EFEMP2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EFEMP2
Entrez Gene ID	30008
Full Name	EGF containing fibulin extracellular matrix protein 2
Synonyms	ARCL1B,FBLN4,MBP1,UPH1
General protein information	Preferred Names EGF containing fibulin extracellular matrix protein 2 Names EGF-containing fibulin-like extracellular matrix protein 2 EGF containing fibulin like extracellular matrix protein 2 FIBL-4 fibulin 4 mutant p53 binding protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.1
Summary	A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. The protein encoded by this gene contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is necessary for elastic fiber formation and connective tissue development. Defects in this gene are cause of an autosomal recessive cutis laxa syndrome. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011].
Disorder MIM:	604633
Disorder Html:	Cutis laxa, autosomal recessive, type IB, 614437 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_016938.4	NP_058634.4	EGF-containing fibulin-like extracellular matrix protein 2 precursor
NM_016938.5	NP_058634.4	EGF-containing fibulin-like extracellular matrix protein 2 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Efemp2	NP_001264270.1
Homo sapiens (human)	EFEMP2	NP_058634.4
Bos taurus (cattle)	EFEMP2	NP_001069517.1
Xenopus tropicalis (tropical clawed frog)	efemp2	XP_002939376.2
Pan troglodytes (chimpanzee)	EFEMP2	XP_508563.3
Mus musculus (house mouse)	Efemp2	NP_001157824.1
Canis lupus familiaris (dog)	EFEMP2	XP_005631503.1
	EFEMP2	XP_001118071.2

Gene Ontology
Bibliography

Related articles in PubMed

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
Ragelle H, Naba A, Larson BL, Zhou F, Priji? M, Whittaker CA, Del Rosario A, Langer R, Hynes RO, Anderson DG
Biomaterials128147-159(2017 06)

Fibulin-4 reduces extracellular matrix production and suppresses chondrocyte differentiation via DKK1- mediated canonical Wnt/?-catenin signaling.
Shangguan L, Ning G, Luo Z, Zhou Y
International journal of biological macromolecules99293-299(2017 Jun)

Fibulin-4 promotes osteosarcoma invasion and metastasis by inducing epithelial to mesenchymal transition via the PI3K/Akt/mTOR pathway.
Zhang D, Wang S, Chen J, Liu H, Lu J, Jiang H, Huang A, Chen Y
International journal of oncology50(5)1513-1530(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

link between Fibulin-4 and the canonical Wnt/beta-catenin pathway that may contribute to our understanding of the molecular mechanisms of OA
Title: Fibulin-4 reduces extracellular matrix production and suppresses chondrocyte differentiation via DKK1- mediated canonical Wnt/?-catenin signaling.

The results revealed that fibulin-4 expression was upregulated in osteosarcoma, and was positively correlated with low differentiation, lymph node metastasis, and poor prognosis. Fibulin-4 was also found to be over-expressed in highly invasive cell lines and in the highly invasive subclones
Title: Fibulin-4 promotes osteosarcoma invasion and metastasis by inducing epithelial to mesenchymal transition via the PI3K/Akt/mTOR pathway.

the expression of fibulin-4 was negatively correlated with the malignant phenotype of endometrial cancer cells. Fibulin-4 may have the ability to suppress endometrial cancer cell invasion and proliferation
Title: Fibulin-4 is associated with prognosis of endometrial cancer patients and inhibits cancer cell invasion and metastasis via Wnt/?-catenin signaling pathway.

Findings suggested that fibulin-4 is important for the proteolytic activation of lysyl oxidase which has a pivotal role in cross-linking of collagen and elastin.
Title: Loss of fibulin-4 results in abnormal collagen fibril assembly in bone, caused by impaired lysyl oxidase processing and collagen cross-linking.

Data indicates that Fibulin-4 is a novel gene that is found overexpressed in ovarian cancer and associated with poor prognostic clinicopathologic features.
Title: Fibulin-4 is associated with tumor progression and a poor prognosis in ovarian carcinomas.

