FOXA3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FOXA3
Entrez Gene ID	3171
Full Name	forkhead box A3
Synonyms	FKHH3,HNF3G,TCF3G
General protein information	Preferred Names forkhead box A3 Names hepatocyte nuclear factor 3-gamma HNF-3-gamma HNF-3G TCF-3G fork head-related protein FKH H3 forkhead box protein A3 transcription factor 3G
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.32
Summary	This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq, Jul 2008].
Disorder MIM:	602295

mRNA and Protein(s)

mRNA	Protein	Name
NM_004497.3	NP_004488.2	hepatocyte nuclear factor 3-gamma
NM_004497.2	NP_004488.2	hepatocyte nuclear factor 3-gamma

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	FOXA3	XP_541549.3
Mus musculus (house mouse)	Foxa3	NP_032286.1
Pan troglodytes (chimpanzee)	FOXA3	XP_512763.2
Rattus norvegicus (Norway rat)	Foxa3	NP_058773.1
Homo sapiens (human)	FOXA3	NP_004488.2
	FOXA3	XP_001111513.1
Bos taurus (cattle)	FOXA3	NP_001028291.1
Danio rerio (zebrafish)	foxa3	NP_571374.1

Gene Ontology
Bibliography

Related articles in PubMed

Analysis of variants and mutations in the human winged helix FOXA3 gene and associations with metabolic traits.
Adler-Wailes DC, Alberobello AT, Ma X, Hugendubler L, Stern EA, Mou Z, Han JC, Kim PW, Sumner AE, Yanovski JA, Mueller E
International journal of obesity (2005)39(6)888-92(2015 Jun)

Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity.
Chen G, Korfhagen TR, Karp CL, Impey S, Xu Y, Randell SH, Kitzmiller J, Maeda Y, Haitchi HM, Sridharan A, Senft AP, Whitsett JA
American journal of respiratory and critical care medicine189(3)301-13(2014 Feb)

The winged helix transcription factor Foxa3 regulates adipocyte differentiation and depot-selective fat tissue expansion.
Xu L, Panel V, Ma X, Du C, Hugendubler L, Gavrilova O, Liu A, McLaughlin T, Kaestner KH, Mueller E
Molecular and cellular biology33(17)3392-9(2013 Sep)

[Caloric restriction suppresses endothelial cells senescence via down-regulation of NOX4 induced by HNF3?].
Liu Q, Li H, Chen HH, Wang J
Yi chuan = Hereditas34(5)573-83(2012 May)

Genetic predictors of interindividual variability in hepatic CYP3A4 expression.
Lamba V, Panetta JC, Strom S, Schuetz EG
The Journal of pharmacology and experimental therapeutics332(3)1088-99(2010 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our study identified novel FOXA3 variants and mutations, assessed the adipogenic capacity of two novel missense alterations in vitro and demonstrated for the first time the associations between FOXA3 SNP rs28666870 with metabolic phenotypes in humans.
Title: Analysis of variants and mutations in the human winged helix FOXA3 gene and associations with metabolic traits.

Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity in asthma and chronic obstructive pulmonary disease.
Title: Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity.

In obese subjects, FOXA3 is differentially expressed in visceral and subcutaneous adipose depots.
Title: The winged helix transcription factor Foxa3 regulates adipocyte differentiation and depot-selective fat tissue expansion.

low caloric intake decreases the production of intracellular reactive oxygen species and suppresses endothelial cells senescence through promoting HNF3gamma binging to NOX4 promoter region and inhibiting NOX4 gene expression induced by up-regulated HNF3gamma
Title: [Caloric restriction suppresses endothelial cells senescence via down-regulation of NOX4 induced by HNF3?].

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic predictors of interindividual variability in hepatic CYP3A4 expression.

The following FOXA3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FOXA3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25423	NM_004497.3 Latest version!	Homo sapiens forkhead box A3 (FOXA3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu25423	NM_004497.2	Homo sapiens forkhead box A3 (FOXA3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FOXA3 ( NM_004497.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004488.2 Homo sapiens forkhead box A3 (FOXA3), mRNA.

