H1-1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	H1-1
Entrez Gene ID	3024
Full Name	histone cluster 1 H1 family member a
Synonyms	H1.1,H1A,H1F1,HIST1
General protein information	Preferred Names histone cluster 1 H1 family member a Names histone H1.1 H1 histone family, member 1 histone 1, H1a histone H1a histone cluster 1, H1a
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.2
Summary	Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015].
Disorder MIM:	142709

mRNA and Protein(s)

mRNA	Protein	Name
NM_005325.3	NP_005316.1	histone H1.1
NM_005325.4	NP_005316.1	histone H1.1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LOC488258	XP_545380.1
Gallus gallus (chicken)	HIST1H111L	NP_001035733.1
Bos taurus (cattle)	HIST1H1A	XP_005223858.1
Homo sapiens (human)	HIST1H1A	NP_005316.1
Pan troglodytes (chimpanzee)	LOC471874	XP_527252.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Anti-histone H1 IgGs possess proliferative activity towards human T-leukaemia CEM cells.
Kit Y, Magorivska I, Bilyi R, Myronovskij S, Stoika R
Experimental oncology39(1)36-41(2017 Mar)

Role of H1 linker histones in mammalian development and stem cell differentiation.
Pan C, Fan Y
Biochimica et biophysica acta1859(3)496-509(2016 Mar)

Interaction of chromatin with a histone H1 containing swapped N- and C-terminal domains.
Hutchinson JB, Cheema MS, Wang J, Missiaen K, Finn R, Gonzalez Romero R, Th'ng JP, Hendzel M, Ausi? J
Bioscience reports35(3)(2015 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that IgGs possessing an affinity to histone H1 were isolated by affinity chromatography and size exclusion chromatography.
Title: Anti-histone H1 IgGs possess proliferative activity towards human T-leukaemia CEM cells.

HIST1 cluster PcG methylation has a role in epigenesis in acute myeloid leukemia
Title: PcG methylation of the HIST1 cluster defines an epigenetic marker of acute myeloid leukemia.

Proper binding of histone H1.1 to chromatin is determined by the simultaneous and synergistic binding of its folded wing helix domain -C-terminal domains to the nucleosome.
Title: Interaction of chromatin with a histone H1 containing swapped N- and C-terminal domains.

Results suggest the potential for histone H1 phosphorylation at threonine 146 as a clinical biomarker in breast cancer.
Title: Histone H1 phosphorylation in breast cancer.

Integration with apoptotic intermediates (via C-terminal tail interactions) may constitute a more generalized function of linker histone isoforms in apoptotic cascades.
Title: The C-terminal domain (CTD) in linker histones antagonizes anti-apoptotic proteins to modulate apoptotic outcomes at the mitochondrion.

The following H1-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H1-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31228	NM_005325.4 Latest version!	Homo sapiens H1.1 linker histone, cluster member (H1-1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31228	NM_005325.3	Homo sapiens histone cluster 1 H1 family member a (HIST1H1A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H1-1 ( NM_005325.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005316.1 Homo sapiens histone cluster 1 H1 family member a (HIST1H1A), mRNA.

