HMX2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HMX2
Entrez Gene ID	3167
Full Name	H6 family homeobox 2
Synonyms	H6L,Nkx5-2
General protein information	Preferred Names H6 family homeobox 2 Names homeobox protein HMX2 homeo box (H6 family) 2 homeobox protein H6 family member 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q26.13
Summary	The protein encoded by this gene is a member of the NKL homeobox family of transcription factors. Members in this family are of ancient origin and play an important role in organ development during embryogenesis. A related mouse protein plays a role in patterning of inner ear structures. In humans, variations in a region containing this gene have been associated with inner ear malformations, vestibular dysfunction, and hearing loss. [provided by RefSeq, Aug 2012].
Disorder MIM:	600647

mRNA and Protein(s)

mRNA	Protein	Name
NM_005519.1	NP_005510.1	homeobox protein HMX2
XM_005269743.3	XP_005269800.1	homeobox protein HMX2 isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Hmx2	NP_666110.1
Gallus gallus (chicken)	HMX2	XP_001231298.2
	HMX2	XP_002805890.1
Canis lupus familiaris (dog)	HMX2	XP_544055.2
Rattus norvegicus (Norway rat)	Hmx2	NP_001099773.1
Homo sapiens (human)	HMX2	NP_005510.1
Bos taurus (cattle)	HMX2	NP_001179544.1
Danio rerio (zebrafish)	hmx2	NP_001108570.1
Xenopus tropicalis (tropical clawed frog)	hmx2	XP_002937849.1
Pan troglodytes (chimpanzee)	HMX2	XP_508091.2

Gene Ontology
Bibliography

Related articles in PubMed

A census of human transcription factors: function, expression and evolution.
Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM
Nature reviews. Genetics10(4)252-63(2009 04)

Molecular (SNP) analyses of overlapping hemizygous deletions of 10q25.3 to 10qter in four patients: evidence for HMX2 and HMX3 as candidate genes in hearing and vestibular function.
Miller ND, Nance MA, Wohler ES, Hoover-Fong JE, Lisi E, Thomas GH, Pevsner J
American journal of medical genetics. Part A149A(4)669-80(2009 Feb)

A whole-genome scan for 24-hour respiration rate: a major locus at 10q26 influences respiration during sleep.
de Geus EJ, Posthuma D, Kupper N, van den Berg M, Willemsen G, Beem AL, Slagboom PE, Boomsma DI
American journal of human genetics76(1)100-11(2005 Jan)

Refined mapping of a gene for split hand-split foot malformation (SHFM3) on chromosome 10q25.
Raas-Rothschild A, Manouvrier S, Gonzales M, Farriaux JP, Lyonnet S, Munnich A
Journal of medical genetics33(12)996-1001(1996 Dec)

Phylogenetic conservation and physical mapping of members of the H6 homeobox gene family.
Stadler HS, Murray JC, Leysens NJ, Goodfellow PJ, Solursh M
Mammalian genome : official journal of the International Mammalian Genome Society6(6)383-8(1995 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

propose that hemizygous deletions of HMX2 and HMX3 are responsible for inner ear malformations, vestibular dysfunction, and congenital sensorineural hearing loss
Title: Molecular (SNP) analyses of overlapping hemizygous deletions of 10q25.3 to 10qter in four patients: evidence for HMX2 and HMX3 as candidate genes in hearing and vestibular function.

The following HMX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HMX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu29733	NM_005519.1 Latest version!	Homo sapiens H6 family homeobox 2 (HMX2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu29733	XM_005269743.3 Latest version!	Homo sapiens H6 family homeobox 2 (HMX2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HMX2 ( NM_005519.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_005510.1 Homo sapiens H6 family homeobox 2 (HMX2), mRNA.

