HOXB1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HOXB1
Entrez Gene ID	3211
Full Name	homeobox B1
Synonyms	HCFP3,HOX2,HOX2I,Hox-2.9
General protein information	Preferred Names homeobox B1 Names homeobox protein Hox-B1 homeobox protein Hox-2I
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.32
Summary	This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17. [provided by RefSeq, Jul 2008].
Disorder MIM:	142968
Disorder Html:	Facial paresis, hereditary congenital, 3, 614744 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_002144.3	NP_002135.2	homeobox protein Hox-B1
NM_002144.4	NP_002135.2	homeobox protein Hox-B1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Hoxb1	XP_220896.4
Pan troglodytes (chimpanzee)	HOXB1	NP_001075041.1
	HOXB1	NP_001074229.1
Bos taurus (cattle)	HOXB1	NP_001192883.1
Homo sapiens (human)	HOXB1	NP_002135.2
Canis lupus familiaris (dog)	HOXB1	XP_548172.3
Gallus gallus (chicken)	HOXB1	NP_001074328.2
Danio rerio (zebrafish)	hoxb1a	NP_571190.1
Xenopus tropicalis (tropical clawed frog)	hoxb1	XP_004918719.1
Mus musculus (house mouse)	Hoxb1	NP_032292.3

Gene Ontology
Bibliography

Related articles in PubMed

A novel homozygous HOXB1 mutation in a Turkish family with hereditary congenital facial paresis.
Sahin Y, G?ng?r O, Ayaz A, G?ng?r G, Sahin B, Yaykasli K, Ceylaner S
Brain & development39(2)166-170(2017 Feb)

Homozygous HOXB1 loss-of-function mutation in a large family with hereditary congenital facial paresis.
Vogel M, Velleuer E, Schmidt-Jim?nez LF, Mayatepek E, Borkhardt A, Alawi M, Kutsche K, Kort?m F
American journal of medical genetics. Part A170(7)1813-9(2016 Jul)

HOXB1 Is a Tumor Suppressor Gene Regulated by miR-3175 in Glioma.
Han L, Liu D, Li Z, Tian N, Han Z, Wang G, Fu Y, Guo Z, Zhu Z, Du C, Tian Y
PloS one10(11)e0142387(2015)

HOXB1 founder mutation in humans recapitulates the phenotype of Hoxb1-/- mice.
Webb BD, Shaaban S, Gaspar H, Cunha LF, Schubert CR, Hao K, Robson CD, Chan WM, Andrews C, MacKinnon S, Oystreck DT, Hunter DG, Iacovelli AJ, Ye X, Camminady A, Engle EC, Jabs EW
American journal of human genetics91(1)171-9(2012 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings revealed a novel homozygous mutation p.Arg230Trp (c.688C>T) within the HOXB1 gene of three members of a Turkish family with hereditary congenital facial paresis (HCFP3)
Title: A novel homozygous HOXB1 mutation in a Turkish family with hereditary congenital facial paresis.

This is the first disease-associated HOXB1 mutation with a likely loss-of-function effect suggesting that all HOXB1 variants reported so far also have severe impact on activity of this transcriptional regulator
Title: Homozygous HOXB1 loss-of-function mutation in a large family with hereditary congenital facial paresis.

HOXB1 functions as a tumor suppressor, regulated by miR-3175 in glioma.
Title: HOXB1 Is a Tumor Suppressor Gene Regulated by miR-3175 in Glioma.

The resulting phenotype includes bilateral facial palsy, hearing loss, and strabismus and correlates extensively with the previously reported Hoxb1(-/-) mouse phenotype.
Title: HOXB1 founder mutation in humans recapitulates the phenotype of Hoxb1-/- mice.

HOXA1 A218G and HOXB1 nINS/INS variants may not contribute significantly to autism spectrum disorders risk
Title: An integrated meta-analysis of two variants in HOXA1/HOXB1 and their effect on the risk of autism spectrum disorders.

The following HOXB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HOXB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19390	NM_002144.4 Latest version!	Homo sapiens homeobox B1 (HOXB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
View Old Accession Versions >>
OHu19390	NM_002144.3	Homo sapiens homeobox B1 (HOXB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HOXB1 ( NM_002144.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002135.2 Homo sapiens homeobox B1 (HOXB1), mRNA.

