HIC1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HIC1
Entrez Gene ID	3090
Full Name	HIC ZBTB transcriptional repressor 1
Synonyms	ZBTB29,ZNF901,hic-1
General protein information	Preferred Names HIC ZBTB transcriptional repressor 1 Names hypermethylated in cancer 1 protein hypermethylated in cancer 1 zinc finger and BTB domain-containing protein 29
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p13.3
Summary	This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2010].
Disorder MIM:	603825

mRNA and Protein(s)

mRNA	Protein	Name
NM_001098202.1	NP_001091672.1	hypermethylated in cancer 1 protein isoform 2
NM_006497.3	NP_006488.2	hypermethylated in cancer 1 protein isoform 1
NM_006497.4	NP_006488.2	hypermethylated in cancer 1 protein isoform 1

Pathways from BioSystems

Homologies

	LOC721284	XP_001117386.2
Mus musculus (house mouse)	Hic1	NP_034560.2
Gallus gallus (chicken)	HIC1	NP_990567.1
Xenopus tropicalis (tropical clawed frog)	hic1	XP_004911694.1
Canis lupus familiaris (dog)	HIC1	XP_548318.2
Danio rerio (zebrafish)	hic1	NP_001002314.1
Rattus norvegicus (Norway rat)	LOC100912068	XP_003750910.1
Homo sapiens (human)	HIC1	NP_001091672.1
Bos taurus (cattle)	HIC1	XP_003587448.2

Gene Ontology
Bibliography

Related articles in PubMed

Tandem repeat variation near the HIC1 (hypermethylated in cancer 1) promoter predicts outcome of oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer.
Okazaki S, Schirripa M, Loupakis F, Cao S, Zhang W, Yang D, Ning Y, Berger MD, Miyamoto Y, Suenaga M, Iqubal S, Barzi A, Cremolini C, Falcone A, Battaglin F, Salvatore L, Borelli B, Helentjaris TG, Lenz HJ
Cancer123(22)4506-4514(2017 Nov)

HIC1 loss promotes prostate cancer metastasis by triggering epithelial-mesenchymal transition.
Hao M, Li Y, Wang J, Qin J, Wang Y, Ding Y, Jiang M, Sun X, Zu L, Chang K, Lin G, Du J, Korinek V, Ye DW, Wang J
The Journal of pathology242(4)409-420(2017 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The VNTR sequence near HIC1 could be a predictive marker for oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer.
Title: Tandem repeat variation near the HIC1 (hypermethylated in cancer 1) promoter predicts outcome of oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer.

HIC1 loss promotes prostate cancer metastasis by triggering epithelial-mesenchymal transition.
Title: HIC1 loss promotes prostate cancer metastasis by triggering epithelial-mesenchymal transition.

Therefore, our data identify HIC1 as a novel factor involved in B cell differentiation acting as an epigenetic repressor of CIITA transcription.
Title: HIC1 epigenetically represses CIITA transcription in B lymphocytes.

Data show that expression of hypermethylated in cancer 1 protein (HIC1) is downregulated in uveal melanoma.
Title: HIC1 modulates uveal melanoma progression by activating lncRNA-numb.

Data show that secretion of IL-6 induced by loss of HIC1 activated STAT3 through IL-6/JAK pathway and was associated with NSCLC progression.
Title: Hypermethylated in cancer 1(HIC1) suppresses non-small cell lung cancer progression by targeting interleukin-6/Stat3 pathway.

