GYS1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GYS1
Entrez Gene ID	2997
Full Name	glycogen synthase 1
Synonyms	GSY,GYS
General protein information	Preferred Names glycogen synthase 1 Names glycogen [starch] synthase, muscle glycogen synthase 1 (muscle)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.33
Summary	The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].
Disorder MIM:	138570
Disorder Html:	Glycogen storage disease 0, muscle, 611556 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001161587.1	NP_001155059.1	glycogen [starch] synthase, muscle isoform 2
NM_001161587.2	NP_001155059.1	glycogen [starch] synthase, muscle isoform 2
NM_002103.4	NP_002094.2	glycogen [starch] synthase, muscle isoform 1
NM_002103.5	NP_002094.2	glycogen [starch] synthase, muscle isoform 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Gys1	NP_001103085.1
Drosophila melanogaster (fruit fly)	CG6904	NP_731967.2
Saccharomyces cerevisiae (baker's yeast)	GSY1	NP_116670.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002586	XP_312352.3
Xenopus tropicalis (tropical clawed frog)	LOC100490155	XP_004916359.1
Homo sapiens (human)	GYS1	NP_002094.2
Danio rerio (zebrafish)	gys1	NP_957474.1
Caenorhabditis elegans (roundworm)	gsy-1	NP_496736.1
Kluyveromyces lactis	KLLA0F23133g	XP_456111.1
Neurospora crassa	NCU06687	XP_961002.1
Pan troglodytes (chimpanzee)	GYS1	XP_003316534.1
	GYS1	NP_001028058.1
Bos taurus (cattle)	GYS1	NP_001094769.1
Mus musculus (house mouse)	Gys1	NP_109603.2
Saccharomyces cerevisiae (baker's yeast)	GSY2	NP_013359.1
Canis lupus familiaris (dog)	GYS1	XP_854809.3
Eremothecium gossypii	AGOS_AAR008W	NP_982549.2
Magnaporthe oryzae (rice blast fungus)	MGG_07289	XP_003715517.1

Gene Ontology
Bibliography

Related articles in PubMed

Acute Hypoglycemia in Healthy Humans Impairs Insulin-Stimulated Glucose Uptake and Glycogen Synthase in Skeletal Muscle: A Randomized Clinical Study.
Voss TS, Vendelbo MH, Kampmann U, Hingst JR, Wojtaszewski JFP, Svart MV, M?ller N, Jessen N
Diabetes66(9)2483-2494(2017 09)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
Yadav L, Tamene F, G??s H, van Drogen A, Katainen R, Aebersold R, Gstaiger M, Varjosalo M
Cell systems4(4)430-444.e5(2017 Apr)

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R,
Nature communications711491(2016 May)

Pathological glycogenesis through glycogen synthase 1 and suppression of excessive AMP kinase activity in myeloid leukemia cells.
Bhanot H, Reddy MM, Nonami A, Weisberg EL, Bonal D, Kirschmeier PT, Salgia S, Podar K, Galinsky I, Chowdary TK, Neuberg D, Tonon G, Stone RM, Asara J, Griffin JD, Sattler M
Leukemia29(7)1555-1563(2015 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Insulin-stimulated glycogen synthase (GS) activity was completely ablated during hyperinsulinemic hypoglycemia, and catecholamine signaling via cAMP-dependent protein kinase (PKA) and phosphorylation of inhibiting sites on GS all increased.
Title: Acute Hypoglycemia in Healthy Humans Impairs Insulin-Stimulated Glucose Uptake and Glycogen Synthase in Skeletal Muscle: A Randomized Clinical Study.

High glycogen synthase 1 expression is associated with myeloid leukemia.
Title: Pathological glycogenesis through glycogen synthase 1 and suppression of excessive AMP kinase activity in myeloid leukemia cells.

