HOXA7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HOXA7
Entrez Gene ID	3204
Full Name	homeobox A7
Synonyms	ANTP,HOX1,HOX1.1,HOX1A
General protein information	Preferred Names homeobox A7 Names homeobox protein Hox-A7 homeo box A7 homeobox protein HOX-1A homeobox protein Hox 1.1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p15.2
Summary	In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. [provided by RefSeq, Jul 2008].
Disorder MIM:	142950

mRNA and Protein(s)

mRNA	Protein	Name
NM_006896.3	NP_008827.2	homeobox protein Hox-A7
NM_006896.4	NP_008827.2	homeobox protein Hox-A7

Pathways from BioSystems

Homologies

Homo sapiens (human)	HOXA7	NP_008827.2
Pan troglodytes (chimpanzee)	HOXA7	NP_001129067.1
Gallus gallus (chicken)	HOXA7	NP_989926.1
Gallus gallus (chicken)	LOC100858856	XP_003640779.1
Gallus gallus (chicken)	LOC100858514	XP_003640750.1
Mus musculus (house mouse)	Hoxa7	NP_034585.1
Rattus norvegicus (Norway rat)	Hoxa9	NP_001102703.2
Rattus norvegicus (Norway rat)	LOC100909678	XP_006236591.1
Bos taurus (cattle)	HOXA7	XP_002686901.1
Rattus norvegicus (Norway rat)	LOC100911622	XP_003752229.1
Xenopus tropicalis (tropical clawed frog)	hoxa7	XP_004915455.1
Canis lupus familiaris (dog)	HOXA7	XP_864678.2

Gene Ontology
Bibliography

Related articles in PubMed

The expression and significance of the HOXA7 gene in oral squamous cell carcinoma.
Duan X, Chen H, Ma H, Song Y
Journal of oral science59(3)329-335(2017 Sep)

HOXA7 plays a critical role in metastasis of liver cancer associated with activation of Snail.
Tang B, Qi G, Sun X, Tang F, Yuan S, Wang Z, Liang X, Li B, Yu S, Liu J, Huang Q, Wei Y, Zhai R, Lei B, Guo X, He S
Molecular cancer15(1)57(2016 09)

All-trans retinoic acid inhibits HOXA7 expression in leukemia cell NB4.
Guo Q, Jiang Q, Liu W, Bai Y
Cellular and molecular biology (Noisy-le-Grand, France)62(1)63-6(2016 Jan)

HOXA7 stimulates human hepatocellular carcinoma proliferation through cyclin E1/CDK2.
Li Y, Yang XH, Fang SJ, Qin CF, Sun RL, Liu ZY, Jiang BY, Wu X, Li G
Oncology reports33(2)990-6(2015 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results showed that HOXA7 was highly expressed in liver cancer cells which related with poorer prognosis. Its overexpression significantly promoted invasion and metastasis of liver cancer cells by activating Snail expression.
Title: HOXA7 plays a critical role in metastasis of liver cancer associated with activation of Snail.

HOXA7 might be a new gene candidate that influences the maturation of acute myeloid leukemia.
Title: All-trans retinoic acid inhibits HOXA7 expression in leukemia cell NB4.

HOXA7 promotes cell proliferation, and these changes were mediated by cyclin E1/CDK2
Title: HOXA7 stimulates human hepatocellular carcinoma proliferation through cyclin E1/CDK2.

variants in the HOXA7 and HOXA9 genes are not common in Chinese women with Mullerian duct abnormalities
Title: Mutation screening of HOXA7 and HOXA9 genes in Chinese women with M?llerian duct abnormalities.

This finding contributes to our understanding of the role HOXA7 plays in regulating the proliferation of ER-positive cancer cells.
Title: Homeobox A7 stimulates breast cancer cell proliferation by up-regulating estrogen receptor-alpha.

The following HOXA7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HOXA7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01103	NM_006896.4 Latest version!	Homo sapiens homeobox A7 (HOXA7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
View Old Accession Versions >>
OHu01103	NM_006896.3	Homo sapiens homeobox A7 (HOXA7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HOXA7 ( NM_006896.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_008827.2 Homo sapiens homeobox A7 (HOXA7), mRNA.

