PILRB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PILRB
Entrez Gene ID	29990
Full Name	paired immunoglobin-like type 2 receptor beta
Synonyms	FDFACT1,FDFACT2
General protein information	Preferred Names paired immunoglobin-like type 2 receptor beta Names paired immunoglobulin-like type 2 receptor beta activating receptor PILR-beta activating receptor PILRbeta cell surface receptor FDFACT cell surface receptor FDFACT1 cell surface receptor FDFACT2 paired immunoglobin-like receptor beta paired immunoglobulin-like receptor beta
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q22.1
Summary	The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. [provided by RefSeq, Jun 2013].
Disorder MIM:	605342

mRNA and Protein(s)

mRNA	Protein	Name
NM_178238.3	NP_839956.1	paired immunoglobulin-like type 2 receptor beta isoform 2 precursor
NM_001371931.1	NP_001358860.1	paired immunoglobulin-like type 2 receptor beta isoform 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PILRB	XP_003951135.1
Mus musculus (house mouse)	Pilrb1	NP_573472.2
Rattus norvegicus (Norway rat)	LOC685157	NP_001108516.1
Rattus norvegicus (Norway rat)	LOC680910	XP_006249112.1
Rattus norvegicus (Norway rat)	RGD1561143	XP_006249255.1
Rattus norvegicus (Norway rat)	LOC681341	XP_006249121.1
Rattus norvegicus (Norway rat)	RGD1559588	XP_006249100.1
Rattus norvegicus (Norway rat)	LOC100909556	XP_003751189.1
Rattus norvegicus (Norway rat)	LOC100910801	XP_003751199.2
	LOC721913	XP_001118109.1
Rattus norvegicus (Norway rat)	LOC685048	XP_006249095.1
Rattus norvegicus (Norway rat)	RGD1563400	XP_006249104.1
Rattus norvegicus (Norway rat)	RGD1562525	XP_006249115.1
Rattus norvegicus (Norway rat)	RGD1566006	XP_006249257.1
Rattus norvegicus (Norway rat)	LOC681266	XP_006249132.1
Rattus norvegicus (Norway rat)	LOC685438	XP_006249109.1
Homo sapiens (human)	PILRB	NP_839956.1
Rattus norvegicus (Norway rat)	LOC685181	XP_006249110.1
Rattus norvegicus (Norway rat)	LOC681182	XP_006249133.1
Mus musculus (house mouse)	Pilrb2	NP_001020103.1
Rattus norvegicus (Norway rat)	RGD1561730	XP_006249119.1
Rattus norvegicus (Norway rat)	LOC100910045	XP_006249126.1
Rattus norvegicus (Norway rat)	LOC681069	XP_006249106.1

Gene Ontology
Bibliography

Related articles in PubMed

PILR? and PILR? have a siglec fold and provide the basis of binding to sialic acid.
Lu Q, Lu G, Qi J, Wang H, Xuan Y, Wang Q, Li Y, Zhang Y, Zheng C, Fan Z, Yan J, Gao GF
Proceedings of the National Academy of Sciences of the United States of America111(22)8221-6(2014 Jun)

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA, Butte NF
PloS one7(12)e51954(2012)

Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: duplication, conversion, and the birth of new genes.
Wilson MD, Cheung J, Martindale DW, Scherer SW, Koop BF
Physiological genomics27(3)201-18(2006 Nov)

Large-scale cDNA transfection screening for genes related to cancer development and progression.
Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J
Proceedings of the National Academy of Sciences of the United States of America101(44)15724-9(2004 Nov)

Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.
Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM
Genomics83(1)153-67(2004 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PILRbeta differs from PILRalpha in one of the three residues (Y2, R95 and W108) on the surface of PILRalpha (L108), explaining its inability to engage gB.
Title: PILR? and PILR? have a siglec fold and provide the basis of binding to sialic acid.

Characterization of paired counterpart PILRA.
Title: FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells.

