HBD cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HBD
Entrez Gene ID	3045
Full Name	hemoglobin subunit delta
General protein information	Preferred Names hemoglobin subunit delta Names hemoglobin subunit delta delta globin delta-globin chain hemoglobin delta chain hemoglobin, delta
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.4
Summary	The delta (HBD) and beta (HBB) genes are normally expressed in the adult: two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin. Two alpha chains plus two delta chains constitute HbA-2, which with HbF comprises the remaining 3% of adult hemoglobin. Five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon--Ggamma--Agamma--delta--beta-3'. Mutations in the delta-globin gene are associated with beta-thalassemia. [provided by RefSeq, Jul 2008].
Disorder MIM:	142000
Disorder Html:	Thalassemia, delta- (3); Thalassemia due to Hb Lepore (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000519.3	NP_000510.1	hemoglobin subunit delta
NM_000519.4	NP_000510.1	hemoglobin subunit delta

Pathways from BioSystems

Homologies

Homo sapiens (human)	HBD	NP_000510.1
Pan troglodytes (chimpanzee)	HBD	XP_001162045.2
Bos taurus (cattle)	HBG	XP_005216202.1
Bos taurus (cattle)	LOC788610	NP_001103979.1
Bos taurus (cattle)	HBB	NP_776342.1

Gene Ontology
Bibliography

Related articles in PubMed

Blood donor homozygous for Hb D Los Angeles.
Silva-Pinto AC, Silva TJ, Moretto EL, Ottoboni M?, Rodrigues ES, Covas DT
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis51(2)219-20(2014 Oct)

In vivo activation of the human ?-globin gene: the therapeutic potential in ?-thalassemic mice.
Manchinu MF, Marongiu MF, Poddie D, Casu C, Latini V, Simbula M, Galanello R, Moi P, Cao A, Porcu S, Ristaldi MS
Haematologica99(1)76-84(2014 Jan)

GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.
Li J, Glessner JT, Zhang H, Hou C, Wei Z, Bradfield JP, Mentch FD, Guo Y, Kim C, Xia Q, Chiavacci RM, Thomas KA, Qiu H, Grant SF, Furth SL, Hakonarson H, Sleiman PM
Human molecular genetics22(7)1457-64(2013 Apr)

Analysis of ?-globin gene mutations in the Chinese population.
Liu N, Xie XM, Zhou JY, Li R, Liao C, Li DZ
Hemoglobin37(1)85-93(2013)

Two complex associations of an HBD mutation and a rare ? hemoglobinopathy.
Joly P, Lacan P, Garcia C, Francina A
Hemoglobin37(5)486-91(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Blood donor homozygous for Hb D Los Angeles.
Title: Blood donor homozygous for Hb D Los Angeles.

The expression of the activated delta-globin gene in a beta-thalassemia mice model greatly improves the phenotype, validating the delta-globin chain as a therapeutic target for beta-hemoglobinopathies.
Title: In vivo activation of the human ?-globin gene: the therapeutic potential in ?-thalassemic mice.

Twenty-one different mutations were detected, and of these 12 have not been previously described.
Title: Analysis of ?-globin gene mutations in the Chinese population.

Data indicate that a delta-globin mutation was suspected in both patients.
Title: Two complex associations of an HBD mutation and a rare ? hemoglobinopathy.

A functional promoter polymorphism of the delta-globin gene is a specific marker of the Arab-Indian haplotype
Title: A functional promoter polymorphism of the ?-globin gene is a specific marker of the Arab-Indian haplotype.

The following HBD gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HBD cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17826	NM_000519.4 Latest version!	Homo sapiens hemoglobin subunit delta (HBD), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu17826	NM_000519.3	Homo sapiens hemoglobin subunit delta (HBD), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HBD ( NM_000519.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000510.1 Homo sapiens hemoglobin subunit delta (HBD), mRNA.

Price & Availability↑

CloneID	OHu17826
Clone ID Related Accession (Same CDS sequence)	NM_000519.3 , NM_000519.4
Accession Version	NM_000519.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 444bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	hemoglobin subunit delta
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY034468.1, BC070282.1 and BU664913.1. This sequence is a reference standard in the RefSeqGene project. On Apr 22, 2005 this sequence version replaced NM_000519.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY034468.1, SRR1163658.247873.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149004, SAMEA2154529 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGCATC TGACTCCTGA GGAGAAGACT GCTGTCAATG CCCTGTGGGG CAAAGTGAAC 
GTGGATGCAG TTGGTGGTGA GGCCCTGGGC AGATTACTGG TGGTCTACCC TTGGACCCAG 
AGGTTCTTTG AGTCCTTTGG GGATCTGTCC TCTCCTGATG CTGTTATGGG CAACCCTAAG 
GTGAAGGCTC ATGGCAAGAA GGTGCTAGGT GCCTTTAGTG ATGGCCTGGC TCACCTGGAC 
AACCTCAAGG GCACTTTTTC TCAGCTGAGT GAGCTGCACT GTGACAAGCT GCACGTGGAT 
CCTGAGAACT TCAGGCTCTT GGGCAATGTG CTGGTGTGTG TGCTGGCCCG CAACTTTGGC 
AAGGAATTCA CCCCACAAAT GCAGGCTGCC TATCAGAAGG TGGTGGCTGG TGTGGCTAAT 
GCCCTGGCTC ACAAGTACCA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000510.1
CDS	196..639
Translation	MVHLTPEEKTAVNALWGKVNVDAVGGEALGRLLVVYPWTQRFFESFGDLSSPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFSQLSELHCDKLHVDPENFRLLGNVLVCVLARNFGKEFTPQMQAAYQKVVAGVANALAHKYH

Target ORF information:

RefSeq Version	NM_000519.3
Organism	Homo sapiens(human)
Definition	Homo sapiens hemoglobin subunit delta (HBD), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000519.3

ORF Insert Sequence:

ATGGTGCATC TGACTCCTGA GGAGAAGACT GCTGTCAATG CCCTGTGGGG CAAAGTGAAC 
GTGGATGCAG TTGGTGGTGA GGCCCTGGGC AGATTACTGG TGGTCTACCC TTGGACCCAG 
AGGTTCTTTG AGTCCTTTGG GGATCTGTCC TCTCCTGATG CTGTTATGGG CAACCCTAAG 
GTGAAGGCTC ATGGCAAGAA GGTGCTAGGT GCCTTTAGTG ATGGCCTGGC TCACCTGGAC 
AACCTCAAGG GCACTTTTTC TCAGCTGAGT GAGCTGCACT GTGACAAGCT GCACGTGGAT 
CCTGAGAACT TCAGGCTCTT GGGCAATGTG CTGGTGTGTG TGCTGGCCCG CAACTTTGGC 
AAGGAATTCA CCCCACAAAT GCAGGCTGCC TATCAGAAGG TGGTGGCTGG TGTGGCTAAT 
GCCCTGGCTC ACAAGTACCA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HBD ( NM_000519.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000510.1 Homo sapiens hemoglobin subunit delta (HBD), mRNA.

Price & Availability↑

CloneID	OHu17826
Clone ID Related Accession (Same CDS sequence)	NM_000519.3 , NM_000519.4
Accession Version	NM_000519.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 444bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	hemoglobin subunit delta
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY034468.1, BC070282.1 and BU664913.1. This sequence is a reference standard in the RefSeqGene project. On Dec 7, 2018 this sequence version replaced NM_000519.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.29352.1, BU663989.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149004, SAMEA2154529 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000650601.1/ ENSP00000497529.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGCATC TGACTCCTGA GGAGAAGACT GCTGTCAATG CCCTGTGGGG CAAAGTGAAC 
GTGGATGCAG TTGGTGGTGA GGCCCTGGGC AGATTACTGG TGGTCTACCC TTGGACCCAG 
AGGTTCTTTG AGTCCTTTGG GGATCTGTCC TCTCCTGATG CTGTTATGGG CAACCCTAAG 
GTGAAGGCTC ATGGCAAGAA GGTGCTAGGT GCCTTTAGTG ATGGCCTGGC TCACCTGGAC 
AACCTCAAGG GCACTTTTTC TCAGCTGAGT GAGCTGCACT GTGACAAGCT GCACGTGGAT 
CCTGAGAACT TCAGGCTCTT GGGCAATGTG CTGGTGTGTG TGCTGGCCCG CAACTTTGGC 
AAGGAATTCA CCCCACAAAT GCAGGCTGCC TATCAGAAGG TGGTGGCTGG TGTGGCTAAT 
GCCCTGGCTC ACAAGTACCA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000510.1
CDS	51..494
Translation	MVHLTPEEKTAVNALWGKVNVDAVGGEALGRLLVVYPWTQRFFESFGDLSSPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFSQLSELHCDKLHVDPENFRLLGNVLVCVLARNFGKEFTPQMQAAYQKVVAGVANALAHKYH

Target ORF information:

RefSeq Version	NM_000519.4
Organism	Homo sapiens(human)
Definition	Homo sapiens hemoglobin subunit delta (HBD), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000519.4

ORF Insert Sequence:

ATGGTGCATC TGACTCCTGA GGAGAAGACT GCTGTCAATG CCCTGTGGGG CAAAGTGAAC 
GTGGATGCAG TTGGTGGTGA GGCCCTGGGC AGATTACTGG TGGTCTACCC TTGGACCCAG 
AGGTTCTTTG AGTCCTTTGG GGATCTGTCC TCTCCTGATG CTGTTATGGG CAACCCTAAG 
GTGAAGGCTC ATGGCAAGAA GGTGCTAGGT GCCTTTAGTG ATGGCCTGGC TCACCTGGAC 
AACCTCAAGG GCACTTTTTC TCAGCTGAGT GAGCTGCACT GTGACAAGCT GCACGTGGAT 
CCTGAGAACT TCAGGCTCTT GGGCAATGTG CTGGTGTGTG TGCTGGCCCG CAACTTTGGC 
AAGGAATTCA CCCCACAAAT GCAGGCTGCC TATCAGAAGG TGGTGGCTGG TGTGGCTAAT 
GCCCTGGCTC ACAAGTACCA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Blood donor homozygous for Hb D Los Angeles.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis51(2)219-20(2014 Oct)
Silva-Pinto AC,Silva TJ,Moretto EL,Ottoboni M?,Rodrigues ES,Covas DT

In vivo activation of the human ?-globin gene: the therapeutic potential in ?-thalassemic mice.
Haematologica99(1)76-84(2014 Jan)
Manchinu MF,Marongiu MF,Poddie D,Casu C,Latini V,Simbula M,Galanello R,Moi P,Cao A,Porcu S,Ristaldi MS

GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.
Human molecular genetics22(7)1457-64(2013 Apr)
Li J,Glessner JT,Zhang H,Hou C,Wei Z,Bradfield JP,Mentch FD,Guo Y,Kim C,Xia Q,Chiavacci RM,Thomas KA,Qiu H,Grant SF,Furth SL,Hakonarson H,Sleiman PM

Analysis of ?-globin gene mutations in the Chinese population.
Hemoglobin37(1)85-93(2013)
Liu N,Xie XM,Zhou JY,Li R,Liao C,Li DZ

Two complex associations of an HBD mutation and a rare ? hemoglobinopathy.
Hemoglobin37(5)486-91(2013)
Joly P,Lacan P,Garcia C,Francina A

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HBD cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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