Price & Availability↑

CloneID	OHu25423
Clone ID Related Accession (Same CDS sequence)	NM_004497.3 , NM_004497.2
Accession Version	NM_004497.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1053bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	hepatocyte nuclear factor 3-gamma
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC016024.1. On Nov 23, 2018 this sequence version replaced NM_004497.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016024.1, AK223473.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000302177.3/ ENSP00000304004.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGGGCT CAGTGAAGAT GGAGGCCCAT GACCTGGCCG AGTGGAGCTA CTACCCGGAG 
GCGGGCGAGG TCTACTCGCC GGTGACCCCA GTGCCCACCA TGGCCCCCCT CAACTCCTAC 
ATGACCCTGA ATCCTCTAAG CTCTCCCTAT CCCCCTGGGG GGCTCCCTGC CTCCCCACTG 
CCCTCAGGAC CCCTGGCACC CCCAGCACCT GCAGCCCCCC TGGGGCCCAC TTTCCCAGGC 
CTGGGTGTCA GCGGTGGCAG CAGCAGCTCC GGGTACGGGG CCCCGGGTCC TGGGCTGGTG 
CACGGGAAGG AGATGCCGAA GGGGTATCGG CGGCCCCTGG CACACGCCAA GCCACCGTAT 
TCCTATATCT CACTCATCAC CATGGCCATC CAGCAGGCGC CGGGCAAGAT GCTGACCTTG 
AGTGAAATCT ACCAGTGGAT CATGGACCTC TTCCCTTACT ACCGGGAGAA TCAGCAGCGC 
TGGCAGAACT CCATTCGCCA CTCGCTGTCT TTCAACGACT GCTTCGTCAA GGTGGCGCGT 
TCCCCAGACA AGCCTGGCAA GGGCTCCTAC TGGGCCCTAC ACCCCAGCTC AGGGAACATG 
TTTGAGAATG GCTGCTACCT GCGCCGCCAG AAACGCTTCA AGCTGGAGGA GAAGGTGAAA 
AAAGGGGGCA GCGGGGCTGC CACCACCACC AGGAACGGGA CAGGGTCTGC TGCCTCGACC 
ACCACCCCCG CGGCCACAGT CACCTCCCCG CCCCAGCCCC CGCCTCCAGC CCCTGAGCCT 
GAGGCCCAGG GCGGGGAAGA TGTGGGGGCT CTGGACTGTG GCTCACCCGC TTCCTCCACA 
CCCTATTTCA CTGGCCTGGA GCTCCCAGGG GAGCTGAAGC TGGACGCGCC CTACAACTTC 
AACCACCCTT TCTCCATCAA CAACCTAATG TCAGAACAGA CACCAGCACC TCCCAAACTG 
GACGTGGGGT TTGGGGGCTA CGGGGCTGAA GGTGGGGAGC CTGGAGTCTA CTACCAGGGC 
CTCTATTCCC GCTCTTTGCT TAATGCATCC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004488.2
CDS	132..1184
Translation	MLGSVKMEAHDLAEWSYYPEAGEVYSPVTPVPTMAPLNSYMTLNPLSSPYPPGGLPASPLPSGPLAPPAPAAPLGPTFPGLGVSGGSSSSGYGAPGPGLVHGKEMPKGYRRPLAHAKPPYSYISLITMAIQQAPGKMLTLSEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPSSGNMFENGCYLRRQKRFKLEEKVKKGGSGAATTTRNGTGSAASTTTPAATVTSPPQPPPPAPEPEAQGGEDVGALDCGSPASSTPYFTGLELPGELKLDAPYNFNHPFSINNLMSEQTPAPPKLDVGFGGYGAEGGEPGVYYQGLYSRSLLNAS

Target ORF information:

RefSeq Version	NM_004497.3
Organism	Homo sapiens(human)
Definition	Homo sapiens forkhead box A3 (FOXA3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004497.3

ORF Insert Sequence:

ATGCTGGGCT CAGTGAAGAT GGAGGCCCAT GACCTGGCCG AGTGGAGCTA CTACCCGGAG 
GCGGGCGAGG TCTACTCGCC GGTGACCCCA GTGCCCACCA TGGCCCCCCT CAACTCCTAC 
ATGACCCTGA ATCCTCTAAG CTCTCCCTAT CCCCCTGGGG GGCTCCCTGC CTCCCCACTG 
CCCTCAGGAC CCCTGGCACC CCCAGCACCT GCAGCCCCCC TGGGGCCCAC TTTCCCAGGC 
CTGGGTGTCA GCGGTGGCAG CAGCAGCTCC GGGTACGGGG CCCCGGGTCC TGGGCTGGTG 
CACGGGAAGG AGATGCCGAA GGGGTATCGG CGGCCCCTGG CACACGCCAA GCCACCGTAT 
TCCTATATCT CACTCATCAC CATGGCCATC CAGCAGGCGC CGGGCAAGAT GCTGACCTTG 
AGTGAAATCT ACCAGTGGAT CATGGACCTC TTCCCTTACT ACCGGGAGAA TCAGCAGCGC 
TGGCAGAACT CCATTCGCCA CTCGCTGTCT TTCAACGACT GCTTCGTCAA GGTGGCGCGT 
TCCCCAGACA AGCCTGGCAA GGGCTCCTAC TGGGCCCTAC ACCCCAGCTC AGGGAACATG 
TTTGAGAATG GCTGCTACCT GCGCCGCCAG AAACGCTTCA AGCTGGAGGA GAAGGTGAAA 
AAAGGGGGCA GCGGGGCTGC CACCACCACC AGGAACGGGA CAGGGTCTGC TGCCTCGACC 
ACCACCCCCG CGGCCACAGT CACCTCCCCG CCCCAGCCCC CGCCTCCAGC CCCTGAGCCT 
GAGGCCCAGG GCGGGGAAGA TGTGGGGGCT CTGGACTGTG GCTCACCCGC TTCCTCCACA 
CCCTATTTCA CTGGCCTGGA GCTCCCAGGG GAGCTGAAGC TGGACGCGCC CTACAACTTC 
AACCACCCTT TCTCCATCAA CAACCTAATG TCAGAACAGA CACCAGCACC TCCCAAACTG 
GACGTGGGGT TTGGGGGCTA CGGGGCTGAA GGTGGGGAGC CTGGAGTCTA CTACCAGGGC 
CTCTATTCCC GCTCTTTGCT TAATGCATCC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FOXA3 ( NM_004497.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004488.2 Homo sapiens forkhead box A3 (FOXA3), mRNA.

Price & Availability↑

CloneID	OHu25423
Clone ID Related Accession (Same CDS sequence)	NM_004497.3 , NM_004497.2
Accession Version	NM_004497.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1053bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	hepatocyte nuclear factor 3-gamma
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC016024.1. On Nov 3, 2002 this sequence version replaced NM_004497.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016024.1, AK223473.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGGGCT CAGTGAAGAT GGAGGCCCAT GACCTGGCCG AGTGGAGCTA CTACCCGGAG 
GCGGGCGAGG TCTACTCGCC GGTGACCCCA GTGCCCACCA TGGCCCCCCT CAACTCCTAC 
ATGACCCTGA ATCCTCTAAG CTCTCCCTAT CCCCCTGGGG GGCTCCCTGC CTCCCCACTG 
CCCTCAGGAC CCCTGGCACC CCCAGCACCT GCAGCCCCCC TGGGGCCCAC TTTCCCAGGC 
CTGGGTGTCA GCGGTGGCAG CAGCAGCTCC GGGTACGGGG CCCCGGGTCC TGGGCTGGTG 
CACGGGAAGG AGATGCCGAA GGGGTATCGG CGGCCCCTGG CACACGCCAA GCCACCGTAT 
TCCTATATCT CACTCATCAC CATGGCCATC CAGCAGGCGC CGGGCAAGAT GCTGACCTTG 
AGTGAAATCT ACCAGTGGAT CATGGACCTC TTCCCTTACT ACCGGGAGAA TCAGCAGCGC 
TGGCAGAACT CCATTCGCCA CTCGCTGTCT TTCAACGACT GCTTCGTCAA GGTGGCGCGT 
TCCCCAGACA AGCCTGGCAA GGGCTCCTAC TGGGCCCTAC ACCCCAGCTC AGGGAACATG 
TTTGAGAATG GCTGCTACCT GCGCCGCCAG AAACGCTTCA AGCTGGAGGA GAAGGTGAAA 
AAAGGGGGCA GCGGGGCTGC CACCACCACC AGGAACGGGA CAGGGTCTGC TGCCTCGACC 
ACCACCCCCG CGGCCACAGT CACCTCCCCG CCCCAGCCCC CGCCTCCAGC CCCTGAGCCT 
GAGGCCCAGG GCGGGGAAGA TGTGGGGGCT CTGGACTGTG GCTCACCCGC TTCCTCCACA 
CCCTATTTCA CTGGCCTGGA GCTCCCAGGG GAGCTGAAGC TGGACGCGCC CTACAACTTC 
AACCACCCTT TCTCCATCAA CAACCTAATG TCAGAACAGA CACCAGCACC TCCCAAACTG 
GACGTGGGGT TTGGGGGCTA CGGGGCTGAA GGTGGGGAGC CTGGAGTCTA CTACCAGGGC 
CTCTATTCCC GCTCTTTGCT TAATGCATCC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004488.2
CDS	198..1250
Translation	MLGSVKMEAHDLAEWSYYPEAGEVYSPVTPVPTMAPLNSYMTLNPLSSPYPPGGLPASPLPSGPLAPPAPAAPLGPTFPGLGVSGGSSSSGYGAPGPGLVHGKEMPKGYRRPLAHAKPPYSYISLITMAIQQAPGKMLTLSEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPSSGNMFENGCYLRRQKRFKLEEKVKKGGSGAATTTRNGTGSAASTTTPAATVTSPPQPPPPAPEPEAQGGEDVGALDCGSPASSTPYFTGLELPGELKLDAPYNFNHPFSINNLMSEQTPAPPKLDVGFGGYGAEGGEPGVYYQGLYSRSLLNAS

