MR1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MR1
Entrez Gene ID	3140
Full Name	major histocompatibility complex, class I-related
Synonyms	HLALS
General protein information	Preferred Names major histocompatibility complex, class I-related Names major histocompatibility complex class I-related gene protein MHC class I-like antigen MR-1 MHC class-I related-gene protein major histocompatibility complex, class I-like sequence
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q25.3
Summary	MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome. [provided by RefSeq, Jul 2015].
Disorder MIM:	600764

mRNA and Protein(s)

mRNA	Protein	Name
XM_011509463.2	XP_011507765.1	major histocompatibility complex class I-related gene protein isoform X2
XM_006711286.3	XP_006711349.1	major histocompatibility complex class I-related gene protein isoform X1
XM_024446611.1	XP_024302379.1	major histocompatibility complex class I-related gene protein isoform X1
NM_001531.2	NP_001522.1	major histocompatibility complex class I-related gene protein isoform 1 precursor
NM_001195000.1	NP_001181929.1	major histocompatibility complex class I-related gene protein isoform 3 precursor
NM_001310213.1	NP_001297142.1	major histocompatibility complex class I-related gene protein isoform 5
NM_001194999.1	NP_001181928.1	major histocompatibility complex class I-related gene protein isoform 2 precursor
NM_001195035.1	NP_001181964.1	major histocompatibility complex class I-related gene protein isoform 4 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	MR1	NP_001522.1
Mus musculus (house mouse)	Mr1	NP_032235.1
Pan troglodytes (chimpanzee)	MR1	NP_001065258.1
Bos taurus (cattle)	MR1	NP_001177227.1
Rattus norvegicus (Norway rat)	Mr1	NP_001094105.1
	LOC718365	XP_001110940.2

Gene Ontology
Bibliography

Related articles in PubMed

Human mucosal-associated invariant T (MAIT) cells possess capacity for B cell help.
Bennett MS, Trivedi S, Iyer AS, Hale JS, Leung DT
Journal of leukocyte biology102(5)1261-1269(2017 Nov)

The Toll-like receptor 9 signalling pathway regulates MR1-mediated bacterial antigen presentation in B cells.
Liu J, Brutkiewicz RR
Immunology152(2)232-242(2017 Oct)

A polymorphism in human MR1 is associated with mRNA expression and susceptibility to tuberculosis.
Seshadri C, Thuong NT, Mai NT, Bang ND, Chau TT, Lewinsohn DM, Thwaites GE, Dunstan SJ, Hawn TR
Genes and immunity18(1)8-14(2017 Jan)

TLR signaling in human antigen-presenting cells regulates MR1-dependent activation of MAIT?cells.
Ussher JE, van Wilgenburg B, Hannaway RF, Ruustal K, Phalora P, Kurioka A, Hansen TH, Willberg CB, Phillips RE, Klenerman P
European journal of immunology46(7)1600-14(2016 07)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Human mucosal-associated invariant T cells possess capacity for B cell help via MR1-mediated immunoglobulins production.
Title: Human mucosal-associated invariant T (MAIT) cells possess capacity for B cell help.

Early endosomal TLR9 activation is important for MR1-mediated bacterial antigen presentation in B cells.
Title: The Toll-like receptor 9 signalling pathway regulates MR1-mediated bacterial antigen presentation in B cells.

Polymorphism in MR1 gene is associated with susceptibility to tuberculosis.
Title: A polymorphism in human MR1 is associated with mRNA expression and susceptibility to tuberculosis.

we have shown that MR1-mediated MAIT cell activation is tightly regulated at several levels. Efficient MR1-mediated MAIT cell activation requires both intact bacteria to access an acidified endolysomal compartment and activation of the APC through NF-kappaB or interferon signaling pathways.
Title: TLR signaling in human antigen-presenting cells regulates MR1-dependent activation of MAIT?cells.

Data show that the major histocompatibility complex, class I-related protein (MR1) antigen presentation is characterized by a rapid 'off-on-off' mechanism that is strictly dependent on antigen availability.
Title: The intracellular pathway for the presentation of vitamin B-related antigens by the antigen-presenting molecule MR1.