The following HIC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HIC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19928	NM_006497.4 Latest version!	Homo sapiens HIC ZBTB transcriptional repressor 1 (HIC1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$359.50-$503.30 $719.00
OHu20102	NM_001098202.1 Latest version!	Homo sapiens HIC ZBTB transcriptional repressor 1 (HIC1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$369.50-$517.30 $739.00
View Old Accession Versions >>
OHu19928	NM_006497.3	Homo sapiens HIC ZBTB transcriptional repressor 1 (HIC1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$359.50-$503.30 $719.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HIC1 ( NM_006497.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006488.2 Homo sapiens HIC ZBTB transcriptional repressor 1 (HIC1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19928
Clone ID Related Accession (Same CDS sequence)	NM_006497.3 , NM_006497.4
Accession Version	NM_006497.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2145bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	hypermethylated in cancer 1 protein isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ583694.1, BC030208.1, AC090617.16 and BQ004706.1. This sequence is a reference standard in the RefSeqGene project. On May 23, 2007 this sequence version replaced NM_006497.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.559534.1, SRR1163658.113896.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCTGGACA CGATGGAGGC GCCCGGCCAC TCCAGGCAGC TGCTGCTGCA GCTCAACAAC 
CAGCGCACCA AGGGCTTCTT GTGCGACGTG ATCATCGTGG TGCAGAACGC CCTCTTCCGC 
GCGCACAAGA ACGTGCTGGC GGCCAGCAGC GCCTACCTCA AGTCCCTGGT GGTGCATGAC 
AACCTGCTCA ACCTGGACCA TGACATGGTG AGCCCGGCCG TGTTCCGCCT GGTGCTGGAC 
TTCATCTACA CCGGCCGCCT GGCTGACGGC GCAGAGGCGG CTGCGGCCGC GGCCGTGGCC 
CCGGGGGCTG AGCCGAGCCT GGGCGCCGTG CTGGCCGCCG CCAGCTACCT GCAGATCCCC 
GACCTCGTGG CGCTGTGCAA GAAACGCCTC AAGCGCCACG GCAAGTACTG CCACCTGCGG 
GGCGGCGGCG GCGGCGGCGG CGGCTACGCG CCCTATGGTC GGCCGGGCCG GGGCCTGCGG 
GCCGCCACGC CGGTCATCCA GGCCTGCTAC CCGTCCCCAG TCGGGCCTCC GCCGCCGCCT 
GCCGCGGAGC CGCCCTCGGG CCCAGAGGCC GCGGTCAACA CGCACTGCGC CGAGCTGTAC 
GCGTCGGGAC CCGGCCCGGC CGCCGCACTC TGTGCCTCGG AGCGCCGCTG CTCCCCTCTT 
TGTGGCCTGG ACCTGTCCAA GAAGAGCCCG CCGGGCTCCG CGGCGCCAGA GCGGCCGCTG 
GCTGAGCGCG AGCTGCCCCC GCGCCCGGAC AGCCCTCCCA GCGCCGGCCC CGCCGCCTAC 