The following PILRB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PILRB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu11707	NM_178238.3 Latest version!	Homo sapiens paired immunoglobin like type 2 receptor beta (PILRB), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
OHu108849	NM_001371931.1 Latest version!	Homo sapiens paired immunoglobin like type 2 receptor beta (PILRB), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PILRB ( NM_178238.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_839956.1 Homo sapiens paired immunoglobin like type 2 receptor beta (PILRB), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu11707
Clone ID Related Accession (Same CDS sequence)	NM_178238.3
Accession Version	NM_178238.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Homo sapiens(human)
Product	paired immunoglobulin-like type 2 receptor beta isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005071.2 and AF161081.1. On Jun 19, 2013 this sequence version replaced NM_178238.2. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AJ400845.1, SRR1163657.14923.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal RefSeq Select criteria :: based on expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGTCGGC CCCTGCTGCT GCCCCTGCTG CTCCTGCTGC AGCCGCCAGC ATTTCTGCAG 
CCTGGTGGCT CCACAGGATC TGGTCCAAGC TACCTTTATG GGGTCACTCA ACCAAAACAC 
CTCTCAGCCT CCATGGGTGG CTCTGTGGAA ATCCCCTTCT CCTTCTATTA CCCCTGGGAG 
TTAGCCATAG TTCCCAACGT GAGAATATCC TGGAGACGGG GCCACTTCCA CGGGCAGTCC 
TTCTACAGCA CAAGGCCGCC TTCCATTCAC AAGGATTATG TGAACCGGCT CTTTCTGAAC 
TGGACAGAGG GTCAGGAGAG CGGCTTCCTC AGGATCTCAA ACCTGCGGAA GGAGGACCAG 
TCTGTGTATT TCTGCCGAGT CGAGCTGGAC ACCCGGAGAT CAGGGAGGCA GCAGTTGCAG 
TCCATCAAGG GGACCAAACT CACCATCACC CAGGCTGTCA CAACCACCAC CACCTGGAGG 
CCCAGCAGCA CAACCACCAT AGCCGGCCTC AGGGTCACAG AAAGCAAAGG GCACTCAGAA 
TCATGGCACC TAAGTCTGGA CACTGCCATC AGGGTTGCAT TGGCTGTCGC TGTGCTCAAA 
ACTGTCATTT TGGGACTGCT GTGCCTCCTC CTCCTGTGGT GGAGGAGAAG GAAAGGTAGC 
AGGGCGCCAA GCAGTGACTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_839956.1
CDS	301..984
Translation	MGRPLLLPLLLLLQPPAFLQPGGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELAIVPNVRISWRRGHFHGQSFYSTRPPSIHKDYVNRLFLNWTEGQESGFLRISNLRKEDQSVYFCRVELDTRRSGRQQLQSIKGTKLTITQAVTTTTTWRPSSTTTIAGLRVTESKGHSESWHLSLDTAIRVALAVAVLKTVILGLLCLLLLWWRRRKGSRAPSSDF

Target ORF information:

RefSeq Version	NM_178238.3
Organism	Homo sapiens(human)
Definition	Homo sapiens paired immunoglobin like type 2 receptor beta (PILRB), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178238.3

ORF Insert Sequence:

ATGGGTCGGC CCCTGCTGCT GCCCCTGCTG CTCCTGCTGC AGCCGCCAGC ATTTCTGCAG 
CCTGGTGGCT CCACAGGATC TGGTCCAAGC TACCTTTATG GGGTCACTCA ACCAAAACAC 
CTCTCAGCCT CCATGGGTGG CTCTGTGGAA ATCCCCTTCT CCTTCTATTA CCCCTGGGAG 
TTAGCCATAG TTCCCAACGT GAGAATATCC TGGAGACGGG GCCACTTCCA CGGGCAGTCC 
TTCTACAGCA CAAGGCCGCC TTCCATTCAC AAGGATTATG TGAACCGGCT CTTTCTGAAC 
TGGACAGAGG GTCAGGAGAG CGGCTTCCTC AGGATCTCAA ACCTGCGGAA GGAGGACCAG 
TCTGTGTATT TCTGCCGAGT CGAGCTGGAC ACCCGGAGAT CAGGGAGGCA GCAGTTGCAG 
TCCATCAAGG GGACCAAACT CACCATCACC CAGGCTGTCA CAACCACCAC CACCTGGAGG 
CCCAGCAGCA CAACCACCAT AGCCGGCCTC AGGGTCACAG AAAGCAAAGG GCACTCAGAA 
TCATGGCACC TAAGTCTGGA CACTGCCATC AGGGTTGCAT TGGCTGTCGC TGTGCTCAAA 
ACTGTCATTT TGGGACTGCT GTGCCTCCTC CTCCTGTGGT GGAGGAGAAG GAAAGGTAGC 
AGGGCGCCAA GCAGTGACTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PILRB ( NM_001371931.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001358860.1 Homo sapiens paired immunoglobin like type 2 receptor beta (PILRB), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu108849
Clone ID Related Accession (Same CDS sequence)	NM_001371931.1
Accession Version	NM_001371931.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-29
Organism	Homo sapiens(human)
Product	paired immunoglobulin-like type 2 receptor beta isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005071.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: ERR279825.666.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal ##RefSeq-Attributes-END##

ATGGGTCGGC CCCTGCTGCT GCCCCTGCTG CTCCTGCTGC AGCCGCCAGC ATTTCTGCAG 
CCTGGTGGCT CCACAGGATC TGGTCCAAGC TACCTTTATG GGGTCACTCA ACCAAAACAC 
CTCTCAGCCT CCATGGGTGG CTCTGTGGAA ATCCCCTTCT CCTTCTATTA CCCCTGGGAG 
TTAGCCATAG TTCCCAACGT GAGAATATCC TGGAGACGGG GCCACTTCCA CGGGCAGTCC 
TTCTACAGCA CAAGGCCGCC TTCCATTCAC AAGGATTATG TGAACCGGCT CTTTCTGAAC 
TGGACAGAGG GTCAGGAGAG CGGCTTCCTC AGGATCTCAA ACCTGCGGAA GGAGGACCAG 
TCTGTGTATT TCTGCCGAGT CGAGCTGGAC ACCCGGAGAT CAGGGAGGCA GCAGTTGCAG 
TCCATCAAGG GGACCAAACT CACCATCACC CAGGCTGTCA CAACCACCAC CACCTGGAGG 
CCCAGCAGCA CAACCACCAT AGCCGGCCTC AGGGTCACAG AAAGCAAAGG GCACTCAGAA 
TCATGGCACC TAAGTCTGGA CACTGCCATC AGGGTTGCAT TGGCTGTCGC TGTGCTCAAA 
ACTGTCATTT TGGGACTGCT GTGCCTCCTC CTCCTGTGGT GGAGGAGAAG GAAAGGCTTG 
AGCCACCGCA CCCGGCCAGT TTGGAATCTG TTATACGGGA GATCCATGTG TGGCATCTCA 
GCAGAGTTGT CCATTGGAAA CTTGGATGTA CACATTTCCA GTTCAAAAGA GAGGACAAGG 
CTCCAGGCAG CAATGAGTTC TACCTCAATA TCCTCCAAAC CTGACAGTAG CAGGGCGCCA 
AGCAGTGACT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001358860.1
CDS	301..1155
Translation	MGRPLLLPLLLLLQPPAFLQPGGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELAIVPNVRISWRRGHFHGQSFYSTRPPSIHKDYVNRLFLNWTEGQESGFLRISNLRKEDQSVYFCRVELDTRRSGRQQLQSIKGTKLTITQAVTTTTTWRPSSTTTIAGLRVTESKGHSESWHLSLDTAIRVALAVAVLKTVILGLLCLLLLWWRRRKGLSHRTRPVWNLLYGRSMCGISAELSIGNLDVHISSSKERTRLQAAMSSTSISSKPDSSRAPSSDF