Price & Availability↑

CloneID	OHu19390
Clone ID Related Accession (Same CDS sequence)	NM_002144.3 , NM_002144.4
Accession Version	NM_002144.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 906bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-01
Organism	Homo sapiens(human)
Product	homeobox protein Hox-B1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X16666.1 and AC103702.3. This sequence is a reference standard in the RefSeqGene project. On Dec 29, 2005 this sequence version replaced NM_002144.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X16666.1, CN264618.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2158188 [ECO:0000348] ##Evidence-Data-END##

ATGGACTATA ATAGGATGAA CTCCTTCTTA GAGTACCCAC TCTGTAACCG GGGACCCAGC 
GCCTACAGCG CCCACAGCGC CCCAACCTCC TTTCCCCCAA GCTCGGCTCA GGCGGTTGAC 
AGCTATGCAA GCGAGGGCCG CTACGGTGGG GGGCTGTCCA GCCCTGCGTT TCAGCAGAAC 
TCCGGCTATC CCGCCCAGCA GCCGCCTTCG ACCCTGGGGG TGCCCTTCCC CAGCTCCGCG 
CCCTCGGGGT ATGCTCCTGC CGCCTGCAGC CCCAGCTACG GGCCTTCTCA GTACTACCCT 
CTGGGTCAAT CAGAAGGAGA CGGAGGCTAT TTTCATCCCT CGAGCTACGG GGCCCAGCTA 
GGGGGCTTGT CCGATGGCTA CGGAGCAGGT GGAGCCGGTC CGGGGCCATA TCCTCCGCAG 
CATCCCCCTT ATGGGAACGA GCAGACCGCG AGCTTTGCAC CGGCCTATGC TGATCTCCTC 
TCCGAGGACA AGGAAACACC CTGCCCTTCA GAACCTAACA CCCCCACGGC CCGGACCTTC 
GACTGGATGA AGGTTAAGAG AAACCCACCC AAGACAGCGA AGGTGTCAGA GCCAGGCCTG 
GGCTCGCCCA GTGGCCTCCG CACCAACTTC ACCACAAGGC AGCTGACAGA ACTGGAAAAG 
GAGTTCCATT TCAACAAGTA CCTGAGCCGG GCCCGGAGGG TGGAGATTGC CGCCACCCTG 
GAGCTCAATG AAACACAGGT CAAGATTTGG TTCCAGAACC GACGAATGAA GCAGAAGAAG 
CGCGAGCGAG AGGAAGGTCG GGTCCCCCCA GCCCCACCAG GCTGCCCCAA GGAGGCAGCT 
GGAGATGCCT CAGACCAGTC GACATGCACC TCCCCGGAAG CCTCACCCAG CTCTGTCACC 
TCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002135.2
CDS	7..912
Translation	MDYNRMNSFLEYPLCNRGPSAYSAHSAPTSFPPSSAQAVDSYASEGRYGGGLSSPAFQQNSGYPAQQPPSTLGVPFPSSAPSGYAPAACSPSYGPSQYYPLGQSEGDGGYFHPSSYGAQLGGLSDGYGAGGAGPGPYPPQHPPYGNEQTASFAPAYADLLSEDKETPCPSEPNTPTARTFDWMKVKRNPPKTAKVSEPGLGSPSGLRTNFTTRQLTELEKEFHFNKYLSRARRVEIAATLELNETQVKIWFQNRRMKQKKREREEGRVPPAPPGCPKEAAGDASDQSTCTSPEASPSSVTS

Target ORF information:

RefSeq Version	NM_002144.3
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox B1 (HOXB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002144.3

ORF Insert Sequence:

ATGGACTATA ATAGGATGAA CTCCTTCTTA GAGTACCCAC TCTGTAACCG GGGACCCAGC 
GCCTACAGCG CCCACAGCGC CCCAACCTCC TTTCCCCCAA GCTCGGCTCA GGCGGTTGAC 
AGCTATGCAA GCGAGGGCCG CTACGGTGGG GGGCTGTCCA GCCCTGCGTT TCAGCAGAAC 
TCCGGCTATC CCGCCCAGCA GCCGCCTTCG ACCCTGGGGG TGCCCTTCCC CAGCTCCGCG 
CCCTCGGGGT ATGCTCCTGC CGCCTGCAGC CCCAGCTACG GGCCTTCTCA GTACTACCCT 
CTGGGTCAAT CAGAAGGAGA CGGAGGCTAT TTTCATCCCT CGAGCTACGG GGCCCAGCTA 
GGGGGCTTGT CCGATGGCTA CGGAGCAGGT GGAGCCGGTC CGGGGCCATA TCCTCCGCAG 
CATCCCCCTT ATGGGAACGA GCAGACCGCG AGCTTTGCAC CGGCCTATGC TGATCTCCTC 
TCCGAGGACA AGGAAACACC CTGCCCTTCA GAACCTAACA CCCCCACGGC CCGGACCTTC 
GACTGGATGA AGGTTAAGAG AAACCCACCC AAGACAGCGA AGGTGTCAGA GCCAGGCCTG 
GGCTCGCCCA GTGGCCTCCG CACCAACTTC ACCACAAGGC AGCTGACAGA ACTGGAAAAG 
GAGTTCCATT TCAACAAGTA CCTGAGCCGG GCCCGGAGGG TGGAGATTGC CGCCACCCTG 
GAGCTCAATG AAACACAGGT CAAGATTTGG TTCCAGAACC GACGAATGAA GCAGAAGAAG 
CGCGAGCGAG AGGAAGGTCG GGTCCCCCCA GCCCCACCAG GCTGCCCCAA GGAGGCAGCT 
GGAGATGCCT CAGACCAGTC GACATGCACC TCCCCGGAAG CCTCACCCAG CTCTGTCACC 
TCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOXB1 ( NM_002144.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002135.2 Homo sapiens homeobox B1 (HOXB1), mRNA.

Price & Availability↑

CloneID	OHu19390
Clone ID Related Accession (Same CDS sequence)	NM_002144.3 , NM_002144.4
Accession Version	NM_002144.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 906bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	homeobox protein Hox-B1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC103702.3 and X16666.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_002144.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X16666.1, CN264618.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2158188 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000239174.7/ ENSP00000355140.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACTATA ATAGGATGAA CTCCTTCTTA GAGTACCCAC TCTGTAACCG GGGACCCAGC 
GCCTACAGCG CCCACAGCGC CCCAACCTCC TTTCCCCCAA GCTCGGCTCA GGCGGTTGAC 
AGCTATGCAA GCGAGGGCCG CTACGGTGGG GGGCTGTCCA GCCCTGCGTT TCAGCAGAAC 
TCCGGCTATC CCGCCCAGCA GCCGCCTTCG ACCCTGGGGG TGCCCTTCCC CAGCTCCGCG 
CCCTCGGGGT ATGCTCCTGC CGCCTGCAGC CCCAGCTACG GGCCTTCTCA GTACTACCCT 
CTGGGTCAAT CAGAAGGAGA CGGAGGCTAT TTTCATCCCT CGAGCTACGG GGCCCAGCTA 
GGGGGCTTGT CCGATGGCTA CGGAGCAGGT GGAGCCGGTC CGGGGCCATA TCCTCCGCAG 
CATCCCCCTT ATGGGAACGA GCAGACCGCG AGCTTTGCAC CGGCCTATGC TGATCTCCTC 
TCCGAGGACA AGGAAACACC CTGCCCTTCA GAACCTAACA CCCCCACGGC CCGGACCTTC 
GACTGGATGA AGGTTAAGAG AAACCCACCC AAGACAGCGA AGGTGTCAGA GCCAGGCCTG 
GGCTCGCCCA GTGGCCTCCG CACCAACTTC ACCACAAGGC AGCTGACAGA ACTGGAAAAG 
GAGTTCCATT TCAACAAGTA CCTGAGCCGG GCCCGGAGGG TGGAGATTGC CGCCACCCTG 
GAGCTCAATG AAACACAGGT CAAGATTTGG TTCCAGAACC GACGAATGAA GCAGAAGAAG 
CGCGAGCGAG AGGAAGGTCG GGTCCCCCCA GCCCCACCAG GCTGCCCCAA GGAGGCAGCT 
GGAGATGCCT CAGACCAGTC GACATGCACC TCCCCGGAAG CCTCACCCAG CTCTGTCACC 
TCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002135.2
CDS	108..1013
Translation	MDYNRMNSFLEYPLCNRGPSAYSAHSAPTSFPPSSAQAVDSYASEGRYGGGLSSPAFQQNSGYPAQQPPSTLGVPFPSSAPSGYAPAACSPSYGPSQYYPLGQSEGDGGYFHPSSYGAQLGGLSDGYGAGGAGPGPYPPQHPPYGNEQTASFAPAYADLLSEDKETPCPSEPNTPTARTFDWMKVKRNPPKTAKVSEPGLGSPSGLRTNFTTRQLTELEKEFHFNKYLSRARRVEIAATLELNETQVKIWFQNRRMKQKKREREEGRVPPAPPGCPKEAAGDASDQSTCTSPEASPSSVTS