AAGGAGCCGC CTCTCGCCCT GCCGTCGCTG CCGCCGCTGC CCTTCCAGAA GCTGGAGGAG 
GCCGCACCGC CTTCCGACCC ATTTCGCGGC GGCAGCGGCA GCCCGGGACC CGAGCCCCCC 
GGCCGCCCCG ACGGGCCTAG TCTCCTCTAT CGCTGGATGA AGCACGAGCC GGGCCTGGGT 
AGCTATGGCG ACGAGCTGGG CCGGGAGCGC GGCTCCCCCA GCGAGCGCTG CGAAGAGCGT 
GGTGGGGACG CGGCCGTCTC GCCCGGGGGG CCCCCGCTCG GCCTGGCGCC GCCGCCGCGC 
TACCCTGGCA GCCTGGACGG GCCCGGCGCG GGCGGCGACG GCGACGACTA CAAGAGCAGC 
AGCGAGGAGA CCGGTAGCAG CGAGGACCCC AGCCCGCCTG GCGGCCACCT CGAGGGCTAC 
CCATGCCCGC ACCTGGCCTA TGGCGAGCCC GAGAGCTTCG GTGACAACCT GTACGTGTGC 
ATTCCGTGCG GCAAGGGCTT CCCCAGCTCT GAGCAGCTGA ACGCGCACGT GGAGGCTCAC 
GTGGAGGAGG AGGAAGCGCT GTACGGCAGG GCCGAGGCGG CCGAAGTGGC CGCTGGGGCC 
GCCGGCCTAG GGCCCCCTTT TGGAGGCGGC GGGGACAAGG TCGCCGGGGC TCCGGGTGGC 
CTGGGAGAGC TGCTGCGGCC CTACCGCTGC GCGTCGTGCG ACAAGAGCTA CAAGGACCCG 
GCCACGCTGC GGCAGCACGA GAAGACGCAC TGGCTGACCC GGCCCTACCC ATGCACCATC 
TGCGGGAAGA AGTTCACGCA GCGTGGGACC ATGACGCGCC ACATGCGCAG CCACCTGGGC 
CTCAAGCCCT TCGCGTGCGA CGCGTGCGGC ATGCGGTTCA CGCGCCAGTA CCGCCTCACG 
GAGCACATGC GCATCCACTC GGGCGAGAAG CCCTACGAGT GCCAGGTGTG CGGCGGCAAG 
TTCGCACAGC AACGCAACCT CATCAGCCAC ATGAAGATGC ACGCCGTGGG GGGCGCGGCC 
GGCGCGGCCG GGGCGCTGGC GGGCTTGGGG GGGCTCCCCG GCGTCCCCGG CCCCGACGGC 
AAGGGCAAGC TCGACTTCCC CGAGGGCGTC TTTGCTGTGG CTCGCCTCAC GGCCGAGCAG 
CTGAGCCTGA AGCAGCAGGA CAAGGCGGCC GCGGCCGAGC TGCTGGCGCA GACCACGCAC 
TTCCTGCACG ACCCCAAGGT GGCGCTGGAG AGCCTCTACC CGCTGGCCAA GTTCACGGCC 
GAGCTGGGCC TCAGCCCCGA CAAGGCGGCC GAGGTGCTGA GCCAGGGCGC TCACCTGGCG 
GCCGGGCCCG ACGGCCGGAC CATCGACCGT TTCTCTCCCA CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006488.2
CDS	161..2305
Translation	MLDTMEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRLADGAEAAAAAAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKYCHLRGGGGGGGGYAPYGRPGRGLRAATPVIQACYPSPVGPPPPPAAEPPSGPEAAVNTHCAELYASGPGPAAALCASERRCSPLCGLDLSKKSPPGSAAPERPLAERELPPRPDSPPSAGPAAYKEPPLALPSLPPLPFQKLEEAAPPSDPFRGGSGSPGPEPPGRPDGPSLLYRWMKHEPGLGSYGDELGRERGSPSERCEERGGDAAVSPGGPPLGLAPPPRYPGSLDGPGAGGDGDDYKSSSEETGSSEDPSPPGGHLEGYPCPHLAYGEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHVEEEEALYGRAEAAEVAAGAAGLGPPFGGGGDKVAGAPGGLGELLRPYRCASCDKSYKDPATLRQHEKTHWLTRPYPCTICGKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISHMKMHAVGGAAGAAGALAGLGGLPGVPGPDGKGKLDFPEGVFAVARLTAEQLSLKQQDKAAAAELLAQTTHFLHDPKVALESLYPLAKFTAELGLSPDKAAEVLSQGAHLAAGPDGRTIDRFSPT

