HMGCS2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HMGCS2
Entrez Gene ID	3158
Full Name	3-hydroxy-3-methylglutaryl-CoA synthase 2
General protein information	Preferred Names 3-hydroxy-3-methylglutaryl-CoA synthase 2 Names hydroxymethylglutaryl-CoA synthase, mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) HMG-CoA synthase testicular tissue protein Li 88
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p12
Summary	The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].
Disorder MIM:	600234
Disorder Html:	HMG-CoA synthase-2 deficiency, 605911 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005518.3	NP_005509.1	hydroxymethylglutaryl-CoA synthase, mitochondrial isoform 1 precursor
XM_011541313.2	XP_011539615.1	hydroxymethylglutaryl-CoA synthase, mitochondrial isoform X1
NM_005518.4	NP_005509.1	hydroxymethylglutaryl-CoA synthase, mitochondrial isoform 1 precursor
XM_011541313.1	XP_011539615.1	hydroxymethylglutaryl-CoA synthase, mitochondrial isoform X1
NM_001166107.1	NP_001159579.1	hydroxymethylglutaryl-CoA synthase, mitochondrial isoform 2 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	HMGCS2	XP_849878.1
Mus musculus (house mouse)	Hmgcs2	NP_032282.2
Rattus norvegicus (Norway rat)	Hmgcs2	NP_775117.2
Pan troglodytes (chimpanzee)	HMGCS2	XP_513693.1
	HMGCS2	XP_001114146.1
Homo sapiens (human)	HMGCS2	NP_005509.1
Bos taurus (cattle)	HMGCS2	NP_001039348.1
Gallus gallus (chicken)	HMGCS2	XP_422225.3

Gene Ontology
Bibliography

Related articles in PubMed

Involvement of nutrients and nutritional mediators in mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene expression.
Rescigno T, Capasso A, Tecce MF
Journal of cellular physiology233(4)3306-3314(2018 Apr)

miR-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma.
Su SG, Yang M, Zhang MF, Peng QZ, Li MY, Liu LP, Bao SY
The international journal of biochemistry & cell biology91(Pt A)53-59(2017 Oct)

HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk.
Shukla SK, Liu W, Sikder K, Addya S, Sarkar A, Wei Y, Rafiq K
Scientific reports7(1)4590(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

miR-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma
Title: miR-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma.

this studies demonstrate that HMGCS2 functions as a transcriptional factor that binds to peroxisome proliferator-activated receptor alpha (PPARalpha), resulting in Src expression and activation in a metabolically independent manner
Title: HMGCS2 enhances invasion and metastasis via direct interaction with PPAR? to activate Src signaling in colorectal cancer and oral cancer.

HMGCS2 shares with ketone bodies common features in autophagic clearance of APP, suggesting that ketone bodies play an important role in HMGCS2 regulation of the autophagy.
Title: HMGCS2 promotes autophagic degradation of the amyloid-? precursor protein through ketone body-mediated mechanisms.

High expression of either HSD17B2 or HMGCS2 predicted poor susceptibility of rectal cancer to preoperative chemoradiotherapy.
Title: The prognostic impact of lipid biosynthesis-associated markers, HSD17B2 and HMGCS2, in rectal cancer treated with neoadjuvant concurrent chemoradiotherapy.

FABP7 and HMGCS2 may have roles in apocrine differentiation categorizing apocrine carcinoma of the breast
Title: FABP7 and HMGCS2 are novel protein markers for apocrine differentiation categorizing apocrine carcinoma of the breast.