The following MR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22232	NM_001194999.1 Latest version!	Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu22709	NM_001531.2 Latest version!	Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$144.50-$202.30 $289.00
OHu22183	NM_001195000.1 Latest version!	Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OHu23141	NM_001195035.1 Latest version!	Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OHu58260	NM_001310213.1 Latest version!	Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu34330	XM_006711286.3 Latest version!	Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu34330	XM_024446611.1 Latest version!	Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu34331	XM_011509463.2 Latest version!	Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MR1 ( NM_001194999.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001181928.1 Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu22232
Clone ID Related Accession (Same CDS sequence)	NM_001194999.1
Accession Version	NM_001194999.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 891bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	major histocompatibility complex class I-related gene protein isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC297418.1, BC012485.1 and AL356267.27. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BC012485.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMN03465412 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGAAC TGATGGCGTT CCTGTTACCT CTCATCATTG TGTTAATGGT GAAGCACAGC 
GATTCCCGGA CGCACTCTCT GAGATATTTT CGCCTGGGCG TTTCGGATCC CATCCATGGG 
GTCCCTGAAT TTATTTCGGT TGGGTACGTG GACTCGCACC CTATCACCAC ATATGACAGT 
GTCACTCGGC AGAAGGAGCC ACGGGCCCCA TGGATGGCAG AGAACCTCGC GCCTGATCAC 
TGGGAGAGGT ACACTCAGCT GCTGAGGGGC TGGCAGCAGA TGTTCAAGGT GGAACTGAAG 
CGCCTACAGA GGCACTACAA TCACTCAGAT AATGTGGCTC ACACCATCAA GCAGGCATGG 
GAGGCCAATC AGCATGAGTT GCTGTATCAA AAGAATTGGC TGGAAGAAGA ATGTATTGCC 
TGGCTAAAGA GATTCCTGGA GTATGGGAAA GACACCCTAC AAAGAACAGA GCCCCCACTG 
GTCAGAGTAA ATCGCAAAGA AACTTTTCCA GGGGTTACAG CTCTCTTCTG CAAAGCTCAT 
GGCTTTTACC CCCCAGAAAT TTACATGACA TGGATGAAAA ACGGGGAAGA AATTGTCCAA 
GAAATTGATT ATGGAGACAT TCTTCCCAGT GGGGATGGAA CCTATCAGGC GTGGGCATCA 
ATTGAGCTTG ATCCTCAGAG CAGCAACCTT TACTCCTGTC ATGTGGAGCA CTGCGGTGTC 
CACATGGTTC TTCAGGTCCC CCAGGAATCA GAAACTATCC CTCTTGTGAT GAAAGCTGTC 
TCTGGGTCCA TTGTCCTTGT CATTGTGCTG GCTGGAGTTG GTGTTCTAGT CTGGAGAAGA 
AGGCCCCGAG AGCAAAATGG AGCCATCTAC CTTCCAACAC CAGATCGATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001181928.1
CDS	162..1052
Translation	MGELMAFLLPLIIVLMVKHSDSRTHSLRYFRLGVSDPIHGVPEFISVGYVDSHPITTYDSVTRQKEPRAPWMAENLAPDHWERYTQLLRGWQQMFKVELKRLQRHYNHSDNVAHTIKQAWEANQHELLYQKNWLEEECIAWLKRFLEYGKDTLQRTEPPLVRVNRKETFPGVTALFCKAHGFYPPEIYMTWMKNGEEIVQEIDYGDILPSGDGTYQAWASIELDPQSSNLYSCHVEHCGVHMVLQVPQESETIPLVMKAVSGSIVLVIVLAGVGVLVWRRRPREQNGAIYLPTPDR

Target ORF information:

RefSeq Version	NM_001194999.1
Organism	Homo sapiens(human)
Definition	Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001194999.1

ORF Insert Sequence:

ATGGGGGAAC TGATGGCGTT CCTGTTACCT CTCATCATTG TGTTAATGGT GAAGCACAGC 
GATTCCCGGA CGCACTCTCT GAGATATTTT CGCCTGGGCG TTTCGGATCC CATCCATGGG 
GTCCCTGAAT TTATTTCGGT TGGGTACGTG GACTCGCACC CTATCACCAC ATATGACAGT 
GTCACTCGGC AGAAGGAGCC ACGGGCCCCA TGGATGGCAG AGAACCTCGC GCCTGATCAC 
TGGGAGAGGT ACACTCAGCT GCTGAGGGGC TGGCAGCAGA TGTTCAAGGT GGAACTGAAG 
CGCCTACAGA GGCACTACAA TCACTCAGAT AATGTGGCTC ACACCATCAA GCAGGCATGG 
GAGGCCAATC AGCATGAGTT GCTGTATCAA AAGAATTGGC TGGAAGAAGA ATGTATTGCC 
TGGCTAAAGA GATTCCTGGA GTATGGGAAA GACACCCTAC AAAGAACAGA GCCCCCACTG 
GTCAGAGTAA ATCGCAAAGA AACTTTTCCA GGGGTTACAG CTCTCTTCTG CAAAGCTCAT 
GGCTTTTACC CCCCAGAAAT TTACATGACA TGGATGAAAA ACGGGGAAGA AATTGTCCAA 
GAAATTGATT ATGGAGACAT TCTTCCCAGT GGGGATGGAA CCTATCAGGC GTGGGCATCA 
ATTGAGCTTG ATCCTCAGAG CAGCAACCTT TACTCCTGTC ATGTGGAGCA CTGCGGTGTC 
CACATGGTTC TTCAGGTCCC CCAGGAATCA GAAACTATCC CTCTTGTGAT GAAAGCTGTC 
TCTGGGTCCA TTGTCCTTGT CATTGTGCTG GCTGGAGTTG GTGTTCTAGT CTGGAGAAGA 
AGGCCCCGAG AGCAAAATGG AGCCATCTAC CTTCCAACAC CAGATCGATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MR1 ( NM_001531.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001522.1 Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22709
Clone ID Related Accession (Same CDS sequence)	NM_001531.2
Accession Version	NM_001531.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1026bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	major histocompatibility complex class I-related gene protein isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC297418.1, U22963.1 and AL356267.27. This sequence is a reference standard in the RefSeqGene project. On Aug 18, 2010 this sequence version replaced NM_001531.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.235674.1, SRR1660805.355083.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGGGAAC TGATGGCGTT CCTGTTACCT CTCATCATTG TGTTAATGGT GAAGCACAGC 
GATTCCCGGA CGCACTCTCT GAGATATTTT CGCCTGGGCG TTTCGGATCC CATCCATGGG 
GTCCCTGAAT TTATTTCGGT TGGGTACGTG GACTCGCACC CTATCACCAC ATATGACAGT 
GTCACTCGGC AGAAGGAGCC ACGGGCCCCA TGGATGGCAG AGAACCTCGC GCCTGATCAC 
TGGGAGAGGT ACACTCAGCT GCTGAGGGGC TGGCAGCAGA TGTTCAAGGT GGAACTGAAG 
CGCCTACAGA GGCACTACAA TCACTCAGGG TCTCACACTT ACCAGAGAAT GATTGGCTGT 
GAGCTGCTGG AGGATGGAAG CACCACAGGA TTTCTGCAGT ATGCATATGA CGGGCAGGAT 
TTCCTGATCT TCAATAAAGA CACCCTCTCC TGGCTGGCTG TAGATAATGT GGCTCACACC 
ATCAAGCAGG CATGGGAGGC CAATCAGCAT GAGTTGCTGT ATCAAAAGAA TTGGCTGGAA 
GAAGAATGTA TTGCCTGGCT AAAGAGATTC CTGGAGTATG GGAAAGACAC CCTACAAAGA 
ACAGAGCCCC CACTGGTCAG AGTAAATCGC AAAGAAACTT TTCCAGGGGT TACAGCTCTC 
TTCTGCAAAG CTCATGGCTT TTACCCCCCA GAAATTTACA TGACATGGAT GAAAAACGGG 
GAAGAAATTG TCCAAGAAAT TGATTATGGA GACATTCTTC CCAGTGGGGA TGGAACCTAT 
CAGGCGTGGG CATCAATTGA GCTTGATCCT CAGAGCAGCA ACCTTTACTC CTGTCATGTG 
GAGCACTGCG GTGTCCACAT GGTTCTTCAG GTCCCCCAGG AATCAGAAAC TATCCCTCTT 
GTGATGAAAG CTGTCTCTGG GTCCATTGTC CTTGTCATTG TGCTGGCTGG AGTTGGTGTT 
CTAGTCTGGA GAAGAAGGCC CCGAGAGCAA AATGGAGCCA TCTACCTTCC AACACCAGAT 
CGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001522.1
CDS	162..1187
Translation	MGELMAFLLPLIIVLMVKHSDSRTHSLRYFRLGVSDPIHGVPEFISVGYVDSHPITTYDSVTRQKEPRAPWMAENLAPDHWERYTQLLRGWQQMFKVELKRLQRHYNHSGSHTYQRMIGCELLEDGSTTGFLQYAYDGQDFLIFNKDTLSWLAVDNVAHTIKQAWEANQHELLYQKNWLEEECIAWLKRFLEYGKDTLQRTEPPLVRVNRKETFPGVTALFCKAHGFYPPEIYMTWMKNGEEIVQEIDYGDILPSGDGTYQAWASIELDPQSSNLYSCHVEHCGVHMVLQVPQESETIPLVMKAVSGSIVLVIVLAGVGVLVWRRRPREQNGAIYLPTPDR

