HHEX cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HHEX
Entrez Gene ID	3087
Full Name	hematopoietically expressed homeobox
Synonyms	HEX,HMPH,HOX11L-PEN,PRH,PRHX
General protein information	Preferred Names hematopoietically expressed homeobox Names hematopoietically-expressed homeobox protein HHEX homeobox protein HEX homeobox protein PRH homeobox, hematopoietically expressed proline-rich homeodomain-containing transcription factor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q23.33
Summary	This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008].
Disorder MIM:	604420

mRNA and Protein(s)

mRNA	Protein	Name
NM_002729.4	NP_002720.1	hematopoietically-expressed homeobox protein HHEX
NM_002729.5	NP_002720.1	hematopoietically-expressed homeobox protein HHEX

Pathways from BioSystems

Homologies

Homo sapiens (human)	HHEX	NP_002720.1
Bos taurus (cattle)	HHEX	NP_001098894.1
Rattus norvegicus (Norway rat)	Hhex	NP_077361.1
	HHEX	XP_001090715.1
Danio rerio (zebrafish)	hhex	NP_571009.1
Xenopus tropicalis (tropical clawed frog)	hhex	NP_989420.1
Pan troglodytes (chimpanzee)	HHEX	XP_003951761.1
Canis lupus familiaris (dog)	HHEX	XP_850204.1
Mus musculus (house mouse)	Hhex	NP_032271.1
Gallus gallus (chicken)	HHEX	NP_990583.1

Gene Ontology
Bibliography

Related articles in PubMed

Protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism.
Wadey KS, Brown BA, Sala-Newby GB, Jayaraman PS, Gaston K, George SJ
Vascular pharmacology9934-44(2017 Dec)

Overexpression of HHEX in Acute Myeloid Leukemia with t(8;21)(q22;q22) Translocation.
Zhang S, Ma L, Chen Y, Xu H, Chen S, Wu W
Annals of clinical and laboratory science47(6)687-697(2017 Nov)

HHEX: A Crosstalker between HCMV Infection and Proliferation of VSMCs.
Li L, Liu M, Kang L, Li Y, Dai Z, Wang B, Liu S, Chen L, Tan Y, Wu G
Frontiers in cellular and infection microbiology6169(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Vascular smooth muscle protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism.
Title: Protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism.

The aim of this study was to examine the association between HHEX (rs5015480) and PROX1 (rs340874) gene polymorphisms and Gestational diabetes mellitus (GDM) .The HHEX gene rs5015480 C allele may be a risk allele of GDM that is associated with increased BMI during pregnancy
Title: Hematopoietically expressed homeobox (HHEX) gene polymorphism (rs5015480) is associated with increased risk of gestational diabetes mellitus.

These studies identify uPA-dependent de-repression of vegfr1 and vegfr2 gene transcription through binding to HHEX/PRH as a novel mechanism by which uPA mediates the pro-angiogenic effects of VEGF and identifies a potential new target for control of pathologic angiogenesis.
Title: Urokinase-type Plasminogen Activator (uPA) Promotes Angiogenesis by Attenuating Proline-rich Homeodomain Protein (PRH) Transcription Factor Activity and De-repressing Vascular Endothelial Growth Factor (VEGF) Receptor Expression.

The multivariate logistic regression analysis with reference to both alleles and genotypes of CDKAL1 SNPs showed significant association, suggesting an important role for this gene in the T2DM pathophysiology. INTERPRETATION & CONCLUSIONS: A significant association was seen of all the three SNPs of CDKAL1 and CDKN2A/B genes with T2DM but none of the two SNPs of HHEX.
Title: Association of CDKAL1, CDKN2A/B & HHEX gene polymorphisms with type 2 diabetes mellitus in the population of Hyderabad, India.

HHEX over expression induced by human cytomegalovirus infection closely associated with vascular proliferative diseases.
Title: HHEX: A Crosstalker between HCMV Infection and Proliferation of VSMCs.