The following HMGCS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HMGCS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18287	NM_005518.4 Latest version!	Homo sapiens 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu18848	NM_001166107.1 Latest version!	Homo sapiens 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu58269	XM_011541313.2 Latest version!	Homo sapiens 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu18287	NM_005518.3	Homo sapiens 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu58269	XM_011541313.1	Homo sapiens 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HMGCS2 ( NM_005518.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005509.1 Homo sapiens 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18287
Clone ID Related Accession (Same CDS sequence)	NM_005518.3 , NM_005518.4
Accession Version	NM_005518.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1527bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	hydroxymethylglutaryl-CoA synthase, mitochondrial isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP420631.1, BC044217.1, BX104280.1 and AI215948.1. This sequence is a reference standard in the RefSeqGene project. On Oct 7, 2009 this sequence version replaced NM_005518.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X83618.1, BC044217.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162895 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAGCGTC TGTTGACTCC AGTGAAGCGC ATTCTGCAAC TGACAAGAGC GGTGCAGGAA 
ACCTCCCTCA CACCTGCTCG CCTGCTCCCA GTAGCCCACC AAAGGTTTTC TACAGCCTCT 
GCTGTCCCCC TGGCCAAAAC AGATACTTGG CCAAAGGACG TGGGCATCCT GGCCCTGGAG 
GTCTACTTCC CAGCCCAATA TGTGGACCAA ACTGACCTGG AGAAGTATAA CAATGTGGAA 
GCAGGAAAGT ATACAGTGGG CTTGGGCCAG ACCCGTATGG GCTTCTGCTC AGTCCAAGAG 
GACATCAACT CCCTGTGCCT GACGGTGGTG CAACGGCTGA TGGAGCGCAT ACAGCTCCCA 
TGGGACTCTG TGGGCAGGCT GGAAGTAGGC ACTGAGACCA TCATTGACAA GTCCAAAGCT 
GTCAAAACAG TGCTCATGGA ACTCTTCCAG GATTCAGGCA ATACTGATAT TGAGGGCATA 
GATACCACCA ATGCCTGCTA CGGTGGTACT GCCTCCCTCT TCAATGCTGC CAACTGGATG 
GAGTCCAGTT CCTGGGATGG TCGTTATGCC ATGGTGGTCT GTGGAGACAT TGCCGTCTAT 
CCCAGTGGTA ATGCTCGTCC CACAGGTGGG GCCGGAGCTG TGGCTATGCT GATTGGGCCC 
AAGGCCCCTC TGGCCCTGGA GCGAGGGCTG AGGGGAACCC ATATGGAGAA TGTGTATGAC 
TTCTACAAAC CAAATTTGGC CTCGGAGTAC CCAATAGTGG ATGGGAAGCT TTCCATCCAG 
TGCTACTTGC GGGCCTTGGA TCGATGTTAC ACATCATACC GTAAAAAAAT CCAGAATCAG 
TGGAAGCAAG CTGGCAGCGA TCGACCCTTC ACCCTTGACG ATTTACAGTA CATGATCTTT 
CATACACCCT TTTGCAAGAT GGTCCAGAAG TCTCTGGCTC GCCTGATGTT CAATGACTTC 
CTGTCAGCCA GCAGTGACAC ACAAACCAGC TTATATAAGG GGCTGGAGGC TTTCGGGGGG 
CTAAAGCTGG AAGACACCTA CACCAACAAG GACCTGGATA AAGCACTTCT AAAGGCCTCT 
CAGGACATGT TCGACAAGAA AACCAAGGCT TCCCTTTACC TCTCCACTCA CAATGGGAAC 
ATGTACACCT CATCCCTGTA CGGGTGCCTG GCCTCGCTTC TGTCCCACCA CTCTGCCCAA 
GAACTGGCTG GCTCCAGGAT TGGTGCCTTC TCTTATGGCT CTGGTTTAGC AGCAAGTTTC 
TTTTCATTTC GAGTATCCCA GGATGCTGCT CCAGGCTCTC CCCTGGACAA GTTGGTGTCC 
AGCACATCAG ACCTGCCAAA ACGCCTAGCC TCCCGAAAGT GTGTGTCTCC TGAGGAGTTC 
ACAGAAATAA TGAACCAAAG AGAGCAATTC TACCATAAGG TGAATTTCTC CCCACCTGGT 
GACACAAACA GCCTTTTCCC AGGTACTTGG TACCTGGAGC GAGTGGACGA GCAGCATCGC 
CGAAAGTATG CCCGGCGTCC CGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005509.1
CDS	89..1615
Translation	MQRLLTPVKRILQLTRAVQETSLTPARLLPVAHQRFSTASAVPLAKTDTWPKDVGILALEVYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALERGLRGTHMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFTLDDLQYMIFHTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKASQDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARRPV

Target ORF information:

RefSeq Version	NM_005518.3
Organism	Homo sapiens(human)
Definition	Homo sapiens 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005518.3

ORF Insert Sequence:

ATGCAGCGTC TGTTGACTCC AGTGAAGCGC ATTCTGCAAC TGACAAGAGC GGTGCAGGAA 
ACCTCCCTCA CACCTGCTCG CCTGCTCCCA GTAGCCCACC AAAGGTTTTC TACAGCCTCT 
GCTGTCCCCC TGGCCAAAAC AGATACTTGG CCAAAGGACG TGGGCATCCT GGCCCTGGAG 
GTCTACTTCC CAGCCCAATA TGTGGACCAA ACTGACCTGG AGAAGTATAA CAATGTGGAA 
GCAGGAAAGT ATACAGTGGG CTTGGGCCAG ACCCGTATGG GCTTCTGCTC AGTCCAAGAG 
GACATCAACT CCCTGTGCCT GACGGTGGTG CAACGGCTGA TGGAGCGCAT ACAGCTCCCA 
TGGGACTCTG TGGGCAGGCT GGAAGTAGGC ACTGAGACCA TCATTGACAA GTCCAAAGCT 
GTCAAAACAG TGCTCATGGA ACTCTTCCAG GATTCAGGCA ATACTGATAT TGAGGGCATA 
GATACCACCA ATGCCTGCTA CGGTGGTACT GCCTCCCTCT TCAATGCTGC CAACTGGATG 
GAGTCCAGTT CCTGGGATGG TCGTTATGCC ATGGTGGTCT GTGGAGACAT TGCCGTCTAT 
CCCAGTGGTA ATGCTCGTCC CACAGGTGGG GCCGGAGCTG TGGCTATGCT GATTGGGCCC 
AAGGCCCCTC TGGCCCTGGA GCGAGGGCTG AGGGGAACCC ATATGGAGAA TGTGTATGAC 
TTCTACAAAC CAAATTTGGC CTCGGAGTAC CCAATAGTGG ATGGGAAGCT TTCCATCCAG 
TGCTACTTGC GGGCCTTGGA TCGATGTTAC ACATCATACC GTAAAAAAAT CCAGAATCAG 
TGGAAGCAAG CTGGCAGCGA TCGACCCTTC ACCCTTGACG ATTTACAGTA CATGATCTTT 
CATACACCCT TTTGCAAGAT GGTCCAGAAG TCTCTGGCTC GCCTGATGTT CAATGACTTC 
CTGTCAGCCA GCAGTGACAC ACAAACCAGC TTATATAAGG GGCTGGAGGC TTTCGGGGGG 
CTAAAGCTGG AAGACACCTA CACCAACAAG GACCTGGATA AAGCACTTCT AAAGGCCTCT 
CAGGACATGT TCGACAAGAA AACCAAGGCT TCCCTTTACC TCTCCACTCA CAATGGGAAC 
ATGTACACCT CATCCCTGTA CGGGTGCCTG GCCTCGCTTC TGTCCCACCA CTCTGCCCAA 
GAACTGGCTG GCTCCAGGAT TGGTGCCTTC TCTTATGGCT CTGGTTTAGC AGCAAGTTTC 
TTTTCATTTC GAGTATCCCA GGATGCTGCT CCAGGCTCTC CCCTGGACAA GTTGGTGTCC 
AGCACATCAG ACCTGCCAAA ACGCCTAGCC TCCCGAAAGT GTGTGTCTCC TGAGGAGTTC 
ACAGAAATAA TGAACCAAAG AGAGCAATTC TACCATAAGG TGAATTTCTC CCCACCTGGT 
GACACAAACA GCCTTTTCCC AGGTACTTGG TACCTGGAGC GAGTGGACGA GCAGCATCGC 
CGAAAGTATG CCCGGCGTCC CGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HMGCS2 ( NM_005518.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005509.1 Homo sapiens 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18287
Clone ID Related Accession (Same CDS sequence)	NM_005518.3 , NM_005518.4
Accession Version	NM_005518.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1527bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	hydroxymethylglutaryl-CoA synthase, mitochondrial isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP420631.1, BC044217.1, BX104280.1 and AI215948.1. On Aug 31, 2019 this sequence version replaced NM_005518.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC044217.1, X83618.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAGCGTC TGTTGACTCC AGTGAAGCGC ATTCTGCAAC TGACAAGAGC GGTGCAGGAA 
ACCTCCCTCA CACCTGCTCG CCTGCTCCCA GTAGCCCACC AAAGGTTTTC TACAGCCTCT 
GCTGTCCCCC TGGCCAAAAC AGATACTTGG CCAAAGGACG TGGGCATCCT GGCCCTGGAG 
GTCTACTTCC CAGCCCAATA TGTGGACCAA ACTGACCTGG AGAAGTATAA CAATGTGGAA 
GCAGGAAAGT ATACAGTGGG CTTGGGCCAG ACCCGTATGG GCTTCTGCTC AGTCCAAGAG 
GACATCAACT CCCTGTGCCT GACGGTGGTG CAACGGCTGA TGGAGCGCAT ACAGCTCCCA 
TGGGACTCTG TGGGCAGGCT GGAAGTAGGC ACTGAGACCA TCATTGACAA GTCCAAAGCT 
GTCAAAACAG TGCTCATGGA ACTCTTCCAG GATTCAGGCA ATACTGATAT TGAGGGCATA 
GATACCACCA ATGCCTGCTA CGGTGGTACT GCCTCCCTCT TCAATGCTGC CAACTGGATG 
GAGTCCAGTT CCTGGGATGG TCGTTATGCC ATGGTGGTCT GTGGAGACAT TGCCGTCTAT 
CCCAGTGGTA ATGCTCGTCC CACAGGTGGG GCCGGAGCTG TGGCTATGCT GATTGGGCCC 
AAGGCCCCTC TGGCCCTGGA GCGAGGGCTG AGGGGAACCC ATATGGAGAA TGTGTATGAC 
TTCTACAAAC CAAATTTGGC CTCGGAGTAC CCAATAGTGG ATGGGAAGCT TTCCATCCAG 
TGCTACTTGC GGGCCTTGGA TCGATGTTAC ACATCATACC GTAAAAAAAT CCAGAATCAG 
TGGAAGCAAG CTGGCAGCGA TCGACCCTTC ACCCTTGACG ATTTACAGTA CATGATCTTT 
CATACACCCT TTTGCAAGAT GGTCCAGAAG TCTCTGGCTC GCCTGATGTT CAATGACTTC 
CTGTCAGCCA GCAGTGACAC ACAAACCAGC TTATATAAGG GGCTGGAGGC TTTCGGGGGG 
CTAAAGCTGG AAGACACCTA CACCAACAAG GACCTGGATA AAGCACTTCT AAAGGCCTCT 
CAGGACATGT TCGACAAGAA AACCAAGGCT TCCCTTTACC TCTCCACTCA CAATGGGAAC 
ATGTACACCT CATCCCTGTA CGGGTGCCTG GCCTCGCTTC TGTCCCACCA CTCTGCCCAA 
GAACTGGCTG GCTCCAGGAT TGGTGCCTTC TCTTATGGCT CTGGTTTAGC AGCAAGTTTC 
TTTTCATTTC GAGTATCCCA GGATGCTGCT CCAGGCTCTC CCCTGGACAA GTTGGTGTCC 
AGCACATCAG ACCTGCCAAA ACGCCTAGCC TCCCGAAAGT GTGTGTCTCC TGAGGAGTTC 
ACAGAAATAA TGAACCAAAG AGAGCAATTC TACCATAAGG TGAATTTCTC CCCACCTGGT 
GACACAAACA GCCTTTTCCC AGGTACTTGG TACCTGGAGC GAGTGGACGA GCAGCATCGC 
CGAAAGTATG CCCGGCGTCC CGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005509.1
CDS	62..1588
Translation	MQRLLTPVKRILQLTRAVQETSLTPARLLPVAHQRFSTASAVPLAKTDTWPKDVGILALEVYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALERGLRGTHMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFTLDDLQYMIFHTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKASQDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARRPV

Target ORF information:

RefSeq Version	NM_005518.4
Organism	Homo sapiens(human)
Definition	Homo sapiens 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005518.4

ORF Insert Sequence:

ATGCAGCGTC TGTTGACTCC AGTGAAGCGC ATTCTGCAAC TGACAAGAGC GGTGCAGGAA 
ACCTCCCTCA CACCTGCTCG CCTGCTCCCA GTAGCCCACC AAAGGTTTTC TACAGCCTCT 
GCTGTCCCCC TGGCCAAAAC AGATACTTGG CCAAAGGACG TGGGCATCCT GGCCCTGGAG 
GTCTACTTCC CAGCCCAATA TGTGGACCAA ACTGACCTGG AGAAGTATAA CAATGTGGAA 
GCAGGAAAGT ATACAGTGGG CTTGGGCCAG ACCCGTATGG GCTTCTGCTC AGTCCAAGAG 
GACATCAACT CCCTGTGCCT GACGGTGGTG CAACGGCTGA TGGAGCGCAT ACAGCTCCCA 
TGGGACTCTG TGGGCAGGCT GGAAGTAGGC ACTGAGACCA TCATTGACAA GTCCAAAGCT 
GTCAAAACAG TGCTCATGGA ACTCTTCCAG GATTCAGGCA ATACTGATAT TGAGGGCATA 
GATACCACCA ATGCCTGCTA CGGTGGTACT GCCTCCCTCT TCAATGCTGC CAACTGGATG 
GAGTCCAGTT CCTGGGATGG TCGTTATGCC ATGGTGGTCT GTGGAGACAT TGCCGTCTAT 
CCCAGTGGTA ATGCTCGTCC CACAGGTGGG GCCGGAGCTG TGGCTATGCT GATTGGGCCC 
AAGGCCCCTC TGGCCCTGGA GCGAGGGCTG AGGGGAACCC ATATGGAGAA TGTGTATGAC 
TTCTACAAAC CAAATTTGGC CTCGGAGTAC CCAATAGTGG ATGGGAAGCT TTCCATCCAG 
TGCTACTTGC GGGCCTTGGA TCGATGTTAC ACATCATACC GTAAAAAAAT CCAGAATCAG 
TGGAAGCAAG CTGGCAGCGA TCGACCCTTC ACCCTTGACG ATTTACAGTA CATGATCTTT 
CATACACCCT TTTGCAAGAT GGTCCAGAAG TCTCTGGCTC GCCTGATGTT CAATGACTTC 
CTGTCAGCCA GCAGTGACAC ACAAACCAGC TTATATAAGG GGCTGGAGGC TTTCGGGGGG 
CTAAAGCTGG AAGACACCTA CACCAACAAG GACCTGGATA AAGCACTTCT AAAGGCCTCT 
CAGGACATGT TCGACAAGAA AACCAAGGCT TCCCTTTACC TCTCCACTCA CAATGGGAAC 
ATGTACACCT CATCCCTGTA CGGGTGCCTG GCCTCGCTTC TGTCCCACCA CTCTGCCCAA 
GAACTGGCTG GCTCCAGGAT TGGTGCCTTC TCTTATGGCT CTGGTTTAGC AGCAAGTTTC 
TTTTCATTTC GAGTATCCCA GGATGCTGCT CCAGGCTCTC CCCTGGACAA GTTGGTGTCC 
AGCACATCAG ACCTGCCAAA ACGCCTAGCC TCCCGAAAGT GTGTGTCTCC TGAGGAGTTC 
ACAGAAATAA TGAACCAAAG AGAGCAATTC TACCATAAGG TGAATTTCTC CCCACCTGGT 
GACACAAACA GCCTTTTCCC AGGTACTTGG TACCTGGAGC GAGTGGACGA GCAGCATCGC 
CGAAAGTATG CCCGGCGTCC CGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HMGCS2 ( NM_001166107.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001159579.1 Homo sapiens 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu18848
Clone ID Related Accession (Same CDS sequence)	NM_001166107.1
Accession Version	NM_001166107.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1401bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	hydroxymethylglutaryl-CoA synthase, mitochondrial isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP420631.1, AK303777.1, BC044217.1, BX104280.1 and AI215948.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (2) is missing an in-frame coding exon compared to variant 1. This results in a shorter isoform (2) lacking an internal protein segment compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK303777.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968189 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAGCGTC TGTTGACTCC AGTGAAGCGC ATTCTGCAAC TGACAAGAGC GGTGCAGGAA 
ACCTCCCTCA CACCTGCTCG CCTGCTCCCA GTAGCCCACC AAAGGTTTTC TACAGCCTCT 
GCTGTCCCCC TGGCCAAAAC AGATACTTGG CCAAAGGACG TGGGCATCCT GGCCCTGGAG 
GTCTACTTCC CAGCCCAATA TGTGGACCAA ACTGACCTGG AGAAGTATAA CAATGTGGAA 
GCAGGAAAGT ATACAGTGGG CTTGGGCCAG ACCCGTATGG GCTTCTGCTC AGTCCAAGAG 
GACATCAACT CCCTGTGCCT GACGGTGGTG CAACGGCTGA TGGAGCGCAT ACAGCTCCCA 
TGGGACTCTG TGGGCAGGCT GGAAGTAGGC ACTGAGACCA TCATTGACAA GTCCAAAGCT 
GTCAAAACAG TGCTCATGGA ACTCTTCCAG GATTCAGGCA ATACTGATAT TGAGGGCATA 
GATACCACCA ATGCCTGCTA CGGTGGTACT GCCTCCCTCT TCAATGCTGC CAACTGGATG 
GAGTCCAGTT CCTGGGATGG GCTGAGGGGA ACCCATATGG AGAATGTGTA TGACTTCTAC 
AAACCAAATT TGGCCTCGGA GTACCCAATA GTGGATGGGA AGCTTTCCAT CCAGTGCTAC 
TTGCGGGCCT TGGATCGATG TTACACATCA TACCGTAAAA AAATCCAGAA TCAGTGGAAG 
CAAGCTGGCA GCGATCGACC CTTCACCCTT GACGATTTAC AGTACATGAT CTTTCATACA 
CCCTTTTGCA AGATGGTCCA GAAGTCTCTG GCTCGCCTGA TGTTCAATGA CTTCCTGTCA 
GCCAGCAGTG ACACACAAAC CAGCTTATAT AAGGGGCTGG AGGCTTTCGG GGGGCTAAAG 
CTGGAAGACA CCTACACCAA CAAGGACCTG GATAAAGCAC TTCTAAAGGC CTCTCAGGAC 
ATGTTCGACA AGAAAACCAA GGCTTCCCTT TACCTCTCCA CTCACAATGG GAACATGTAC 
ACCTCATCCC TGTACGGGTG CCTGGCCTCG CTTCTGTCCC ACCACTCTGC CCAAGAACTG 
GCTGGCTCCA GGATTGGTGC CTTCTCTTAT GGCTCTGGTT TAGCAGCAAG TTTCTTTTCA 
TTTCGAGTAT CCCAGGATGC TGCTCCAGGC TCTCCCCTGG ACAAGTTGGT GTCCAGCACA 
TCAGACCTGC CAAAACGCCT AGCCTCCCGA AAGTGTGTGT CTCCTGAGGA GTTCACAGAA 
ATAATGAACC AAAGAGAGCA ATTCTACCAT AAGGTGAATT TCTCCCCACC TGGTGACACA 
AACAGCCTTT TCCCAGGTAC TTGGTACCTG GAGCGAGTGG ACGAGCAGCA TCGCCGAAAG 
TATGCCCGGC GTCCCGTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001159579.1
CDS	89..1489
Translation	MQRLLTPVKRILQLTRAVQETSLTPARLLPVAHQRFSTASAVPLAKTDTWPKDVGILALEVYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSSWDGLRGTHMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFTLDDLQYMIFHTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKASQDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARRPV

Target ORF information:

RefSeq Version	NM_001166107.1
Organism	Homo sapiens(human)
Definition	Homo sapiens 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001166107.1

ORF Insert Sequence:

ATGCAGCGTC TGTTGACTCC AGTGAAGCGC ATTCTGCAAC TGACAAGAGC GGTGCAGGAA 
ACCTCCCTCA CACCTGCTCG CCTGCTCCCA GTAGCCCACC AAAGGTTTTC TACAGCCTCT 
GCTGTCCCCC TGGCCAAAAC AGATACTTGG CCAAAGGACG TGGGCATCCT GGCCCTGGAG 
GTCTACTTCC CAGCCCAATA TGTGGACCAA ACTGACCTGG AGAAGTATAA CAATGTGGAA 
GCAGGAAAGT ATACAGTGGG CTTGGGCCAG ACCCGTATGG GCTTCTGCTC AGTCCAAGAG 
GACATCAACT CCCTGTGCCT GACGGTGGTG CAACGGCTGA TGGAGCGCAT ACAGCTCCCA 
TGGGACTCTG TGGGCAGGCT GGAAGTAGGC ACTGAGACCA TCATTGACAA GTCCAAAGCT 
GTCAAAACAG TGCTCATGGA ACTCTTCCAG GATTCAGGCA ATACTGATAT TGAGGGCATA 
GATACCACCA ATGCCTGCTA CGGTGGTACT GCCTCCCTCT TCAATGCTGC CAACTGGATG 
GAGTCCAGTT CCTGGGATGG GCTGAGGGGA ACCCATATGG AGAATGTGTA TGACTTCTAC 
AAACCAAATT TGGCCTCGGA GTACCCAATA GTGGATGGGA AGCTTTCCAT CCAGTGCTAC 
TTGCGGGCCT TGGATCGATG TTACACATCA TACCGTAAAA AAATCCAGAA TCAGTGGAAG 
CAAGCTGGCA GCGATCGACC CTTCACCCTT GACGATTTAC AGTACATGAT CTTTCATACA 
CCCTTTTGCA AGATGGTCCA GAAGTCTCTG GCTCGCCTGA TGTTCAATGA CTTCCTGTCA 
GCCAGCAGTG ACACACAAAC CAGCTTATAT AAGGGGCTGG AGGCTTTCGG GGGGCTAAAG 
CTGGAAGACA CCTACACCAA CAAGGACCTG GATAAAGCAC TTCTAAAGGC CTCTCAGGAC 
ATGTTCGACA AGAAAACCAA GGCTTCCCTT TACCTCTCCA CTCACAATGG GAACATGTAC 
ACCTCATCCC TGTACGGGTG CCTGGCCTCG CTTCTGTCCC ACCACTCTGC CCAAGAACTG 
GCTGGCTCCA GGATTGGTGC CTTCTCTTAT GGCTCTGGTT TAGCAGCAAG TTTCTTTTCA 
TTTCGAGTAT CCCAGGATGC TGCTCCAGGC TCTCCCCTGG ACAAGTTGGT GTCCAGCACA 
TCAGACCTGC CAAAACGCCT AGCCTCCCGA AAGTGTGTGT CTCCTGAGGA GTTCACAGAA 
ATAATGAACC AAAGAGAGCA ATTCTACCAT AAGGTGAATT TCTCCCCACC TGGTGACACA 
AACAGCCTTT TCCCAGGTAC TTGGTACCTG GAGCGAGTGG ACGAGCAGCA TCGCCGAAAG 
TATGCCCGGC GTCCCGTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HMGCS2 ( XM_011541313.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011539615.1 Homo sapiens 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), transcript variant X1, mRNA.