The following EFEMP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EFEMP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21435	NM_016938.5 Latest version!	Homo sapiens EGF containing fibulin extracellular matrix protein 2 (EFEMP2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu21435	NM_016938.4	Homo sapiens EGF containing fibulin extracellular matrix protein 2 (EFEMP2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EFEMP2 ( NM_016938.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_058634.4 Homo sapiens EGF containing fibulin extracellular matrix protein 2 (EFEMP2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21435
Clone ID Related Accession (Same CDS sequence)	NM_016938.4 , NM_016938.5
Accession Version	NM_016938.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1332bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	EGF-containing fibulin-like extracellular matrix protein 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP001201.7, BP382163.1, BC010456.1, BQ478413.1, AF124486.1 and BC018871.2. This sequence is a reference standard in the RefSeqGene project. On Jan 27, 2011 this sequence version replaced NM_016938.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK292079.1, AK075453.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCCCCT GCGCCTCCTG CCTACCCGGG TCTCTACTGC TCTGGGCGCT GCTACTGTTG 
CTCTTGGGAT CAGCTTCTCC TCAGGATTCT GAAGAGCCCG ACAGCTACAC GGAATGCACA 
GATGGCTATG AGTGGGACCC AGACAGCCAG CACTGCCGGG ATGTCAACGA GTGTCTGACC 
ATCCCTGAGG CCTGCAAGGG GGAAATGAAG TGCATCAACC ACTACGGGGG CTACTTGTGC 
CTGCCCCGCT CCGCTGCCGT CATCAACGAC CTACACGGCG AGGGACCCCC GCCACCAGTG 
CCTCCCGCTC AACACCCCAA CCCCTGCCCA CCAGGCTATG AGCCCGACGA TCAGGACAGC 
TGTGTGGATG TGGACGAGTG TGCCCAGGCC CTGCACGACT GTCGCCCCAG CCAGGACTGC 
CATAACTTGC CTGGCTCCTA TCAGTGCACC TGCCCTGATG GTTACCGCAA GATCGGGCCC 
GAGTGTGTGG ACATAGACGA GTGCCGCTAC CGCTACTGCC AGCACCGCTG CGTGAACCTG 
CCTGGCTCCT TCCGCTGCCA GTGCGAGCCG GGCTTCCAGC TGGGGCCTAA CAACCGCTCC 
TGTGTTGATG TGAACGAGTG TGACATGGGG GCCCCATGCG AGCAGCGCTG CTTCAACTCC 
TATGGGACCT TCCTGTGTCG CTGCCACCAG GGCTATGAGC TGCATCGGGA TGGCTTCTCC 
TGCAGTGATA TTGATGAGTG TAGCTACTCC AGCTACCTCT GTCAGTACCG CTGCATCAAC 
GAGCCAGGCC GTTTCTCCTG CCACTGCCCA CAGGGTTACC AGCTGCTGGC CACACGCCTC 
TGCCAAGACA TTGATGAGTG TGAGTCTGGT GCGCACCAGT GCTCCGAGGC CCAAACCTGT 
GTCAACTTCC ATGGGGGCTA CCGCTGCGTG GACACCAACC GCTGCGTGGA GCCCTACATC 
CAGGTCTCTG AGAACCGCTG TCTCTGCCCG GCCTCCAACC CTCTATGTCG AGAGCAGCCT 
TCATCCATTG TGCACCGCTA CATGACCATC ACCTCGGAGC GGAGCGTGCC CGCTGACGTG 
TTCCAGATCC AGGCGACCTC CGTCTACCCC GGTGCCTACA ATGCCTTTCA GATCCGTGCT 
GGAAACTCGC AGGGGGACTT TTACATTAGG CAAATCAACA ACGTCAGCGC CATGCTGGTC 
CTCGCCCGGC CGGTGACGGG CCCCCGGGAG TACGTGCTGG ACCTGGAGAT GGTCACCATG 
AATTCCCTCA TGAGCTACCG GGCCAGCTCT GTACTGAGGC TCACCGTCTT TGTAGGGGCC 
TACACCTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058634.4
CDS	260..1591
Translation	MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCINEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTITSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF

Target ORF information:

RefSeq Version	NM_016938.4
Organism	Homo sapiens(human)
Definition	Homo sapiens EGF containing fibulin extracellular matrix protein 2 (EFEMP2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016938.4

ORF Insert Sequence:

ATGCTCCCCT GCGCCTCCTG CCTACCCGGG TCTCTACTGC TCTGGGCGCT GCTACTGTTG 
CTCTTGGGAT CAGCTTCTCC TCAGGATTCT GAAGAGCCCG ACAGCTACAC GGAATGCACA 
GATGGCTATG AGTGGGACCC AGACAGCCAG CACTGCCGGG ATGTCAACGA GTGTCTGACC 
ATCCCTGAGG CCTGCAAGGG GGAAATGAAG TGCATCAACC ACTACGGGGG CTACTTGTGC 
CTGCCCCGCT CCGCTGCCGT CATCAACGAC CTACACGGCG AGGGACCCCC GCCACCAGTG 
CCTCCCGCTC AACACCCCAA CCCCTGCCCA CCAGGCTATG AGCCCGACGA TCAGGACAGC 
TGTGTGGATG TGGACGAGTG TGCCCAGGCC CTGCACGACT GTCGCCCCAG CCAGGACTGC 
CATAACTTGC CTGGCTCCTA TCAGTGCACC TGCCCTGATG GTTACCGCAA GATCGGGCCC 
GAGTGTGTGG ACATAGACGA GTGCCGCTAC CGCTACTGCC AGCACCGCTG CGTGAACCTG 
CCTGGCTCCT TCCGCTGCCA GTGCGAGCCG GGCTTCCAGC TGGGGCCTAA CAACCGCTCC 
TGTGTTGATG TGAACGAGTG TGACATGGGG GCCCCATGCG AGCAGCGCTG CTTCAACTCC 
TATGGGACCT TCCTGTGTCG CTGCCACCAG GGCTATGAGC TGCATCGGGA TGGCTTCTCC 
TGCAGTGATA TTGATGAGTG TAGCTACTCC AGCTACCTCT GTCAGTACCG CTGCATCAAC 
GAGCCAGGCC GTTTCTCCTG CCACTGCCCA CAGGGTTACC AGCTGCTGGC CACACGCCTC 
TGCCAAGACA TTGATGAGTG TGAGTCTGGT GCGCACCAGT GCTCCGAGGC CCAAACCTGT 
GTCAACTTCC ATGGGGGCTA CCGCTGCGTG GACACCAACC GCTGCGTGGA GCCCTACATC 
CAGGTCTCTG AGAACCGCTG TCTCTGCCCG GCCTCCAACC CTCTATGTCG AGAGCAGCCT 
TCATCCATTG TGCACCGCTA CATGACCATC ACCTCGGAGC GGAGCGTGCC CGCTGACGTG 
TTCCAGATCC AGGCGACCTC CGTCTACCCC GGTGCCTACA ATGCCTTTCA GATCCGTGCT 
GGAAACTCGC AGGGGGACTT TTACATTAGG CAAATCAACA ACGTCAGCGC CATGCTGGTC 
CTCGCCCGGC CGGTGACGGG CCCCCGGGAG TACGTGCTGG ACCTGGAGAT GGTCACCATG 
AATTCCCTCA TGAGCTACCG GGCCAGCTCT GTACTGAGGC TCACCGTCTT TGTAGGGGCC 
TACACCTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EFEMP2 ( NM_016938.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_058634.4 Homo sapiens EGF containing fibulin extracellular matrix protein 2 (EFEMP2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21435
Clone ID Related Accession (Same CDS sequence)	NM_016938.4 , NM_016938.5
