HBM cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HBM
Entrez Gene ID	3042
Full Name	hemoglobin subunit mu
Synonyms	HBAP2,HBK
General protein information	Preferred Names hemoglobin subunit mu Names hemoglobin subunit mu alpha globin pseudogene 2 hemoglobin mu chain hemoglobin, alpha pseudogene 2 hemoglobin, mu mu-globin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p13.3
Summary	The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. This gene has an ORF encoding a 141 aa polypeptide which is similar to the delta globins found in reptiles and birds. This locus was originally described as a pseudogene; however, it is currently thought to be a protein-coding gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	609639

mRNA and Protein(s)

mRNA	Protein	Name
NM_001003938.3	NP_001003938.1	hemoglobin subunit mu
NM_001003938.4	NP_001003938.1	hemoglobin subunit mu

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	HBM	XP_003639177.1
Bos taurus (cattle)	HBM	NP_001077237.1
Homo sapiens (human)	HBM	NP_001003938.1
Pan troglodytes (chimpanzee)	HBM	XP_003314933.1

Gene Ontology
Bibliography

Related articles in PubMed

Persistent cyanosis in a 4 month old infant with severe pneumonia and haemoglobin M.
H?tten M, Kohne E, Yagmur E, Schaible T, Wenzl T, Wagner N, Heimann K
Klinische Padiatrie221(5)305-7(2009 Sep)

The mammalian alphaD-globin gene lineage and a new model for the molecular evolution of alpha-globin gene clusters at the stem of the mammalian radiation.
Cooper SJ, Wheeler D, De Leo A, Cheng JF, Holland RA, Marshall Graves JA, Hope RM
Molecular phylogenetics and evolution38(2)439-48(2006 Feb)

A newly discovered human alpha-globin gene.
Goh SH, Lee YT, Bhanu NV, Cam MC, Desper R, Martin BM, Moharram R, Gherman RB, Miller JL
Blood106(4)1466-72(2005 Aug)

Unusual features of CpG-rich (HTF) islands in the human alpha globin complex: association with non-functional pseudogenes and presence within the 3' portion of the zeta gene.
Fischel-Ghodsian N, Nicholls RD, Higgs DR
Nucleic acids research15(22)9215-25(1987 Nov)

A previously undetected pseudogene in the human alpha globin gene cluster.
Hardison RC, Sawada I, Cheng JF, Shen CK, Schmid CW
Nucleic acids research14(4)1903-11(1986 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HbM Saskatoon is normally a harmless variant. However, in conjunction with severe pneumonia, we assume that it did not only affect clinical evaluation, but also exacerbated pneumonia by reducing the oxygen binding capacity.
Title: Persistent cyanosis in a 4 month old infant with severe pneumonia and haemoglobin M.

results suggest the human genome encodes a previously unrecognized globin member of the avian alpha-D family that is transcribed in a highly regulated pattern in erythroid cells
Title: A newly discovered human alpha-globin gene.

The following HBM gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HBM cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25698	NM_001003938.4 Latest version!	Homo sapiens hemoglobin subunit mu (HBM), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu25698	NM_001003938.3	Homo sapiens hemoglobin subunit mu (HBM), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HBM ( NM_001003938.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001003938.1 Homo sapiens hemoglobin subunit mu (HBM), mRNA.

Price & Availability↑

CloneID	OHu25698
Clone ID Related Accession (Same CDS sequence)	NM_001003938.3 , NM_001003938.4
Accession Version	NM_001003938.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 426bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	hemoglobin subunit mu
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY698022.2 and BC035682.1. This sequence is a reference standard in the RefSeqGene project. On May 4, 2006 this sequence version replaced NM_001003938.2. ##Evidence-Data-START## Transcript exon combination :: AY698022.2, BC067870.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2149004 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCAGCG CCCAGGAGCG CGCCCAAATC GCGCAGGTCT GGGACCTGAT TGCGGGCCAC 
GAGGCGCAAT TCGGGGCGGA GCTGCTGCTC AGGCTCTTCA CGGTGTACCC CAGCACCAAG 
GTCTACTTCC CGCACCTGAG CGCCTGCCAG GACGCGACGC AGCTGCTGAG CCACGGGCAG 
CGCATGCTGG CGGCTGTGGG CGCGGCGGTG CAGCACGTGG ACAACCTGCG CGCCGCGCTG 
AGCCCGCTGG CGGACCTGCA CGCGCTCGTG CTGCGCGTGG ACCCAGCCAA CTTTCCGCTG 
CTAATCCAGT GTTTCCACGT CGTGCTGGCC TCCCACCTGC AGGACGAGTT CACCGTGCAA 
ATGCAAGCGG CGTGGGACAA GTTCCTGACT GGTGTGGCCG TGGTGCTGAC CGAAAAATAC 
CGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003938.1
CDS	25..450
Translation	MLSAQERAQIAQVWDLIAGHEAQFGAELLLRLFTVYPSTKVYFPHLSACQDATQLLSHGQRMLAAVGAAVQHVDNLRAALSPLADLHALVLRVDPANFPLLIQCFHVVLASHLQDEFTVQMQAAWDKFLTGVAVVLTEKYR

Target ORF information:

RefSeq Version	NM_001003938.3
Organism	Homo sapiens(human)
Definition	Homo sapiens hemoglobin subunit mu (HBM), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003938.3

ORF Insert Sequence:

ATGCTCAGCG CCCAGGAGCG CGCCCAAATC GCGCAGGTCT GGGACCTGAT TGCGGGCCAC 
GAGGCGCAAT TCGGGGCGGA GCTGCTGCTC AGGCTCTTCA CGGTGTACCC CAGCACCAAG 
GTCTACTTCC CGCACCTGAG CGCCTGCCAG GACGCGACGC AGCTGCTGAG CCACGGGCAG 
CGCATGCTGG CGGCTGTGGG CGCGGCGGTG CAGCACGTGG ACAACCTGCG CGCCGCGCTG 
AGCCCGCTGG CGGACCTGCA CGCGCTCGTG CTGCGCGTGG ACCCAGCCAA CTTTCCGCTG 
CTAATCCAGT GTTTCCACGT CGTGCTGGCC TCCCACCTGC AGGACGAGTT CACCGTGCAA 
ATGCAAGCGG CGTGGGACAA GTTCCTGACT GGTGTGGCCG TGGTGCTGAC CGAAAAATAC 
CGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HBM ( NM_001003938.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001003938.1 Homo sapiens hemoglobin subunit mu (HBM), mRNA.

Price & Availability↑

CloneID	OHu25698
Clone ID Related Accession (Same CDS sequence)	NM_001003938.3 , NM_001003938.4
Accession Version	NM_001003938.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 426bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	hemoglobin subunit mu
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY698022.2 and BC035682.1. On Nov 23, 2018 this sequence version replaced NM_001003938.3. ##Evidence-Data-START## Transcript exon combination :: BC067870.1, AY698022.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2149004 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000356815.4/ ENSP00000349270.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTCAGCG CCCAGGAGCG CGCCCAAATC GCGCAGGTCT GGGACCTGAT TGCGGGCCAC 
GAGGCGCAAT TCGGGGCGGA GCTGCTGCTC AGGCTCTTCA CGGTGTACCC CAGCACCAAG 
GTCTACTTCC CGCACCTGAG CGCCTGCCAG GACGCGACGC AGCTGCTGAG CCACGGGCAG 
CGCATGCTGG CGGCTGTGGG CGCGGCGGTG CAGCACGTGG ACAACCTGCG CGCCGCGCTG 
AGCCCGCTGG CGGACCTGCA CGCGCTCGTG CTGCGCGTGG ACCCAGCCAA CTTTCCGCTG 
CTAATCCAGT GTTTCCACGT CGTGCTGGCC TCCCACCTGC AGGACGAGTT CACCGTGCAA 
ATGCAAGCGG CGTGGGACAA GTTCCTGACT GGTGTGGCCG TGGTGCTGAC CGAAAAATAC 
CGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003938.1
CDS	21..446
Translation	MLSAQERAQIAQVWDLIAGHEAQFGAELLLRLFTVYPSTKVYFPHLSACQDATQLLSHGQRMLAAVGAAVQHVDNLRAALSPLADLHALVLRVDPANFPLLIQCFHVVLASHLQDEFTVQMQAAWDKFLTGVAVVLTEKYR

Target ORF information:

RefSeq Version	NM_001003938.4
Organism	Homo sapiens(human)
Definition	Homo sapiens hemoglobin subunit mu (HBM), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003938.4

ORF Insert Sequence:

ATGCTCAGCG CCCAGGAGCG CGCCCAAATC GCGCAGGTCT GGGACCTGAT TGCGGGCCAC 
GAGGCGCAAT TCGGGGCGGA GCTGCTGCTC AGGCTCTTCA CGGTGTACCC CAGCACCAAG 
GTCTACTTCC CGCACCTGAG CGCCTGCCAG GACGCGACGC AGCTGCTGAG CCACGGGCAG 
CGCATGCTGG CGGCTGTGGG CGCGGCGGTG CAGCACGTGG ACAACCTGCG CGCCGCGCTG 
AGCCCGCTGG CGGACCTGCA CGCGCTCGTG CTGCGCGTGG ACCCAGCCAA CTTTCCGCTG 
CTAATCCAGT GTTTCCACGT CGTGCTGGCC TCCCACCTGC AGGACGAGTT CACCGTGCAA 
ATGCAAGCGG CGTGGGACAA GTTCCTGACT GGTGTGGCCG TGGTGCTGAC CGAAAAATAC 
CGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Persistent cyanosis in a 4 month old infant with severe pneumonia and haemoglobin M.
Klinische Padiatrie221(5)305-7(2009 Sep)
H?tten M,Kohne E,Yagmur E,Schaible T,Wenzl T,Wagner N,Heimann K

The mammalian alphaD-globin gene lineage and a new model for the molecular evolution of alpha-globin gene clusters at the stem of the mammalian radiation.
Molecular phylogenetics and evolution38(2)439-48(2006 Feb)
Cooper SJ,Wheeler D,De Leo A,Cheng JF,Holland RA,Marshall Graves JA,Hope RM

A newly discovered human alpha-globin gene.
Blood106(4)1466-72(2005 Aug)
Goh SH,Lee YT,Bhanu NV,Cam MC,Desper R,Martin BM,Moharram R,Gherman RB,Miller JL

Unusual features of CpG-rich (HTF) islands in the human alpha globin complex: association with non-functional pseudogenes and presence within the 3' portion of the zeta gene.
Nucleic acids research15(22)9215-25(1987 Nov)
Fischel-Ghodsian N,Nicholls RD,Higgs DR

A previously undetected pseudogene in the human alpha globin gene cluster.
Nucleic acids research14(4)1903-11(1986 Feb)
Hardison RC,Sawada I,Cheng JF,Shen CK,Schmid CW

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HBM cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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