Target ORF information:

RefSeq Version	NM_006497.3
Organism	Homo sapiens(human)
Definition	Homo sapiens HIC ZBTB transcriptional repressor 1 (HIC1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006497.3

ORF Insert Sequence:

ATGCTGGACA CGATGGAGGC GCCCGGCCAC TCCAGGCAGC TGCTGCTGCA GCTCAACAAC 
CAGCGCACCA AGGGCTTCTT GTGCGACGTG ATCATCGTGG TGCAGAACGC CCTCTTCCGC 
GCGCACAAGA ACGTGCTGGC GGCCAGCAGC GCCTACCTCA AGTCCCTGGT GGTGCATGAC 
AACCTGCTCA ACCTGGACCA TGACATGGTG AGCCCGGCCG TGTTCCGCCT GGTGCTGGAC 
TTCATCTACA CCGGCCGCCT GGCTGACGGC GCAGAGGCGG CTGCGGCCGC GGCCGTGGCC 
CCGGGGGCTG AGCCGAGCCT GGGCGCCGTG CTGGCCGCCG CCAGCTACCT GCAGATCCCC 
GACCTCGTGG CGCTGTGCAA GAAACGCCTC AAGCGCCACG GCAAGTACTG CCACCTGCGG 
GGCGGCGGCG GCGGCGGCGG CGGCTACGCG CCCTATGGTC GGCCGGGCCG GGGCCTGCGG 
GCCGCCACGC CGGTCATCCA GGCCTGCTAC CCGTCCCCAG TCGGGCCTCC GCCGCCGCCT 
GCCGCGGAGC CGCCCTCGGG CCCAGAGGCC GCGGTCAACA CGCACTGCGC CGAGCTGTAC 
GCGTCGGGAC CCGGCCCGGC CGCCGCACTC TGTGCCTCGG AGCGCCGCTG CTCCCCTCTT 
TGTGGCCTGG ACCTGTCCAA GAAGAGCCCG CCGGGCTCCG CGGCGCCAGA GCGGCCGCTG 
GCTGAGCGCG AGCTGCCCCC GCGCCCGGAC AGCCCTCCCA GCGCCGGCCC CGCCGCCTAC 
AAGGAGCCGC CTCTCGCCCT GCCGTCGCTG CCGCCGCTGC CCTTCCAGAA GCTGGAGGAG 
GCCGCACCGC CTTCCGACCC ATTTCGCGGC GGCAGCGGCA GCCCGGGACC CGAGCCCCCC 
GGCCGCCCCG ACGGGCCTAG TCTCCTCTAT CGCTGGATGA AGCACGAGCC GGGCCTGGGT 
AGCTATGGCG ACGAGCTGGG CCGGGAGCGC GGCTCCCCCA GCGAGCGCTG CGAAGAGCGT 
GGTGGGGACG CGGCCGTCTC GCCCGGGGGG CCCCCGCTCG GCCTGGCGCC GCCGCCGCGC 
TACCCTGGCA GCCTGGACGG GCCCGGCGCG GGCGGCGACG GCGACGACTA CAAGAGCAGC 
AGCGAGGAGA CCGGTAGCAG CGAGGACCCC AGCCCGCCTG GCGGCCACCT CGAGGGCTAC 
CCATGCCCGC ACCTGGCCTA TGGCGAGCCC GAGAGCTTCG GTGACAACCT GTACGTGTGC 
ATTCCGTGCG GCAAGGGCTT CCCCAGCTCT GAGCAGCTGA ACGCGCACGT GGAGGCTCAC 
GTGGAGGAGG AGGAAGCGCT GTACGGCAGG GCCGAGGCGG CCGAAGTGGC CGCTGGGGCC 
GCCGGCCTAG GGCCCCCTTT TGGAGGCGGC GGGGACAAGG TCGCCGGGGC TCCGGGTGGC 
CTGGGAGAGC TGCTGCGGCC CTACCGCTGC GCGTCGTGCG ACAAGAGCTA CAAGGACCCG 
GCCACGCTGC GGCAGCACGA GAAGACGCAC TGGCTGACCC GGCCCTACCC ATGCACCATC 
TGCGGGAAGA AGTTCACGCA GCGTGGGACC ATGACGCGCC ACATGCGCAG CCACCTGGGC 
CTCAAGCCCT TCGCGTGCGA CGCGTGCGGC ATGCGGTTCA CGCGCCAGTA CCGCCTCACG 
GAGCACATGC GCATCCACTC GGGCGAGAAG CCCTACGAGT GCCAGGTGTG CGGCGGCAAG 
TTCGCACAGC AACGCAACCT CATCAGCCAC ATGAAGATGC ACGCCGTGGG GGGCGCGGCC 
GGCGCGGCCG GGGCGCTGGC GGGCTTGGGG GGGCTCCCCG GCGTCCCCGG CCCCGACGGC 
AAGGGCAAGC TCGACTTCCC CGAGGGCGTC TTTGCTGTGG CTCGCCTCAC GGCCGAGCAG 
CTGAGCCTGA AGCAGCAGGA CAAGGCGGCC GCGGCCGAGC TGCTGGCGCA GACCACGCAC 
TTCCTGCACG ACCCCAAGGT GGCGCTGGAG AGCCTCTACC CGCTGGCCAA GTTCACGGCC 
GAGCTGGGCC TCAGCCCCGA CAAGGCGGCC GAGGTGCTGA GCCAGGGCGC TCACCTGGCG 
GCCGGGCCCG ACGGCCGGAC CATCGACCGT TTCTCTCCCA CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HIC1 ( NM_006497.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006488.2 Homo sapiens HIC ZBTB transcriptional repressor 1 (HIC1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19928
Clone ID Related Accession (Same CDS sequence)	NM_006497.3 , NM_006497.4
Accession Version	NM_006497.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2145bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	hypermethylated in cancer 1 protein isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ583694.1, BC030208.1, AC090617.16 and BQ004706.1. On Nov 22, 2018 this sequence version replaced NM_006497.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.559534.1, SRR1163658.113896.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000619757.5/ ENSP00000477858.1 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGGACA CGATGGAGGC GCCCGGCCAC TCCAGGCAGC TGCTGCTGCA GCTCAACAAC 