Accession Version	NM_016938.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1332bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	EGF-containing fibulin-like extracellular matrix protein 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP382163.1, BC010456.1, BQ478413.1, AF124486.1 and BC018871.2. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_016938.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1057676.1, SRR3476690.151404.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000307998.11/ ENSP00000309953.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTCCCCT GCGCCTCCTG CCTACCCGGG TCTCTACTGC TCTGGGCGCT GCTACTGTTG 
CTCTTGGGAT CAGCTTCTCC TCAGGATTCT GAAGAGCCCG ACAGCTACAC GGAATGCACA 
GATGGCTATG AGTGGGACCC AGACAGCCAG CACTGCCGGG ATGTCAACGA GTGTCTGACC 
ATCCCTGAGG CCTGCAAGGG GGAAATGAAG TGCATCAACC ACTACGGGGG CTACTTGTGC 
CTGCCCCGCT CCGCTGCCGT CATCAACGAC CTACACGGCG AGGGACCCCC GCCACCAGTG 
CCTCCCGCTC AACACCCCAA CCCCTGCCCA CCAGGCTATG AGCCCGACGA TCAGGACAGC 
TGTGTGGATG TGGACGAGTG TGCCCAGGCC CTGCACGACT GTCGCCCCAG CCAGGACTGC 
CATAACTTGC CTGGCTCCTA TCAGTGCACC TGCCCTGATG GTTACCGCAA GATCGGGCCC 
GAGTGTGTGG ACATAGACGA GTGCCGCTAC CGCTACTGCC AGCACCGCTG CGTGAACCTG 
CCTGGCTCCT TCCGCTGCCA GTGCGAGCCG GGCTTCCAGC TGGGGCCTAA CAACCGCTCC 
TGTGTTGATG TGAACGAGTG TGACATGGGG GCCCCATGCG AGCAGCGCTG CTTCAACTCC 
TATGGGACCT TCCTGTGTCG CTGCCACCAG GGCTATGAGC TGCATCGGGA TGGCTTCTCC 
TGCAGTGATA TTGATGAGTG TAGCTACTCC AGCTACCTCT GTCAGTACCG CTGCATCAAC 
GAGCCAGGCC GTTTCTCCTG CCACTGCCCA CAGGGTTACC AGCTGCTGGC CACACGCCTC 
TGCCAAGACA TTGATGAGTG TGAGTCTGGT GCGCACCAGT GCTCCGAGGC CCAAACCTGT 
GTCAACTTCC ATGGGGGCTA CCGCTGCGTG GACACCAACC GCTGCGTGGA GCCCTACATC 
CAGGTCTCTG AGAACCGCTG TCTCTGCCCG GCCTCCAACC CTCTATGTCG AGAGCAGCCT 
TCATCCATTG TGCACCGCTA CATGACCATC ACCTCGGAGC GGAGCGTGCC CGCTGACGTG 
TTCCAGATCC AGGCGACCTC CGTCTACCCC GGTGCCTACA ATGCCTTTCA GATCCGTGCT 
GGAAACTCGC AGGGGGACTT TTACATTAGG CAAATCAACA ACGTCAGCGC CATGCTGGTC 
CTCGCCCGGC CGGTGACGGG CCCCCGGGAG TACGTGCTGG ACCTGGAGAT GGTCACCATG 
AATTCCCTCA TGAGCTACCG GGCCAGCTCT GTACTGAGGC TCACCGTCTT TGTAGGGGCC 
TACACCTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058634.4
CDS	126..1457
Translation	MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCINEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTITSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF

Target ORF information:

RefSeq Version	NM_016938.5
Organism	Homo sapiens(human)
Definition	Homo sapiens EGF containing fibulin extracellular matrix protein 2 (EFEMP2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016938.5

ORF Insert Sequence:

ATGCTCCCCT GCGCCTCCTG CCTACCCGGG TCTCTACTGC TCTGGGCGCT GCTACTGTTG 
CTCTTGGGAT CAGCTTCTCC TCAGGATTCT GAAGAGCCCG ACAGCTACAC GGAATGCACA 
GATGGCTATG AGTGGGACCC AGACAGCCAG CACTGCCGGG ATGTCAACGA GTGTCTGACC 
ATCCCTGAGG CCTGCAAGGG GGAAATGAAG TGCATCAACC ACTACGGGGG CTACTTGTGC 
CTGCCCCGCT CCGCTGCCGT CATCAACGAC CTACACGGCG AGGGACCCCC GCCACCAGTG 
CCTCCCGCTC AACACCCCAA CCCCTGCCCA CCAGGCTATG AGCCCGACGA TCAGGACAGC 
TGTGTGGATG TGGACGAGTG TGCCCAGGCC CTGCACGACT GTCGCCCCAG CCAGGACTGC 
CATAACTTGC CTGGCTCCTA TCAGTGCACC TGCCCTGATG GTTACCGCAA GATCGGGCCC 
GAGTGTGTGG ACATAGACGA GTGCCGCTAC CGCTACTGCC AGCACCGCTG CGTGAACCTG 
CCTGGCTCCT TCCGCTGCCA GTGCGAGCCG GGCTTCCAGC TGGGGCCTAA CAACCGCTCC 
TGTGTTGATG TGAACGAGTG TGACATGGGG GCCCCATGCG AGCAGCGCTG CTTCAACTCC 
TATGGGACCT TCCTGTGTCG CTGCCACCAG GGCTATGAGC TGCATCGGGA TGGCTTCTCC 
TGCAGTGATA TTGATGAGTG TAGCTACTCC AGCTACCTCT GTCAGTACCG CTGCATCAAC 
GAGCCAGGCC GTTTCTCCTG CCACTGCCCA CAGGGTTACC AGCTGCTGGC CACACGCCTC 
TGCCAAGACA TTGATGAGTG TGAGTCTGGT GCGCACCAGT GCTCCGAGGC CCAAACCTGT 
GTCAACTTCC ATGGGGGCTA CCGCTGCGTG GACACCAACC GCTGCGTGGA GCCCTACATC 
CAGGTCTCTG AGAACCGCTG TCTCTGCCCG GCCTCCAACC CTCTATGTCG AGAGCAGCCT 
TCATCCATTG TGCACCGCTA CATGACCATC ACCTCGGAGC GGAGCGTGCC CGCTGACGTG 
TTCCAGATCC AGGCGACCTC CGTCTACCCC GGTGCCTACA ATGCCTTTCA GATCCGTGCT 
GGAAACTCGC AGGGGGACTT TTACATTAGG CAAATCAACA ACGTCAGCGC CATGCTGGTC 
CTCGCCCGGC CGGTGACGGG CCCCCGGGAG TACGTGCTGG ACCTGGAGAT GGTCACCATG 
AATTCCCTCA TGAGCTACCG GGCCAGCTCT GTACTGAGGC TCACCGTCTT TGTAGGGGCC 
TACACCTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
Biomaterials128147-159(2017 06)
Ragelle H,Naba A,Larson BL,Zhou F,Priji? M,Whittaker CA,Del Rosario A,Langer R,Hynes RO,Anderson DG

Fibulin-4 reduces extracellular matrix production and suppresses chondrocyte differentiation via DKK1- mediated canonical Wnt/?-catenin signaling.
International journal of biological macromolecules99293-299(2017 Jun)
Shangguan L,Ning G,Luo Z,Zhou Y

Fibulin-4 promotes osteosarcoma invasion and metastasis by inducing epithelial to mesenchymal transition via the PI3K/Akt/mTOR pathway.
International journal of oncology50(5)1513-1530(2017 May)
Zhang D,Wang S,Chen J,Liu H,Lu J,Jiang H,Huang A,Chen Y

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EFEMP2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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