Price & Availability↑

CloneID	OHu31228
Clone ID Related Accession (Same CDS sequence)	NM_005325.3 , NM_005325.4
Accession Version	NM_005325.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-06
Organism	Homo sapiens(human)
Product	histone H1.1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC112140.1. On Oct 17, 2006 this sequence version replaced NM_005325.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC112140.1, BC101593.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTGAAA CAGTGCCTCC CGCCCCCGCC GCTTCTGCTG CTCCTGAGAA ACCTTTAGCT 
GGCAAGAAGG CAAAGAAACC TGCTAAGGCT GCAGCAGCCT CCAAGAAAAA ACCCGCTGGC 
CCTTCCGTGT CAGAGCTGAT CGTGCAGGCT GCTTCCTCCT CTAAGGAGCG TGGTGGTGTG 
TCGTTGGCAG CTCTTAAAAA GGCGCTGGCG GCCGCAGGCT ACGACGTGGA GAAGAACAAC 
AGCCGCATTA AGCTGGGCAT TAAGAGCCTG GTAAGCAAGG GAACGTTGGT GCAGACAAAG 
GGTACCGGAG CCTCGGGTTC CTTCAAGCTC AACAAGAAGG CGTCCTCCGT GGAAACCAAG 
CCCGGCGCCT CAAAGGTGGC TACAAAAACT AAGGCAACGG GTGCATCTAA AAAGCTCAAA 
AAGGCCACGG GGGCTAGCAA AAAGAGCGTC AAGACTCCGA AAAAGGCTAA AAAGCCTGCG 
GCAACAAGGA AATCCTCCAA GAATCCAAAA AAACCCAAAA CTGTAAAGCC CAAGAAAGTA 
GCTAAAAGCC CTGCTAAAGC TAAGGCTGTA AAACCCAAGG CGGCCAAGGC TAGGGTGACG 
AAGCCAAAGA CTGCCAAACC CAAGAAAGCG GCACCCAAGA AAAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005316.1
CDS	81..728
Translation	MSETVPPAPAASAAPEKPLAGKKAKKPAKAAAASKKKPAGPSVSELIVQAASSSKERGGVSLAALKKALAAAGYDVEKNNSRIKLGIKSLVSKGTLVQTKGTGASGSFKLNKKASSVETKPGASKVATKTKATGASKKLKKATGASKKSVKTPKKAKKPAATRKSSKNPKKPKTVKPKKVAKSPAKAKAVKPKAAKARVTKPKTAKPKKAAPKKK

Target ORF information:

RefSeq Version	NM_005325.3
Organism	Homo sapiens(human)
Definition	Homo sapiens histone cluster 1 H1 family member a (HIST1H1A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005325.3

ORF Insert Sequence:

ATGTCTGAAA CAGTGCCTCC CGCCCCCGCC GCTTCTGCTG CTCCTGAGAA ACCTTTAGCT 
GGCAAGAAGG CAAAGAAACC TGCTAAGGCT GCAGCAGCCT CCAAGAAAAA ACCCGCTGGC 
CCTTCCGTGT CAGAGCTGAT CGTGCAGGCT GCTTCCTCCT CTAAGGAGCG TGGTGGTGTG 
TCGTTGGCAG CTCTTAAAAA GGCGCTGGCG GCCGCAGGCT ACGACGTGGA GAAGAACAAC 
AGCCGCATTA AGCTGGGCAT TAAGAGCCTG GTAAGCAAGG GAACGTTGGT GCAGACAAAG 
GGTACCGGAG CCTCGGGTTC CTTCAAGCTC AACAAGAAGG CGTCCTCCGT GGAAACCAAG 
CCCGGCGCCT CAAAGGTGGC TACAAAAACT AAGGCAACGG GTGCATCTAA AAAGCTCAAA 
AAGGCCACGG GGGCTAGCAA AAAGAGCGTC AAGACTCCGA AAAAGGCTAA AAAGCCTGCG 
GCAACAAGGA AATCCTCCAA GAATCCAAAA AAACCCAAAA CTGTAAAGCC CAAGAAAGTA 
GCTAAAAGCC CTGCTAAAGC TAAGGCTGTA AAACCCAAGG CGGCCAAGGC TAGGGTGACG 
AAGCCAAAGA CTGCCAAACC CAAGAAAGCG GCACCCAAGA AAAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H1-1 ( NM_005325.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005316.1 Homo sapiens H1.1 linker histone, cluster member (H1-1), mRNA.

