NXPH1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NXPH1
Entrez Gene ID	30010
Full Name	neurexophilin 1
Synonyms	NPH1,Nbla00697
General protein information	Preferred Names neurexophilin 1 Names neurexophilin-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p21.3
Summary	This gene is a member of the neurexophilin family and encodes a secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons. [provided by RefSeq, Jul 2008].
Disorder MIM:	604639

mRNA and Protein(s)

mRNA	Protein	Name
NM_152745.3	NP_689958.1	neurexophilin-1 precursor
NM_152745.2	NP_689958.1	neurexophilin-1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NXPH1	XP_001147634.2
Canis lupus familiaris (dog)	NXPH1	XP_852937.1
Rattus norvegicus (Norway rat)	Nxph1	NP_037126.1
	NXPH1	XP_001085129.2
Gallus gallus (chicken)	NXPH1	XP_418683.2
Homo sapiens (human)	NXPH1	NP_689958.1
Bos taurus (cattle)	NXPH1	NP_001029934.1
Mus musculus (house mouse)	Nxph1	NP_032777.3
Danio rerio (zebrafish)	nxph1	NP_001002733.1
Xenopus tropicalis (tropical clawed frog)	nxph1	NP_001120374.1

Gene Ontology
Bibliography

Related articles in PubMed

Plasma Triglyceride Levels May Be Modulated by Gene Expression of IQCJ, NXPH1, PHF17 and MYB in Humans.
Vall?e Marcotte B, Gu?nard F, Cormier H, Lemieux S, Couture P, Rudkowska I, Vohl MC
International journal of molecular sciences18(2)(2017 Jan)

The detection of tumor location and lymph node metastasis by aberrant NXPH1 and NXPH2 expressions in pancreatic ductal adenocarcinomas.
Jin JS, Tsai WC
The Chinese journal of physiology59(6)348-354(2016 Dec)

Novel Genetic Loci Associated with the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation.
Vall?e Marcotte B, Cormier H, Gu?nard F, Rudkowska I, Lemieux S, Couture P, Vohl MC
Journal of nutrigenetics and nutrigenomics9(1)1-11(2016)

[The Role of Neurotrophins and Neurexins Genes in the Risk of Paranoid Schizophrenia in Russians and Tatars].
Gareeva AE, Traks T, Koks S, Khusnutdinova EK
Genetika51(7)799-811(2015 Jul)

Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome.
Wouters MM, Lambrechts D, Knapp M, Cleynen I, Whorwell P, Agr?us L, Dlugosz A, Schmidt PT, Halfvarson J, Simr?n M, Ohlsson B, Karling P, Van Wanrooy S, Mondelaers S, Vermeire S, Lindberg G, Spiller R, Dukes G, D'Amato M, Boeckxstaens G
Gut63(7)1103-11(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A genome-wide association study (GWAS) identified loci associated with the plasma triglyceride (TG) response to omega-3 fatty acid (FA) supplementation in IQCJ, NXPH1, PHF17 and MYB.
Title: Plasma Triglyceride Levels May Be Modulated by Gene Expression of IQCJ, NXPH1, PHF17 and MYB in Humans.

expression inversely correlated with N stage in pancreatic ductal adenocarcinoma
Title: The detection of tumor location and lymph node metastasis by aberrant NXPH1 and NXPH2 expressions in pancreatic ductal adenocarcinomas.

identification of SNPs within the IQCJ, NXPH1, PHF17 and MYB genes partly explaining the large interindividual variability observed in plasma triglyceride levels in response to an n-3 fatty acid supplementation
Title: Novel Genetic Loci Associated with the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation.

The role of NXPH1 in in paranoid schizophrenia development in Russians.
Title: [The Role of Neurotrophins and Neurexins Genes in the Risk of Paranoid Schizophrenia in Russians and Tatars].

Rs2349775 (NXPH1) and rs17837965 (CDC42) were associated with diarrhoea and constipation predominant irritable bowel syndrome, respectively, in two independent cohorts.
Title: Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome.