CAGCGCACCA AGGGCTTCTT GTGCGACGTG ATCATCGTGG TGCAGAACGC CCTCTTCCGC 
GCGCACAAGA ACGTGCTGGC GGCCAGCAGC GCCTACCTCA AGTCCCTGGT GGTGCATGAC 
AACCTGCTCA ACCTGGACCA TGACATGGTG AGCCCGGCCG TGTTCCGCCT GGTGCTGGAC 
TTCATCTACA CCGGCCGCCT GGCTGACGGC GCAGAGGCGG CTGCGGCCGC GGCCGTGGCC 
CCGGGGGCTG AGCCGAGCCT GGGCGCCGTG CTGGCCGCCG CCAGCTACCT GCAGATCCCC 
GACCTCGTGG CGCTGTGCAA GAAACGCCTC AAGCGCCACG GCAAGTACTG CCACCTGCGG 
GGCGGCGGCG GCGGCGGCGG CGGCTACGCG CCCTATGGTC GGCCGGGCCG GGGCCTGCGG 
GCCGCCACGC CGGTCATCCA GGCCTGCTAC CCGTCCCCAG TCGGGCCTCC GCCGCCGCCT 
GCCGCGGAGC CGCCCTCGGG CCCAGAGGCC GCGGTCAACA CGCACTGCGC CGAGCTGTAC 
GCGTCGGGAC CCGGCCCGGC CGCCGCACTC TGTGCCTCGG AGCGCCGCTG CTCCCCTCTT 
TGTGGCCTGG ACCTGTCCAA GAAGAGCCCG CCGGGCTCCG CGGCGCCAGA GCGGCCGCTG 
GCTGAGCGCG AGCTGCCCCC GCGCCCGGAC AGCCCTCCCA GCGCCGGCCC CGCCGCCTAC 
AAGGAGCCGC CTCTCGCCCT GCCGTCGCTG CCGCCGCTGC CCTTCCAGAA GCTGGAGGAG 
GCCGCACCGC CTTCCGACCC ATTTCGCGGC GGCAGCGGCA GCCCGGGACC CGAGCCCCCC 
GGCCGCCCCG ACGGGCCTAG TCTCCTCTAT CGCTGGATGA AGCACGAGCC GGGCCTGGGT 
AGCTATGGCG ACGAGCTGGG CCGGGAGCGC GGCTCCCCCA GCGAGCGCTG CGAAGAGCGT 
GGTGGGGACG CGGCCGTCTC GCCCGGGGGG CCCCCGCTCG GCCTGGCGCC GCCGCCGCGC 
TACCCTGGCA GCCTGGACGG GCCCGGCGCG GGCGGCGACG GCGACGACTA CAAGAGCAGC 
AGCGAGGAGA CCGGTAGCAG CGAGGACCCC AGCCCGCCTG GCGGCCACCT CGAGGGCTAC 
CCATGCCCGC ACCTGGCCTA TGGCGAGCCC GAGAGCTTCG GTGACAACCT GTACGTGTGC 
ATTCCGTGCG GCAAGGGCTT CCCCAGCTCT GAGCAGCTGA ACGCGCACGT GGAGGCTCAC 
GTGGAGGAGG AGGAAGCGCT GTACGGCAGG GCCGAGGCGG CCGAAGTGGC CGCTGGGGCC 
GCCGGCCTAG GGCCCCCTTT TGGAGGCGGC GGGGACAAGG TCGCCGGGGC TCCGGGTGGC 
CTGGGAGAGC TGCTGCGGCC CTACCGCTGC GCGTCGTGCG ACAAGAGCTA CAAGGACCCG 
GCCACGCTGC GGCAGCACGA GAAGACGCAC TGGCTGACCC GGCCCTACCC ATGCACCATC 
TGCGGGAAGA AGTTCACGCA GCGTGGGACC ATGACGCGCC ACATGCGCAG CCACCTGGGC 
CTCAAGCCCT TCGCGTGCGA CGCGTGCGGC ATGCGGTTCA CGCGCCAGTA CCGCCTCACG 
GAGCACATGC GCATCCACTC GGGCGAGAAG CCCTACGAGT GCCAGGTGTG CGGCGGCAAG 
TTCGCACAGC AACGCAACCT CATCAGCCAC ATGAAGATGC ACGCCGTGGG GGGCGCGGCC 
GGCGCGGCCG GGGCGCTGGC GGGCTTGGGG GGGCTCCCCG GCGTCCCCGG CCCCGACGGC 
AAGGGCAAGC TCGACTTCCC CGAGGGCGTC TTTGCTGTGG CTCGCCTCAC GGCCGAGCAG 
CTGAGCCTGA AGCAGCAGGA CAAGGCGGCC GCGGCCGAGC TGCTGGCGCA GACCACGCAC 
TTCCTGCACG ACCCCAAGGT GGCGCTGGAG AGCCTCTACC CGCTGGCCAA GTTCACGGCC 
GAGCTGGGCC TCAGCCCCGA CAAGGCGGCC GAGGTGCTGA GCCAGGGCGC TCACCTGGCG 
GCCGGGCCCG ACGGCCGGAC CATCGACCGT TTCTCTCCCA CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006488.2
CDS	157..2301
Translation	MLDTMEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRLADGAEAAAAAAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKYCHLRGGGGGGGGYAPYGRPGRGLRAATPVIQACYPSPVGPPPPPAAEPPSGPEAAVNTHCAELYASGPGPAAALCASERRCSPLCGLDLSKKSPPGSAAPERPLAERELPPRPDSPPSAGPAAYKEPPLALPSLPPLPFQKLEEAAPPSDPFRGGSGSPGPEPPGRPDGPSLLYRWMKHEPGLGSYGDELGRERGSPSERCEERGGDAAVSPGGPPLGLAPPPRYPGSLDGPGAGGDGDDYKSSSEETGSSEDPSPPGGHLEGYPCPHLAYGEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHVEEEEALYGRAEAAEVAAGAAGLGPPFGGGGDKVAGAPGGLGELLRPYRCASCDKSYKDPATLRQHEKTHWLTRPYPCTICGKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISHMKMHAVGGAAGAAGALAGLGGLPGVPGPDGKGKLDFPEGVFAVARLTAEQLSLKQQDKAAAAELLAQTTHFLHDPKVALESLYPLAKFTAELGLSPDKAAEVLSQGAHLAAGPDGRTIDRFSPT

