H1-5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	H1-5
Entrez Gene ID	3009
Full Name	histone cluster 1 H1 family member b
Synonyms	H1,H1.5,H1B,H1F5,H1s-3
General protein information	Preferred Names histone cluster 1 H1 family member b Names histone H1.5 H1 histone family, member 5 histone 1, H1b histone H1a histone H1b histone H1s-3 histone cluster 1, H1b
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.1
Summary	Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015].
Disorder MIM:	142711

mRNA and Protein(s)

mRNA	Protein	Name
NM_005322.2	NP_005313.1	histone H1.5
NM_005322.3	NP_005313.1	histone H1.5

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LOC471906	XP_527284.1
Canis lupus familiaris (dog)	LOC488305	XP_545427.3
	HIST1H1B	XP_001096781.1
Homo sapiens (human)	HIST1H1B	NP_005313.1

Gene Ontology
Bibliography

Related articles in PubMed

Role of H1 linker histones in mammalian development and stem cell differentiation.
Pan C, Fan Y
Biochimica et biophysica acta1859(3)496-509(2016 Mar)

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

Immunohistochemical detection of promyelocytic leukemia zinc finger and histone 1.5 in uterine leiomyosarcoma and leiomyoma.
Momeni M, Kalir T, Farag S, Kinoshita Y, Roman TY, Chuang L, Fishman DA, Burstein DE
Reproductive sciences (Thousand Oaks, Calif.)21(9)1171-6(2014 Sep)

Expression of H1.5 and PLZF in granulosa cell tumors and normal ovarian tissues: a short report.
Momeni M, Kalir T, Farag S, Chuang L, Fishman D, Burstein DE
Cellular oncology (Dordrecht)37(3)229-34(2014 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Statistically significant differences in staining patterns were found for histone H1.5, distinguishing leiomyosarcomas from leiomyomas.
Title: Immunohistochemical detection of promyelocytic leukemia zinc finger and histone 1.5 in uterine leiomyosarcoma and leiomyoma.

Data indicate that normal ovarian tissues strongly expressed histone H1.5, whereas ovarian granulosa cell tumors (GCTs) weakly expressed this protein; in contrast, PLZF protein expression was not significantly different between both study groups.
Title: Expression of H1.5 and PLZF in granulosa cell tumors and normal ovarian tissues: a short report.

Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma.
Title: Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma.

Promyelocytic leukemia zinc finger and histone H1.5 differentially stain low- and high-grade pulmonary neuroendocrine tumors
Title: Promyelocytic leukemia zinc finger and histone H1.5 differentially stain low- and high-grade pulmonary neuroendocrine tumors: a pilot immunohistochemical study.

FoxP3 interacts with H1.5 to alter its binding to target genes to modulate their expression and to program Treg function.
Title: FoxP3 interacts with linker histone H1.5 to modulate gene expression and program Treg cell activity.

The following H1-5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H1-5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24186	NM_005322.3 Latest version!	Homo sapiens H1.5 linker histone, cluster member (H1-5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu24186	NM_005322.2	Homo sapiens histone cluster 1 H1 family member b (HIST1H1B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H1-5 ( NM_005322.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005313.1 Homo sapiens histone cluster 1 H1 family member b (HIST1H1B), mRNA.