Target ORF information:

RefSeq Version	NM_001531.2
Organism	Homo sapiens(human)
Definition	Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001531.2

ORF Insert Sequence:

ATGGGGGAAC TGATGGCGTT CCTGTTACCT CTCATCATTG TGTTAATGGT GAAGCACAGC 
GATTCCCGGA CGCACTCTCT GAGATATTTT CGCCTGGGCG TTTCGGATCC CATCCATGGG 
GTCCCTGAAT TTATTTCGGT TGGGTACGTG GACTCGCACC CTATCACCAC ATATGACAGT 
GTCACTCGGC AGAAGGAGCC ACGGGCCCCA TGGATGGCAG AGAACCTCGC GCCTGATCAC 
TGGGAGAGGT ACACTCAGCT GCTGAGGGGC TGGCAGCAGA TGTTCAAGGT GGAACTGAAG 
CGCCTACAGA GGCACTACAA TCACTCAGGG TCTCACACTT ACCAGAGAAT GATTGGCTGT 
GAGCTGCTGG AGGATGGAAG CACCACAGGA TTTCTGCAGT ATGCATATGA CGGGCAGGAT 
TTCCTGATCT TCAATAAAGA CACCCTCTCC TGGCTGGCTG TAGATAATGT GGCTCACACC 
ATCAAGCAGG CATGGGAGGC CAATCAGCAT GAGTTGCTGT ATCAAAAGAA TTGGCTGGAA 
GAAGAATGTA TTGCCTGGCT AAAGAGATTC CTGGAGTATG GGAAAGACAC CCTACAAAGA 
ACAGAGCCCC CACTGGTCAG AGTAAATCGC AAAGAAACTT TTCCAGGGGT TACAGCTCTC 
TTCTGCAAAG CTCATGGCTT TTACCCCCCA GAAATTTACA TGACATGGAT GAAAAACGGG 
GAAGAAATTG TCCAAGAAAT TGATTATGGA GACATTCTTC CCAGTGGGGA TGGAACCTAT 
CAGGCGTGGG CATCAATTGA GCTTGATCCT CAGAGCAGCA ACCTTTACTC CTGTCATGTG 
GAGCACTGCG GTGTCCACAT GGTTCTTCAG GTCCCCCAGG AATCAGAAAC TATCCCTCTT 
GTGATGAAAG CTGTCTCTGG GTCCATTGTC CTTGTCATTG TGCTGGCTGG AGTTGGTGTT 
CTAGTCTGGA GAAGAAGGCC CCGAGAGCAA AATGGAGCCA TCTACCTTCC AACACCAGAT 
CGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MR1 ( NM_001195000.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001181929.1 Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu22183
Clone ID Related Accession (Same CDS sequence)	NM_001195000.1
Accession Version	NM_001195000.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 750bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	major histocompatibility complex class I-related gene protein isoform 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC297418.1, AF031469.1 and AL356267.27. Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: SRR1660805.4057.1, SRR1803615.177657.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGAAC TGATGGCGTT CCTGTTACCT CTCATCATTG TGTTAATGGT GAAGCACAGC 
GATTCCCGGA CGCACTCTCT GAGATATTTT CGCCTGGGCG TTTCGGATCC CATCCATGGG 
GTCCCTGAAT TTATTTCGGT TGGGTACGTG GACTCGCACC CTATCACCAC ATATGACAGT 
GTCACTCGGC AGAAGGAGCC ACGGGCCCCA TGGATGGCAG AGAACCTCGC GCCTGATCAC 
TGGGAGAGGT ACACTCAGCT GCTGAGGGGC TGGCAGCAGA TGTTCAAGGT GGAACTGAAG 
CGCCTACAGA GGCACTACAA TCACTCAGGG TCTCACACTT ACCAGAGAAT GATTGGCTGT 
GAGCTGCTGG AGGATGGAAG CACCACAGGA TTTCTGCAGT ATGCATATGA CGGGCAGGAT 
TTCCTGATCT TCAATAAAGA CACCCTCTCC TGGCTGGCTG TAGATAATGT GGCTCACACC 
ATCAAGCAGG CATGGGAGGC CAATCAGCAT GAGTTGCTGT ATCAAAAGAA TTGGCTGGAA 
GAAGAATGTA TTGCCTGGCT AAAGAGATTC CTGGAGTATG GGAAAGACAC CCTACAAAGA 
ACAGAATCAG AAACTATCCC TCTTGTGATG AAAGCTGTCT CTGGGTCCAT TGTCCTTGTC 
ATTGTGCTGG CTGGAGTTGG TGTTCTAGTC TGGAGAAGAA GGCCCCGAGA GCAAAATGGA 
GCCATCTACC TTCCAACACC AGATCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001181929.1
CDS	162..911
Translation	MGELMAFLLPLIIVLMVKHSDSRTHSLRYFRLGVSDPIHGVPEFISVGYVDSHPITTYDSVTRQKEPRAPWMAENLAPDHWERYTQLLRGWQQMFKVELKRLQRHYNHSGSHTYQRMIGCELLEDGSTTGFLQYAYDGQDFLIFNKDTLSWLAVDNVAHTIKQAWEANQHELLYQKNWLEEECIAWLKRFLEYGKDTLQRTESETIPLVMKAVSGSIVLVIVLAGVGVLVWRRRPREQNGAIYLPTPDR