The following NXPH1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NXPH1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30231	NM_152745.3 Latest version!	Homo sapiens neurexophilin 1 (NXPH1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu30231	NM_152745.2	Homo sapiens neurexophilin 1 (NXPH1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NXPH1 ( NM_152745.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_689958.1 Homo sapiens neurexophilin 1 (NXPH1), mRNA.

Price & Availability↑

CloneID	OHu30231
Clone ID Related Accession (Same CDS sequence)	NM_152745.3 , NM_152745.2
Accession Version	NM_152745.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	neurexophilin-1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC004861.1, AB047362.1, AC004613.1, AA575925.1 and BX107562.1. On Nov 22, 2018 this sequence version replaced NM_152745.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB073665.1, SRR1660805.179279.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2145544 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000405863.6/ ENSP00000384551.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGGCTG CGTGCTGGTA CGTGCTTTTC CTCCTGCAGC CCACCGTCTA CTTGGTCACA 
TGTGCCAATT TAACGAACGG TGGAAAGTCA GAACTTCTGA AATCAGGAAG CAGCAAATCC 
ACACTAAAGC ACATATGGAC AGAAAGCAGC AAAGACTTGT CTATCAGCCG ACTCCTGTCA 
CAGACTTTTC GTGGCAAAGA GAATGATACA GATTTGGACC TGAGATATGA CACCCCAGAA 
CCTTATTCTG AGCAAGACCT CTGGGACTGG CTGAGGAACT CCACAGACCT TCAAGAGCCT 
CGGCCCAGGG CCAAGAGAAG GCCCATTGTT AAAACGGGCA AGTTTAAGAA AATGTTTGGA 
TGGGGCGATT TTCATTCCAA CATCAAAACA GTGAAGCTGA ACCTGTTGAT AACTGGGAAA 
ATTGTAGATC ATGGCAATGG GACATTTAGT GTTTATTTCA GGCATAATTC AACTGGTCAA 
GGGAATGTAT CTGTCAGCTT GGTACCCCCT ACAAAAATCG TGGAATTTGA CTTGGCACAA 
CAAACCGTGA TTGATGCCAA AGATTCCAAG TCTTTTAATT GTCGCATTGA ATATGAAAAG 
GTTGACAAGG CTACCAAGAA CACACTCTGC AACTATGACC CTTCAAAAAC CTGTTACCAG 
GAGCAAACCC AAAGTCATGT ATCCTGGCTC TGCTCCAAGC CCTTTAAGGT GATCTGTATT 
TACATTTCCT TTTATAGTAC AGATTATAAA CTGGTACAGA AAGTGTGCCC TGACTACAAC 
TACCACAGTG ACACACCTTA CTTTCCCTCG GGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689958.1
CDS	1258..2073
Translation	MQAACWYVLFLLQPTVYLVTCANLTNGGKSELLKSGSSKSTLKHIWTESSKDLSISRLLSQTFRGKENDTDLDLRYDTPEPYSEQDLWDWLRNSTDLQEPRPRAKRRPIVKTGKFKKMFGWGDFHSNIKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGQGNVSVSLVPPTKIVEFDLAQQTVIDAKDSKSFNCRIEYEKVDKATKNTLCNYDPSKTCYQEQTQSHVSWLCSKPFKVICIYISFYSTDYKLVQKVCPDYNYHSDTPYFPSG

Target ORF information:

RefSeq Version	NM_152745.3
Organism	Homo sapiens(human)
Definition	Homo sapiens neurexophilin 1 (NXPH1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152745.3

ORF Insert Sequence:

ATGCAGGCTG CGTGCTGGTA CGTGCTTTTC CTCCTGCAGC CCACCGTCTA CTTGGTCACA 
TGTGCCAATT TAACGAACGG TGGAAAGTCA GAACTTCTGA AATCAGGAAG CAGCAAATCC 
ACACTAAAGC ACATATGGAC AGAAAGCAGC AAAGACTTGT CTATCAGCCG ACTCCTGTCA 
CAGACTTTTC GTGGCAAAGA GAATGATACA GATTTGGACC TGAGATATGA CACCCCAGAA 
CCTTATTCTG AGCAAGACCT CTGGGACTGG CTGAGGAACT CCACAGACCT TCAAGAGCCT 
CGGCCCAGGG CCAAGAGAAG GCCCATTGTT AAAACGGGCA AGTTTAAGAA AATGTTTGGA 
TGGGGCGATT TTCATTCCAA CATCAAAACA GTGAAGCTGA ACCTGTTGAT AACTGGGAAA 
ATTGTAGATC ATGGCAATGG GACATTTAGT GTTTATTTCA GGCATAATTC AACTGGTCAA 
GGGAATGTAT CTGTCAGCTT GGTACCCCCT ACAAAAATCG TGGAATTTGA CTTGGCACAA 
CAAACCGTGA TTGATGCCAA AGATTCCAAG TCTTTTAATT GTCGCATTGA ATATGAAAAG 
GTTGACAAGG CTACCAAGAA CACACTCTGC AACTATGACC CTTCAAAAAC CTGTTACCAG 
GAGCAAACCC AAAGTCATGT ATCCTGGCTC TGCTCCAAGC CCTTTAAGGT GATCTGTATT 
TACATTTCCT TTTATAGTAC AGATTATAAA CTGGTACAGA AAGTGTGCCC TGACTACAAC 
TACCACAGTG ACACACCTTA CTTTCCCTCG GGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NXPH1 ( NM_152745.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_689958.1 Homo sapiens neurexophilin 1 (NXPH1), mRNA.

Price & Availability↑

CloneID	OHu30231
Clone ID Related Accession (Same CDS sequence)	NM_152745.3 , NM_152745.2
Accession Version	NM_152745.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-19
Organism	Homo sapiens(human)
Product	neurexophilin-1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB047362.1, AC004613.1, AA575925.1 and BX107562.1. On Apr 21, 2006 this sequence version replaced NM_152745.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB073665.1, SRR1660805.253387.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2145544 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGGCTG CGTGCTGGTA CGTGCTTTTC CTCCTGCAGC CCACCGTCTA CTTGGTCACA 
TGTGCCAATT TAACGAACGG TGGAAAGTCA GAACTTCTGA AATCAGGAAG CAGCAAATCC 
ACACTAAAGC ACATATGGAC AGAAAGCAGC AAAGACTTGT CTATCAGCCG ACTCCTGTCA 
CAGACTTTTC GTGGCAAAGA GAATGATACA GATTTGGACC TGAGATATGA CACCCCAGAA 
CCTTATTCTG AGCAAGACCT CTGGGACTGG CTGAGGAACT CCACAGACCT TCAAGAGCCT 
CGGCCCAGGG CCAAGAGAAG GCCCATTGTT AAAACGGGCA AGTTTAAGAA AATGTTTGGA 
TGGGGCGATT TTCATTCCAA CATCAAAACA GTGAAGCTGA ACCTGTTGAT AACTGGGAAA 
ATTGTAGATC ATGGCAATGG GACATTTAGT GTTTATTTCA GGCATAATTC AACTGGTCAA 
GGGAATGTAT CTGTCAGCTT GGTACCCCCT ACAAAAATCG TGGAATTTGA CTTGGCACAA 
CAAACCGTGA TTGATGCCAA AGATTCCAAG TCTTTTAATT GTCGCATTGA ATATGAAAAG 
GTTGACAAGG CTACCAAGAA CACACTCTGC AACTATGACC CTTCAAAAAC CTGTTACCAG 
GAGCAAACCC AAAGTCATGT ATCCTGGCTC TGCTCCAAGC CCTTTAAGGT GATCTGTATT 
TACATTTCCT TTTATAGTAC AGATTATAAA CTGGTACAGA AAGTGTGCCC TGACTACAAC 
TACCACAGTG ACACACCTTA CTTTCCCTCG GGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689958.1
CDS	912..1727
Translation	MQAACWYVLFLLQPTVYLVTCANLTNGGKSELLKSGSSKSTLKHIWTESSKDLSISRLLSQTFRGKENDTDLDLRYDTPEPYSEQDLWDWLRNSTDLQEPRPRAKRRPIVKTGKFKKMFGWGDFHSNIKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGQGNVSVSLVPPTKIVEFDLAQQTVIDAKDSKSFNCRIEYEKVDKATKNTLCNYDPSKTCYQEQTQSHVSWLCSKPFKVICIYISFYSTDYKLVQKVCPDYNYHSDTPYFPSG