Target ORF information:

RefSeq Version	NM_001371931.1
Organism	Homo sapiens(human)
Definition	Homo sapiens paired immunoglobin like type 2 receptor beta (PILRB), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001371931.1

ORF Insert Sequence:

ATGGGTCGGC CCCTGCTGCT GCCCCTGCTG CTCCTGCTGC AGCCGCCAGC ATTTCTGCAG 
CCTGGTGGCT CCACAGGATC TGGTCCAAGC TACCTTTATG GGGTCACTCA ACCAAAACAC 
CTCTCAGCCT CCATGGGTGG CTCTGTGGAA ATCCCCTTCT CCTTCTATTA CCCCTGGGAG 
TTAGCCATAG TTCCCAACGT GAGAATATCC TGGAGACGGG GCCACTTCCA CGGGCAGTCC 
TTCTACAGCA CAAGGCCGCC TTCCATTCAC AAGGATTATG TGAACCGGCT CTTTCTGAAC 
TGGACAGAGG GTCAGGAGAG CGGCTTCCTC AGGATCTCAA ACCTGCGGAA GGAGGACCAG 
TCTGTGTATT TCTGCCGAGT CGAGCTGGAC ACCCGGAGAT CAGGGAGGCA GCAGTTGCAG 
TCCATCAAGG GGACCAAACT CACCATCACC CAGGCTGTCA CAACCACCAC CACCTGGAGG 
CCCAGCAGCA CAACCACCAT AGCCGGCCTC AGGGTCACAG AAAGCAAAGG GCACTCAGAA 
TCATGGCACC TAAGTCTGGA CACTGCCATC AGGGTTGCAT TGGCTGTCGC TGTGCTCAAA 
ACTGTCATTT TGGGACTGCT GTGCCTCCTC CTCCTGTGGT GGAGGAGAAG GAAAGGCTTG 
AGCCACCGCA CCCGGCCAGT TTGGAATCTG TTATACGGGA GATCCATGTG TGGCATCTCA 
GCAGAGTTGT CCATTGGAAA CTTGGATGTA CACATTTCCA GTTCAAAAGA GAGGACAAGG 
CTCCAGGCAG CAATGAGTTC TACCTCAATA TCCTCCAAAC CTGACAGTAG CAGGGCGCCA 
AGCAGTGACT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PILR? and PILR? have a siglec fold and provide the basis of binding to sialic acid.
Proceedings of the National Academy of Sciences of the United States of America111(22)8221-6(2014 Jun)
Lu Q,Lu G,Qi J,Wang H,Xuan Y,Wang Q,Li Y,Zhang Y,Zheng C,Fan Z,Yan J,Gao GF

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
PloS one7(12)e51954(2012)
Comuzzie AG,Cole SA,Laston SL,Voruganti VS,Haack K,Gibbs RA,Butte NF

Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: duplication, conversion, and the birth of new genes.
Physiological genomics27(3)201-18(2006 Nov)
Wilson MD,Cheung J,Martindale DW,Scherer SW,Koop BF

Large-scale cDNA transfection screening for genes related to cancer development and progression.
Proceedings of the National Academy of Sciences of the United States of America101(44)15724-9(2004 Nov)
Wan D,Gong Y,Qin W,Zhang P,Li J,Wei L,Zhou X,Li H,Qiu X,Zhong F,He L,Yu J,Yao G,Jiang H,Qian L,Yu Y,Shu H,Chen X,Xu H,Guo M,Pan Z,Chen Y,Ge C,Yang S,Gu J

Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.
Genomics83(1)153-67(2004 Jan)
Lehner B,Semple JI,Brown SE,Counsell D,Campbell RD,Sanderson CM

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PILRB cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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