Gene Symbol | TBX21 |
Entrez Gene ID | 30009 |
Full Name | T-box 21 |
Synonyms | T-PET,T-bet,TBET,TBLYM |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | {Asthma, aspirin-induced, susceptibility to}, 208550 (3); Asthma and nasal polyps, 208550 (3) |