Price & Availability↑

CloneID	OHu29733
Clone ID Related Accession (Same CDS sequence)	NM_005519.1 , XM_005269743.3
Accession Version	NM_005519.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Homo sapiens(human)
Product	homeobox protein HMX2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ929484.1 and AC012391.10. On Jul 13, 2005 this sequence version replaced XM_370580.2. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.148280.1, SRR1163658.176619.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2145774 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGCAGCA AAGAAGATGC GGGCAAGGGG TGTCCGGCGG CCGGTGGCGT CTCCAGCTTC 
ACCATCCAGT CCATCCTGGG CGGGGGCCCC TCGGAGGCAC CGCGGGAGCC CGTCGGCTGG 
CCAGCCAGGA AGCGCAGCCT GTCCGTGTCC TCGGAGGAGG AGGAGCCGGA CGACGGCTGG 
AAGGCGCCCG CCTGCTTCTG CCCAGACCAG CACGGCCCTA AGGAGCAGGG CCCCAAGCAC 
CATCCCCCCA TCCCTTTTCC TTGCCTGGGT ACCCCCAAGG GCAGCGGAGG CTCGGGCCCG 
GGCGGCTTGG AGCGCACGCC TTTCCTCTCT CCTTCGCACT CGGACTTTAA AGAAGAGAAA 
GAGAGGCTCC TGCCCGCGGG CTCGCCCTCG CCGGGGTCCG AGCGGCCGCG GGACGGCGGC 
GCTGAGCGGC AGGCCGGCGC GGCCAAGAAG AAGACGCGCA CCGTCTTTTC GCGCAGCCAG 
GTGTACCAGC TCGAGTCCAC CTTCGACATG AAGCGCTACC TGAGCAGCTC GGAGCGCGCC 
TGCCTCGCCT CCAGCCTGCA GCTCACGGAG ACCCAGGTAA AGACTTGGTT CCAGAACCGC 
CGCAACAAGT GGAAGCGGCA GCTCTCGGCT GAGCTGGAGG CGGCCAACAT GGCGCACGCG 
TCGGCGCAGA CTCTGGTGAG CATGCCGCTG GTGTTCCGGG ACAGTTCGCT GCTGCGCGTG 
CCGGTGCCGC GCTCGCTCGC CTTTCCCGCG CCGCTCTACT ACCCGGGAAG CAACCTCTCG 
GCCTTACCTC TCTACAACCT ATACAACAAG CTCGACTACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005510.1
CDS	258..1079
Translation	MGSKEDAGKGCPAAGGVSSFTIQSILGGGPSEAPREPVGWPARKRSLSVSSEEEEPDDGWKAPACFCPDQHGPKEQGPKHHPPIPFPCLGTPKGSGGSGPGGLERTPFLSPSHSDFKEEKERLLPAGSPSPGSERPRDGGAERQAGAAKKKTRTVFSRSQVYQLESTFDMKRYLSSSERACLASSLQLTETQVKTWFQNRRNKWKRQLSAELEAANMAHASAQTLVSMPLVFRDSSLLRVPVPRSLAFPAPLYYPGSNLSALPLYNLYNKLDY

Target ORF information:

RefSeq Version	NM_005519.1
Organism	Homo sapiens(human)
Definition	Homo sapiens H6 family homeobox 2 (HMX2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005519.1

ORF Insert Sequence:

ATGGGCAGCA AAGAAGATGC GGGCAAGGGG TGTCCGGCGG CCGGTGGCGT CTCCAGCTTC 
ACCATCCAGT CCATCCTGGG CGGGGGCCCC TCGGAGGCAC CGCGGGAGCC CGTCGGCTGG 
CCAGCCAGGA AGCGCAGCCT GTCCGTGTCC TCGGAGGAGG AGGAGCCGGA CGACGGCTGG 
AAGGCGCCCG CCTGCTTCTG CCCAGACCAG CACGGCCCTA AGGAGCAGGG CCCCAAGCAC 
CATCCCCCCA TCCCTTTTCC TTGCCTGGGT ACCCCCAAGG GCAGCGGAGG CTCGGGCCCG 
GGCGGCTTGG AGCGCACGCC TTTCCTCTCT CCTTCGCACT CGGACTTTAA AGAAGAGAAA 
GAGAGGCTCC TGCCCGCGGG CTCGCCCTCG CCGGGGTCCG AGCGGCCGCG GGACGGCGGC 
GCTGAGCGGC AGGCCGGCGC GGCCAAGAAG AAGACGCGCA CCGTCTTTTC GCGCAGCCAG 
GTGTACCAGC TCGAGTCCAC CTTCGACATG AAGCGCTACC TGAGCAGCTC GGAGCGCGCC 
TGCCTCGCCT CCAGCCTGCA GCTCACGGAG ACCCAGGTAA AGACTTGGTT CCAGAACCGC 
CGCAACAAGT GGAAGCGGCA GCTCTCGGCT GAGCTGGAGG CGGCCAACAT GGCGCACGCG 
TCGGCGCAGA CTCTGGTGAG CATGCCGCTG GTGTTCCGGG ACAGTTCGCT GCTGCGCGTG 
CCGGTGCCGC GCTCGCTCGC CTTTCCCGCG CCGCTCTACT ACCCGGGAAG CAACCTCTCG 
GCCTTACCTC TCTACAACCT ATACAACAAG CTCGACTACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HMX2 ( XM_005269743.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005269800.1 Homo sapiens H6 family homeobox 2 (HMX2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu29733
Clone ID Related Accession (Same CDS sequence)	NM_005519.1 , XM_005269743.3
Accession Version	XM_005269743.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	homeobox protein HMX2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005269743.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCAGCA AAGAAGATGC GGGCAAGGGG TGTCCGGCGG CCGGTGGCGT CTCCAGCTTC 
ACCATCCAGT CCATCCTGGG CGGGGGCCCC TCGGAGGCAC CGCGGGAGCC CGTCGGCTGG 
CCAGCCAGGA AGCGCAGCCT GTCCGTGTCC TCGGAGGAGG AGGAGCCGGA CGACGGCTGG 
AAGGCGCCCG CCTGCTTCTG CCCAGACCAG CACGGCCCTA AGGAGCAGGG CCCCAAGCAC 
CATCCCCCCA TCCCTTTTCC TTGCCTGGGT ACCCCCAAGG GCAGCGGAGG CTCGGGCCCG 
GGCGGCTTGG AGCGCACGCC TTTCCTCTCT CCTTCGCACT CGGACTTTAA AGAAGAGAAA 
GAGAGGCTCC TGCCCGCGGG CTCGCCCTCG CCGGGGTCCG AGCGGCCGCG GGACGGCGGC 
GCTGAGCGGC AGGCCGGCGC GGCCAAGAAG AAGACGCGCA CCGTCTTTTC GCGCAGCCAG 
GTGTACCAGC TCGAGTCCAC CTTCGACATG AAGCGCTACC TGAGCAGCTC GGAGCGCGCC 
TGCCTCGCCT CCAGCCTGCA GCTCACGGAG ACCCAGGTAA AGACTTGGTT CCAGAACCGC 
CGCAACAAGT GGAAGCGGCA GCTCTCGGCT GAGCTGGAGG CGGCCAACAT GGCGCACGCG 
TCGGCGCAGA CTCTGGTGAG CATGCCGCTG GTGTTCCGGG ACAGTTCGCT GCTGCGCGTG 
CCGGTGCCGC GCTCGCTCGC CTTTCCCGCG CCGCTCTACT ACCCGGGAAG CAACCTCTCG 
GCCTTACCTC TCTACAACCT ATACAACAAG CTCGACTACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005269800.1
CDS	120..941
Translation	MGSKEDAGKGCPAAGGVSSFTIQSILGGGPSEAPREPVGWPARKRSLSVSSEEEEPDDGWKAPACFCPDQHGPKEQGPKHHPPIPFPCLGTPKGSGGSGPGGLERTPFLSPSHSDFKEEKERLLPAGSPSPGSERPRDGGAERQAGAAKKKTRTVFSRSQVYQLESTFDMKRYLSSSERACLASSLQLTETQVKTWFQNRRNKWKRQLSAELEAANMAHASAQTLVSMPLVFRDSSLLRVPVPRSLAFPAPLYYPGSNLSALPLYNLYNKLDY