Target ORF information:

RefSeq Version	NM_001195000.1
Organism	Homo sapiens(human)
Definition	Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001195000.1

ORF Insert Sequence:

ATGGGGGAAC TGATGGCGTT CCTGTTACCT CTCATCATTG TGTTAATGGT GAAGCACAGC 
GATTCCCGGA CGCACTCTCT GAGATATTTT CGCCTGGGCG TTTCGGATCC CATCCATGGG 
GTCCCTGAAT TTATTTCGGT TGGGTACGTG GACTCGCACC CTATCACCAC ATATGACAGT 
GTCACTCGGC AGAAGGAGCC ACGGGCCCCA TGGATGGCAG AGAACCTCGC GCCTGATCAC 
TGGGAGAGGT ACACTCAGCT GCTGAGGGGC TGGCAGCAGA TGTTCAAGGT GGAACTGAAG 
CGCCTACAGA GGCACTACAA TCACTCAGGG TCTCACACTT ACCAGAGAAT GATTGGCTGT 
GAGCTGCTGG AGGATGGAAG CACCACAGGA TTTCTGCAGT ATGCATATGA CGGGCAGGAT 
TTCCTGATCT TCAATAAAGA CACCCTCTCC TGGCTGGCTG TAGATAATGT GGCTCACACC 
ATCAAGCAGG CATGGGAGGC CAATCAGCAT GAGTTGCTGT ATCAAAAGAA TTGGCTGGAA 
GAAGAATGTA TTGCCTGGCT AAAGAGATTC CTGGAGTATG GGAAAGACAC CCTACAAAGA 
ACAGAATCAG AAACTATCCC TCTTGTGATG AAAGCTGTCT CTGGGTCCAT TGTCCTTGTC 
ATTGTGCTGG CTGGAGTTGG TGTTCTAGTC TGGAGAAGAA GGCCCCGAGA GCAAAATGGA 
GCCATCTACC TTCCAACACC AGATCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MR1 ( NM_001195035.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001181964.1 Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu23141
Clone ID Related Accession (Same CDS sequence)	NM_001195035.1
Accession Version	NM_001195035.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 645bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	major histocompatibility complex class I-related gene protein isoform 4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC297418.1, AK304645.1 and AL356267.27. Transcript Variant: This variant (4) lacks two consecutive in-frame exons in the coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AK304645.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA2144335, SAMEA2145245 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGAAC TGATGGCGTT CCTGTTACCT CTCATCATTG TGTTAATGGT GAAGCACAGC 
GATTCCCGGA CGCACTCTCT GAGATATTTT CGCCTGGGCG TTTCGGATCC CATCCATGGG 
GTCCCTGAAT TTATTTCGGT TGGGTACGTG GACTCGCACC CTATCACCAC ATATGACAGT 
GTCACTCGGC AGAAGGAGCC ACGGGCCCCA TGGATGGCAG AGAACCTCGC GCCTGATCAC 
TGGGAGAGGT ACACTCAGCT GCTGAGGGGC TGGCAGCAGA TGTTCAAGGT GGAACTGAAG 
CGCCTACAGA GGCACTACAA TCACTCAGGG TCTCACACTT ACCAGAGAAT GATTGGCTGT 
GAGCTGCTGG AGGATGGAAG CACCACAGGA TTTCTGCAGT ATGCATATGA CGGGCAGGAT 
TTCCTGATCT TCAATAAAGA CACCCTCTCC TGGCTGGCTG TAGATAATGT GGCTCACACC 
ATCAAGCAGG CATGGGAGGC CAATCAGCAT GAGTTGCTGT ATCAAAAGAA TTGGCTGGAA 
GAAGAATGTA TTGCCTGGCT AAAGAGATTC CTGGAGTATG GGAAAGACAC CCTACAAAGA 
ACAGAGCAAA ATGGAGCCAT CTACCTTCCA ACACCAGATC GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001181964.1
CDS	162..806
Translation	MGELMAFLLPLIIVLMVKHSDSRTHSLRYFRLGVSDPIHGVPEFISVGYVDSHPITTYDSVTRQKEPRAPWMAENLAPDHWERYTQLLRGWQQMFKVELKRLQRHYNHSGSHTYQRMIGCELLEDGSTTGFLQYAYDGQDFLIFNKDTLSWLAVDNVAHTIKQAWEANQHELLYQKNWLEEECIAWLKRFLEYGKDTLQRTEQNGAIYLPTPDR

