KCNIP3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNIP3
Entrez Gene ID	30818
Full Name	potassium voltage-gated channel interacting protein 3
Synonyms	CSEN,DREAM,KCHIP3
General protein information	Preferred Names potassium voltage-gated channel interacting protein 3 Names calsenilin A-type potassium channel modulatory protein 3 DRE-antagonist modulator Kv channel interacting protein 3, calsenilin calsenilin, presenilin-binding protein, EF hand transcription factor kv channel-interacting protein 3 potassium channel interacting protein 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q11.1
Summary	This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Disorder MIM:	604662

mRNA and Protein(s)

mRNA	Protein	Name
NM_001034914.1	NP_001030086.1	calsenilin isoform 2 precursor
NM_013434.4	NP_038462.1	calsenilin isoform 1
NM_013434.5	NP_038462.1	calsenilin isoform 1
NM_001034914.2	NP_001030086.1	calsenilin isoform 2 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	KCNIP3	XP_002691206.2
Mus musculus (house mouse)	Kcnip3	NP_062763.2
Danio rerio (zebrafish)	kcnip3b	NP_957076.1
Rattus norvegicus (Norway rat)	Kcnip3	NP_115851.1
Danio rerio (zebrafish)	kcnip3a	NP_957113.1
Canis lupus familiaris (dog)	KCNIP3	XP_003639644.2
Homo sapiens (human)	KCNIP3	NP_038462.1
Pan troglodytes (chimpanzee)	KCNIP3	XP_515619.1
	KCNIP3	XP_001096300.1
Xenopus tropicalis (tropical clawed frog)	LOC100494097	XP_004912653.1

Gene Ontology
Bibliography

Related articles in PubMed

SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression.
Gonyo P, Bergom C, Brandt AC, Tsaih SW, Sun Y, Bigley TM, Lorimer EL, Terhune SS, Rui H, Flister MJ, Long RM, Williams CL
Oncogene36(50)6873-6883(2017 Dec)

Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes.
Fischer M, M?ller GA
Critical reviews in biochemistry and molecular biology52(6)638-662(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

targeting SmgGDS induces nucleolar stress, resulting in profound loss of DREAM target gene expression required for G1, S and G2 progression, and ultimately resulting in cell cycle arrest.
Title: SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression.

Disruption of DREAM and RB-E2F complexes by oncoproteins from DNA tumor viruses leads to upregulation of cell cycle genes and impairs growth-inhibiting pathways, including the p53-mediated downregulation of cell cycle genes. [review]
Title: Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes.

This study shows the application of hydrogen-deuterium exchange mass spectrometry and site-directed mutagenesis to investigate the Ca(2+) binding properties and the subsequent conformational changes of full-length DREAM. EF-hands undergo large conformation changes upon calcium binding even though the EF-1 hand is not capable of binding to Ca(2+).
Title: Hydrogen-Deuterium Exchange Mass Spectrometry Reveals Calcium Binding Properties and Allosteric Regulation of Downstream Regulatory Element Antagonist Modulator (DREAM).

Our approach yields high confidence ranked target gene maps for TP53, DREAM, MMB-FOXM1 and RB-E2F and enables prediction and distinction of CC regulation. A web-based atlas at www.targetgenereg.org enables assessing the regulation of any human gene of interest.
Title: Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks.

downregulation of these genes through the p53-p21-DREAM-CDE/CHR pathway appears to be a principal mechanism for G2/M cell cycle arrest by p53.
Title: The p53-p21-DREAM-CDE/CHR pathway regulates G2/M cell cycle genes.