Price & Availability↑

CloneID	OHu24186
Clone ID Related Accession (Same CDS sequence)	NM_005322.2 , NM_005322.3
Accession Version	NM_005322.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 681bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-06
Organism	Homo sapiens(human)
Product	histone H1.5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X83509.1. On Sep 21, 2001 this sequence version replaced NM_005322.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC069101.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGGAAA CCGCTCCTGC CGAGACAGCC ACCCCAGCGC CGGTGGAGAA ATCCCCGGCT 
AAGAAGAAGG CAACTAAGAA GGCTGCCGGC GCCGGCGCTG CTAAGCGCAA AGCGACGGGG 
CCCCCAGTCT CAGAGCTGAT CACCAAGGCT GTGGCTGCTT CTAAGGAGCG CAATGGCCTT 
TCTTTGGCAG CCCTTAAGAA GGCCTTAGCG GCCGGTGGCT ACGACGTGGA GAAGAATAAC 
AGCCGCATTA AGCTGGGCCT CAAGAGCTTG GTGAGCAAGG GCACCCTGGT GCAGACCAAG 
GGCACTGGTG CTTCTGGCTC CTTTAAACTC AACAAGAAGG CGGCCTCCGG GGAAGCCAAG 
CCCAAAGCCA AGAAGGCAGG CGCCGCTAAA GCTAAGAAGC CCGCGGGGGC CACGCCTAAG 
AAGGCCAAGA AGGCTGCAGG GGCGAAAAAG GCAGTGAAGA AGACTCCGAA GAAGGCGAAG 
AAGCCCGCGG CGGCTGGCGT CAAAAAGGTG GCGAAGAGCC CTAAGAAGGC CAAGGCCGCT 
GCCAAACCGA AAAAGGCAAC CAAGAGTCCT GCCAAGCCCA AGGCAGTTAA GCCGAAGGCG 
GCAAAGCCCA AAGCCGCTAA GCCCAAAGCA GCAAAACCTA AAGCTGCAAA GGCCAAGAAG 
GCGGCTGCCA AAAAGAAGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005313.1
CDS	53..733
Translation	MSETAPAETATPAPVEKSPAKKKATKKAAGAGAAKRKATGPPVSELITKAVAASKERNGLSLAALKKALAAGGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKAKKAGAAKAKKPAGATPKKAKKAAGAKKAVKKTPKKAKKPAAAGVKKVAKSPKKAKAAAKPKKATKSPAKPKAVKPKAAKPKAAKPKAAKPKAAKAKKAAAKKK

Target ORF information:

RefSeq Version	NM_005322.2
Organism	Homo sapiens(human)
Definition	Homo sapiens histone cluster 1 H1 family member b (HIST1H1B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005322.2

ORF Insert Sequence:

ATGTCGGAAA CCGCTCCTGC CGAGACAGCC ACCCCAGCGC CGGTGGAGAA ATCCCCGGCT 
AAGAAGAAGG CAACTAAGAA GGCTGCCGGC GCCGGCGCTG CTAAGCGCAA AGCGACGGGG 
CCCCCAGTCT CAGAGCTGAT CACCAAGGCT GTGGCTGCTT CTAAGGAGCG CAATGGCCTT 
TCTTTGGCAG CCCTTAAGAA GGCCTTAGCG GCCGGTGGCT ACGACGTGGA GAAGAATAAC 
AGCCGCATTA AGCTGGGCCT CAAGAGCTTG GTGAGCAAGG GCACCCTGGT GCAGACCAAG 
GGCACTGGTG CTTCTGGCTC CTTTAAACTC AACAAGAAGG CGGCCTCCGG GGAAGCCAAG 
CCCAAAGCCA AGAAGGCAGG CGCCGCTAAA GCTAAGAAGC CCGCGGGGGC CACGCCTAAG 
AAGGCCAAGA AGGCTGCAGG GGCGAAAAAG GCAGTGAAGA AGACTCCGAA GAAGGCGAAG 
AAGCCCGCGG CGGCTGGCGT CAAAAAGGTG GCGAAGAGCC CTAAGAAGGC CAAGGCCGCT 
GCCAAACCGA AAAAGGCAAC CAAGAGTCCT GCCAAGCCCA AGGCAGTTAA GCCGAAGGCG 
GCAAAGCCCA AAGCCGCTAA GCCCAAAGCA GCAAAACCTA AAGCTGCAAA GGCCAAGAAG 
GCGGCTGCCA AAAAGAAGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H1-5 ( NM_005322.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005313.1 Homo sapiens H1.5 linker histone, cluster member (H1-5), mRNA.