The following HHEX gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HHEX cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14117	NM_002729.5 Latest version!	Homo sapiens hematopoietically expressed homeobox (HHEX), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu14117	NM_002729.4	Homo sapiens hematopoietically expressed homeobox (HHEX), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HHEX ( NM_002729.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002720.1 Homo sapiens hematopoietically expressed homeobox (HHEX), mRNA.

Price & Availability↑

CloneID	OHu14117
Clone ID Related Accession (Same CDS sequence)	NM_002729.4 , NM_002729.5
Accession Version	NM_002729.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 813bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	hematopoietically-expressed homeobox protein HHEX
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB504532.1, BC015110.1 and BM543214.1. On Feb 23, 2007 this sequence version replaced NM_002729.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC015110.1, SRR1163655.93677.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGTACC CGCACCCCGG GCCGGCGGCG GGCGCCGTGG GGGTGCCGCT GTACGCGCCC 
ACGCCGCTGC TGCAACCCGC ACACCCGACG CCCTTTTACA TCGAGGACAT CCTGGGCCGC 
GGGCCCGCCG CGCCCACGCC CGCCCCCACG CTGCCGTCCC CCAACTCCTC CTTCACCAGC 
CTCGTGTCCC CCTACCGGAC CCCGGTGTAC GAGCCCACGC CGATCCATCC AGCCTTCTCG 
CACCACTCCG CCGCCGCGCT GGCCGCTGCC TACGGACCCG GCGGCTTCGG GGGCCCTCTG 
TACCCCTTCC CGCGGACGGT GAACGACTAC ACGCACGCCC TGCTCCGCCA CGACCCCCTG 
GGCAAACCTC TACTCTGGAG CCCCTTCTTG CAGAGGCCTC TGCATAAAAG GAAAGGCGGC 
CAGGTGAGAT TCTCCAACGA CCAGACCATC GAGCTGGAGA AGAAATTCGA GACGCAGAAA 
TATCTCTCTC CGCCCGAGAG GAAGCGTCTG GCCAAGATGC TGCAGCTCAG CGAGAGACAG 
GTCAAAACCT GGTTTCAGAA TCGACGCGCT AAATGGAGGA GACTAAAACA GGAGAACCCT 
CAAAGCAATA AAAAAGAAGA ACTGGAAAGT TTGGACAGTT CCTGTGATCA GAGGCAAGAT 
TTGCCCAGTG AACAGAATAA AGGTGCTTCT TTGGATAGCT CTCAATGTTC GCCCTCCCCT 
GCCTCCCAGG AAGACCTTGA ATCAGAGATT TCAGAGGATT CTGATCAGGA AGTGGACATT 
GAGGGCGATA AAAGCTATTT TAATGCTGGA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002720.1
CDS	64..876
Translation	MQYPHPGPAAGAVGVPLYAPTPLLQPAHPTPFYIEDILGRGPAAPTPAPTLPSPNSSFTSLVSPYRTPVYEPTPIHPAFSHHSAAALAAAYGPGGFGGPLYPFPRTVNDYTHALLRHDPLGKPLLWSPFLQRPLHKRKGGQVRFSNDQTIELEKKFETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQENPQSNKKEELESLDSSCDQRQDLPSEQNKGASLDSSQCSPSPASQEDLESEISEDSDQEVDIEGDKSYFNAG

Target ORF information:

RefSeq Version	NM_002729.4
Organism	Homo sapiens(human)
Definition	Homo sapiens hematopoietically expressed homeobox (HHEX), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002729.4

ORF Insert Sequence:

ATGCAGTACC CGCACCCCGG GCCGGCGGCG GGCGCCGTGG GGGTGCCGCT GTACGCGCCC 
ACGCCGCTGC TGCAACCCGC ACACCCGACG CCCTTTTACA TCGAGGACAT CCTGGGCCGC 
GGGCCCGCCG CGCCCACGCC CGCCCCCACG CTGCCGTCCC CCAACTCCTC CTTCACCAGC 
CTCGTGTCCC CCTACCGGAC CCCGGTGTAC GAGCCCACGC CGATCCATCC AGCCTTCTCG 
CACCACTCCG CCGCCGCGCT GGCCGCTGCC TACGGACCCG GCGGCTTCGG GGGCCCTCTG 
TACCCCTTCC CGCGGACGGT GAACGACTAC ACGCACGCCC TGCTCCGCCA CGACCCCCTG 
GGCAAACCTC TACTCTGGAG CCCCTTCTTG CAGAGGCCTC TGCATAAAAG GAAAGGCGGC 
CAGGTGAGAT TCTCCAACGA CCAGACCATC GAGCTGGAGA AGAAATTCGA GACGCAGAAA 
TATCTCTCTC CGCCCGAGAG GAAGCGTCTG GCCAAGATGC TGCAGCTCAG CGAGAGACAG 
GTCAAAACCT GGTTTCAGAA TCGACGCGCT AAATGGAGGA GACTAAAACA GGAGAACCCT 
CAAAGCAATA AAAAAGAAGA ACTGGAAAGT TTGGACAGTT CCTGTGATCA GAGGCAAGAT 
TTGCCCAGTG AACAGAATAA AGGTGCTTCT TTGGATAGCT CTCAATGTTC GCCCTCCCCT 
GCCTCCCAGG AAGACCTTGA ATCAGAGATT TCAGAGGATT CTGATCAGGA AGTGGACATT 
GAGGGCGATA AAAGCTATTT TAATGCTGGA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HHEX ( NM_002729.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002720.1 Homo sapiens hematopoietically expressed homeobox (HHEX), mRNA.

Price & Availability↑

CloneID	OHu14117
Clone ID Related Accession (Same CDS sequence)	NM_002729.4 , NM_002729.5
Accession Version	NM_002729.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 813bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Homo sapiens(human)
Product	hematopoietically-expressed homeobox protein HHEX
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC015110.1 and BM543214.1. On Nov 22, 2018 this sequence version replaced NM_002729.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC050638.1, BC015110.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000282728.10/ ENSP00000282728.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGTACC CGCACCCCGG GCCGGCGGCG GGCGCCGTGG GGGTGCCGCT GTACGCGCCC 
ACGCCGCTGC TGCAACCCGC ACACCCGACG CCCTTTTACA TCGAGGACAT CCTGGGCCGC 
GGGCCCGCCG CGCCCACGCC CGCCCCCACG CTGCCGTCCC CCAACTCCTC CTTCACCAGC 
CTCGTGTCCC CCTACCGGAC CCCGGTGTAC GAGCCCACGC CGATCCATCC AGCCTTCTCG 
CACCACTCCG CCGCCGCGCT GGCCGCTGCC TACGGACCCG GCGGCTTCGG GGGCCCTCTG 
TACCCCTTCC CGCGGACGGT GAACGACTAC ACGCACGCCC TGCTCCGCCA CGACCCCCTG 
GGCAAACCTC TACTCTGGAG CCCCTTCTTG CAGAGGCCTC TGCATAAAAG GAAAGGCGGC 
CAGGTGAGAT TCTCCAACGA CCAGACCATC GAGCTGGAGA AGAAATTCGA GACGCAGAAA 
TATCTCTCTC CGCCCGAGAG GAAGCGTCTG GCCAAGATGC TGCAGCTCAG CGAGAGACAG 
GTCAAAACCT GGTTTCAGAA TCGACGCGCT AAATGGAGGA GACTAAAACA GGAGAACCCT 
CAAAGCAATA AAAAAGAAGA ACTGGAAAGT TTGGACAGTT CCTGTGATCA GAGGCAAGAT 
TTGCCCAGTG AACAGAATAA AGGTGCTTCT TTGGATAGCT CTCAATGTTC GCCCTCCCCT 
GCCTCCCAGG AAGACCTTGA ATCAGAGATT TCAGAGGATT CTGATCAGGA AGTGGACATT 
GAGGGCGATA AAAGCTATTT TAATGCTGGA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002720.1
CDS	33..845
Translation	MQYPHPGPAAGAVGVPLYAPTPLLQPAHPTPFYIEDILGRGPAAPTPAPTLPSPNSSFTSLVSPYRTPVYEPTPIHPAFSHHSAAALAAAYGPGGFGGPLYPFPRTVNDYTHALLRHDPLGKPLLWSPFLQRPLHKRKGGQVRFSNDQTIELEKKFETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQENPQSNKKEELESLDSSCDQRQDLPSEQNKGASLDSSQCSPSPASQEDLESEISEDSDQEVDIEGDKSYFNAG