Target ORF information:

RefSeq Version	NM_006497.4
Organism	Homo sapiens(human)
Definition	Homo sapiens HIC ZBTB transcriptional repressor 1 (HIC1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006497.4

ORF Insert Sequence:

ATGCTGGACA CGATGGAGGC GCCCGGCCAC TCCAGGCAGC TGCTGCTGCA GCTCAACAAC 
CAGCGCACCA AGGGCTTCTT GTGCGACGTG ATCATCGTGG TGCAGAACGC CCTCTTCCGC 
GCGCACAAGA ACGTGCTGGC GGCCAGCAGC GCCTACCTCA AGTCCCTGGT GGTGCATGAC 
AACCTGCTCA ACCTGGACCA TGACATGGTG AGCCCGGCCG TGTTCCGCCT GGTGCTGGAC 
TTCATCTACA CCGGCCGCCT GGCTGACGGC GCAGAGGCGG CTGCGGCCGC GGCCGTGGCC 
CCGGGGGCTG AGCCGAGCCT GGGCGCCGTG CTGGCCGCCG CCAGCTACCT GCAGATCCCC 
GACCTCGTGG CGCTGTGCAA GAAACGCCTC AAGCGCCACG GCAAGTACTG CCACCTGCGG 
GGCGGCGGCG GCGGCGGCGG CGGCTACGCG CCCTATGGTC GGCCGGGCCG GGGCCTGCGG 
GCCGCCACGC CGGTCATCCA GGCCTGCTAC CCGTCCCCAG TCGGGCCTCC GCCGCCGCCT 
GCCGCGGAGC CGCCCTCGGG CCCAGAGGCC GCGGTCAACA CGCACTGCGC CGAGCTGTAC 
GCGTCGGGAC CCGGCCCGGC CGCCGCACTC TGTGCCTCGG AGCGCCGCTG CTCCCCTCTT 
TGTGGCCTGG ACCTGTCCAA GAAGAGCCCG CCGGGCTCCG CGGCGCCAGA GCGGCCGCTG 
GCTGAGCGCG AGCTGCCCCC GCGCCCGGAC AGCCCTCCCA GCGCCGGCCC CGCCGCCTAC 
AAGGAGCCGC CTCTCGCCCT GCCGTCGCTG CCGCCGCTGC CCTTCCAGAA GCTGGAGGAG 
GCCGCACCGC CTTCCGACCC ATTTCGCGGC GGCAGCGGCA GCCCGGGACC CGAGCCCCCC 
GGCCGCCCCG ACGGGCCTAG TCTCCTCTAT CGCTGGATGA AGCACGAGCC GGGCCTGGGT 
AGCTATGGCG ACGAGCTGGG CCGGGAGCGC GGCTCCCCCA GCGAGCGCTG CGAAGAGCGT 
GGTGGGGACG CGGCCGTCTC GCCCGGGGGG CCCCCGCTCG GCCTGGCGCC GCCGCCGCGC 
TACCCTGGCA GCCTGGACGG GCCCGGCGCG GGCGGCGACG GCGACGACTA CAAGAGCAGC 
AGCGAGGAGA CCGGTAGCAG CGAGGACCCC AGCCCGCCTG GCGGCCACCT CGAGGGCTAC 
CCATGCCCGC ACCTGGCCTA TGGCGAGCCC GAGAGCTTCG GTGACAACCT GTACGTGTGC 
ATTCCGTGCG GCAAGGGCTT CCCCAGCTCT GAGCAGCTGA ACGCGCACGT GGAGGCTCAC 
GTGGAGGAGG AGGAAGCGCT GTACGGCAGG GCCGAGGCGG CCGAAGTGGC CGCTGGGGCC 
GCCGGCCTAG GGCCCCCTTT TGGAGGCGGC GGGGACAAGG TCGCCGGGGC TCCGGGTGGC 
CTGGGAGAGC TGCTGCGGCC CTACCGCTGC GCGTCGTGCG ACAAGAGCTA CAAGGACCCG 
GCCACGCTGC GGCAGCACGA GAAGACGCAC TGGCTGACCC GGCCCTACCC ATGCACCATC 
TGCGGGAAGA AGTTCACGCA GCGTGGGACC ATGACGCGCC ACATGCGCAG CCACCTGGGC 
CTCAAGCCCT TCGCGTGCGA CGCGTGCGGC ATGCGGTTCA CGCGCCAGTA CCGCCTCACG 
GAGCACATGC GCATCCACTC GGGCGAGAAG CCCTACGAGT GCCAGGTGTG CGGCGGCAAG 
TTCGCACAGC AACGCAACCT CATCAGCCAC ATGAAGATGC ACGCCGTGGG GGGCGCGGCC 
GGCGCGGCCG GGGCGCTGGC GGGCTTGGGG GGGCTCCCCG GCGTCCCCGG CCCCGACGGC 
AAGGGCAAGC TCGACTTCCC CGAGGGCGTC TTTGCTGTGG CTCGCCTCAC GGCCGAGCAG 
CTGAGCCTGA AGCAGCAGGA CAAGGCGGCC GCGGCCGAGC TGCTGGCGCA GACCACGCAC 
TTCCTGCACG ACCCCAAGGT GGCGCTGGAG AGCCTCTACC CGCTGGCCAA GTTCACGGCC 
GAGCTGGGCC TCAGCCCCGA CAAGGCGGCC GAGGTGCTGA GCCAGGGCGC TCACCTGGCG 
GCCGGGCCCG ACGGCCGGAC CATCGACCGT TTCTCTCCCA CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HIC1 ( NM_001098202.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001091672.1 Homo sapiens HIC ZBTB transcriptional repressor 1 (HIC1), transcript variant 2, mRNA.