Target ORF information:

RefSeq Version	NM_001195035.1
Organism	Homo sapiens(human)
Definition	Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001195035.1

ORF Insert Sequence:

ATGGGGGAAC TGATGGCGTT CCTGTTACCT CTCATCATTG TGTTAATGGT GAAGCACAGC 
GATTCCCGGA CGCACTCTCT GAGATATTTT CGCCTGGGCG TTTCGGATCC CATCCATGGG 
GTCCCTGAAT TTATTTCGGT TGGGTACGTG GACTCGCACC CTATCACCAC ATATGACAGT 
GTCACTCGGC AGAAGGAGCC ACGGGCCCCA TGGATGGCAG AGAACCTCGC GCCTGATCAC 
TGGGAGAGGT ACACTCAGCT GCTGAGGGGC TGGCAGCAGA TGTTCAAGGT GGAACTGAAG 
CGCCTACAGA GGCACTACAA TCACTCAGGG TCTCACACTT ACCAGAGAAT GATTGGCTGT 
GAGCTGCTGG AGGATGGAAG CACCACAGGA TTTCTGCAGT ATGCATATGA CGGGCAGGAT 
TTCCTGATCT TCAATAAAGA CACCCTCTCC TGGCTGGCTG TAGATAATGT GGCTCACACC 
ATCAAGCAGG CATGGGAGGC CAATCAGCAT GAGTTGCTGT ATCAAAAGAA TTGGCTGGAA 
GAAGAATGTA TTGCCTGGCT AAAGAGATTC CTGGAGTATG GGAAAGACAC CCTACAAAGA 
ACAGAGCAAA ATGGAGCCAT CTACCTTCCA ACACCAGATC GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MR1 ( NM_001310213.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001297142.1 Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant 5, mRNA.

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CloneID	OHu58260
Clone ID Related Accession (Same CDS sequence)	NM_001310213.1
Accession Version	NM_001310213.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 537bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	major histocompatibility complex class I-related gene protein isoform 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC297418.1, BX415555.2, AL356267.27 and CA426202.1. Transcript Variant: This variant (5) contains an alternate exon in the 5' end and lacks an alternate in-frame exon compared to variant 1, which results in translation initiation at a downstream start codon compared to variant 1. The encoded isoform (5) is shorter at the N-terminus and lacks an internal segment compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: SRR1660805.4057.1, SRR1163655.65780.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA2145245, SAMN01820687 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAGA ACCTCGCGCC TGATCACTGG GAGAGGTACA CTCAGCTGCT GAGGGGCTGG 
CAGCAGATGT TCAAGGTGGA ACTGAAGCGC CTACAGAGGC ACTACAATCA CTCAGGGTCT 
CACACTTACC AGAGAATGAT TGGCTGTGAG CTGCTGGAGG ATGGAAGCAC CACAGGATTT 
CTGCAGTATG CATATGACGG GCAGGATTTC CTGATCTTCA ATAAAGACAC CCTCTCCTGG 
CTGGCTGTAG ATAATGTGGC TCACACCATC AAGCAGGCAT GGGAGGCCAA TCAGCATGAG 
TTGCTGTATC AAAAGAATTG GCTGGAAGAA GAATGTATTG CCTGGCTAAA GAGATTCCTG 
GAGTATGGGA AAGACACCCT ACAAAGAACA GAATCAGAAA CTATCCCTCT TGTGATGAAA 
GCTGTCTCTG GGTCCATTGT CCTTGTCATT GTGCTGGCTG GAGTTGGTGT TCTAGTCTGG 
AGAAGAAGGC CCCGAGAGCA AAATGGAGCC ATCTACCTTC CAACACCAGA TCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001297142.1
CDS	491..1027
Translation	MAENLAPDHWERYTQLLRGWQQMFKVELKRLQRHYNHSGSHTYQRMIGCELLEDGSTTGFLQYAYDGQDFLIFNKDTLSWLAVDNVAHTIKQAWEANQHELLYQKNWLEEECIAWLKRFLEYGKDTLQRTESETIPLVMKAVSGSIVLVIVLAGVGVLVWRRRPREQNGAIYLPTPDR

Target ORF information:

RefSeq Version	NM_001310213.1
Organism	Homo sapiens(human)
Definition	Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001310213.1

ORF Insert Sequence:

ATGGCAGAGA ACCTCGCGCC TGATCACTGG GAGAGGTACA CTCAGCTGCT GAGGGGCTGG 
CAGCAGATGT TCAAGGTGGA ACTGAAGCGC CTACAGAGGC ACTACAATCA CTCAGGGTCT 
CACACTTACC AGAGAATGAT TGGCTGTGAG CTGCTGGAGG ATGGAAGCAC CACAGGATTT 
CTGCAGTATG CATATGACGG GCAGGATTTC CTGATCTTCA ATAAAGACAC CCTCTCCTGG 
CTGGCTGTAG ATAATGTGGC TCACACCATC AAGCAGGCAT GGGAGGCCAA TCAGCATGAG 
TTGCTGTATC AAAAGAATTG GCTGGAAGAA GAATGTATTG CCTGGCTAAA GAGATTCCTG 
GAGTATGGGA AAGACACCCT ACAAAGAACA GAATCAGAAA CTATCCCTCT TGTGATGAAA 
GCTGTCTCTG GGTCCATTGT CCTTGTCATT GTGCTGGCTG GAGTTGGTGT TCTAGTCTGG 
AGAAGAAGGC CCCGAGAGCA AAATGGAGCC ATCTACCTTC CAACACCAGA TCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MR1 ( XM_006711286.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006711349.1 Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu34330
Clone ID Related Accession (Same CDS sequence)	XM_006711286.3 , XM_024446611.1
Accession Version	XM_006711286.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 939bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	major histocompatibility complex class I-related gene protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006711286.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGGAAC TGATGGCGTT CCTGTTACCT CTCATCATTG TGTTAATGGT GAAGCACAGC 
GATTCCCGGA CGCACTCTCT GAGATATTTT CGCCTGGGCG TTTCGGATCC CATCCATGGG 
GTCCCTGAAT TTATTTCGGT TGGGTACGTG GACTCGCACC CTATCACCAC ATATGACAGT 
GTCACTCGGC AGAAGGAGCC ACGGGCCCCA TGGATGGCAG AGAACCTCGC GCCTGATCAC 
TGGGAGAGGT ACACTCAGCT GCTGAGGGGC TGGCAGCAGA TGTTCAAGGT GGAACTGAAG 
CGCCTACAGA GGCACTACAA TCACTCAGGG TCTCACACTT ACCAGAGAAT GATTGGCTGT 
GAGCTGCTGG AGGATGGAAG CACCACAGGA TTTCTGCAGT ATGCATATGA CGGGCAGGAT 
TTCCTGATCT TCAATAAAGA CACCCTCTCC TGGCTGGCTG TAGATAATGT GGCTCACACC 
ATCAAGCAGG CATGGGAGGC CAATCAGCAT GAGTTGCTGT ATCAAAAGAA TTGGCTGGAA 
GAAGAATGTA TTGCCTGGCT AAAGAGATTC CTGGAGTATG GGAAAGACAC CCTACAAAGA 
ACAGAAATTT ACATGACATG GATGAAAAAC GGGGAAGAAA TTGTCCAAGA AATTGATTAT 
GGAGACATTC TTCCCAGTGG GGATGGAACC TATCAGGCGT GGGCATCAAT TGAGCTTGAT 
CCTCAGAGCA GCAACCTTTA CTCCTGTCAT GTGGAGCACT GCGGTGTCCA CATGGTTCTT 
CAGGTCCCCC AGGAATCAGA AACTATCCCT CTTGTGATGA AAGCTGTCTC TGGGTCCATT 
GTCCTTGTCA TTGTGCTGGC TGGAGTTGGT GTTCTAGTCT GGAGAAGAAG GCCCCGAGAG 
CAAAATGGAG CCATCTACCT TCCAACACCA GATCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006711349.1
CDS	208..1146
Translation	MGELMAFLLPLIIVLMVKHSDSRTHSLRYFRLGVSDPIHGVPEFISVGYVDSHPITTYDSVTRQKEPRAPWMAENLAPDHWERYTQLLRGWQQMFKVELKRLQRHYNHSGSHTYQRMIGCELLEDGSTTGFLQYAYDGQDFLIFNKDTLSWLAVDNVAHTIKQAWEANQHELLYQKNWLEEECIAWLKRFLEYGKDTLQRTEIYMTWMKNGEEIVQEIDYGDILPSGDGTYQAWASIELDPQSSNLYSCHVEHCGVHMVLQVPQESETIPLVMKAVSGSIVLVIVLAGVGVLVWRRRPREQNGAIYLPTPDR

Target ORF information:

RefSeq Version	XM_006711286.3
Organism	Homo sapiens(human)
Definition	Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006711286.3

ORF Insert Sequence:

ATGGGGGAAC TGATGGCGTT CCTGTTACCT CTCATCATTG TGTTAATGGT GAAGCACAGC 
GATTCCCGGA CGCACTCTCT GAGATATTTT CGCCTGGGCG TTTCGGATCC CATCCATGGG 
GTCCCTGAAT TTATTTCGGT TGGGTACGTG GACTCGCACC CTATCACCAC ATATGACAGT 
GTCACTCGGC AGAAGGAGCC ACGGGCCCCA TGGATGGCAG AGAACCTCGC GCCTGATCAC 
TGGGAGAGGT ACACTCAGCT GCTGAGGGGC TGGCAGCAGA TGTTCAAGGT GGAACTGAAG 
CGCCTACAGA GGCACTACAA TCACTCAGGG TCTCACACTT ACCAGAGAAT GATTGGCTGT 
GAGCTGCTGG AGGATGGAAG CACCACAGGA TTTCTGCAGT ATGCATATGA CGGGCAGGAT 
TTCCTGATCT TCAATAAAGA CACCCTCTCC TGGCTGGCTG TAGATAATGT GGCTCACACC 
ATCAAGCAGG CATGGGAGGC CAATCAGCAT GAGTTGCTGT ATCAAAAGAA TTGGCTGGAA 
GAAGAATGTA TTGCCTGGCT AAAGAGATTC CTGGAGTATG GGAAAGACAC CCTACAAAGA 
ACAGAAATTT ACATGACATG GATGAAAAAC GGGGAAGAAA TTGTCCAAGA AATTGATTAT 
GGAGACATTC TTCCCAGTGG GGATGGAACC TATCAGGCGT GGGCATCAAT TGAGCTTGAT 
CCTCAGAGCA GCAACCTTTA CTCCTGTCAT GTGGAGCACT GCGGTGTCCA CATGGTTCTT 
CAGGTCCCCC AGGAATCAGA AACTATCCCT CTTGTGATGA AAGCTGTCTC TGGGTCCATT 
GTCCTTGTCA TTGTGCTGGC TGGAGTTGGT GTTCTAGTCT GGAGAAGAAG GCCCCGAGAG 
CAAAATGGAG CCATCTACCT TCCAACACCA GATCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MR1 ( XM_024446611.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024302379.1 Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu34330
Clone ID Related Accession (Same CDS sequence)	XM_006711286.3 , XM_024446611.1
Accession Version	XM_024446611.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 939bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	major histocompatibility complex class I-related gene protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGGAAC TGATGGCGTT CCTGTTACCT CTCATCATTG TGTTAATGGT GAAGCACAGC 
GATTCCCGGA CGCACTCTCT GAGATATTTT CGCCTGGGCG TTTCGGATCC CATCCATGGG 
GTCCCTGAAT TTATTTCGGT TGGGTACGTG GACTCGCACC CTATCACCAC ATATGACAGT 
GTCACTCGGC AGAAGGAGCC ACGGGCCCCA TGGATGGCAG AGAACCTCGC GCCTGATCAC 
TGGGAGAGGT ACACTCAGCT GCTGAGGGGC TGGCAGCAGA TGTTCAAGGT GGAACTGAAG 
CGCCTACAGA GGCACTACAA TCACTCAGGG TCTCACACTT ACCAGAGAAT GATTGGCTGT 
GAGCTGCTGG AGGATGGAAG CACCACAGGA TTTCTGCAGT ATGCATATGA CGGGCAGGAT 
TTCCTGATCT TCAATAAAGA CACCCTCTCC TGGCTGGCTG TAGATAATGT GGCTCACACC 
ATCAAGCAGG CATGGGAGGC CAATCAGCAT GAGTTGCTGT ATCAAAAGAA TTGGCTGGAA 
GAAGAATGTA TTGCCTGGCT AAAGAGATTC CTGGAGTATG GGAAAGACAC CCTACAAAGA 
ACAGAAATTT ACATGACATG GATGAAAAAC GGGGAAGAAA TTGTCCAAGA AATTGATTAT 
GGAGACATTC TTCCCAGTGG GGATGGAACC TATCAGGCGT GGGCATCAAT TGAGCTTGAT 
CCTCAGAGCA GCAACCTTTA CTCCTGTCAT GTGGAGCACT GCGGTGTCCA CATGGTTCTT 
CAGGTCCCCC AGGAATCAGA AACTATCCCT CTTGTGATGA AAGCTGTCTC TGGGTCCATT 
GTCCTTGTCA TTGTGCTGGC TGGAGTTGGT GTTCTAGTCT GGAGAAGAAG GCCCCGAGAG 
CAAAATGGAG CCATCTACCT TCCAACACCA GATCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024302379.1
CDS	51..989
Translation	MGELMAFLLPLIIVLMVKHSDSRTHSLRYFRLGVSDPIHGVPEFISVGYVDSHPITTYDSVTRQKEPRAPWMAENLAPDHWERYTQLLRGWQQMFKVELKRLQRHYNHSGSHTYQRMIGCELLEDGSTTGFLQYAYDGQDFLIFNKDTLSWLAVDNVAHTIKQAWEANQHELLYQKNWLEEECIAWLKRFLEYGKDTLQRTEIYMTWMKNGEEIVQEIDYGDILPSGDGTYQAWASIELDPQSSNLYSCHVEHCGVHMVLQVPQESETIPLVMKAVSGSIVLVIVLAGVGVLVWRRRPREQNGAIYLPTPDR

Target ORF information:

RefSeq Version	XM_024446611.1
Organism	Homo sapiens(human)
Definition	Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024446611.1

ORF Insert Sequence:

ATGGGGGAAC TGATGGCGTT CCTGTTACCT CTCATCATTG TGTTAATGGT GAAGCACAGC 
GATTCCCGGA CGCACTCTCT GAGATATTTT CGCCTGGGCG TTTCGGATCC CATCCATGGG 
GTCCCTGAAT TTATTTCGGT TGGGTACGTG GACTCGCACC CTATCACCAC ATATGACAGT 
GTCACTCGGC AGAAGGAGCC ACGGGCCCCA TGGATGGCAG AGAACCTCGC GCCTGATCAC 
TGGGAGAGGT ACACTCAGCT GCTGAGGGGC TGGCAGCAGA TGTTCAAGGT GGAACTGAAG 
CGCCTACAGA GGCACTACAA TCACTCAGGG TCTCACACTT ACCAGAGAAT GATTGGCTGT 
GAGCTGCTGG AGGATGGAAG CACCACAGGA TTTCTGCAGT ATGCATATGA CGGGCAGGAT 
TTCCTGATCT TCAATAAAGA CACCCTCTCC TGGCTGGCTG TAGATAATGT GGCTCACACC 
ATCAAGCAGG CATGGGAGGC CAATCAGCAT GAGTTGCTGT ATCAAAAGAA TTGGCTGGAA 
GAAGAATGTA TTGCCTGGCT AAAGAGATTC CTGGAGTATG GGAAAGACAC CCTACAAAGA 
ACAGAAATTT ACATGACATG GATGAAAAAC GGGGAAGAAA TTGTCCAAGA AATTGATTAT 
GGAGACATTC TTCCCAGTGG GGATGGAACC TATCAGGCGT GGGCATCAAT TGAGCTTGAT 
CCTCAGAGCA GCAACCTTTA CTCCTGTCAT GTGGAGCACT GCGGTGTCCA CATGGTTCTT 
CAGGTCCCCC AGGAATCAGA AACTATCCCT CTTGTGATGA AAGCTGTCTC TGGGTCCATT 
GTCCTTGTCA TTGTGCTGGC TGGAGTTGGT GTTCTAGTCT GGAGAAGAAG GCCCCGAGAG 
CAAAATGGAG CCATCTACCT TCCAACACCA GATCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MR1 ( XM_011509463.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011507765.1 Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu34331
Clone ID Related Accession (Same CDS sequence)	XM_011509463.2
Accession Version	XM_011509463.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 765bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	major histocompatibility complex class I-related gene protein isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011509463.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGGAAC TGATGGCGTT CCTGTTACCT CTCATCATTG TGTTAATGGT GAAGCACAGC 
GATTCCCGGT CTCACACTTA CCAGAGAATG ATTGGCTGTG AGCTGCTGGA GGATGGAAGC 
ACCACAGGAT TTCTGCAGTA TGCATATGAC GGGCAGGATT TCCTGATCTT CAATAAAGAC 
ACCCTCTCCT GGCTGGCTGT AGATAATGTG GCTCACACCA TCAAGCAGGC ATGGGAGGCC 
AATCAGCATG AGTTGCTGTA TCAAAAGAAT TGGCTGGAAG AAGAATGTAT TGCCTGGCTA 
AAGAGATTCC TGGAGTATGG GAAAGACACC CTACAAAGAA CAGAGCCCCC ACTGGTCAGA 
GTAAATCGCA AAGAAACTTT TCCAGGGGTT ACAGCTCTCT TCTGCAAAGC TCATGGCTTT 
TACCCCCCAG AAATTTACAT GACATGGATG AAAAACGGGG AAGAAATTGT CCAAGAAATT 
GATTATGGAG ACATTCTTCC CAGTGGGGAT GGAACCTATC AGGCGTGGGC ATCAATTGAG 
CTTGATCCTC AGAGCAGCAA CCTTTACTCC TGTCATGTGG AGCACTGCGG TGTCCACATG 
GTTCTTCAGG TCCCCCAGGA ATCAGAAACT ATCCCTCTTG TGATGAAAGC TGTCTCTGGG 
TCCATTGTCC TTGTCATTGT GCTGGCTGGA GTTGGTGTTC TAGTCTGGAG AAGAAGGCCC 
CGAGAGCAAA ATGGAGCCAT CTACCTTCCA ACACCAGATC GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011507765.1
CDS	195..959
Translation	MGELMAFLLPLIIVLMVKHSDSRSHTYQRMIGCELLEDGSTTGFLQYAYDGQDFLIFNKDTLSWLAVDNVAHTIKQAWEANQHELLYQKNWLEEECIAWLKRFLEYGKDTLQRTEPPLVRVNRKETFPGVTALFCKAHGFYPPEIYMTWMKNGEEIVQEIDYGDILPSGDGTYQAWASIELDPQSSNLYSCHVEHCGVHMVLQVPQESETIPLVMKAVSGSIVLVIVLAGVGVLVWRRRPREQNGAIYLPTPDR

Target ORF information:

RefSeq Version	XM_011509463.2
Organism	Homo sapiens(human)
Definition	Homo sapiens major histocompatibility complex, class I-related (MR1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011509463.2

ORF Insert Sequence:

ATGGGGGAAC TGATGGCGTT CCTGTTACCT CTCATCATTG TGTTAATGGT GAAGCACAGC 
GATTCCCGGT CTCACACTTA CCAGAGAATG ATTGGCTGTG AGCTGCTGGA GGATGGAAGC 
ACCACAGGAT TTCTGCAGTA TGCATATGAC GGGCAGGATT TCCTGATCTT CAATAAAGAC 
ACCCTCTCCT GGCTGGCTGT AGATAATGTG GCTCACACCA TCAAGCAGGC ATGGGAGGCC 
AATCAGCATG AGTTGCTGTA TCAAAAGAAT TGGCTGGAAG AAGAATGTAT TGCCTGGCTA 
AAGAGATTCC TGGAGTATGG GAAAGACACC CTACAAAGAA CAGAGCCCCC ACTGGTCAGA 
GTAAATCGCA AAGAAACTTT TCCAGGGGTT ACAGCTCTCT TCTGCAAAGC TCATGGCTTT 
TACCCCCCAG AAATTTACAT GACATGGATG AAAAACGGGG AAGAAATTGT CCAAGAAATT 
GATTATGGAG ACATTCTTCC CAGTGGGGAT GGAACCTATC AGGCGTGGGC ATCAATTGAG 
CTTGATCCTC AGAGCAGCAA CCTTTACTCC TGTCATGTGG AGCACTGCGG TGTCCACATG 
GTTCTTCAGG TCCCCCAGGA ATCAGAAACT ATCCCTCTTG TGATGAAAGC TGTCTCTGGG 
TCCATTGTCC TTGTCATTGT GCTGGCTGGA GTTGGTGTTC TAGTCTGGAG AAGAAGGCCC 
CGAGAGCAAA ATGGAGCCAT CTACCTTCCA ACACCAGATC GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human mucosal-associated invariant T (MAIT) cells possess capacity for B cell help.
Journal of leukocyte biology102(5)1261-1269(2017 Nov)
Bennett MS,Trivedi S,Iyer AS,Hale JS,Leung DT

The Toll-like receptor 9 signalling pathway regulates MR1-mediated bacterial antigen presentation in B cells.
Immunology152(2)232-242(2017 Oct)
Liu J,Brutkiewicz RR

A polymorphism in human MR1 is associated with mRNA expression and susceptibility to tuberculosis.
Genes and immunity18(1)8-14(2017 Jan)
Seshadri C,Thuong NT,Mai NT,Bang ND,Chau TT,Lewinsohn DM,Thwaites GE,Dunstan SJ,Hawn TR

TLR signaling in human antigen-presenting cells regulates MR1-dependent activation of MAIT?cells.
European journal of immunology46(7)1600-14(2016 07)
Ussher JE,van Wilgenburg B,Hannaway RF,Ruustal K,Phalora P,Kurioka A,Hansen TH,Willberg CB,Phillips RE,Klenerman P

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MR1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

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Target ORF information:

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ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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