Price & Availability↑

CloneID	OHu01103
Clone ID Related Accession (Same CDS sequence)	NM_006896.3 , NM_006896.4
Accession Version	NM_006896.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 693bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	homeobox protein Hox-A7
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC004080.2 and AF026397.1. On Dec 30, 2005 this sequence version replaced NM_006896.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF026397.1, SRR1803614.291174.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGAGTTCTT CGTATTATGT GAACGCGCTT TTTAGCAAAT ATACGGCGGG GGCTTCTCTG 
TTCCAAAATG CCGAGCCGAC TTCTTGCTCC TTTGCTCCCA ACTCACAGAG AAGCGGCTAC 
GGGGCGGGCG CCGGCGCCTT CGCCTCGACC GTTCCGGGCT TATACAATGT CAACAGCCCC 
CTTTATCAGA GCCCCTTTGC GTCCGGCTAC GGCCTGGGCG CCGACGCCTA CGGCAACCTG 
CCCTGCGCCT CCTACGACCA AAACATCCCC GGGCTCTGCA GTGACCTCGC CAAAGGCGCC 
TGCGACAAGA CGGACGAGGG CGCGCTGCAT GGCGCGGCTG AGGCCAATTT CCGCATCTAC 
CCCTGGATGC GGTCTTCAGG ACCTGACAGG AAGCGGGGCC GCCAGACCTA CACGCGCTAC 
CAGACGCTGG AGCTGGAGAA GGAGTTCCAC TTCAACCGCT ACCTGACGCG GCGCCGCCGC 
ATTGAAATCG CCCACGCGCT CTGCCTCACC GAGCGCCAGA TTAAGATCTG GTTCCAGAAC 
CGCCGCATGA AGTGGAAGAA AGAGCATAAG GACGAAGGTC CGACTGCCGC CGCAGCTCCC 
GAGGGCGCCG TGCCCTCTGC CGCCGCCACT GCTGCCGCGG ACAAGGCCGA CGAGGAGGAC 
GATGATGAAG AAGAGGAAGA CGAGGAGGAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008827.2
CDS	133..825
Translation	MSSSYYVNALFSKYTAGASLFQNAEPTSCSFAPNSQRSGYGAGAGAFASTVPGLYNVNSPLYQSPFASGYGLGADAYGNLPCASYDQNIPGLCSDLAKGACDKTDEGALHGAAEANFRIYPWMRSSGPDRKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKDEGPTAAAAPEGAVPSAAATAAADKADEEDDDEEEEDEEE

Target ORF information:

RefSeq Version	NM_006896.3
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox A7 (HOXA7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006896.3

ORF Insert Sequence:

ATGAGTTCTT CGTATTATGT GAACGCGCTT TTTAGCAAAT ATACGGCGGG GGCTTCTCTG 
TTCCAAAATG CCGAGCCGAC TTCTTGCTCC TTTGCTCCCA ACTCACAGAG AAGCGGCTAC 
GGGGCGGGCG CCGGCGCCTT CGCCTCGACC GTTCCGGGCT TATACAATGT CAACAGCCCC 
CTTTATCAGA GCCCCTTTGC GTCCGGCTAC GGCCTGGGCG CCGACGCCTA CGGCAACCTG 
CCCTGCGCCT CCTACGACCA AAACATCCCC GGGCTCTGCA GTGACCTCGC CAAAGGCGCC 
TGCGACAAGA CGGACGAGGG CGCGCTGCAT GGCGCGGCTG AGGCCAATTT CCGCATCTAC 
CCCTGGATGC GGTCTTCAGG ACCTGACAGG AAGCGGGGCC GCCAGACCTA CACGCGCTAC 
CAGACGCTGG AGCTGGAGAA GGAGTTCCAC TTCAACCGCT ACCTGACGCG GCGCCGCCGC 
ATTGAAATCG CCCACGCGCT CTGCCTCACC GAGCGCCAGA TTAAGATCTG GTTCCAGAAC 
CGCCGCATGA AGTGGAAGAA AGAGCATAAG GACGAAGGTC CGACTGCCGC CGCAGCTCCC 
GAGGGCGCCG TGCCCTCTGC CGCCGCCACT GCTGCCGCGG ACAAGGCCGA CGAGGAGGAC 
GATGATGAAG AAGAGGAAGA CGAGGAGGAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOXA7 ( NM_006896.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_008827.2 Homo sapiens homeobox A7 (HOXA7), mRNA.