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CloneID	OHu20102
Clone ID Related Accession (Same CDS sequence)	NM_001098202.1
Accession Version	NM_001098202.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2202bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Homo sapiens(human)
Product	hypermethylated in cancer 1 protein isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC090617.16 and BQ004706.1. Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTTTTC CTGAAGCGGA CATTTTACTT AAATCGGGAG AGTGTGCTGG GCAGACGATG 
CTGGACACGA TGGAGGCGCC CGGCCACTCC AGGCAGCTGC TGCTGCAGCT CAACAACCAG 
CGCACCAAGG GCTTCTTGTG CGACGTGATC ATCGTGGTGC AGAACGCCCT CTTCCGCGCG 
CACAAGAACG TGCTGGCGGC CAGCAGCGCC TACCTCAAGT CCCTGGTGGT GCATGACAAC 
CTGCTCAACC TGGACCATGA CATGGTGAGC CCGGCCGTGT TCCGCCTGGT GCTGGACTTC 
ATCTACACCG GCCGCCTGGC TGACGGCGCA GAGGCGGCTG CGGCCGCGGC CGTGGCCCCG 
GGGGCTGAGC CGAGCCTGGG CGCCGTGCTG GCCGCCGCCA GCTACCTGCA GATCCCCGAC 
CTCGTGGCGC TGTGCAAGAA ACGCCTCAAG CGCCACGGCA AGTACTGCCA CCTGCGGGGC 
GGCGGCGGCG GCGGCGGCGG CTACGCGCCC TATGGTCGGC CGGGCCGGGG CCTGCGGGCC 
GCCACGCCGG TCATCCAGGC CTGCTACCCG TCCCCAGTCG GGCCTCCGCC GCCGCCTGCC 
GCGGAGCCGC CCTCGGGCCC AGAGGCCGCG GTCAACACGC ACTGCGCCGA GCTGTACGCG 
TCGGGACCCG GCCCGGCCGC CGCACTCTGT GCCTCGGAGC GCCGCTGCTC CCCTCTTTGT 
GGCCTGGACC TGTCCAAGAA GAGCCCGCCG GGCTCCGCGG CGCCAGAGCG GCCGCTGGCT 
GAGCGCGAGC TGCCCCCGCG CCCGGACAGC CCTCCCAGCG CCGGCCCCGC CGCCTACAAG 
GAGCCGCCTC TCGCCCTGCC GTCGCTGCCG CCGCTGCCCT TCCAGAAGCT GGAGGAGGCC 
GCACCGCCTT CCGACCCATT TCGCGGCGGC AGCGGCAGCC CGGGACCCGA GCCCCCCGGC 
CGCCCCGACG GGCCTAGTCT CCTCTATCGC TGGATGAAGC ACGAGCCGGG CCTGGGTAGC 
TATGGCGACG AGCTGGGCCG GGAGCGCGGC TCCCCCAGCG AGCGCTGCGA AGAGCGTGGT 
GGGGACGCGG CCGTCTCGCC CGGGGGGCCC CCGCTCGGCC TGGCGCCGCC GCCGCGCTAC 
CCTGGCAGCC TGGACGGGCC CGGCGCGGGC GGCGACGGCG ACGACTACAA GAGCAGCAGC 
GAGGAGACCG GTAGCAGCGA GGACCCCAGC CCGCCTGGCG GCCACCTCGA GGGCTACCCA 
TGCCCGCACC TGGCCTATGG CGAGCCCGAG AGCTTCGGTG ACAACCTGTA CGTGTGCATT 
CCGTGCGGCA AGGGCTTCCC CAGCTCTGAG CAGCTGAACG CGCACGTGGA GGCTCACGTG 
GAGGAGGAGG AAGCGCTGTA CGGCAGGGCC GAGGCGGCCG AAGTGGCCGC TGGGGCCGCC 
GGCCTAGGGC CCCCTTTTGG AGGCGGCGGG GACAAGGTCG CCGGGGCTCC GGGTGGCCTG 
GGAGAGCTGC TGCGGCCCTA CCGCTGCGCG TCGTGCGACA AGAGCTACAA GGACCCGGCC 
ACGCTGCGGC AGCACGAGAA GACGCACTGG CTGACCCGGC CCTACCCATG CACCATCTGC 
GGGAAGAAGT TCACGCAGCG TGGGACCATG ACGCGCCACA TGCGCAGCCA CCTGGGCCTC 
AAGCCCTTCG CGTGCGACGC GTGCGGCATG CGGTTCACGC GCCAGTACCG CCTCACGGAG 
CACATGCGCA TCCACTCGGG CGAGAAGCCC TACGAGTGCC AGGTGTGCGG CGGCAAGTTC 
GCACAGCAAC GCAACCTCAT CAGCCACATG AAGATGCACG CCGTGGGGGG CGCGGCCGGC 
GCGGCCGGGG CGCTGGCGGG CTTGGGGGGG CTCCCCGGCG TCCCCGGCCC CGACGGCAAG 
GGCAAGCTCG ACTTCCCCGA GGGCGTCTTT GCTGTGGCTC GCCTCACGGC CGAGCAGCTG 
AGCCTGAAGC AGCAGGACAA GGCGGCCGCG GCCGAGCTGC TGGCGCAGAC CACGCACTTC 
CTGCACGACC CCAAGGTGGC GCTGGAGAGC CTCTACCCGC TGGCCAAGTT CACGGCCGAG 
CTGGGCCTCA GCCCCGACAA GGCGGCCGAG GTGCTGAGCC AGGGCGCTCA CCTGGCGGCC 
GGGCCCGACG GCCGGACCAT CGACCGTTTC TCTCCCACCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001091672.1
CDS	1..2202
Translation	MTFPEADILLKSGECAGQTMLDTMEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRLADGAEAAAAAAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKYCHLRGGGGGGGGYAPYGRPGRGLRAATPVIQACYPSPVGPPPPPAAEPPSGPEAAVNTHCAELYASGPGPAAALCASERRCSPLCGLDLSKKSPPGSAAPERPLAERELPPRPDSPPSAGPAAYKEPPLALPSLPPLPFQKLEEAAPPSDPFRGGSGSPGPEPPGRPDGPSLLYRWMKHEPGLGSYGDELGRERGSPSERCEERGGDAAVSPGGPPLGLAPPPRYPGSLDGPGAGGDGDDYKSSSEETGSSEDPSPPGGHLEGYPCPHLAYGEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHVEEEEALYGRAEAAEVAAGAAGLGPPFGGGGDKVAGAPGGLGELLRPYRCASCDKSYKDPATLRQHEKTHWLTRPYPCTICGKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISHMKMHAVGGAAGAAGALAGLGGLPGVPGPDGKGKLDFPEGVFAVARLTAEQLSLKQQDKAAAAELLAQTTHFLHDPKVALESLYPLAKFTAELGLSPDKAAEVLSQGAHLAAGPDGRTIDRFSPT

