TAX1BP3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TAX1BP3
Entrez Gene ID	30851
Full Name	Tax1 binding protein 3
Synonyms	TIP-1,TIP1
General protein information	Preferred Names Tax1 binding protein 3 Names tax1-binding protein 3 Tax interaction protein 1 Tax1 (human T-cell leukemia virus type I) binding protein 3 glutaminase-interacting protein 3 tax-interacting protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p13.2
Summary	This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017].
Disorder MIM:	616484

mRNA and Protein(s)

mRNA	Protein	Name
NM_014604.3	NP_055419.1	tax1-binding protein 3 isoform 1
NM_001204698.1	NP_001191627.1	tax1-binding protein 3 isoform 2
NM_014604.4	NP_055419.1	tax1-binding protein 3 isoform 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TAX1BP3	XP_003639313.1
Mus musculus (house mouse)	Tax1bp3	NP_083840.1
Danio rerio (zebrafish)	tax1bp3	NP_998635.1
Homo sapiens (human)	TAX1BP3	NP_055419.1
Xenopus tropicalis (tropical clawed frog)	tax1bp3	NP_989230.1
Bos taurus (cattle)	TAX1BP3	NP_001029646.1
Gallus gallus (chicken)	TAX1BP3	XP_415850.1
	TAX1BP3	XP_001090196.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in TAX1BP3 cause dilated cardiomyopathy with septo-optic dysplasia.
Reinstein E, Orvin K, Tayeb-Fligelman E, Stiebel-Kalish H, Tzur S, Pimienta AL, Bazak L, Bengal T, Cohen L, Gaton DD, Bormans C, Landau M, Kornowski R, Shohat M, Behar DM
Human mutation36(4)439-42(2015 Apr)

Tax-interacting protein 1 coordinates the spatiotemporal activation of Rho GTPases and regulates the infiltrative growth of human glioblastoma.
Wang H, Han M, Whetsell W Jr, Wang J, Rich J, Hallahan D, Han Z
Oncogene33(12)1558-69(2014 Mar)

New partner proteins containing novel internal recognition motif for human glutaminase interacting protein (hGIP).
Zencir S, Banerjee M, Dobson MJ, Ayaydin F, Fodor EA, Topcu Z, Mohanty S
Biochemical and biophysical research communications432(1)10-5(2013 Mar)

Specificity and promiscuity in human glutaminase interacting protein recognition: insight from the binding of the internal and C-terminal motif.
Banerjee M, Zoetewey DL, Ovee M, Mazumder S, Petrenko VA, Samoylova TI, Mohanty S
Biochemistry51(35)6950-60(2012 Sep)

Expression of TIP-1 confers radioresistance of malignant glioma cells.
Han M, Wang H, Zhang HT, Han Z
PloS one7(9)e45402(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mutations in TAX1BP3 cause dilated cardiomyopathy with septo-optic dysplasia
Title: Mutations in TAX1BP3 cause dilated cardiomyopathy with septo-optic dysplasia.

ARHGEF7, a guanine nucleotide exchange factor for Rho GTPases, as one novel TIP-1-interacting protein in human glioblastoma cells
Title: Tax-interacting protein 1 coordinates the spatiotemporal activation of Rho GTPases and regulates the infiltrative growth of human glioblastoma.

this study reports the identification of two new hGIP-interacting partners, DTX1 and STAU1.
Title: New partner proteins containing novel internal recognition motif for human glutaminase interacting protein (hGIP).

The study reports the identification of 18 new glutaminase-interacting protein - binding peptides with novel internal motifs that map to a number of candidate human glutaminase-interacting protein partner proteins.
Title: Specificity and promiscuity in human glutaminase interacting protein recognition: insight from the binding of the internal and C-terminal motif.

The study provided the first evidence showing that TIP-1 modulates p53 protein stability and is involved in the radioresistance of malignant gliomas.
Title: Expression of TIP-1 confers radioresistance of malignant glioma cells.