Target ORF information:

RefSeq Version	NM_002729.5
Organism	Homo sapiens(human)
Definition	Homo sapiens hematopoietically expressed homeobox (HHEX), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002729.5

ORF Insert Sequence:

ATGCAGTACC CGCACCCCGG GCCGGCGGCG GGCGCCGTGG GGGTGCCGCT GTACGCGCCC 
ACGCCGCTGC TGCAACCCGC ACACCCGACG CCCTTTTACA TCGAGGACAT CCTGGGCCGC 
GGGCCCGCCG CGCCCACGCC CGCCCCCACG CTGCCGTCCC CCAACTCCTC CTTCACCAGC 
CTCGTGTCCC CCTACCGGAC CCCGGTGTAC GAGCCCACGC CGATCCATCC AGCCTTCTCG 
CACCACTCCG CCGCCGCGCT GGCCGCTGCC TACGGACCCG GCGGCTTCGG GGGCCCTCTG 
TACCCCTTCC CGCGGACGGT GAACGACTAC ACGCACGCCC TGCTCCGCCA CGACCCCCTG 
GGCAAACCTC TACTCTGGAG CCCCTTCTTG CAGAGGCCTC TGCATAAAAG GAAAGGCGGC 
CAGGTGAGAT TCTCCAACGA CCAGACCATC GAGCTGGAGA AGAAATTCGA GACGCAGAAA 
TATCTCTCTC CGCCCGAGAG GAAGCGTCTG GCCAAGATGC TGCAGCTCAG CGAGAGACAG 
GTCAAAACCT GGTTTCAGAA TCGACGCGCT AAATGGAGGA GACTAAAACA GGAGAACCCT 
CAAAGCAATA AAAAAGAAGA ACTGGAAAGT TTGGACAGTT CCTGTGATCA GAGGCAAGAT 
TTGCCCAGTG AACAGAATAA AGGTGCTTCT TTGGATAGCT CTCAATGTTC GCCCTCCCCT 
GCCTCCCAGG AAGACCTTGA ATCAGAGATT TCAGAGGATT CTGATCAGGA AGTGGACATT 
GAGGGCGATA AAAGCTATTT TAATGCTGGA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism.
Vascular pharmacology9934-44(2017 Dec)
Wadey KS,Brown BA,Sala-Newby GB,Jayaraman PS,Gaston K,George SJ

Overexpression of HHEX in Acute Myeloid Leukemia with t(8;21)(q22;q22) Translocation.
Annals of clinical and laboratory science47(6)687-697(2017 Nov)
Zhang S,Ma L,Chen Y,Xu H,Chen S,Wu W

HHEX: A Crosstalker between HCMV Infection and Proliferation of VSMCs.
Frontiers in cellular and infection microbiology6169(2016)
Li L,Liu M,Kang L,Li Y,Dai Z,Wang B,Liu S,Chen L,Tan Y,Wu G

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HHEX cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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