Target ORF information:

RefSeq Version	NM_004497.2
Organism	Homo sapiens(human)
Definition	Homo sapiens forkhead box A3 (FOXA3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004497.2

ORF Insert Sequence:

ATGCTGGGCT CAGTGAAGAT GGAGGCCCAT GACCTGGCCG AGTGGAGCTA CTACCCGGAG 
GCGGGCGAGG TCTACTCGCC GGTGACCCCA GTGCCCACCA TGGCCCCCCT CAACTCCTAC 
ATGACCCTGA ATCCTCTAAG CTCTCCCTAT CCCCCTGGGG GGCTCCCTGC CTCCCCACTG 
CCCTCAGGAC CCCTGGCACC CCCAGCACCT GCAGCCCCCC TGGGGCCCAC TTTCCCAGGC 
CTGGGTGTCA GCGGTGGCAG CAGCAGCTCC GGGTACGGGG CCCCGGGTCC TGGGCTGGTG 
CACGGGAAGG AGATGCCGAA GGGGTATCGG CGGCCCCTGG CACACGCCAA GCCACCGTAT 
TCCTATATCT CACTCATCAC CATGGCCATC CAGCAGGCGC CGGGCAAGAT GCTGACCTTG 
AGTGAAATCT ACCAGTGGAT CATGGACCTC TTCCCTTACT ACCGGGAGAA TCAGCAGCGC 
TGGCAGAACT CCATTCGCCA CTCGCTGTCT TTCAACGACT GCTTCGTCAA GGTGGCGCGT 
TCCCCAGACA AGCCTGGCAA GGGCTCCTAC TGGGCCCTAC ACCCCAGCTC AGGGAACATG 
TTTGAGAATG GCTGCTACCT GCGCCGCCAG AAACGCTTCA AGCTGGAGGA GAAGGTGAAA 
AAAGGGGGCA GCGGGGCTGC CACCACCACC AGGAACGGGA CAGGGTCTGC TGCCTCGACC 
ACCACCCCCG CGGCCACAGT CACCTCCCCG CCCCAGCCCC CGCCTCCAGC CCCTGAGCCT 
GAGGCCCAGG GCGGGGAAGA TGTGGGGGCT CTGGACTGTG GCTCACCCGC TTCCTCCACA 
CCCTATTTCA CTGGCCTGGA GCTCCCAGGG GAGCTGAAGC TGGACGCGCC CTACAACTTC 
AACCACCCTT TCTCCATCAA CAACCTAATG TCAGAACAGA CACCAGCACC TCCCAAACTG 
GACGTGGGGT TTGGGGGCTA CGGGGCTGAA GGTGGGGAGC CTGGAGTCTA CTACCAGGGC 
CTCTATTCCC GCTCTTTGCT TAATGCATCC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Analysis of variants and mutations in the human winged helix FOXA3 gene and associations with metabolic traits.
International journal of obesity (2005)39(6)888-92(2015 Jun)
Adler-Wailes DC,Alberobello AT,Ma X,Hugendubler L,Stern EA,Mou Z,Han JC,Kim PW,Sumner AE,Yanovski JA,Mueller E

Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity.
American journal of respiratory and critical care medicine189(3)301-13(2014 Feb)
Chen G,Korfhagen TR,Karp CL,Impey S,Xu Y,Randell SH,Kitzmiller J,Maeda Y,Haitchi HM,Sridharan A,Senft AP,Whitsett JA

The winged helix transcription factor Foxa3 regulates adipocyte differentiation and depot-selective fat tissue expansion.
Molecular and cellular biology33(17)3392-9(2013 Sep)
Xu L,Panel V,Ma X,Du C,Hugendubler L,Gavrilova O,Liu A,McLaughlin T,Kaestner KH,Mueller E

[Caloric restriction suppresses endothelial cells senescence via down-regulation of NOX4 induced by HNF3?].
Yi chuan = Hereditas34(5)573-83(2012 May)
Liu Q,Li H,Chen HH,Wang J

Genetic predictors of interindividual variability in hepatic CYP3A4 expression.
The Journal of pharmacology and experimental therapeutics332(3)1088-99(2010 Mar)
Lamba V,Panetta JC,Strom S,Schuetz EG

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FOXA3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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