (HOXB4), mRNA.

Price & Availability↑

CloneID	OHu29112
Clone ID Related Accession (Same CDS sequence)	NM_024015.4 , NM_024015.5
Accession Version	NM_024015.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 756bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	homeobox protein Hox-B4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC049204.1, AC103702.3 and AL137449.1. On Nov 22, 2018 this sequence version replaced NM_024015.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL137449.1, BC049204.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000332503.6/ ENSP00000328928.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTATGA GTTCTTTTTT GATCAACTCA AACTATGTCG ACCCCAAGTT CCCTCCATGC 
GAGGAATATT CACAGAGCGA TTACCTACCC AGCGACCACT CGCCCGGGTA CTACGCCGGC 
GGCCAGAGGC GAGAGAGCAG CTTCCAGCCG GAGGCGGGCT TCGGGCGGCG CGCGGCGTGC 
ACCGTGCAGC GCTACGCGGC CTGCCGGGAC CCTGGGCCCC CGCCGCCTCC GCCACCACCC 
CCGCCGCCCC CGCCACCGCC CGGTCTGTCC CCTCGGGCTC CTGCGCCGCC ACCCGCCGGG 
GCCCTCCTCC CGGAGCCCGG CCAGCGCTGC GAGGCGGTCA GCAGCAGCCC CCCGCCGCCT 
CCCTGCGCCC AGAACCCCCT GCACCCCAGC CCGTCCCACT CCGCGTGCAA AGAGCCCGTC 
GTCTACCCCT GGATGCGCAA AGTTCACGTG AGCACGGTAA ACCCCAATTA CGCCGGCGGG 
GAGCCCAAGC GCTCTCGGAC CGCCTACACG CGCCAGCAGG TCTTGGAGCT GGAGAAGGAA 
TTTCACTACA ACCGCTACCT GACACGGCGC CGGAGGGTGG AGATCGCCCA CGCGCTCTGC 
CTCTCCGAGC GCCAGATCAA GATCTGGTTC CAGAACCGGC GCATGAAGTG GAAAAAAGAC 
CACAAGTTGC CCAACACCAA GATCCGCTCG GGTGGTGCGG CAGGCTCAGC CGGAGGGCCC 
CCTGGCCGGC CCAATGGAGG CCCCCGCGCG CTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076920.1
CDS	32..787
Translation	MAMSSFLINSNYVDPKFPPCEEYSQSDYLPSDHSPGYYAGGQRRESSFQPEAGFGRRAACTVQRYAACRDPGPPPPPPPPPPPPPPPGLSPRAPAPPPAGALLPEPGQRCEAVSSSPPPPPCAQNPLHPSPSHSACKEPVVYPWMRKVHVSTVNPNYAGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRVEIAHALCLSERQIKIWFQNRRMKWKKDHKLPNTKIRSGGAAGSAGGPPGRPNGGPRAL

Target ORF information:

RefSeq Version	NM_024015.5
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox B4 (HOXB4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024015.5

ORF Insert Sequence:

ATGGCTATGA GTTCTTTTTT GATCAACTCA AACTATGTCG ACCCCAAGTT CCCTCCATGC 
GAGGAATATT CACAGAGCGA TTACCTACCC AGCGACCACT CGCCCGGGTA CTACGCCGGC 
GGCCAGAGGC GAGAGAGCAG CTTCCAGCCG GAGGCGGGCT TCGGGCGGCG CGCGGCGTGC 
ACCGTGCAGC GCTACGCGGC CTGCCGGGAC CCTGGGCCCC CGCCGCCTCC GCCACCACCC 
CCGCCGCCCC CGCCACCGCC CGGTCTGTCC CCTCGGGCTC CTGCGCCGCC ACCCGCCGGG 
GCCCTCCTCC CGGAGCCCGG CCAGCGCTGC GAGGCGGTCA GCAGCAGCCC CCCGCCGCCT 
CCCTGCGCCC AGAACCCCCT GCACCCCAGC CCGTCCCACT CCGCGTGCAA AGAGCCCGTC 
GTCTACCCCT GGATGCGCAA AGTTCACGTG AGCACGGTAA ACCCCAATTA CGCCGGCGGG 
GAGCCCAAGC GCTCTCGGAC CGCCTACACG CGCCAGCAGG TCTTGGAGCT GGAGAAGGAA 
TTTCACTACA ACCGCTACCT GACACGGCGC CGGAGGGTGG AGATCGCCCA CGCGCTCTGC 
CTCTCCGAGC GCCAGATCAA GATCTGGTTC CAGAACCGGC GCATGAAGTG GAAAAAAGAC 
CACAAGTTGC CCAACACCAA GATCCGCTCG GGTGGTGCGG CAGGCTCAGC CGGAGGGCCC 
CCTGGCCGGC CCAATGGAGG CCCCCGCGCG CTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Functional analysis of HOXA10 and HOXB4 in human medulloblastoma cell lines.
International journal of oncology51(6)1929-1940(2017 Dec)
Bonfim-Silva R,Ferreira Melo FU,Thom? CH,Abraham KJ,De Souza FAL,Ramalho FS,Machado HR,De Oliveira RS,Cardoso AA,Covas DT,Fontes AM

HOXB4 Immunoreactivity in Endometrial Tissues From Women With or Without Endometriosis.
Reproductive sciences (Thousand Oaks, Calif.)1933719117732164(2017 Jan)
AlKusayer GM,Pon JR,Peng B,Klausen C,Lisonkova S,Kinloch M,Yong P,Muhammad EMS,Leung PCK,Bedaiwy MA

HOXB4 knockdown reverses multidrug resistance of human myelogenous leukemia K562/ADM cells by downregulating P-gp, MRP1 and BCRP expression via PI3K/Akt signaling pathway.
International journal of oncology49(6)2529-2537(2016 Dec)
Wang H,Jia XH,Chen JR,Yi YJ,Wang JY,Li YJ,Xie SY

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HOXB4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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