Target ORF information:

RefSeq Version	NM_002144.4
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox B1 (HOXB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002144.4

ORF Insert Sequence:

ATGGACTATA ATAGGATGAA CTCCTTCTTA GAGTACCCAC TCTGTAACCG GGGACCCAGC 
GCCTACAGCG CCCACAGCGC CCCAACCTCC TTTCCCCCAA GCTCGGCTCA GGCGGTTGAC 
AGCTATGCAA GCGAGGGCCG CTACGGTGGG GGGCTGTCCA GCCCTGCGTT TCAGCAGAAC 
TCCGGCTATC CCGCCCAGCA GCCGCCTTCG ACCCTGGGGG TGCCCTTCCC CAGCTCCGCG 
CCCTCGGGGT ATGCTCCTGC CGCCTGCAGC CCCAGCTACG GGCCTTCTCA GTACTACCCT 
CTGGGTCAAT CAGAAGGAGA CGGAGGCTAT TTTCATCCCT CGAGCTACGG GGCCCAGCTA 
GGGGGCTTGT CCGATGGCTA CGGAGCAGGT GGAGCCGGTC CGGGGCCATA TCCTCCGCAG 
CATCCCCCTT ATGGGAACGA GCAGACCGCG AGCTTTGCAC CGGCCTATGC TGATCTCCTC 
TCCGAGGACA AGGAAACACC CTGCCCTTCA GAACCTAACA CCCCCACGGC CCGGACCTTC 
GACTGGATGA AGGTTAAGAG AAACCCACCC AAGACAGCGA AGGTGTCAGA GCCAGGCCTG 
GGCTCGCCCA GTGGCCTCCG CACCAACTTC ACCACAAGGC AGCTGACAGA ACTGGAAAAG 
GAGTTCCATT TCAACAAGTA CCTGAGCCGG GCCCGGAGGG TGGAGATTGC CGCCACCCTG 
GAGCTCAATG AAACACAGGT CAAGATTTGG TTCCAGAACC GACGAATGAA GCAGAAGAAG 
CGCGAGCGAG AGGAAGGTCG GGTCCCCCCA GCCCCACCAG GCTGCCCCAA GGAGGCAGCT 
GGAGATGCCT CAGACCAGTC GACATGCACC TCCCCGGAAG CCTCACCCAG CTCTGTCACC 
TCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel homozygous HOXB1 mutation in a Turkish family with hereditary congenital facial paresis.
Brain & development39(2)166-170(2017 Feb)
Sahin Y,G?ng?r O,Ayaz A,G?ng?r G,Sahin B,Yaykasli K,Ceylaner S

Homozygous HOXB1 loss-of-function mutation in a large family with hereditary congenital facial paresis.
American journal of medical genetics. Part A170(7)1813-9(2016 Jul)
Vogel M,Velleuer E,Schmidt-Jim?nez LF,Mayatepek E,Borkhardt A,Alawi M,Kutsche K,Kort?m F

HOXB1 Is a Tumor Suppressor Gene Regulated by miR-3175 in Glioma.
PloS one10(11)e0142387(2015)
Han L,Liu D,Li Z,Tian N,Han Z,Wang G,Fu Y,Guo Z,Zhu Z,Du C,Tian Y

HOXB1 founder mutation in humans recapitulates the phenotype of Hoxb1-/- mice.
American journal of human genetics91(1)171-9(2012 Jul)
Webb BD,Shaaban S,Gaspar H,Cunha LF,Schubert CR,Hao K,Robson CD,Chan WM,Andrews C,MacKinnon S,Oystreck DT,Hunter DG,Iacovelli AJ,Ye X,Camminady A,Engle EC,Jabs EW

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HOXB1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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