HLA-DRA cDNA ORF clone, Homo sapiens(human)

Microglia in the dorsal raphe nucleus plays a potential role in both suicide facilitation and prevention in affective disorders.
Brisch R, Steiner J, Mawrin C, Krzy?anowska M, Jankowski Z, Gos T
European archives of psychiatry and clinical neuroscience267(5)403-415(2017 Aug)

HLA-DRA/HLA-DRB5 polymorphism affects risk of sporadic ALS and survival in a southwest Chinese cohort.
Yang X, Zheng J, Tian S, Chen Y, An R, Zhao Q, Xu Y
Journal of the neurological sciences373124-128(2017 Feb)

Human leucocyte antigen (HLA-DR) gene expression is reduced in sepsis and correlates with impaired TNF? response: A diagnostic tool for immunosuppression?
Winkler MS, Rissiek A, Priefler M, Schwedhelm E, Robbe L, Bauer A, Zahrte C, Zoellner C, Kluge S, Nierhaus A
PloS one12(8)e0182427(2017)

Major Histocompatibility Complex Class II HLA-DR? Is Downregulated by Kaposi's Sarcoma-Associated Herpesvirus-Encoded Lytic Transactivator RTA and MARCH8.
Sun Z, Jha HC, Pei YG, Robertson ES
Journal of virology90(18)8047-58(2016 09)

Quantitative Real-Time Polymerase Chain Reaction Measurement of HLA-DRA Gene Expression in Whole Blood Is Highly Reproducible and Shows Changes That Reflect Dynamic Shifts in Monocyte Surface HLA-DR Expression during the Course of Sepsis.
Cajander S, Tina E, B?ckman A, Magnuson A, Str?lin K, S?derquist B, K?llman J
PloS one11(5)e0154690(2016)

Case-control study in Han Chinese from the southwest of the country suggests that risk of ALS is increased by the AA genotype at rs9268856 in the HLA-DRA/HLA-DRB5 gene, but not by the SNPs rs9268877 in HLA-DRA/HLA-DRB5, rs1980493 in BTNL2 or rs302668 in RAB38/CTSC
Title: HLA-DRA/HLA-DRB5 polymorphism affects risk of sporadic ALS and survival in a southwest Chinese cohort.

Low HLA-DRA expression is associated with sepsis.
Title: Human leucocyte antigen (HLA-DR) gene expression is reduced in sepsis and correlates with impaired TNF? response: A diagnostic tool for immunosuppression?

Kaposi's sarcoma-associated herpesvirus RTA not only downregulated HLA-DRalpha at the protein level through direct binding and degradation through the proteasome pathway but also indirectly downregulated the protein level of HLA-DRalpha by enhancing the expression of MARCH8, a member of the membrane-associated RING-CH (MARCH) proteins.
Title: Major Histocompatibility Complex Class II HLA-DR? Is Downregulated by Kaposi's Sarcoma-Associated Herpesvirus-Encoded Lytic Transactivator RTA and MARCH8.

In this prospective study we evaluated dynamic changes in monocyte HLA-DR expression during sepsis in relation to changes in HLA-DRA gene expression and Class II transactivator (CIITA), measured by quantitative Real-Time Polymerase Chain Reaction (qRT-PCR).
Title: Quantitative Real-Time Polymerase Chain Reaction Measurement of HLA-DRA Gene Expression in Whole Blood Is Highly Reproducible and Shows Changes That Reflect Dynamic Shifts in Monocyte Surface HLA-DR Expression during the Course of Sepsis.

The frequency of CD14(+)HLA-DR-/low MDSCs could be considered as a poor prognostic predictor in small-cell lung cancer (SCLC) and the elimination of MDSCs during medical interventions may improve the prognosis of SCLC patients.
Title: Increased circulating CD14(+)HLA-DR-/low myeloid-derived suppressor cells are associated with poor prognosis in patients with small-cell lung cancer.