The following KCNIP3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNIP3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02179	NM_013434.5 Latest version!	Homo sapiens potassium voltage-gated channel interacting protein 3 (KCNIP3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04607	NM_001034914.2 Latest version!	Homo sapiens potassium voltage-gated channel interacting protein 3 (KCNIP3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
View Old Accession Versions >>
OHu02179	NM_013434.4	Homo sapiens potassium voltage-gated channel interacting protein 3 (KCNIP3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04607	NM_001034914.1	Homo sapiens potassium voltage-gated channel interacting protein 3 (KCNIP3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNIP3 ( NM_013434.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_038462.1 Homo sapiens potassium voltage-gated channel interacting protein 3 (KCNIP3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02179
Clone ID Related Accession (Same CDS sequence)	NM_013434.4 , NM_013434.5
Accession Version	NM_013434.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 771bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	calsenilin isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX491997.1, BI755669.1 and BC012850.1. On Oct 27, 2005 this sequence version replaced NM_013434.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ131730.2, SRR1803615.231512.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144120, SAMEA2145240 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGCCGG CTAAGGAAGT GACAAAGGCG TCGGACGGCA GCCTCCTGGG GGACCTCGGG 
CACACACCAC TTAGCAAGAA GGAGGGTATC AAGTGGCAGA GGCCGAGGCT CAGCCGCCAG 
GCTTTGATGA GATGCTGCCT GGTCAAGTGG ATCCTGTCCA GCACAGCCCC ACAGGGCTCA 
GATAGCAGCG ACAGTGAGCT GGAGCTGTCC ACGGTGCGCC ACCAGCCAGA GGGGCTGGAC 
CAGCTGCAGG CCCAGACCAA GTTCACCAAG AAGGAGCTGC AGTCTCTCTA CAGGGGCTTT 
AAGAATGAGT GTCCCACGGG CCTGGTGGAC GAAGACACCT TCAAACTCAT TTACGCGCAG 
TTCTTCCCTC AGGGAGATGC CACCACCTAT GCACACTTCC TCTTCAACGC CTTTGATGCG 
GACGGGAACG GGGCCATCCA CTTTGAGGAC TTTGTGGTTG GCCTCTCCAT CCTGCTGCGG 
GGCACAGTCC ACGAGAAGCT CAAGTGGGCC TTTAATCTCT ACGACATTAA CAAGGATGGC 
TACATCACCA AAGAGGAGAT GCTGGCCATC ATGAAGTCCA TCTATGACAT GATGGGCCGC 
CACACCTACC CCATCCTGCG GGAGGACGCG CCGGCGGAGC ACGTGGAGAG GTTCTTCGAG 
AAAATGGACC GGAACCAGGA TGGGGTAGTG ACCATTGAAG AGTTCCTGGA GGCCTGTCAG 
AAGGATGAGA ACATCATGAG CTCCATGCAG CTGTTTGAGA ATGTCATCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038462.1
CDS	116..886
Translation	MQPAKEVTKASDGSLLGDLGHTPLSKKEGIKWQRPRLSRQALMRCCLVKWILSSTAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGYITKEEMLAIMKSIYDMMGRHTYPILREDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQKDENIMSSMQLFENVI

Target ORF information:

RefSeq Version	NM_013434.4
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel interacting protein 3 (KCNIP3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013434.4

ORF Insert Sequence:

ATGCAGCCGG CTAAGGAAGT GACAAAGGCG TCGGACGGCA GCCTCCTGGG GGACCTCGGG 
CACACACCAC TTAGCAAGAA GGAGGGTATC AAGTGGCAGA GGCCGAGGCT CAGCCGCCAG 
GCTTTGATGA GATGCTGCCT GGTCAAGTGG ATCCTGTCCA GCACAGCCCC ACAGGGCTCA 
GATAGCAGCG ACAGTGAGCT GGAGCTGTCC ACGGTGCGCC ACCAGCCAGA GGGGCTGGAC 
CAGCTGCAGG CCCAGACCAA GTTCACCAAG AAGGAGCTGC AGTCTCTCTA CAGGGGCTTT 
AAGAATGAGT GTCCCACGGG CCTGGTGGAC GAAGACACCT TCAAACTCAT TTACGCGCAG 
TTCTTCCCTC AGGGAGATGC CACCACCTAT GCACACTTCC TCTTCAACGC CTTTGATGCG 
GACGGGAACG GGGCCATCCA CTTTGAGGAC TTTGTGGTTG GCCTCTCCAT CCTGCTGCGG 
GGCACAGTCC ACGAGAAGCT CAAGTGGGCC TTTAATCTCT ACGACATTAA CAAGGATGGC 
TACATCACCA AAGAGGAGAT GCTGGCCATC ATGAAGTCCA TCTATGACAT GATGGGCCGC 
CACACCTACC CCATCCTGCG GGAGGACGCG CCGGCGGAGC ACGTGGAGAG GTTCTTCGAG 
AAAATGGACC GGAACCAGGA TGGGGTAGTG ACCATTGAAG AGTTCCTGGA GGCCTGTCAG 
AAGGATGAGA ACATCATGAG CTCCATGCAG CTGTTTGAGA ATGTCATCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNIP3 ( NM_013434.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_038462.1 Homo sapiens potassium voltage-gated channel interacting protein 3 (KCNIP3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02179
Clone ID Related Accession (Same CDS sequence)	NM_013434.4 , NM_013434.5
Accession Version	NM_013434.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 771bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	calsenilin isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX491997.1, BI755669.1 and BC012850.1. On Sep 7, 2018 this sequence version replaced NM_013434.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.168528.1, SRR1803613.45045.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144120, SAMEA2145240 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000295225.10/ ENSP00000295225.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAGCCGG CTAAGGAAGT GACAAAGGCG TCGGACGGCA GCCTCCTGGG GGACCTCGGG 
CACACACCAC TTAGCAAGAA GGAGGGTATC AAGTGGCAGA GGCCGAGGCT CAGCCGCCAG 
GCTTTGATGA GATGCTGCCT GGTCAAGTGG ATCCTGTCCA GCACAGCCCC ACAGGGCTCA 
GATAGCAGCG ACAGTGAGCT GGAGCTGTCC ACGGTGCGCC ACCAGCCAGA GGGGCTGGAC 
CAGCTGCAGG CCCAGACCAA GTTCACCAAG AAGGAGCTGC AGTCTCTCTA CAGGGGCTTT 
AAGAATGAGT GTCCCACGGG CCTGGTGGAC GAAGACACCT TCAAACTCAT TTACGCGCAG 
TTCTTCCCTC AGGGAGATGC CACCACCTAT GCACACTTCC TCTTCAACGC CTTTGATGCG 
GACGGGAACG GGGCCATCCA CTTTGAGGAC TTTGTGGTTG GCCTCTCCAT CCTGCTGCGG 
GGCACAGTCC ACGAGAAGCT CAAGTGGGCC TTTAATCTCT ACGACATTAA CAAGGATGGC 
TACATCACCA AAGAGGAGAT GCTGGCCATC ATGAAGTCCA TCTATGACAT GATGGGCCGC 
CACACCTACC CCATCCTGCG GGAGGACGCG CCGGCGGAGC ACGTGGAGAG GTTCTTCGAG 
AAAATGGACC GGAACCAGGA TGGGGTAGTG ACCATTGAAG AGTTCCTGGA GGCCTGTCAG 
AAGGATGAGA ACATCATGAG CTCCATGCAG CTGTTTGAGA ATGTCATCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038462.1
CDS	93..863
Translation	MQPAKEVTKASDGSLLGDLGHTPLSKKEGIKWQRPRLSRQALMRCCLVKWILSSTAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGYITKEEMLAIMKSIYDMMGRHTYPILREDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQKDENIMSSMQLFENVI

Target ORF information:

RefSeq Version	NM_013434.5
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel interacting protein 3 (KCNIP3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013434.5

ORF Insert Sequence:

ATGCAGCCGG CTAAGGAAGT GACAAAGGCG TCGGACGGCA GCCTCCTGGG GGACCTCGGG 
CACACACCAC TTAGCAAGAA GGAGGGTATC AAGTGGCAGA GGCCGAGGCT CAGCCGCCAG 
GCTTTGATGA GATGCTGCCT GGTCAAGTGG ATCCTGTCCA GCACAGCCCC ACAGGGCTCA 
GATAGCAGCG ACAGTGAGCT GGAGCTGTCC ACGGTGCGCC ACCAGCCAGA GGGGCTGGAC 
CAGCTGCAGG CCCAGACCAA GTTCACCAAG AAGGAGCTGC AGTCTCTCTA CAGGGGCTTT 
AAGAATGAGT GTCCCACGGG CCTGGTGGAC GAAGACACCT TCAAACTCAT TTACGCGCAG 
TTCTTCCCTC AGGGAGATGC CACCACCTAT GCACACTTCC TCTTCAACGC CTTTGATGCG 
GACGGGAACG GGGCCATCCA CTTTGAGGAC TTTGTGGTTG GCCTCTCCAT CCTGCTGCGG 
GGCACAGTCC ACGAGAAGCT CAAGTGGGCC TTTAATCTCT ACGACATTAA CAAGGATGGC 
TACATCACCA AAGAGGAGAT GCTGGCCATC ATGAAGTCCA TCTATGACAT GATGGGCCGC 
CACACCTACC CCATCCTGCG GGAGGACGCG CCGGCGGAGC ACGTGGAGAG GTTCTTCGAG 
AAAATGGACC GGAACCAGGA TGGGGTAGTG ACCATTGAAG AGTTCCTGGA GGCCTGTCAG 
AAGGATGAGA ACATCATGAG CTCCATGCAG CTGTTTGAGA ATGTCATCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNIP3 ( NM_001034914.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001030086.1 Homo sapiens potassium voltage-gated channel interacting protein 3 (KCNIP3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04607
Clone ID Related Accession (Same CDS sequence)	NM_001034914.1 , NM_001034914.2
Accession Version	NM_001034914.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 693bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	calsenilin isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ148486.1 and BC012850.1. Transcript Variant: This variant (2) includes an alternate in-frame segment in the 5' coding region and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter and has a unique N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ148486.1, ERR279848.6934.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCATCC AGGGCATGGA GCTGTGCGCC ATGGCCGTGG TGGTGCTGCT GTTCATCGCC 
GTCCTCAAGC AGTTCGGCAT CCTGGAGCCC ATATCCATGG AAGATAGCAG CGACAGTGAG 
CTGGAGCTGT CCACGGTGCG CCACCAGCCA GAGGGGCTGG ACCAGCTGCA GGCCCAGACC 
AAGTTCACCA AGAAGGAGCT GCAGTCTCTC TACAGGGGCT TTAAGAATGA GTGTCCCACG 
GGCCTGGTGG ACGAAGACAC CTTCAAACTC ATTTACGCGC AGTTCTTCCC TCAGGGAGAT 
GCCACCACCT ATGCACACTT CCTCTTCAAC GCCTTTGATG CGGACGGGAA CGGGGCCATC 
CACTTTGAGG ACTTTGTGGT TGGCCTCTCC ATCCTGCTGC GGGGCACAGT CCACGAGAAG 
CTCAAGTGGG CCTTTAATCT CTACGACATT AACAAGGATG GCTACATCAC CAAAGAGGAG 
ATGCTGGCCA TCATGAAGTC CATCTATGAC ATGATGGGCC GCCACACCTA CCCCATCCTG 
CGGGAGGACG CGCCGGCGGA GCACGTGGAG AGGTTCTTCG AGAAAATGGA CCGGAACCAG 
GATGGGGTAG TGACCATTGA AGAGTTCCTG GAGGCCTGTC AGAAGGATGA GAACATCATG 
AGCTCCATGC AGCTGTTTGA GAATGTCATC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001030086.1
CDS	1..693
Translation	MGIQGMELCAMAVVVLLFIAVLKQFGILEPISMEDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGYITKEEMLAIMKSIYDMMGRHTYPILREDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQKDENIMSSMQLFENVI

Target ORF information:

RefSeq Version	NM_001034914.1
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel interacting protein 3 (KCNIP3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001034914.1

ORF Insert Sequence:

ATGGGCATCC AGGGCATGGA GCTGTGCGCC ATGGCCGTGG TGGTGCTGCT GTTCATCGCC 
GTCCTCAAGC AGTTCGGCAT CCTGGAGCCC ATATCCATGG AAGATAGCAG CGACAGTGAG 
CTGGAGCTGT CCACGGTGCG CCACCAGCCA GAGGGGCTGG ACCAGCTGCA GGCCCAGACC 
AAGTTCACCA AGAAGGAGCT GCAGTCTCTC TACAGGGGCT TTAAGAATGA GTGTCCCACG 
GGCCTGGTGG ACGAAGACAC CTTCAAACTC ATTTACGCGC AGTTCTTCCC TCAGGGAGAT 
GCCACCACCT ATGCACACTT CCTCTTCAAC GCCTTTGATG CGGACGGGAA CGGGGCCATC 
CACTTTGAGG ACTTTGTGGT TGGCCTCTCC ATCCTGCTGC GGGGCACAGT CCACGAGAAG 
CTCAAGTGGG CCTTTAATCT CTACGACATT AACAAGGATG GCTACATCAC CAAAGAGGAG 
ATGCTGGCCA TCATGAAGTC CATCTATGAC ATGATGGGCC GCCACACCTA CCCCATCCTG 
CGGGAGGACG CGCCGGCGGA GCACGTGGAG AGGTTCTTCG AGAAAATGGA CCGGAACCAG 
GATGGGGTAG TGACCATTGA AGAGTTCCTG GAGGCCTGTC AGAAGGATGA GAACATCATG 
AGCTCCATGC AGCTGTTTGA GAATGTCATC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNIP3 ( NM_001034914.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001030086.1 Homo sapiens potassium voltage-gated channel interacting protein 3 (KCNIP3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04607
Clone ID Related Accession (Same CDS sequence)	NM_001034914.1 , NM_001034914.2
Accession Version	NM_001034914.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 693bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	calsenilin isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY076476.1, AC009238.4, DQ148486.1 and BC012850.1. On Sep 7, 2018 this sequence version replaced NM_001034914.1. Transcript Variant: This variant (2) includes an alternate in-frame segment in the 5' coding region and uses an alternate start codon, compared to variant 1. The resulting protein (isoform 2) is shorter and has a unique N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279848.6934.1, AL540923.3 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCATCC AGGGCATGGA GCTGTGCGCC ATGGCCGTGG TGGTGCTGCT GTTCATCGCC 
GTCCTCAAGC AGTTCGGCAT CCTGGAGCCC ATATCCATGG AAGATAGCAG CGACAGTGAG 
CTGGAGCTGT CCACGGTGCG CCACCAGCCA GAGGGGCTGG ACCAGCTGCA GGCCCAGACC 
AAGTTCACCA AGAAGGAGCT GCAGTCTCTC TACAGGGGCT TTAAGAATGA GTGTCCCACG 
GGCCTGGTGG ACGAAGACAC CTTCAAACTC ATTTACGCGC AGTTCTTCCC TCAGGGAGAT 
GCCACCACCT ATGCACACTT CCTCTTCAAC GCCTTTGATG CGGACGGGAA CGGGGCCATC 
CACTTTGAGG ACTTTGTGGT TGGCCTCTCC ATCCTGCTGC GGGGCACAGT CCACGAGAAG 
CTCAAGTGGG CCTTTAATCT CTACGACATT AACAAGGATG GCTACATCAC CAAAGAGGAG 
ATGCTGGCCA TCATGAAGTC CATCTATGAC ATGATGGGCC GCCACACCTA CCCCATCCTG 
CGGGAGGACG CGCCGGCGGA GCACGTGGAG AGGTTCTTCG AGAAAATGGA CCGGAACCAG 
GATGGGGTAG TGACCATTGA AGAGTTCCTG GAGGCCTGTC AGAAGGATGA GAACATCATG 
AGCTCCATGC AGCTGTTTGA GAATGTCATC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001030086.1
CDS	363..1055
Translation	MGIQGMELCAMAVVVLLFIAVLKQFGILEPISMEDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGYITKEEMLAIMKSIYDMMGRHTYPILREDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQKDENIMSSMQLFENVI

Target ORF information:

RefSeq Version	NM_001034914.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel interacting protein 3 (KCNIP3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001034914.2

ORF Insert Sequence:

ATGGGCATCC AGGGCATGGA GCTGTGCGCC ATGGCCGTGG TGGTGCTGCT GTTCATCGCC 
GTCCTCAAGC AGTTCGGCAT CCTGGAGCCC ATATCCATGG AAGATAGCAG CGACAGTGAG 
CTGGAGCTGT CCACGGTGCG CCACCAGCCA GAGGGGCTGG ACCAGCTGCA GGCCCAGACC 
AAGTTCACCA AGAAGGAGCT GCAGTCTCTC TACAGGGGCT TTAAGAATGA GTGTCCCACG 
GGCCTGGTGG ACGAAGACAC CTTCAAACTC ATTTACGCGC AGTTCTTCCC TCAGGGAGAT 
GCCACCACCT ATGCACACTT CCTCTTCAAC GCCTTTGATG CGGACGGGAA CGGGGCCATC 
CACTTTGAGG ACTTTGTGGT TGGCCTCTCC ATCCTGCTGC GGGGCACAGT CCACGAGAAG 
CTCAAGTGGG CCTTTAATCT CTACGACATT AACAAGGATG GCTACATCAC CAAAGAGGAG 
ATGCTGGCCA TCATGAAGTC CATCTATGAC ATGATGGGCC GCCACACCTA CCCCATCCTG 
CGGGAGGACG CGCCGGCGGA GCACGTGGAG AGGTTCTTCG AGAAAATGGA CCGGAACCAG 
GATGGGGTAG TGACCATTGA AGAGTTCCTG GAGGCCTGTC AGAAGGATGA GAACATCATG 
AGCTCCATGC AGCTGTTTGA GAATGTCATC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression.
Oncogene36(50)6873-6883(2017 Dec)
Gonyo P,Bergom C,Brandt AC,Tsaih SW,Sun Y,Bigley TM,Lorimer EL,Terhune SS,Rui H,Flister MJ,Long RM,Williams CL

Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes.
Critical reviews in biochemistry and molecular biology52(6)638-662(2017 Dec)
Fischer M,M?ller GA

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KCNIP3 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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