Price & Availability↑

CloneID	OHu31228
Clone ID Related Accession (Same CDS sequence)	NM_005325.3 , NM_005325.4
Accession Version	NM_005325.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	histone H1.1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U91328.1. On Dec 3, 2019 this sequence version replaced NM_005325.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC112140.1, EL736229.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTGAAA CAGTGCCTCC CGCCCCCGCC GCTTCTGCTG CTCCTGAGAA ACCTTTAGCT 
GGCAAGAAGG CAAAGAAACC TGCTAAGGCT GCAGCAGCCT CCAAGAAAAA ACCCGCTGGC 
CCTTCCGTGT CAGAGCTGAT CGTGCAGGCT GCTTCCTCCT CTAAGGAGCG TGGTGGTGTG 
TCGTTGGCAG CTCTTAAAAA GGCGCTGGCG GCCGCAGGCT ACGACGTGGA GAAGAACAAC 
AGCCGCATTA AGCTGGGCAT TAAGAGCCTG GTAAGCAAGG GAACGTTGGT GCAGACAAAG 
GGTACCGGAG CCTCGGGTTC CTTCAAGCTC AACAAGAAGG CGTCCTCCGT GGAAACCAAG 
CCCGGCGCCT CAAAGGTGGC TACAAAAACT AAGGCAACGG GTGCATCTAA AAAGCTCAAA 
AAGGCCACGG GGGCTAGCAA AAAGAGCGTC AAGACTCCGA AAAAGGCTAA AAAGCCTGCG 
GCAACAAGGA AATCCTCCAA GAATCCAAAA AAACCCAAAA CTGTAAAGCC CAAGAAAGTA 
GCTAAAAGCC CTGCTAAAGC TAAGGCTGTA AAACCCAAGG CGGCCAAGGC TAGGGTGACG 
AAGCCAAAGA CTGCCAAACC CAAGAAAGCG GCACCCAAGA AAAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005316.1
CDS	56..703
Translation	MSETVPPAPAASAAPEKPLAGKKAKKPAKAAAASKKKPAGPSVSELIVQAASSSKERGGVSLAALKKALAAAGYDVEKNNSRIKLGIKSLVSKGTLVQTKGTGASGSFKLNKKASSVETKPGASKVATKTKATGASKKLKKATGASKKSVKTPKKAKKPAATRKSSKNPKKPKTVKPKKVAKSPAKAKAVKPKAAKARVTKPKTAKPKKAAPKKK

Target ORF information:

RefSeq Version	NM_005325.4
Organism	Homo sapiens(human)
Definition	Homo sapiens H1.1 linker histone, cluster member (H1-1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005325.4

ORF Insert Sequence:

ATGTCTGAAA CAGTGCCTCC CGCCCCCGCC GCTTCTGCTG CTCCTGAGAA ACCTTTAGCT 
GGCAAGAAGG CAAAGAAACC TGCTAAGGCT GCAGCAGCCT CCAAGAAAAA ACCCGCTGGC 
CCTTCCGTGT CAGAGCTGAT CGTGCAGGCT GCTTCCTCCT CTAAGGAGCG TGGTGGTGTG 
TCGTTGGCAG CTCTTAAAAA GGCGCTGGCG GCCGCAGGCT ACGACGTGGA GAAGAACAAC 
AGCCGCATTA AGCTGGGCAT TAAGAGCCTG GTAAGCAAGG GAACGTTGGT GCAGACAAAG 
GGTACCGGAG CCTCGGGTTC CTTCAAGCTC AACAAGAAGG CGTCCTCCGT GGAAACCAAG 
CCCGGCGCCT CAAAGGTGGC TACAAAAACT AAGGCAACGG GTGCATCTAA AAAGCTCAAA 
AAGGCCACGG GGGCTAGCAA AAAGAGCGTC AAGACTCCGA AAAAGGCTAA AAAGCCTGCG 
GCAACAAGGA AATCCTCCAA GAATCCAAAA AAACCCAAAA CTGTAAAGCC CAAGAAAGTA 
GCTAAAAGCC CTGCTAAAGC TAAGGCTGTA AAACCCAAGG CGGCCAAGGC TAGGGTGACG 
AAGCCAAAGA CTGCCAAACC CAAGAAAGCG GCACCCAAGA AAAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Anti-histone H1 IgGs possess proliferative activity towards human T-leukaemia CEM cells.
Experimental oncology39(1)36-41(2017 Mar)
Kit Y,Magorivska I,Bilyi R,Myronovskij S,Stoika R

Role of H1 linker histones in mammalian development and stem cell differentiation.
Biochimica et biophysica acta1859(3)496-509(2016 Mar)
Pan C,Fan Y

Interaction of chromatin with a histone H1 containing swapped N- and C-terminal domains.
Bioscience reports35(3)(2015 Apr)
Hutchinson JB,Cheema MS,Wang J,Missiaen K,Finn R,Gonzalez Romero R,Th'ng JP,Hendzel M,Ausi? J

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H1-1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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