Target ORF information:

RefSeq Version	NM_152745.2
Organism	Homo sapiens(human)
Definition	Homo sapiens neurexophilin 1 (NXPH1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152745.2

ORF Insert Sequence:

ATGCAGGCTG CGTGCTGGTA CGTGCTTTTC CTCCTGCAGC CCACCGTCTA CTTGGTCACA 
TGTGCCAATT TAACGAACGG TGGAAAGTCA GAACTTCTGA AATCAGGAAG CAGCAAATCC 
ACACTAAAGC ACATATGGAC AGAAAGCAGC AAAGACTTGT CTATCAGCCG ACTCCTGTCA 
CAGACTTTTC GTGGCAAAGA GAATGATACA GATTTGGACC TGAGATATGA CACCCCAGAA 
CCTTATTCTG AGCAAGACCT CTGGGACTGG CTGAGGAACT CCACAGACCT TCAAGAGCCT 
CGGCCCAGGG CCAAGAGAAG GCCCATTGTT AAAACGGGCA AGTTTAAGAA AATGTTTGGA 
TGGGGCGATT TTCATTCCAA CATCAAAACA GTGAAGCTGA ACCTGTTGAT AACTGGGAAA 
ATTGTAGATC ATGGCAATGG GACATTTAGT GTTTATTTCA GGCATAATTC AACTGGTCAA 
GGGAATGTAT CTGTCAGCTT GGTACCCCCT ACAAAAATCG TGGAATTTGA CTTGGCACAA 
CAAACCGTGA TTGATGCCAA AGATTCCAAG TCTTTTAATT GTCGCATTGA ATATGAAAAG 
GTTGACAAGG CTACCAAGAA CACACTCTGC AACTATGACC CTTCAAAAAC CTGTTACCAG 
GAGCAAACCC AAAGTCATGT ATCCTGGCTC TGCTCCAAGC CCTTTAAGGT GATCTGTATT 
TACATTTCCT TTTATAGTAC AGATTATAAA CTGGTACAGA AAGTGTGCCC TGACTACAAC 
TACCACAGTG ACACACCTTA CTTTCCCTCG GGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Plasma Triglyceride Levels May Be Modulated by Gene Expression of IQCJ, NXPH1, PHF17 and MYB in Humans.
International journal of molecular sciences18(2)(2017 Jan)
Vall?e Marcotte B,Gu?nard F,Cormier H,Lemieux S,Couture P,Rudkowska I,Vohl MC

The detection of tumor location and lymph node metastasis by aberrant NXPH1 and NXPH2 expressions in pancreatic ductal adenocarcinomas.
The Chinese journal of physiology59(6)348-354(2016 Dec)
Jin JS,Tsai WC

Novel Genetic Loci Associated with the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation.
Journal of nutrigenetics and nutrigenomics9(1)1-11(2016)
Vall?e Marcotte B,Cormier H,Gu?nard F,Rudkowska I,Lemieux S,Couture P,Vohl MC

[The Role of Neurotrophins and Neurexins Genes in the Risk of Paranoid Schizophrenia in Russians and Tatars].
Genetika51(7)799-811(2015 Jul)
Gareeva AE,Traks T,Koks S,Khusnutdinova EK

Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome.
Gut63(7)1103-11(2014 Jul)
Wouters MM,Lambrechts D,Knapp M,Cleynen I,Whorwell P,Agr?us L,Dlugosz A,Schmidt PT,Halfvarson J,Simr?n M,Ohlsson B,Karling P,Van Wanrooy S,Mondelaers S,Vermeire S,Lindberg G,Spiller R,Dukes G,D'Amato M,Boeckxstaens G

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NXPH1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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