Target ORF information:

RefSeq Version	XM_005269743.3
Organism	Homo sapiens(human)
Definition	Homo sapiens H6 family homeobox 2 (HMX2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005269743.3

ORF Insert Sequence:

ATGGGCAGCA AAGAAGATGC GGGCAAGGGG TGTCCGGCGG CCGGTGGCGT CTCCAGCTTC 
ACCATCCAGT CCATCCTGGG CGGGGGCCCC TCGGAGGCAC CGCGGGAGCC CGTCGGCTGG 
CCAGCCAGGA AGCGCAGCCT GTCCGTGTCC TCGGAGGAGG AGGAGCCGGA CGACGGCTGG 
AAGGCGCCCG CCTGCTTCTG CCCAGACCAG CACGGCCCTA AGGAGCAGGG CCCCAAGCAC 
CATCCCCCCA TCCCTTTTCC TTGCCTGGGT ACCCCCAAGG GCAGCGGAGG CTCGGGCCCG 
GGCGGCTTGG AGCGCACGCC TTTCCTCTCT CCTTCGCACT CGGACTTTAA AGAAGAGAAA 
GAGAGGCTCC TGCCCGCGGG CTCGCCCTCG CCGGGGTCCG AGCGGCCGCG GGACGGCGGC 
GCTGAGCGGC AGGCCGGCGC GGCCAAGAAG AAGACGCGCA CCGTCTTTTC GCGCAGCCAG 
GTGTACCAGC TCGAGTCCAC CTTCGACATG AAGCGCTACC TGAGCAGCTC GGAGCGCGCC 
TGCCTCGCCT CCAGCCTGCA GCTCACGGAG ACCCAGGTAA AGACTTGGTT CCAGAACCGC 
CGCAACAAGT GGAAGCGGCA GCTCTCGGCT GAGCTGGAGG CGGCCAACAT GGCGCACGCG 
TCGGCGCAGA CTCTGGTGAG CATGCCGCTG GTGTTCCGGG ACAGTTCGCT GCTGCGCGTG 
CCGGTGCCGC GCTCGCTCGC CTTTCCCGCG CCGCTCTACT ACCCGGGAAG CAACCTCTCG 
GCCTTACCTC TCTACAACCT ATACAACAAG CTCGACTACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A census of human transcription factors: function, expression and evolution.
Nature reviews. Genetics10(4)252-63(2009 04)
Vaquerizas JM,Kummerfeld SK,Teichmann SA,Luscombe NM

Molecular (SNP) analyses of overlapping hemizygous deletions of 10q25.3 to 10qter in four patients: evidence for HMX2 and HMX3 as candidate genes in hearing and vestibular function.
American journal of medical genetics. Part A149A(4)669-80(2009 Feb)
Miller ND,Nance MA,Wohler ES,Hoover-Fong JE,Lisi E,Thomas GH,Pevsner J

A whole-genome scan for 24-hour respiration rate: a major locus at 10q26 influences respiration during sleep.
American journal of human genetics76(1)100-11(2005 Jan)
de Geus EJ,Posthuma D,Kupper N,van den Berg M,Willemsen G,Beem AL,Slagboom PE,Boomsma DI

Refined mapping of a gene for split hand-split foot malformation (SHFM3) on chromosome 10q25.
Journal of medical genetics33(12)996-1001(1996 Dec)
Raas-Rothschild A,Manouvrier S,Gonzales M,Farriaux JP,Lyonnet S,Munnich A

Phylogenetic conservation and physical mapping of members of the H6 homeobox gene family.
Mammalian genome : official journal of the International Mammalian Genome Society6(6)383-8(1995 Jun)
Stadler HS,Murray JC,Leysens NJ,Goodfellow PJ,Solursh M

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HMX2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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