Target ORF information:

RefSeq Version	NM_001098202.1
Organism	Homo sapiens(human)
Definition	Homo sapiens HIC ZBTB transcriptional repressor 1 (HIC1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001098202.1

ORF Insert Sequence:

ATGACTTTTC CTGAAGCGGA CATTTTACTT AAATCGGGAG AGTGTGCTGG GCAGACGATG 
CTGGACACGA TGGAGGCGCC CGGCCACTCC AGGCAGCTGC TGCTGCAGCT CAACAACCAG 
CGCACCAAGG GCTTCTTGTG CGACGTGATC ATCGTGGTGC AGAACGCCCT CTTCCGCGCG 
CACAAGAACG TGCTGGCGGC CAGCAGCGCC TACCTCAAGT CCCTGGTGGT GCATGACAAC 
CTGCTCAACC TGGACCATGA CATGGTGAGC CCGGCCGTGT TCCGCCTGGT GCTGGACTTC 
ATCTACACCG GCCGCCTGGC TGACGGCGCA GAGGCGGCTG CGGCCGCGGC CGTGGCCCCG 
GGGGCTGAGC CGAGCCTGGG CGCCGTGCTG GCCGCCGCCA GCTACCTGCA GATCCCCGAC 
CTCGTGGCGC TGTGCAAGAA ACGCCTCAAG CGCCACGGCA AGTACTGCCA CCTGCGGGGC 
GGCGGCGGCG GCGGCGGCGG CTACGCGCCC TATGGTCGGC CGGGCCGGGG CCTGCGGGCC 
GCCACGCCGG TCATCCAGGC CTGCTACCCG TCCCCAGTCG GGCCTCCGCC GCCGCCTGCC 
GCGGAGCCGC CCTCGGGCCC AGAGGCCGCG GTCAACACGC ACTGCGCCGA GCTGTACGCG 
TCGGGACCCG GCCCGGCCGC CGCACTCTGT GCCTCGGAGC GCCGCTGCTC CCCTCTTTGT 
GGCCTGGACC TGTCCAAGAA GAGCCCGCCG GGCTCCGCGG CGCCAGAGCG GCCGCTGGCT 
GAGCGCGAGC TGCCCCCGCG CCCGGACAGC CCTCCCAGCG CCGGCCCCGC CGCCTACAAG 
GAGCCGCCTC TCGCCCTGCC GTCGCTGCCG CCGCTGCCCT TCCAGAAGCT GGAGGAGGCC 
GCACCGCCTT CCGACCCATT TCGCGGCGGC AGCGGCAGCC CGGGACCCGA GCCCCCCGGC 
CGCCCCGACG GGCCTAGTCT CCTCTATCGC TGGATGAAGC ACGAGCCGGG CCTGGGTAGC 
TATGGCGACG AGCTGGGCCG GGAGCGCGGC TCCCCCAGCG AGCGCTGCGA AGAGCGTGGT 
GGGGACGCGG CCGTCTCGCC CGGGGGGCCC CCGCTCGGCC TGGCGCCGCC GCCGCGCTAC 
CCTGGCAGCC TGGACGGGCC CGGCGCGGGC GGCGACGGCG ACGACTACAA GAGCAGCAGC 
GAGGAGACCG GTAGCAGCGA GGACCCCAGC CCGCCTGGCG GCCACCTCGA GGGCTACCCA 
TGCCCGCACC TGGCCTATGG CGAGCCCGAG AGCTTCGGTG ACAACCTGTA CGTGTGCATT 
CCGTGCGGCA AGGGCTTCCC CAGCTCTGAG CAGCTGAACG CGCACGTGGA GGCTCACGTG 
GAGGAGGAGG AAGCGCTGTA CGGCAGGGCC GAGGCGGCCG AAGTGGCCGC TGGGGCCGCC 
GGCCTAGGGC CCCCTTTTGG AGGCGGCGGG GACAAGGTCG CCGGGGCTCC GGGTGGCCTG 
GGAGAGCTGC TGCGGCCCTA CCGCTGCGCG TCGTGCGACA AGAGCTACAA GGACCCGGCC 
ACGCTGCGGC AGCACGAGAA GACGCACTGG CTGACCCGGC CCTACCCATG CACCATCTGC 
GGGAAGAAGT TCACGCAGCG TGGGACCATG ACGCGCCACA TGCGCAGCCA CCTGGGCCTC 
AAGCCCTTCG CGTGCGACGC GTGCGGCATG CGGTTCACGC GCCAGTACCG CCTCACGGAG 
CACATGCGCA TCCACTCGGG CGAGAAGCCC TACGAGTGCC AGGTGTGCGG CGGCAAGTTC 
GCACAGCAAC GCAACCTCAT CAGCCACATG AAGATGCACG CCGTGGGGGG CGCGGCCGGC 
GCGGCCGGGG CGCTGGCGGG CTTGGGGGGG CTCCCCGGCG TCCCCGGCCC CGACGGCAAG 
GGCAAGCTCG ACTTCCCCGA GGGCGTCTTT GCTGTGGCTC GCCTCACGGC CGAGCAGCTG 
AGCCTGAAGC AGCAGGACAA GGCGGCCGCG GCCGAGCTGC TGGCGCAGAC CACGCACTTC 
CTGCACGACC CCAAGGTGGC GCTGGAGAGC CTCTACCCGC TGGCCAAGTT CACGGCCGAG 
CTGGGCCTCA GCCCCGACAA GGCGGCCGAG GTGCTGAGCC AGGGCGCTCA CCTGGCGGCC 
GGGCCCGACG GCCGGACCAT CGACCGTTTC TCTCCCACCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tandem repeat variation near the HIC1 (hypermethylated in cancer 1) promoter predicts outcome of oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer.
Cancer123(22)4506-4514(2017 Nov)
Okazaki S,Schirripa M,Loupakis F,Cao S,Zhang W,Yang D,Ning Y,Berger MD,Miyamoto Y,Suenaga M,Iqubal S,Barzi A,Cremolini C,Falcone A,Battaglin F,Salvatore L,Borelli B,Helentjaris TG,Lenz HJ

HIC1 loss promotes prostate cancer metastasis by triggering epithelial-mesenchymal transition.
The Journal of pathology242(4)409-420(2017 Aug)
Hao M,Li Y,Wang J,Qin J,Wang Y,Ding Y,Jiang M,Sun X,Zu L,Chang K,Lin G,Du J,Korinek V,Ye DW,Wang J

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HIC1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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