The following TAX1BP3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TAX1BP3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23645	NM_014604.4 Latest version!	Homo sapiens Tax1 binding protein 3 (TAX1BP3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu23378	NM_001204698.1 Latest version!	Homo sapiens Tax1 binding protein 3 (TAX1BP3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu23645	NM_014604.3	Homo sapiens Tax1 binding protein 3 (TAX1BP3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TAX1BP3 ( NM_014604.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055419.1 Homo sapiens Tax1 binding protein 3 (TAX1BP3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23645
Clone ID Related Accession (Same CDS sequence)	NM_014604.3 , NM_014604.4
Accession Version	NM_014604.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	tax1-binding protein 3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF028823.2, AF277318.1 and BM973411.1. This sequence is a reference standard in the RefSeqGene project. On Mar 4, 2011 this sequence version replaced NM_014604.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF028823.2, SRR1163657.460228.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCTACA TCCCGGGCCA GCCGGTCACC GCCGTGGTGC AAAGAGTTGA AATTCACAAG 
CTGCGTCAAG GTGAGAACTT AATCCTGGGT TTCAGCATTG GAGGTGGAAT CGACCAGGAT 
CCTTCCCAGA ATCCCTTCTC TGAAGACAAG ACGGACAAGG GTATTTATGT CACACGGGTG 
TCTGAAGGAG GCCCTGCTGA AATCGCTGGG CTGCAGATTG GAGACAAGAT CATGCAGGTG 
AACGGCTGGG ACATGACCAT GGTCACACAC GACCAGGCCC GCAAGCGGCT CACCAAGCGC 
TCGGAGGAGG TGGTGCGTCT GCTGGTGACG CGGCAGTCGC TGCAGAAGGC CGTGCAGCAG 
TCCATGCTGT CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055419.1
CDS	154..528
Translation	MSYIPGQPVTAVVQRVEIHKLRQGENLILGFSIGGGIDQDPSQNPFSEDKTDKGIYVTRVSEGGPAEIAGLQIGDKIMQVNGWDMTMVTHDQARKRLTKRSEEVVRLLVTRQSLQKAVQQSMLS

Target ORF information:

RefSeq Version	NM_014604.3
Organism	Homo sapiens(human)
Definition	Homo sapiens Tax1 binding protein 3 (TAX1BP3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014604.3

ORF Insert Sequence:

ATGTCCTACA TCCCGGGCCA GCCGGTCACC GCCGTGGTGC AAAGAGTTGA AATTCACAAG 
CTGCGTCAAG GTGAGAACTT AATCCTGGGT TTCAGCATTG GAGGTGGAAT CGACCAGGAT 
CCTTCCCAGA ATCCCTTCTC TGAAGACAAG ACGGACAAGG GTATTTATGT CACACGGGTG 
TCTGAAGGAG GCCCTGCTGA AATCGCTGGG CTGCAGATTG GAGACAAGAT CATGCAGGTG 
AACGGCTGGG ACATGACCAT GGTCACACAC GACCAGGCCC GCAAGCGGCT CACCAAGCGC 
TCGGAGGAGG TGGTGCGTCT GCTGGTGACG CGGCAGTCGC TGCAGAAGGC CGTGCAGCAG 
TCCATGCTGT CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TAX1BP3 ( NM_014604.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055419.1 Homo sapiens Tax1 binding protein 3 (TAX1BP3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23645
Clone ID Related Accession (Same CDS sequence)	NM_014604.3 , NM_014604.4
Accession Version	NM_014604.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	tax1-binding protein 3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF028823.2, AF277318.1 and BM973411.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_014604.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF028823.2, SRR3476690.118198.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000225525.4/ ENSP00000225525.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCTACA TCCCGGGCCA GCCGGTCACC GCCGTGGTGC AAAGAGTTGA AATTCACAAG 
CTGCGTCAAG GTGAGAACTT AATCCTGGGT TTCAGCATTG GAGGTGGAAT CGACCAGGAT 
CCTTCCCAGA ATCCCTTCTC TGAAGACAAG ACGGACAAGG GTATTTATGT CACACGGGTG 
TCTGAAGGAG GCCCTGCTGA AATCGCTGGG CTGCAGATTG GAGACAAGAT CATGCAGGTG 
AACGGCTGGG ACATGACCAT GGTCACACAC GACCAGGCCC GCAAGCGGCT CACCAAGCGC 
TCGGAGGAGG TGGTGCGTCT GCTGGTGACG CGGCAGTCGC TGCAGAAGGC CGTGCAGCAG 
TCCATGCTGT CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055419.1
CDS	53..427
Translation	MSYIPGQPVTAVVQRVEIHKLRQGENLILGFSIGGGIDQDPSQNPFSEDKTDKGIYVTRVSEGGPAEIAGLQIGDKIMQVNGWDMTMVTHDQARKRLTKRSEEVVRLLVTRQSLQKAVQQSMLS

Target ORF information:

RefSeq Version	NM_014604.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Tax1 binding protein 3 (TAX1BP3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014604.4

ORF Insert Sequence:

ATGTCCTACA TCCCGGGCCA GCCGGTCACC GCCGTGGTGC AAAGAGTTGA AATTCACAAG 
CTGCGTCAAG GTGAGAACTT AATCCTGGGT TTCAGCATTG GAGGTGGAAT CGACCAGGAT 
CCTTCCCAGA ATCCCTTCTC TGAAGACAAG ACGGACAAGG GTATTTATGT CACACGGGTG 
TCTGAAGGAG GCCCTGCTGA AATCGCTGGG CTGCAGATTG GAGACAAGAT CATGCAGGTG 
AACGGCTGGG ACATGACCAT GGTCACACAC GACCAGGCCC GCAAGCGGCT CACCAAGCGC 
TCGGAGGAGG TGGTGCGTCT GCTGGTGACG CGGCAGTCGC TGCAGAAGGC CGTGCAGCAG 
TCCATGCTGT CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TAX1BP3 ( NM_001204698.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001191627.1 Homo sapiens Tax1 binding protein 3 (TAX1BP3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu23378
Clone ID Related Accession (Same CDS sequence)	NM_001204698.1
Accession Version	NM_001204698.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 297bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	tax1-binding protein 3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF028823.2, CB129195.1, AF277318.1 and BM973411.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.287531.1, CB129195.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCTACA TCCCGGGCCA GCCGGTCACC GCCGTGGTGC AAAGAGTTGA AATTCACAAG 
CTGCGTCAAG GTGAGAACTT AATCCTGGGT TTCAGCATTG GAGGTGGAAT CGACCAGGAT 
CCTTCCCAGA ATCCCTTCTC TGAAGACAAG ACGGACAAGG TGAACGGCTG GGACATGACC 
ATGGTCACAC ACGACCAGGC CCGCAAGCGG CTCACCAAGC GCTCGGAGGA GGTGGTGCGT 
CTGCTGGTGA CGCGGCAGTC GCTGCAGAAG GCCGTGCAGC AGTCCATGCT GTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001191627.1
CDS	154..450
Translation	MSYIPGQPVTAVVQRVEIHKLRQGENLILGFSIGGGIDQDPSQNPFSEDKTDKVNGWDMTMVTHDQARKRLTKRSEEVVRLLVTRQSLQKAVQQSMLS

Target ORF information:

RefSeq Version	NM_001204698.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Tax1 binding protein 3 (TAX1BP3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001204698.1

ORF Insert Sequence:

ATGTCCTACA TCCCGGGCCA GCCGGTCACC GCCGTGGTGC AAAGAGTTGA AATTCACAAG 
CTGCGTCAAG GTGAGAACTT AATCCTGGGT TTCAGCATTG GAGGTGGAAT CGACCAGGAT 
CCTTCCCAGA ATCCCTTCTC TGAAGACAAG ACGGACAAGG TGAACGGCTG GGACATGACC 
ATGGTCACAC ACGACCAGGC CCGCAAGCGG CTCACCAAGC GCTCGGAGGA GGTGGTGCGT 
CTGCTGGTGA CGCGGCAGTC GCTGCAGAAG GCCGTGCAGC AGTCCATGCT GTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in TAX1BP3 cause dilated cardiomyopathy with septo-optic dysplasia.
Human mutation36(4)439-42(2015 Apr)
Reinstein E,Orvin K,Tayeb-Fligelman E,Stiebel-Kalish H,Tzur S,Pimienta AL,Bazak L,Bengal T,Cohen L,Gaton DD,Bormans C,Landau M,Kornowski R,Shohat M,Behar DM

Tax-interacting protein 1 coordinates the spatiotemporal activation of Rho GTPases and regulates the infiltrative growth of human glioblastoma.
Oncogene33(12)1558-69(2014 Mar)
Wang H,Han M,Whetsell W Jr,Wang J,Rich J,Hallahan D,Han Z

New partner proteins containing novel internal recognition motif for human glutaminase interacting protein (hGIP).
Biochemical and biophysical research communications432(1)10-5(2013 Mar)
Zencir S,Banerjee M,Dobson MJ,Ayaydin F,Fodor EA,Topcu Z,Mohanty S

Specificity and promiscuity in human glutaminase interacting protein recognition: insight from the binding of the internal and C-terminal motif.
Biochemistry51(35)6950-60(2012 Sep)
Banerjee M,Zoetewey DL,Ovee M,Mazumder S,Petrenko VA,Samoylova TI,Mohanty S

Expression of TIP-1 confers radioresistance of malignant glioma cells.
PloS one7(9)e45402(2012)
Han M,Wang H,Zhang HT,Han Z

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TAX1BP3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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