Price & Availability↑

CloneID	OHu24186
Clone ID Related Accession (Same CDS sequence)	NM_005322.2 , NM_005322.3
Accession Version	NM_005322.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 681bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	histone H1.5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z98744.2. On Dec 3, 2019 this sequence version replaced NM_005322.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC069101.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGGAAA CCGCTCCTGC CGAGACAGCC ACCCCAGCGC CGGTGGAGAA ATCCCCGGCT 
AAGAAGAAGG CAACTAAGAA GGCTGCCGGC GCCGGCGCTG CTAAGCGCAA AGCGACGGGG 
CCCCCAGTCT CAGAGCTGAT CACCAAGGCT GTGGCTGCTT CTAAGGAGCG CAATGGCCTT 
TCTTTGGCAG CCCTTAAGAA GGCCTTAGCG GCCGGTGGCT ACGACGTGGA GAAGAATAAC 
AGCCGCATTA AGCTGGGCCT CAAGAGCTTG GTGAGCAAGG GCACCCTGGT GCAGACCAAG 
GGCACTGGTG CTTCTGGCTC CTTTAAACTC AACAAGAAGG CGGCCTCCGG GGAAGCCAAG 
CCCAAAGCCA AGAAGGCAGG CGCCGCTAAA GCTAAGAAGC CCGCGGGGGC CACGCCTAAG 
AAGGCCAAGA AGGCTGCAGG GGCGAAAAAG GCAGTGAAGA AGACTCCGAA GAAGGCGAAG 
AAGCCCGCGG CGGCTGGCGT CAAAAAGGTG GCGAAGAGCC CTAAGAAGGC CAAGGCCGCT 
GCCAAACCGA AAAAGGCAAC CAAGAGTCCT GCCAAGCCCA AGGCAGTTAA GCCGAAGGCG 
GCAAAGCCCA AAGCCGCTAA GCCCAAAGCA GCAAAACCTA AAGCTGCAAA GGCCAAGAAG 
GCGGCTGCCA AAAAGAAGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005313.1
CDS	60..740
Translation	MSETAPAETATPAPVEKSPAKKKATKKAAGAGAAKRKATGPPVSELITKAVAASKERNGLSLAALKKALAAGGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKAKKAGAAKAKKPAGATPKKAKKAAGAKKAVKKTPKKAKKPAAAGVKKVAKSPKKAKAAAKPKKATKSPAKPKAVKPKAAKPKAAKPKAAKPKAAKAKKAAAKKK

Target ORF information:

RefSeq Version	NM_005322.3
Organism	Homo sapiens(human)
Definition	Homo sapiens H1.5 linker histone, cluster member (H1-5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005322.3

ORF Insert Sequence:

ATGTCGGAAA CCGCTCCTGC CGAGACAGCC ACCCCAGCGC CGGTGGAGAA ATCCCCGGCT 
AAGAAGAAGG CAACTAAGAA GGCTGCCGGC GCCGGCGCTG CTAAGCGCAA AGCGACGGGG 
CCCCCAGTCT CAGAGCTGAT CACCAAGGCT GTGGCTGCTT CTAAGGAGCG CAATGGCCTT 
TCTTTGGCAG CCCTTAAGAA GGCCTTAGCG GCCGGTGGCT ACGACGTGGA GAAGAATAAC 
AGCCGCATTA AGCTGGGCCT CAAGAGCTTG GTGAGCAAGG GCACCCTGGT GCAGACCAAG 
GGCACTGGTG CTTCTGGCTC CTTTAAACTC AACAAGAAGG CGGCCTCCGG GGAAGCCAAG 
CCCAAAGCCA AGAAGGCAGG CGCCGCTAAA GCTAAGAAGC CCGCGGGGGC CACGCCTAAG 
AAGGCCAAGA AGGCTGCAGG GGCGAAAAAG GCAGTGAAGA AGACTCCGAA GAAGGCGAAG 
AAGCCCGCGG CGGCTGGCGT CAAAAAGGTG GCGAAGAGCC CTAAGAAGGC CAAGGCCGCT 
GCCAAACCGA AAAAGGCAAC CAAGAGTCCT GCCAAGCCCA AGGCAGTTAA GCCGAAGGCG 
GCAAAGCCCA AAGCCGCTAA GCCCAAAGCA GCAAAACCTA AAGCTGCAAA GGCCAAGAAG 
GCGGCTGCCA AAAAGAAGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of H1 linker histones in mammalian development and stem cell differentiation.
Biochimica et biophysica acta1859(3)496-509(2016 Mar)
Pan C,Fan Y

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

Immunohistochemical detection of promyelocytic leukemia zinc finger and histone 1.5 in uterine leiomyosarcoma and leiomyoma.
Reproductive sciences (Thousand Oaks, Calif.)21(9)1171-6(2014 Sep)
Momeni M,Kalir T,Farag S,Kinoshita Y,Roman TY,Chuang L,Fishman DA,Burstein DE

Expression of H1.5 and PLZF in granulosa cell tumors and normal ovarian tissues: a short report.
Cellular oncology (Dordrecht)37(3)229-34(2014 Jun)
Momeni M,Kalir T,Farag S,Chuang L,Fishman D,Burstein DE

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H1-5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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