PILRA cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PILRA
Entrez Gene ID	29992
Full Name	paired immunoglobin like type 2 receptor alpha
Synonyms	FDF03
General protein information	Preferred Names paired immunoglobin like type 2 receptor alpha Names paired immunoglobulin-like type 2 receptor alpha cell surface receptor FDF03 inhibitory receptor PILR-alpha
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q22.1
Summary	Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq, Jul 2008].
Disorder MIM:	605341

mRNA and Protein(s)

mRNA	Protein	Name
NM_178273.2	NP_840057.1	paired immunoglobulin-like type 2 receptor alpha isoform 3 precursor
NM_178272.1	NP_840056.1	paired immunoglobulin-like type 2 receptor alpha isoform 2 precursor
NM_178272.2	NP_840056.1	paired immunoglobulin-like type 2 receptor alpha isoform 2 precursor
XM_024446739.1	XP_024302507.1	paired immunoglobulin-like type 2 receptor alpha isoform X1
NM_013439.2	NP_038467.2	paired immunoglobulin-like type 2 receptor alpha isoform 1 precursor
NM_178273.1	NP_840057.1	paired immunoglobulin-like type 2 receptor alpha isoform 3 precursor
NM_013439.3	NP_038467.2	paired immunoglobulin-like type 2 receptor alpha isoform 1 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	PILRA	NP_001193279.1
Mus musculus (house mouse)	Pilra	NP_705730.1
Rattus norvegicus (Norway rat)	LOC100910669	XP_003751197.1
Rattus norvegicus (Norway rat)	LOC100910497	XP_003751201.2
Homo sapiens (human)	PILRA	NP_038467.2
Pan troglodytes (chimpanzee)	PILRA	XP_001148542.1
Canis lupus familiaris (dog)	LOC100686271	XP_005621119.1
Bos taurus (cattle)	LOC617785	XP_002698183.1
Canis lupus familiaris (dog)	PILRA	XP_005621105.1

Gene Ontology
Bibliography

Related articles in PubMed

Transcriptome-wide association study revealed two novel genes associated with nonobstructive azoospermia in a Chinese population.
Jiang T, Wang Y, Zhu M, Wang Y, Huang M, Jin G, Guo X, Sha J, Dai J, Hu Z
Fertility and sterility108(6)1056-1062.e4(2017 Dec)

Structural and thermodynamic analyses reveal critical features of glycopeptide recognition by the human PILR? immune cell receptor.
Furukawa A, Kakita K, Yamada T, Ishizuka M, Sakamoto J, Hatori N, Maeda N, Ohsaka F, Saitoh T, Nomura T, Kuroki K, Nambu H, Arase H, Matsunaga S, Anada M, Ose T, Hashimoto S, Maenaka K
The Journal of biological chemistry292(51)21128-21136(2017 Dec)

Whole-exome sequencing of the BDR cohort: evidence to support the role of the PILRA gene in Alzheimer's disease.
Patel T, Brookes KJ, Turton J, Chaudhury S, Guetta-Baranes T, Guerreiro R, Bras J, Hernandez D, Singleton A, Francis PT, Hardy J, Morgan K
Neuropathology and applied neurobiology(2017 Nov)

PILR? binds an unknown receptor expressed primarily on CD56bright and decidual-NK cells and activates NK cell functions.
Ophir Y, Duev-Cohen A, Yamin R, Tsukerman P, Bauman Y, Gamliel M, Mandelboim O
Oncotarget7(27)40953-40964(2016 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Transcriptome wide association study results identified two novel genes as statistically significantly associated with nonobstructive azoospermia susceptibility: PILRA and ZNF676.
Title: Transcriptome-wide association study revealed two novel genes associated with nonobstructive azoospermia in a Chinese population.

The interaction of NK cells with PILRalpha expressing targets lead to elevated IFNgamma secretion and cytotoxicity. In conclusion, PILRalpha is a novel NK activating ligand which binds and activates an unknown NK receptor expressed on a unique NK cell subset.
Title: PILR? binds an unknown receptor expressed primarily on CD56bright and decidual-NK cells and activates NK cell functions.

We demonstrated that three residues (Y2, R95, and W108) presented on the surface of PILRalpha form the sialic acid binding site equivalent to those in siglecs but are arranged in a unique linear mode.
Title: PILR? and PILR? have a siglec fold and provide the basis of binding to sialic acid.

PILRalpha exhibits large conformational change to recognize simultaneously both the sTn O-glycan and the compact peptide structure constrained by proline residues
Title: Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILR?.

These results contribute our knowledge of the biological functions of HBVDNAPTP1 and provide novel data to aid in the further analysis of the regulatory mechanism of this protein.
Title: Identification of paired immunoglobulin-like type 2 receptor ? as hepatitis B virus DNA polymerase transactivated protein 1 interacting proteins.