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CloneID	OHu58269
Clone ID Related Accession (Same CDS sequence)	XM_011541313.2 , XM_011541313.1
Accession Version	XM_011541313.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1362bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	hydroxymethylglutaryl-CoA synthase, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011541313.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGCGTC TGTTGACTCC AGTGAAGCGC ATTCTGCAAC TGACAAGAGC GGTGCAGGAA 
ACCTCCCTCA CACCTGCTCG CCTGCTCCCA GTAGCCCACC AAAGGTTTTC TACAGCCTCT 
GCTGTCCCCC TGGCCAAAAC AGATACTTGG CCAAAGGACG TGGGCATCCT GGCCCTGGAG 
GTCTACTTCC CAGCCCAATA TGTGGACCAA ACTGACCTGG AGAAGTATAA CAATGTGGAA 
GCAGGAAAGT ATACAGTGGG CTTGGGCCAG ACCCGTATGG GCTTCTGCTC AGTCCAAGAG 
GACATCAACT CCCTGTGCCT GACGGTGGTG CAACGGCTGA TGGAGCGCAT ACAGCTCCCA 
TGGGACTCTG TGGGCAGGCT GGAAGTAGGC ACTGAGACCA TCATTGACAA GTCCAAAGCT 
GTCAAAACAG TGCTCATGGA ACTCTTCCAG GATTCAGGCA ATACTGATAT TGAGGGCATA 
GATACCACCA ATGCCTGCTA CGGTGGTACT GCCTCCCTCT TCAATGCTGC CAACTGGATG 
GAGTCCAGTT CCTGGGATGG TCGTTATGCC ATGGTGGTCT GTGGAGACAT TGCCGTCTAT 
CCCAGTGGTA ATGCTCGTCC CACAGGTGGG GCCGGAGCTG TGGCTATGCT GATTGGGCCC 
AAGGCCCCTC TGGCCCTGGA GCGAGCTGGC AGCGATCGAC CCTTCACCCT TGACGATTTA 
CAGTACATGA TCTTTCATAC ACCCTTTTGC AAGATGGTCC AGAAGTCTCT GGCTCGCCTG 
ATGTTCAATG ACTTCCTGTC AGCCAGCAGT GACACACAAA CCAGCTTATA TAAGGGGCTG 
GAGGCTTTCG GGGGGCTAAA GCTGGAAGAC ACCTACACCA ACAAGGACCT GGATAAAGCA 
CTTCTAAAGG CCTCTCAGGA CATGTTCGAC AAGAAAACCA AGGCTTCCCT TTACCTCTCC 
ACTCACAATG GGAACATGTA CACCTCATCC CTGTACGGGT GCCTGGCCTC GCTTCTGTCC 
CACCACTCTG CCCAAGAACT GGCTGGCTCC AGGATTGGTG CCTTCTCTTA TGGCTCTGGT 
TTAGCAGCAA GTTTCTTTTC ATTTCGAGTA TCCCAGGATG CTGCTCCAGG CTCTCCCCTG 
GACAAGTTGG TGTCCAGCAC ATCAGACCTG CCAAAACGCC TAGCCTCCCG AAAGTGTGTG 
TCTCCTGAGG AGTTCACAGA AATAATGAAC CAAAGAGAGC AATTCTACCA TAAGGTGAAT 
TTCTCCCCAC CTGGTGACAC AAACAGCCTT TTCCCAGGTA CTTGGTACCT GGAGCGAGTG 
GACGAGCAGC ATCGCCGAAA GTATGCCCGG CGTCCCGTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011539615.1
CDS	65..1426
Translation	MQRLLTPVKRILQLTRAVQETSLTPARLLPVAHQRFSTASAVPLAKTDTWPKDVGILALEVYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALERAGSDRPFTLDDLQYMIFHTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKASQDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARRPV

Target ORF information:

RefSeq Version	XM_011541313.2
Organism	Homo sapiens(human)
Definition	Homo sapiens 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011541313.2

ORF Insert Sequence:

ATGCAGCGTC TGTTGACTCC AGTGAAGCGC ATTCTGCAAC TGACAAGAGC GGTGCAGGAA 
ACCTCCCTCA CACCTGCTCG CCTGCTCCCA GTAGCCCACC AAAGGTTTTC TACAGCCTCT 
GCTGTCCCCC TGGCCAAAAC AGATACTTGG CCAAAGGACG TGGGCATCCT GGCCCTGGAG 
GTCTACTTCC CAGCCCAATA TGTGGACCAA ACTGACCTGG AGAAGTATAA CAATGTGGAA 
GCAGGAAAGT ATACAGTGGG CTTGGGCCAG ACCCGTATGG GCTTCTGCTC AGTCCAAGAG 
GACATCAACT CCCTGTGCCT GACGGTGGTG CAACGGCTGA TGGAGCGCAT ACAGCTCCCA 
TGGGACTCTG TGGGCAGGCT GGAAGTAGGC ACTGAGACCA TCATTGACAA GTCCAAAGCT 
GTCAAAACAG TGCTCATGGA ACTCTTCCAG GATTCAGGCA ATACTGATAT TGAGGGCATA 
GATACCACCA ATGCCTGCTA CGGTGGTACT GCCTCCCTCT TCAATGCTGC CAACTGGATG 
GAGTCCAGTT CCTGGGATGG TCGTTATGCC ATGGTGGTCT GTGGAGACAT TGCCGTCTAT 
CCCAGTGGTA ATGCTCGTCC CACAGGTGGG GCCGGAGCTG TGGCTATGCT GATTGGGCCC 
AAGGCCCCTC TGGCCCTGGA GCGAGCTGGC AGCGATCGAC CCTTCACCCT TGACGATTTA 
CAGTACATGA TCTTTCATAC ACCCTTTTGC AAGATGGTCC AGAAGTCTCT GGCTCGCCTG 
ATGTTCAATG ACTTCCTGTC AGCCAGCAGT GACACACAAA CCAGCTTATA TAAGGGGCTG 
GAGGCTTTCG GGGGGCTAAA GCTGGAAGAC ACCTACACCA ACAAGGACCT GGATAAAGCA 
CTTCTAAAGG CCTCTCAGGA CATGTTCGAC AAGAAAACCA AGGCTTCCCT TTACCTCTCC 
ACTCACAATG GGAACATGTA CACCTCATCC CTGTACGGGT GCCTGGCCTC GCTTCTGTCC 
CACCACTCTG CCCAAGAACT GGCTGGCTCC AGGATTGGTG CCTTCTCTTA TGGCTCTGGT 
TTAGCAGCAA GTTTCTTTTC ATTTCGAGTA TCCCAGGATG CTGCTCCAGG CTCTCCCCTG 
GACAAGTTGG TGTCCAGCAC ATCAGACCTG CCAAAACGCC TAGCCTCCCG AAAGTGTGTG 
TCTCCTGAGG AGTTCACAGA AATAATGAAC CAAAGAGAGC AATTCTACCA TAAGGTGAAT 
TTCTCCCCAC CTGGTGACAC AAACAGCCTT TTCCCAGGTA CTTGGTACCT GGAGCGAGTG 
GACGAGCAGC ATCGCCGAAA GTATGCCCGG CGTCCCGTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HMGCS2 ( XM_011541313.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011539615.1 Homo sapiens 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu58269
Clone ID Related Accession (Same CDS sequence)	XM_011541313.2 , XM_011541313.1
Accession Version	XM_011541313.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1362bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	hydroxymethylglutaryl-CoA synthase, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGCGTC TGTTGACTCC AGTGAAGCGC ATTCTGCAAC TGACAAGAGC GGTGCAGGAA 
ACCTCCCTCA CACCTGCTCG CCTGCTCCCA GTAGCCCACC AAAGGTTTTC TACAGCCTCT 
GCTGTCCCCC TGGCCAAAAC AGATACTTGG CCAAAGGACG TGGGCATCCT GGCCCTGGAG 
GTCTACTTCC CAGCCCAATA TGTGGACCAA ACTGACCTGG AGAAGTATAA CAATGTGGAA 
GCAGGAAAGT ATACAGTGGG CTTGGGCCAG ACCCGTATGG GCTTCTGCTC AGTCCAAGAG 
GACATCAACT CCCTGTGCCT GACGGTGGTG CAACGGCTGA TGGAGCGCAT ACAGCTCCCA 
TGGGACTCTG TGGGCAGGCT GGAAGTAGGC ACTGAGACCA TCATTGACAA GTCCAAAGCT 
GTCAAAACAG TGCTCATGGA ACTCTTCCAG GATTCAGGCA ATACTGATAT TGAGGGCATA 
GATACCACCA ATGCCTGCTA CGGTGGTACT GCCTCCCTCT TCAATGCTGC CAACTGGATG 
GAGTCCAGTT CCTGGGATGG TCGTTATGCC ATGGTGGTCT GTGGAGACAT TGCCGTCTAT 
CCCAGTGGTA ATGCTCGTCC CACAGGTGGG GCCGGAGCTG TGGCTATGCT GATTGGGCCC 
AAGGCCCCTC TGGCCCTGGA GCGAGCTGGC AGCGATCGAC CCTTCACCCT TGACGATTTA 
CAGTACATGA TCTTTCATAC ACCCTTTTGC AAGATGGTCC AGAAGTCTCT GGCTCGCCTG 
ATGTTCAATG ACTTCCTGTC AGCCAGCAGT GACACACAAA CCAGCTTATA TAAGGGGCTG 
GAGGCTTTCG GGGGGCTAAA GCTGGAAGAC ACCTACACCA ACAAGGACCT GGATAAAGCA 
CTTCTAAAGG CCTCTCAGGA CATGTTCGAC AAGAAAACCA AGGCTTCCCT TTACCTCTCC 
ACTCACAATG GGAACATGTA CACCTCATCC CTGTACGGGT GCCTGGCCTC GCTTCTGTCC 
CACCACTCTG CCCAAGAACT GGCTGGCTCC AGGATTGGTG CCTTCTCTTA TGGCTCTGGT 
TTAGCAGCAA GTTTCTTTTC ATTTCGAGTA TCCCAGGATG CTGCTCCAGG CTCTCCCCTG 
GACAAGTTGG TGTCCAGCAC ATCAGACCTG CCAAAACGCC TAGCCTCCCG AAAGTGTGTG 
TCTCCTGAGG AGTTCACAGA AATAATGAAC CAAAGAGAGC AATTCTACCA TAAGGTGAAT 
TTCTCCCCAC CTGGTGACAC AAACAGCCTT TTCCCAGGTA CTTGGTACCT GGAGCGAGTG 
GACGAGCAGC ATCGCCGAAA GTATGCCCGG CGTCCCGTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011539615.1
CDS	282..1643
Translation	MQRLLTPVKRILQLTRAVQETSLTPARLLPVAHQRFSTASAVPLAKTDTWPKDVGILALEVYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALERAGSDRPFTLDDLQYMIFHTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKASQDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARRPV

Target ORF information:

RefSeq Version	XM_011541313.1
Organism	Homo sapiens(human)
Definition	Homo sapiens 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011541313.1

ORF Insert Sequence:

ATGCAGCGTC TGTTGACTCC AGTGAAGCGC ATTCTGCAAC TGACAAGAGC GGTGCAGGAA 
ACCTCCCTCA CACCTGCTCG CCTGCTCCCA GTAGCCCACC AAAGGTTTTC TACAGCCTCT 
GCTGTCCCCC TGGCCAAAAC AGATACTTGG CCAAAGGACG TGGGCATCCT GGCCCTGGAG 
GTCTACTTCC CAGCCCAATA TGTGGACCAA ACTGACCTGG AGAAGTATAA CAATGTGGAA 
GCAGGAAAGT ATACAGTGGG CTTGGGCCAG ACCCGTATGG GCTTCTGCTC AGTCCAAGAG 
GACATCAACT CCCTGTGCCT GACGGTGGTG CAACGGCTGA TGGAGCGCAT ACAGCTCCCA 
TGGGACTCTG TGGGCAGGCT GGAAGTAGGC ACTGAGACCA TCATTGACAA GTCCAAAGCT 
GTCAAAACAG TGCTCATGGA ACTCTTCCAG GATTCAGGCA ATACTGATAT TGAGGGCATA 
GATACCACCA ATGCCTGCTA CGGTGGTACT GCCTCCCTCT TCAATGCTGC CAACTGGATG 
GAGTCCAGTT CCTGGGATGG TCGTTATGCC ATGGTGGTCT GTGGAGACAT TGCCGTCTAT 
CCCAGTGGTA ATGCTCGTCC CACAGGTGGG GCCGGAGCTG TGGCTATGCT GATTGGGCCC 
AAGGCCCCTC TGGCCCTGGA GCGAGCTGGC AGCGATCGAC CCTTCACCCT TGACGATTTA 
CAGTACATGA TCTTTCATAC ACCCTTTTGC AAGATGGTCC AGAAGTCTCT GGCTCGCCTG 
ATGTTCAATG ACTTCCTGTC AGCCAGCAGT GACACACAAA CCAGCTTATA TAAGGGGCTG 
GAGGCTTTCG GGGGGCTAAA GCTGGAAGAC ACCTACACCA ACAAGGACCT GGATAAAGCA 
CTTCTAAAGG CCTCTCAGGA CATGTTCGAC AAGAAAACCA AGGCTTCCCT TTACCTCTCC 
ACTCACAATG GGAACATGTA CACCTCATCC CTGTACGGGT GCCTGGCCTC GCTTCTGTCC 
CACCACTCTG CCCAAGAACT GGCTGGCTCC AGGATTGGTG CCTTCTCTTA TGGCTCTGGT 
TTAGCAGCAA GTTTCTTTTC ATTTCGAGTA TCCCAGGATG CTGCTCCAGG CTCTCCCCTG 
GACAAGTTGG TGTCCAGCAC ATCAGACCTG CCAAAACGCC TAGCCTCCCG AAAGTGTGTG 
TCTCCTGAGG AGTTCACAGA AATAATGAAC CAAAGAGAGC AATTCTACCA TAAGGTGAAT 
TTCTCCCCAC CTGGTGACAC AAACAGCCTT TTCCCAGGTA CTTGGTACCT GGAGCGAGTG 
GACGAGCAGC ATCGCCGAAA GTATGCCCGG CGTCCCGTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Involvement of nutrients and nutritional mediators in mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene expression.
Journal of cellular physiology233(4)3306-3314(2018 Apr)
Rescigno T,Capasso A,Tecce MF

miR-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma.
The international journal of biochemistry & cell biology91(Pt A)53-59(2017 Oct)
Su SG,Yang M,Zhang MF,Peng QZ,Li MY,Liu LP,Bao SY

HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk.
Scientific reports7(1)4590(2017 Jul)
Shukla SK,Liu W,Sikder K,Addya S,Sarkar A,Wei Y,Rafiq K

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HMGCS2 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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