Price & Availability↑

CloneID	OHu01103
Clone ID Related Accession (Same CDS sequence)	NM_006896.3 , NM_006896.4
Accession Version	NM_006896.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 693bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	homeobox protein Hox-A7
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC004080.2 and AF026397.1. On Nov 23, 2018 this sequence version replaced NM_006896.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1100454.1, SRR1803614.291174.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000242159.5/ ENSP00000242159.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGTTCTT CGTATTATGT GAACGCGCTT TTTAGCAAAT ATACGGCGGG GGCTTCTCTG 
TTCCAAAATG CCGAGCCGAC TTCTTGCTCC TTTGCTCCCA ACTCACAGAG AAGCGGCTAC 
GGGGCGGGCG CCGGCGCCTT CGCCTCGACC GTTCCGGGCT TATACAATGT CAACAGCCCC 
CTTTATCAGA GCCCCTTTGC GTCCGGCTAC GGCCTGGGCG CCGACGCCTA CGGCAACCTG 
CCCTGCGCCT CCTACGACCA AAACATCCCC GGGCTCTGCA GTGACCTCGC CAAAGGCGCC 
TGCGACAAGA CGGACGAGGG CGCGCTGCAT GGCGCGGCTG AGGCCAATTT CCGCATCTAC 
CCCTGGATGC GGTCTTCAGG ACCTGACAGG AAGCGGGGCC GCCAGACCTA CACGCGCTAC 
CAGACGCTGG AGCTGGAGAA GGAGTTCCAC TTCAACCGCT ACCTGACGCG GCGCCGCCGC 
ATTGAAATCG CCCACGCGCT CTGCCTCACC GAGCGCCAGA TTAAGATCTG GTTCCAGAAC 
CGCCGCATGA AGTGGAAGAA AGAGCATAAG GACGAAGGTC CGACTGCCGC CGCAGCTCCC 
GAGGGCGCCG TGCCCTCTGC CGCCGCCACT GCTGCCGCGG ACAAGGCCGA CGAGGAGGAC 
GATGATGAAG AAGAGGAAGA CGAGGAGGAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008827.2
CDS	131..823
Translation	MSSSYYVNALFSKYTAGASLFQNAEPTSCSFAPNSQRSGYGAGAGAFASTVPGLYNVNSPLYQSPFASGYGLGADAYGNLPCASYDQNIPGLCSDLAKGACDKTDEGALHGAAEANFRIYPWMRSSGPDRKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKDEGPTAAAAPEGAVPSAAATAAADKADEEDDDEEEEDEEE

Target ORF information:

RefSeq Version	NM_006896.4
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox A7 (HOXA7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006896.4

ORF Insert Sequence:

ATGAGTTCTT CGTATTATGT GAACGCGCTT TTTAGCAAAT ATACGGCGGG GGCTTCTCTG 
TTCCAAAATG CCGAGCCGAC TTCTTGCTCC TTTGCTCCCA ACTCACAGAG AAGCGGCTAC 
GGGGCGGGCG CCGGCGCCTT CGCCTCGACC GTTCCGGGCT TATACAATGT CAACAGCCCC 
CTTTATCAGA GCCCCTTTGC GTCCGGCTAC GGCCTGGGCG CCGACGCCTA CGGCAACCTG 
CCCTGCGCCT CCTACGACCA AAACATCCCC GGGCTCTGCA GTGACCTCGC CAAAGGCGCC 
TGCGACAAGA CGGACGAGGG CGCGCTGCAT GGCGCGGCTG AGGCCAATTT CCGCATCTAC 
CCCTGGATGC GGTCTTCAGG ACCTGACAGG AAGCGGGGCC GCCAGACCTA CACGCGCTAC 
CAGACGCTGG AGCTGGAGAA GGAGTTCCAC TTCAACCGCT ACCTGACGCG GCGCCGCCGC 
ATTGAAATCG CCCACGCGCT CTGCCTCACC GAGCGCCAGA TTAAGATCTG GTTCCAGAAC 
CGCCGCATGA AGTGGAAGAA AGAGCATAAG GACGAAGGTC CGACTGCCGC CGCAGCTCCC 
GAGGGCGCCG TGCCCTCTGC CGCCGCCACT GCTGCCGCGG ACAAGGCCGA CGAGGAGGAC 
GATGATGAAG AAGAGGAAGA CGAGGAGGAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The expression and significance of the HOXA7 gene in oral squamous cell carcinoma.
Journal of oral science59(3)329-335(2017 Sep)
Duan X,Chen H,Ma H,Song Y

HOXA7 plays a critical role in metastasis of liver cancer associated with activation of Snail.
Molecular cancer15(1)57(2016 09)
Tang B,Qi G,Sun X,Tang F,Yuan S,Wang Z,Liang X,Li B,Yu S,Liu J,Huang Q,Wei Y,Zhai R,Lei B,Guo X,He S

All-trans retinoic acid inhibits HOXA7 expression in leukemia cell NB4.
Cellular and molecular biology (Noisy-le-Grand, France)62(1)63-6(2016 Jan)
Guo Q,Jiang Q,Liu W,Bai Y

HOXA7 stimulates human hepatocellular carcinoma proliferation through cyclin E1/CDK2.
Oncology reports33(2)990-6(2015 Feb)
Li Y,Yang XH,Fang SJ,Qin CF,Sun RL,Liu ZY,Jiang BY,Wu X,Li G

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HOXA7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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