The following PILRA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PILRA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19481	NM_013439.3 Latest version!	Homo sapiens paired immunoglobin like type 2 receptor alpha (PILRA), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu19481	XM_024446739.1 Latest version!	Homo sapiens paired immunoglobin like type 2 receptor alpha (PILRA), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu07474	NM_178272.2 Latest version!	Homo sapiens paired immunoglobin like type 2 receptor alpha (PILRA), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu07475	NM_178273.2 Latest version!	Homo sapiens paired immunoglobin like type 2 receptor alpha (PILRA), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu07474	NM_178272.1	Homo sapiens paired immunoglobin like type 2 receptor alpha (PILRA), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu07475	NM_178273.1	Homo sapiens paired immunoglobin like type 2 receptor alpha (PILRA), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu19481	NM_013439.2	Homo sapiens paired immunoglobin like type 2 receptor alpha (PILRA), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PILRA ( NM_013439.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_038467.2 Homo sapiens paired immunoglobin like type 2 receptor alpha (PILRA), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19481
Clone ID Related Accession (Same CDS sequence)	XM_024446739.1 , NM_013439.2 , NM_013439.3
Accession Version	NM_013439.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	paired immunoglobulin-like type 2 receptor alpha isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ400841.1, AF161080.1 and BF432841.1. This sequence is a reference standard in the RefSeqGene project. On Apr 29, 2003 this sequence version replaced NM_013439.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF161080.1, AJ400841.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGGTCGGC CCCTGCTGCT GCCCCTACTG CCCTTGCTGC TGCCGCCAGC ATTTCTGCAG 
CCTAGTGGCT CCACAGGATC TGGTCCAAGC TACCTTTATG GGGTCACTCA ACCAAAACAC 
CTCTCAGCCT CCATGGGTGG CTCTGTGGAA ATCCCCTTCT CCTTCTATTA CCCCTGGGAG 
TTAGCCACAG CTCCCGACGT GAGAATATCC TGGAGACGGG GCCACTTCCA CAGGCAGTCC 
TTCTACAGCA CAAGGCCGCC TTCCATTCAC AAGGATTATG TGAACCGGCT CTTTCTGAAC 
TGGACAGAGG GTCAGAAGAG CGGCTTCCTC AGGATCTCCA ACCTGCAGAA GCAGGACCAG 
TCTGTGTATT TCTGCCGAGT TGAGCTGGAC ACACGGAGCT CAGGGAGGCA GCAGTGGCAG 
TCCATCGAGG GGACCAAACT CTCCATCACC CAGGCTGTCA CGACCACCAC CCAGAGGCCC 
AGCAGCATGA CTACCACCTG GAGGCTCAGT AGCACAACCA CCACAACCGG CCTCAGGGTC 
ACACAGGGCA AACGACGCTC AGACTCTTGG CACATAAGTC TGGAGACTGC TGTGGGGGTG 
GCAGTGGCTG TCACTGTGCT CGGAATCATG ATTTTGGGAC TGATCTGCCT CCTCAGGTGG 
AGGAGAAGGA AAGGTCAGCA GCGGACTAAA GCCACAACCC CAGCCAGGGA ACCCTTCCAA 
AACACAGAGG AGCCATATGA GAATATCAGG AATGAAGGAC AAAATACAGA TCCCAAGCTA 
AATCCCAAGG ATGACGGCAT CGTCTATGCT TCCCTTGCCC TCTCCAGCTC CACCTCACCC 
AGAGCACCTC CCAGCCACCG TCCCCTCAAG AGCCCCCAGA ACGAGACCCT GTACTCTGTC 
TTAAAGGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038467.2
CDS	213..1124
Translation	MGRPLLLPLLPLLLPPAFLQPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHRQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSITQAVTTTTQRPSSMTTTWRLSSTTTTTGLRVTQGKRRSDSWHISLETAVGVAVAVTVLGIMILGLICLLRWRRRKGQQRTKATTPAREPFQNTEEPYENIRNEGQNTDPKLNPKDDGIVYASLALSSSTSPRAPPSHRPLKSPQNETLYSVLKA

Target ORF information:

RefSeq Version	NM_013439.2
Organism	Homo sapiens(human)
Definition	Homo sapiens paired immunoglobin like type 2 receptor alpha (PILRA), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013439.2

ORF Insert Sequence:

ATGGGTCGGC CCCTGCTGCT GCCCCTACTG CCCTTGCTGC TGCCGCCAGC ATTTCTGCAG 
CCTAGTGGCT CCACAGGATC TGGTCCAAGC TACCTTTATG GGGTCACTCA ACCAAAACAC 
CTCTCAGCCT CCATGGGTGG CTCTGTGGAA ATCCCCTTCT CCTTCTATTA CCCCTGGGAG 
TTAGCCACAG CTCCCGACGT GAGAATATCC TGGAGACGGG GCCACTTCCA CAGGCAGTCC 
TTCTACAGCA CAAGGCCGCC TTCCATTCAC AAGGATTATG TGAACCGGCT CTTTCTGAAC 
TGGACAGAGG GTCAGAAGAG CGGCTTCCTC AGGATCTCCA ACCTGCAGAA GCAGGACCAG 
TCTGTGTATT TCTGCCGAGT TGAGCTGGAC ACACGGAGCT CAGGGAGGCA GCAGTGGCAG 
TCCATCGAGG GGACCAAACT CTCCATCACC CAGGCTGTCA CGACCACCAC CCAGAGGCCC 
AGCAGCATGA CTACCACCTG GAGGCTCAGT AGCACAACCA CCACAACCGG CCTCAGGGTC 
ACACAGGGCA AACGACGCTC AGACTCTTGG CACATAAGTC TGGAGACTGC TGTGGGGGTG 
GCAGTGGCTG TCACTGTGCT CGGAATCATG ATTTTGGGAC TGATCTGCCT CCTCAGGTGG 
AGGAGAAGGA AAGGTCAGCA GCGGACTAAA GCCACAACCC CAGCCAGGGA ACCCTTCCAA 
AACACAGAGG AGCCATATGA GAATATCAGG AATGAAGGAC AAAATACAGA TCCCAAGCTA 
AATCCCAAGG ATGACGGCAT CGTCTATGCT TCCCTTGCCC TCTCCAGCTC CACCTCACCC 
AGAGCACCTC CCAGCCACCG TCCCCTCAAG AGCCCCCAGA ACGAGACCCT GTACTCTGTC 
TTAAAGGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PILRA ( NM_013439.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_038467.2 Homo sapiens paired immunoglobin like type 2 receptor alpha (PILRA), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19481
Clone ID Related Accession (Same CDS sequence)	XM_024446739.1 , NM_013439.2 , NM_013439.3
Accession Version	NM_013439.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Homo sapiens(human)
Product	paired immunoglobulin-like type 2 receptor alpha isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005071.2. This sequence is a reference standard in the RefSeqGene project. On Nov 26, 2018 this sequence version replaced NM_013439.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF161080.1, SRR5189664.66632.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000198536.7/ ENSP00000198536.2 RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGTCGGC CCCTGCTGCT GCCCCTACTG CCCTTGCTGC TGCCGCCAGC ATTTCTGCAG 
CCTAGTGGCT CCACAGGATC TGGTCCAAGC TACCTTTATG GGGTCACTCA ACCAAAACAC 
CTCTCAGCCT CCATGGGTGG CTCTGTGGAA ATCCCCTTCT CCTTCTATTA CCCCTGGGAG 
TTAGCCACAG CTCCCGACGT GAGAATATCC TGGAGACGGG GCCACTTCCA CAGGCAGTCC 
TTCTACAGCA CAAGGCCGCC TTCCATTCAC AAGGATTATG TGAACCGGCT CTTTCTGAAC 
TGGACAGAGG GTCAGAAGAG CGGCTTCCTC AGGATCTCCA ACCTGCAGAA GCAGGACCAG 
TCTGTGTATT TCTGCCGAGT TGAGCTGGAC ACACGGAGCT CAGGGAGGCA GCAGTGGCAG 
TCCATCGAGG GGACCAAACT CTCCATCACC CAGGCTGTCA CGACCACCAC CCAGAGGCCC 
AGCAGCATGA CTACCACCTG GAGGCTCAGT AGCACAACCA CCACAACCGG CCTCAGGGTC 
ACACAGGGCA AACGACGCTC AGACTCTTGG CACATAAGTC TGGAGACTGC TGTGGGGGTG 
GCAGTGGCTG TCACTGTGCT CGGAATCATG ATTTTGGGAC TGATCTGCCT CCTCAGGTGG 
AGGAGAAGGA AAGGTCAGCA GCGGACTAAA GCCACAACCC CAGCCAGGGA ACCCTTCCAA 
AACACAGAGG AGCCATATGA GAATATCAGG AATGAAGGAC AAAATACAGA TCCCAAGCTA 
AATCCCAAGG ATGACGGCAT CGTCTATGCT TCCCTTGCCC TCTCCAGCTC CACCTCACCC 
AGAGCACCTC CCAGCCACCG TCCCCTCAAG AGCCCCCAGA ACGAGACCCT GTACTCTGTC 
TTAAAGGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038467.2
CDS	171..1082
Translation	MGRPLLLPLLPLLLPPAFLQPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHRQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSITQAVTTTTQRPSSMTTTWRLSSTTTTTGLRVTQGKRRSDSWHISLETAVGVAVAVTVLGIMILGLICLLRWRRRKGQQRTKATTPAREPFQNTEEPYENIRNEGQNTDPKLNPKDDGIVYASLALSSSTSPRAPPSHRPLKSPQNETLYSVLKA

Target ORF information:

RefSeq Version	NM_013439.3
Organism	Homo sapiens(human)
Definition	Homo sapiens paired immunoglobin like type 2 receptor alpha (PILRA), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013439.3

ORF Insert Sequence:

ATGGGTCGGC CCCTGCTGCT GCCCCTACTG CCCTTGCTGC TGCCGCCAGC ATTTCTGCAG 
CCTAGTGGCT CCACAGGATC TGGTCCAAGC TACCTTTATG GGGTCACTCA ACCAAAACAC 
CTCTCAGCCT CCATGGGTGG CTCTGTGGAA ATCCCCTTCT CCTTCTATTA CCCCTGGGAG 
TTAGCCACAG CTCCCGACGT GAGAATATCC TGGAGACGGG GCCACTTCCA CAGGCAGTCC 
TTCTACAGCA CAAGGCCGCC TTCCATTCAC AAGGATTATG TGAACCGGCT CTTTCTGAAC 
TGGACAGAGG GTCAGAAGAG CGGCTTCCTC AGGATCTCCA ACCTGCAGAA GCAGGACCAG 
TCTGTGTATT TCTGCCGAGT TGAGCTGGAC ACACGGAGCT CAGGGAGGCA GCAGTGGCAG 
TCCATCGAGG GGACCAAACT CTCCATCACC CAGGCTGTCA CGACCACCAC CCAGAGGCCC 
AGCAGCATGA CTACCACCTG GAGGCTCAGT AGCACAACCA CCACAACCGG CCTCAGGGTC 
ACACAGGGCA AACGACGCTC AGACTCTTGG CACATAAGTC TGGAGACTGC TGTGGGGGTG 
GCAGTGGCTG TCACTGTGCT CGGAATCATG ATTTTGGGAC TGATCTGCCT CCTCAGGTGG 
AGGAGAAGGA AAGGTCAGCA GCGGACTAAA GCCACAACCC CAGCCAGGGA ACCCTTCCAA 
AACACAGAGG AGCCATATGA GAATATCAGG AATGAAGGAC AAAATACAGA TCCCAAGCTA 
AATCCCAAGG ATGACGGCAT CGTCTATGCT TCCCTTGCCC TCTCCAGCTC CACCTCACCC 
AGAGCACCTC CCAGCCACCG TCCCCTCAAG AGCCCCCAGA ACGAGACCCT GTACTCTGTC 
TTAAAGGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PILRA ( XM_024446739.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024302507.1 Homo sapiens paired immunoglobin like type 2 receptor alpha (PILRA), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu19481
Clone ID Related Accession (Same CDS sequence)	XM_024446739.1 , NM_013439.2 , NM_013439.3
Accession Version	XM_024446739.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	paired immunoglobulin-like type 2 receptor alpha isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGTCGGC CCCTGCTGCT GCCCCTACTG CCCTTGCTGC TGCCGCCAGC ATTTCTGCAG 
CCTAGTGGCT CCACAGGATC TGGTCCAAGC TACCTTTATG GGGTCACTCA ACCAAAACAC 
CTCTCAGCCT CCATGGGTGG CTCTGTGGAA ATCCCCTTCT CCTTCTATTA CCCCTGGGAG 
TTAGCCACAG CTCCCGACGT GAGAATATCC TGGAGACGGG GCCACTTCCA CAGGCAGTCC 
TTCTACAGCA CAAGGCCGCC TTCCATTCAC AAGGATTATG TGAACCGGCT CTTTCTGAAC 
TGGACAGAGG GTCAGAAGAG CGGCTTCCTC AGGATCTCCA ACCTGCAGAA GCAGGACCAG 
TCTGTGTATT TCTGCCGAGT TGAGCTGGAC ACACGGAGCT CAGGGAGGCA GCAGTGGCAG 
TCCATCGAGG GGACCAAACT CTCCATCACC CAGGCTGTCA CGACCACCAC CCAGAGGCCC 
AGCAGCATGA CTACCACCTG GAGGCTCAGT AGCACAACCA CCACAACCGG CCTCAGGGTC 
ACACAGGGCA AACGACGCTC AGACTCTTGG CACATAAGTC TGGAGACTGC TGTGGGGGTG 
GCAGTGGCTG TCACTGTGCT CGGAATCATG ATTTTGGGAC TGATCTGCCT CCTCAGGTGG 
AGGAGAAGGA AAGGTCAGCA GCGGACTAAA GCCACAACCC CAGCCAGGGA ACCCTTCCAA 
AACACAGAGG AGCCATATGA GAATATCAGG AATGAAGGAC AAAATACAGA TCCCAAGCTA 
AATCCCAAGG ATGACGGCAT CGTCTATGCT TCCCTTGCCC TCTCCAGCTC CACCTCACCC 
AGAGCACCTC CCAGCCACCG TCCCCTCAAG AGCCCCCAGA ACGAGACCCT GTACTCTGTC 
TTAAAGGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024302507.1
CDS	94..1005
Translation	MGRPLLLPLLPLLLPPAFLQPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHRQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSITQAVTTTTQRPSSMTTTWRLSSTTTTTGLRVTQGKRRSDSWHISLETAVGVAVAVTVLGIMILGLICLLRWRRRKGQQRTKATTPAREPFQNTEEPYENIRNEGQNTDPKLNPKDDGIVYASLALSSSTSPRAPPSHRPLKSPQNETLYSVLKA

Target ORF information:

RefSeq Version	XM_024446739.1
Organism	Homo sapiens(human)
Definition	Homo sapiens paired immunoglobin like type 2 receptor alpha (PILRA), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024446739.1

ORF Insert Sequence:

ATGGGTCGGC CCCTGCTGCT GCCCCTACTG CCCTTGCTGC TGCCGCCAGC ATTTCTGCAG 
CCTAGTGGCT CCACAGGATC TGGTCCAAGC TACCTTTATG GGGTCACTCA ACCAAAACAC 
CTCTCAGCCT CCATGGGTGG CTCTGTGGAA ATCCCCTTCT CCTTCTATTA CCCCTGGGAG 
TTAGCCACAG CTCCCGACGT GAGAATATCC TGGAGACGGG GCCACTTCCA CAGGCAGTCC 
TTCTACAGCA CAAGGCCGCC TTCCATTCAC AAGGATTATG TGAACCGGCT CTTTCTGAAC 
TGGACAGAGG GTCAGAAGAG CGGCTTCCTC AGGATCTCCA ACCTGCAGAA GCAGGACCAG 
TCTGTGTATT TCTGCCGAGT TGAGCTGGAC ACACGGAGCT CAGGGAGGCA GCAGTGGCAG 
TCCATCGAGG GGACCAAACT CTCCATCACC CAGGCTGTCA CGACCACCAC CCAGAGGCCC 
AGCAGCATGA CTACCACCTG GAGGCTCAGT AGCACAACCA CCACAACCGG CCTCAGGGTC 
ACACAGGGCA AACGACGCTC AGACTCTTGG CACATAAGTC TGGAGACTGC TGTGGGGGTG 
GCAGTGGCTG TCACTGTGCT CGGAATCATG ATTTTGGGAC TGATCTGCCT CCTCAGGTGG 
AGGAGAAGGA AAGGTCAGCA GCGGACTAAA GCCACAACCC CAGCCAGGGA ACCCTTCCAA 
AACACAGAGG AGCCATATGA GAATATCAGG AATGAAGGAC AAAATACAGA TCCCAAGCTA 
AATCCCAAGG ATGACGGCAT CGTCTATGCT TCCCTTGCCC TCTCCAGCTC CACCTCACCC 
AGAGCACCTC CCAGCCACCG TCCCCTCAAG AGCCCCCAGA ACGAGACCCT GTACTCTGTC 
TTAAAGGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PILRA ( NM_178272.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_840056.1 Homo sapiens paired immunoglobin like type 2 receptor alpha (PILRA), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07474
Clone ID Related Accession (Same CDS sequence)	NM_178272.1 , NM_178272.2
Accession Version	NM_178272.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 693bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-09
Organism	Homo sapiens(human)
Product	paired immunoglobulin-like type 2 receptor alpha isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ400842.1, AF161080.1 and BF432841.1. Transcript Variant: This variant (2) lacks a coding exon, compared to variant 1, resulting in a protein (isoform 2) with a missing internal segment, compared to isoform 1. Isoform 2 is thought to be a soluble protein, since it lacks the transmembrane domain found in isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ400842.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGGTCGGC CCCTGCTGCT GCCCCTACTG CCCTTGCTGC TGCCGCCAGC ATTTCTGCAG 
CCTAGTGGCT CCACAGGATC TGGTCCAAGC TACCTTTATG GGGTCACTCA ACCAAAACAC 
CTCTCAGCCT CCATGGGTGG CTCTGTGGAA ATCCCCTTCT CCTTCTATTA CCCCTGGGAG 
TTAGCCACAG CTCCCGACGT GAGAATATCC TGGAGACGGG GCCACTTCCA CAGGCAGTCC 
TTCTACAGCA CAAGGCCGCC TTCCATTCAC AAGGATTATG TGAACCGGCT CTTTCTGAAC 
TGGACAGAGG GTCAGAAGAG CGGCTTCCTC AGGATCTCCA ACCTGCAGAA GCAGGACCAG 
TCTGTGTATT TCTGCCGAGT TGAGCTGGAC ACACGGAGCT CAGGGAGGCA GCAGTGGCAG 
TCCATCGAGG GGACCAAACT CTCCATCACC CAGGGTCAGC AGCGGACTAA AGCCACAACC 
CCAGCCAGGG AACCCTTCCA AAACACAGAG GAGCCATATG AGAATATCAG GAATGAAGGA 
CAAAATACAG ATCCCAAGCT AAATCCCAAG GATGACGGCA TCGTCTATGC TTCCCTTGCC 
CTCTCCAGCT CCACCTCACC CAGAGCACCT CCCAGCCACC GTCCCCTCAA GAGCCCCCAG 
AACGAGACCC TGTACTCTGT CTTAAAGGCC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_840056.1
CDS	213..905
Translation	MGRPLLLPLLPLLLPPAFLQPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHRQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSITQGQQRTKATTPAREPFQNTEEPYENIRNEGQNTDPKLNPKDDGIVYASLALSSSTSPRAPPSHRPLKSPQNETLYSVLKA

Target ORF information:

RefSeq Version	NM_178272.1
Organism	Homo sapiens(human)
Definition	Homo sapiens paired immunoglobin like type 2 receptor alpha (PILRA), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178272.1

