HMGN2 cDNA ORF clone, Homo sapiens(human)

HMGN1 and 2 remodel core and linker histone tail domains within chromatin.
Murphy KJ, Cutter AR, Fang H, Postnikov YV, Bustin M, Hayes JJ
Nucleic acids research45(17)9917-9930(2017 Sep)

Nuclear protein HMGN2 attenuates pyocyanin-induced oxidative stress via Nrf2 signaling and inhibits Pseudomonas aeruginosa internalization in A549 cells.
Liu K, Wang X, Sha K, Zhang F, Xiong F, Wang X, Chen J, Li J, Churilov LP, Chen S, Wang Y, Huang N
Free radical biology & medicine108404-417(2017 Jul)

Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells.
Schauwecker SM, Kim JJ, Licht JD, Clevenger CV
The Journal of biological chemistry292(6)2237-2254(2017 02)

Knockdown of HMGN2 increases the internalization of Klebsiella?pneumoniae by respiratory epithelial cells through the regulation of ?5?1 integrin expression.
Wang X, Li J, Chen S, Shen X, Yang X, Teng Y, Deng L, Wang Y, Chen J, Wang X, Huang N
International journal of molecular medicine38(3)737-46(2016 Sep)

HMGN1 and HMGN2 remodel core and linker histone tail domains within chromatin.
Title: HMGN1 and 2 remodel core and linker histone tail domains within chromatin.

elucidate a novel mechanism whereby the linker histone H1 prevents STAT5 binding at promoter DNA, and the PRL-induced dissociation of H1 mediated by HMGN2 is necessary to allow full STAT5 recruitment and promote the biological effects of PRL signaling
Title: Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells.

Results provide evidence that HDAC6 could regulate HMGN2 acetylation levels and binding to Stat5a-responsive promoters, and therefore, Stat5a transcriptional activity in breast cancer cells.
Title: HDAC6 Deacetylates HMGN2 to Regulate Stat5a Activity and Breast Cancer Growth.

Data show that high mobility group nucleosomal binding domain 2 (HMGN2) knockdown induced the increased expression of alpha5beta1 integrin on cell membranes, which resulted in a significant increase in Klebsiella pneumoniae internalization.
Title: Knockdown of HMGN2 increases the internalization of Klebsiella?pneumoniae by respiratory epithelial cells through the regulation of ?5?1 integrin expression.

enhanced expression of HMGN2 in osteosarcoma cells by HMGN2 lentivirus, exerts inhibitory effects on growth and migration of osteosarcoma cells.
Title: Nucleosome-binding protein HMGN2 exhibits antitumor activity in human SaO2 and U2-OS osteosarcoma cell lines.