ORF Insert Sequence:

ATGGGTCGGC CCCTGCTGCT GCCCCTACTG CCCTTGCTGC TGCCGCCAGC ATTTCTGCAG 
CCTAGTGGCT CCACAGGATC TGGTCCAAGC TACCTTTATG GGGTCACTCA ACCAAAACAC 
CTCTCAGCCT CCATGGGTGG CTCTGTGGAA ATCCCCTTCT CCTTCTATTA CCCCTGGGAG 
TTAGCCACAG CTCCCGACGT GAGAATATCC TGGAGACGGG GCCACTTCCA CAGGCAGTCC 
TTCTACAGCA CAAGGCCGCC TTCCATTCAC AAGGATTATG TGAACCGGCT CTTTCTGAAC 
TGGACAGAGG GTCAGAAGAG CGGCTTCCTC AGGATCTCCA ACCTGCAGAA GCAGGACCAG 
TCTGTGTATT TCTGCCGAGT TGAGCTGGAC ACACGGAGCT CAGGGAGGCA GCAGTGGCAG 
TCCATCGAGG GGACCAAACT CTCCATCACC CAGGGTCAGC AGCGGACTAA AGCCACAACC 
CCAGCCAGGG AACCCTTCCA AAACACAGAG GAGCCATATG AGAATATCAG GAATGAAGGA 
CAAAATACAG ATCCCAAGCT AAATCCCAAG GATGACGGCA TCGTCTATGC TTCCCTTGCC 
CTCTCCAGCT CCACCTCACC CAGAGCACCT CCCAGCCACC GTCCCCTCAA GAGCCCCCAG 
AACGAGACCC TGTACTCTGT CTTAAAGGCC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PILRA ( NM_178272.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_840056.1 Homo sapiens paired immunoglobin like type 2 receptor alpha (PILRA), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07474
Clone ID Related Accession (Same CDS sequence)	NM_178272.1 , NM_178272.2
Accession Version	NM_178272.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 693bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Homo sapiens(human)
Product	paired immunoglobulin-like type 2 receptor alpha isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005071.2. On Jun 2, 2019 this sequence version replaced NM_178272.1. Transcript Variant: This variant (2) lacks a coding exon, compared to variant 1, resulting in a protein (isoform 2) with a missing internal segment, compared to isoform 1. Isoform 2 is thought to be a soluble protein, since it lacks the transmembrane domain found in isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DRR138517.357608.1, AJ400842.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGGTCGGC CCCTGCTGCT GCCCCTACTG CCCTTGCTGC TGCCGCCAGC ATTTCTGCAG 
CCTAGTGGCT CCACAGGATC TGGTCCAAGC TACCTTTATG GGGTCACTCA ACCAAAACAC 
CTCTCAGCCT CCATGGGTGG CTCTGTGGAA ATCCCCTTCT CCTTCTATTA CCCCTGGGAG 
TTAGCCACAG CTCCCGACGT GAGAATATCC TGGAGACGGG GCCACTTCCA CAGGCAGTCC 
TTCTACAGCA CAAGGCCGCC TTCCATTCAC AAGGATTATG TGAACCGGCT CTTTCTGAAC 
TGGACAGAGG GTCAGAAGAG CGGCTTCCTC AGGATCTCCA ACCTGCAGAA GCAGGACCAG 
TCTGTGTATT TCTGCCGAGT TGAGCTGGAC ACACGGAGCT CAGGGAGGCA GCAGTGGCAG 
TCCATCGAGG GGACCAAACT CTCCATCACC CAGGGTCAGC AGCGGACTAA AGCCACAACC 
CCAGCCAGGG AACCCTTCCA AAACACAGAG GAGCCATATG AGAATATCAG GAATGAAGGA 
CAAAATACAG ATCCCAAGCT AAATCCCAAG GATGACGGCA TCGTCTATGC TTCCCTTGCC 
CTCTCCAGCT CCACCTCACC CAGAGCACCT CCCAGCCACC GTCCCCTCAA GAGCCCCCAG 
AACGAGACCC TGTACTCTGT CTTAAAGGCC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_840056.1
CDS	171..863
Translation	MGRPLLLPLLPLLLPPAFLQPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHRQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSITQGQQRTKATTPAREPFQNTEEPYENIRNEGQNTDPKLNPKDDGIVYASLALSSSTSPRAPPSHRPLKSPQNETLYSVLKA

Target ORF information:

RefSeq Version	NM_178272.2
Organism	Homo sapiens(human)
Definition	Homo sapiens paired immunoglobin like type 2 receptor alpha (PILRA), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178272.2

ORF Insert Sequence:

ATGGGTCGGC CCCTGCTGCT GCCCCTACTG CCCTTGCTGC TGCCGCCAGC ATTTCTGCAG 
CCTAGTGGCT CCACAGGATC TGGTCCAAGC TACCTTTATG GGGTCACTCA ACCAAAACAC 
CTCTCAGCCT CCATGGGTGG CTCTGTGGAA ATCCCCTTCT CCTTCTATTA CCCCTGGGAG 
TTAGCCACAG CTCCCGACGT GAGAATATCC TGGAGACGGG GCCACTTCCA CAGGCAGTCC 
TTCTACAGCA CAAGGCCGCC TTCCATTCAC AAGGATTATG TGAACCGGCT CTTTCTGAAC 
TGGACAGAGG GTCAGAAGAG CGGCTTCCTC AGGATCTCCA ACCTGCAGAA GCAGGACCAG 
TCTGTGTATT TCTGCCGAGT TGAGCTGGAC ACACGGAGCT CAGGGAGGCA GCAGTGGCAG 
TCCATCGAGG GGACCAAACT CTCCATCACC CAGGGTCAGC AGCGGACTAA AGCCACAACC 
CCAGCCAGGG AACCCTTCCA AAACACAGAG GAGCCATATG AGAATATCAG GAATGAAGGA 
CAAAATACAG ATCCCAAGCT AAATCCCAAG GATGACGGCA TCGTCTATGC TTCCCTTGCC 
CTCTCCAGCT CCACCTCACC CAGAGCACCT CCCAGCCACC GTCCCCTCAA GAGCCCCCAG 
AACGAGACCC TGTACTCTGT CTTAAAGGCC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PILRA ( NM_178273.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_840057.1 Homo sapiens paired immunoglobin like type 2 receptor alpha (PILRA), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu07475
Clone ID Related Accession (Same CDS sequence)	NM_178273.2 , NM_178273.1
Accession Version	NM_178273.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Homo sapiens(human)
Product	paired immunoglobulin-like type 2 receptor alpha isoform 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005071.2. On Jun 2, 2019 this sequence version replaced NM_178273.1. Transcript Variant: This variant (3) lacks two internal coding exons, compared to variant 1, which causes a frameshift and results in the shortest isoform (3) that has a distinct C-terminus, compared to isoform 1. Isoform 3 is thought to be a soluble protein, since it lacks the transmembrane domain found in isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ400843.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153031, SAMEA2155751 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGGTCGGC CCCTGCTGCT GCCCCTACTG CCCTTGCTGC TGCCGCCAGC ATTTCTGCAG 
CCTAGTGGCT CCACAGGATC TGGTCCAAGC TACCTTTATG GGGTCACTCA ACCAAAACAC 
CTCTCAGCCT CCATGGGTGG CTCTGTGGAA ATCCCCTTCT CCTTCTATTA CCCCTGGGAG 
TTAGCCACAG CTCCCGACGT GAGAATATCC TGGAGACGGG GCCACTTCCA CAGGCAGTCC 
TTCTACAGCA CAAGGCCGCC TTCCATTCAC AAGGATTATG TGAACCGGCT CTTTCTGAAC 
TGGACAGAGG GTCAGAAGAG CGGCTTCCTC AGGATCTCCA ACCTGCAGAA GCAGGACCAG 
TCTGTGTATT TCTGCCGAGT TGAGCTGGAC ACACGGAGCT CAGGGAGGCA GCAGTGGCAG 
TCCATCGAGG GGACCAAACT CTCCATCACC CAGGGGAACC CTTCCAAAAC ACAGAGGAGC 
CATATGAGAA TATCAGGAAT GAAGGACAAA ATACAGATCC CAAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_840057.1
CDS	171..698
Translation	MGRPLLLPLLPLLLPPAFLQPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHRQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSITQGNPSKTQRSHMRISGMKDKIQIPS

Target ORF information:

RefSeq Version	NM_178273.2
Organism	Homo sapiens(human)
Definition	Homo sapiens paired immunoglobin like type 2 receptor alpha (PILRA), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178273.2

ORF Insert Sequence:

ATGGGTCGGC CCCTGCTGCT GCCCCTACTG CCCTTGCTGC TGCCGCCAGC ATTTCTGCAG 
CCTAGTGGCT CCACAGGATC TGGTCCAAGC TACCTTTATG GGGTCACTCA ACCAAAACAC 
CTCTCAGCCT CCATGGGTGG CTCTGTGGAA ATCCCCTTCT CCTTCTATTA CCCCTGGGAG 
TTAGCCACAG CTCCCGACGT GAGAATATCC TGGAGACGGG GCCACTTCCA CAGGCAGTCC 
TTCTACAGCA CAAGGCCGCC TTCCATTCAC AAGGATTATG TGAACCGGCT CTTTCTGAAC 
TGGACAGAGG GTCAGAAGAG CGGCTTCCTC AGGATCTCCA ACCTGCAGAA GCAGGACCAG 
TCTGTGTATT TCTGCCGAGT TGAGCTGGAC ACACGGAGCT CAGGGAGGCA GCAGTGGCAG 
TCCATCGAGG GGACCAAACT CTCCATCACC CAGGGGAACC CTTCCAAAAC ACAGAGGAGC 
CATATGAGAA TATCAGGAAT GAAGGACAAA ATACAGATCC CAAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PILRA ( NM_178273.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_840057.1 Homo sapiens paired immunoglobin like type 2 receptor alpha (PILRA), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu07475
Clone ID Related Accession (Same CDS sequence)	NM_178273.2 , NM_178273.1
Accession Version	NM_178273.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-09
Organism	Homo sapiens(human)
Product	paired immunoglobulin-like type 2 receptor alpha isoform 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ400843.1, AF161080.1 and BF432841.1. Transcript Variant: This variant (3) lacks two internal coding exons, compared to variant 1, which causes a frameshift and results in the shortest isoform (3) that has a distinct C-terminus, compared to isoform 1. Isoform 3 is thought to be a soluble protein, since it lacks the transmembrane domain found in isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ400843.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153031, SAMEA2155751 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGGTCGGC CCCTGCTGCT GCCCCTACTG CCCTTGCTGC TGCCGCCAGC ATTTCTGCAG 
CCTAGTGGCT CCACAGGATC TGGTCCAAGC TACCTTTATG GGGTCACTCA ACCAAAACAC 
CTCTCAGCCT CCATGGGTGG CTCTGTGGAA ATCCCCTTCT CCTTCTATTA CCCCTGGGAG 
TTAGCCACAG CTCCCGACGT GAGAATATCC TGGAGACGGG GCCACTTCCA CAGGCAGTCC 
TTCTACAGCA CAAGGCCGCC TTCCATTCAC AAGGATTATG TGAACCGGCT CTTTCTGAAC 
TGGACAGAGG GTCAGAAGAG CGGCTTCCTC AGGATCTCCA ACCTGCAGAA GCAGGACCAG 
TCTGTGTATT TCTGCCGAGT TGAGCTGGAC ACACGGAGCT CAGGGAGGCA GCAGTGGCAG 
TCCATCGAGG GGACCAAACT CTCCATCACC CAGGGGAACC CTTCCAAAAC ACAGAGGAGC 
CATATGAGAA TATCAGGAAT GAAGGACAAA ATACAGATCC CAAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_840057.1
CDS	213..740
Translation	MGRPLLLPLLPLLLPPAFLQPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHRQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSITQGNPSKTQRSHMRISGMKDKIQIPS

Target ORF information:

RefSeq Version	NM_178273.1
Organism	Homo sapiens(human)
Definition	Homo sapiens paired immunoglobin like type 2 receptor alpha (PILRA), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178273.1

ORF Insert Sequence:

ATGGGTCGGC CCCTGCTGCT GCCCCTACTG CCCTTGCTGC TGCCGCCAGC ATTTCTGCAG 
CCTAGTGGCT CCACAGGATC TGGTCCAAGC TACCTTTATG GGGTCACTCA ACCAAAACAC 
CTCTCAGCCT CCATGGGTGG CTCTGTGGAA ATCCCCTTCT CCTTCTATTA CCCCTGGGAG 
TTAGCCACAG CTCCCGACGT GAGAATATCC TGGAGACGGG GCCACTTCCA CAGGCAGTCC 
TTCTACAGCA CAAGGCCGCC TTCCATTCAC AAGGATTATG TGAACCGGCT CTTTCTGAAC 
TGGACAGAGG GTCAGAAGAG CGGCTTCCTC AGGATCTCCA ACCTGCAGAA GCAGGACCAG 
TCTGTGTATT TCTGCCGAGT TGAGCTGGAC ACACGGAGCT CAGGGAGGCA GCAGTGGCAG 
TCCATCGAGG GGACCAAACT CTCCATCACC CAGGGGAACC CTTCCAAAAC ACAGAGGAGC 
CATATGAGAA TATCAGGAAT GAAGGACAAA ATACAGATCC CAAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Transcriptome-wide association study revealed two novel genes associated with nonobstructive azoospermia in a Chinese population.
Fertility and sterility108(6)1056-1062.e4(2017 Dec)
Jiang T,Wang Y,Zhu M,Wang Y,Huang M,Jin G,Guo X,Sha J,Dai J,Hu Z

Structural and thermodynamic analyses reveal critical features of glycopeptide recognition by the human PILR? immune cell receptor.
The Journal of biological chemistry292(51)21128-21136(2017 Dec)
Furukawa A,Kakita K,Yamada T,Ishizuka M,Sakamoto J,Hatori N,Maeda N,Ohsaka F,Saitoh T,Nomura T,Kuroki K,Nambu H,Arase H,Matsunaga S,Anada M,Ose T,Hashimoto S,Maenaka K

Whole-exome sequencing of the BDR cohort: evidence to support the role of the PILRA gene in Alzheimer's disease.
Neuropathology and applied neurobiology(2017 Nov)
Patel T,Brookes KJ,Turton J,Chaudhury S,Guetta-Baranes T,Guerreiro R,Bras J,Hernandez D,Singleton A,Francis PT,Hardy J,Morgan K

PILR? binds an unknown receptor expressed primarily on CD56bright and decidual-NK cells and activates NK cell functions.
Oncotarget7(27)40953-40964(2016 Jul)
Ophir Y,Duev-Cohen A,Yamin R,Tsukerman P,Bauman Y,Gamliel M,Mandelboim O

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PILRA cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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