Overexpression of GYS1, MIF, and MYC is associated with adverse outcome and poor response to azacitidine in myelodysplastic syndromes and acute myeloid leukemia
Title: Overexpression of GYS1, MIF, and MYC is associated with adverse outcome and poor response to azacitidine in myelodysplastic syndromes and acute myeloid leukemia.

over-expression of muscle glycogen synthase (MGS)was detected in diabetic human kidney
Title: Over-expression of muscle glycogen synthase in human diabetic nephropathy.

Data suggest that although COOH-terminal dephosphorylation is likely necessary for GS activation, protein kinase Akt-2- (Akt2)-dependent NH2-terminal dephosphorylation is site for "fine-tuning" insulin-mediated GS activation in skeletal muscle.
Title: Akt2 influences glycogen synthase activity in human skeletal muscle through regulation of NH?-terminal (sites 2 + 2a) phosphorylation.

The following GYS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GYS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14737	NM_001161587.2 Latest version!	Homo sapiens glycogen synthase 1 (GYS1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu19222	NM_002103.5 Latest version!	Homo sapiens glycogen synthase 1 (GYS1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu14737	NM_001161587.1	Homo sapiens glycogen synthase 1 (GYS1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu19222	NM_002103.4	Homo sapiens glycogen synthase 1 (GYS1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GYS1 ( NM_001161587.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001155059.1 Homo sapiens glycogen synthase 1 (GYS1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu14737
Clone ID Related Accession (Same CDS sequence)	NM_001161587.1 , NM_001161587.2
Accession Version	NM_001161587.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2022bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	glycogen [starch] synthase, muscle isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP313940.1, BC003182.1 and BC002617.2. Transcript Variant: This variant (2) is missing an in-frame coding exon at the 3' end compared to variant 1, resulting in a shorter isoform (2) lacking an internal protein segment compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC003182.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTTTAA ACCGCACTTT GTCCATGTCC TCACTGCCAG GACTGGAGGA CTGGGAGGAT 
GAATTCGACC TGGAGAACGC AGTGCTCTTC GAAGTGGCCT GGGAGGTGGC TAACAAGGTG 
GGTGGCATCT ACACGGTGCT GCAGACGAAG GCGAAGGTGA CAGGGGACGA ATGGGGCGAC 
AACTACTTCC TGGTGGGGCC GTACACGGAG CAGGGCGTGA GGACCCAGGT GGAACTGCTG 
GAGGCCCCCA CCCCGGCCCT GAAGAGGACA CTGGATTCCA TGAACAGCAA GGGCTGCAAG 
TTCCTGGCAC AGAGTGAGGA GAAGCCACAT GTGGTTGCTC ACTTCCATGA GTGGTTGGCA 
GGCGTTGGAC TCTGCCTGTG TCGTGCCCGG CGACTGCCTG TAGCAACCAT CTTCACCACC 
CATGCCACGC TGCTGGGGCG CTACCTGTGT GCCGGTGCCG TGGACTTCTA CAACAACCTG 
GAGAACTTCA ACGTGGACAA GGAAGCAGGG GAGAGGCAGA TCTACCACCG ATACTGCATG 
GAAAGGGCGG CAGCCCACTG CGCTCACGTC TTCACTACTG TGTCCCAGAT CACCGCCATC 
GAGGCACAGC ACTTGCTCAA GAGGAAACCA GATATTGTGA CCCCCAATGG GCTGAATGTG 
AAGAAGTTTT CTGCCATGCA TGAGTTCCAG AACCTCCATG CTCAGAGCAA GGCTCGAATC 
CAGGAGTTTG TGCGGGGCCA TTTTTATGGG CATCTGGACT TCAACTTGGA CAAGACCTTA 
TACTTCTTTA TCGCCGGCCG CTATGAGTTC TCCAACAAGG GTGCTGACGT CTTCCTGGAG 
GCATTGGCTC GGCTCAACTA TCTGCTCAGA GTGAACGGCA GCGAGCAGAC AGTGGTTGCC 
TTCTTCATCA TGCCAGCGCG GACCAACAAT TTCAACGTGG AAACCCTCAA AGGCCAAGCT 
GTGCGCAAAC AGCTTTGGGA CACGGCCAAC ACGGTGAAGG AAAAGTTCGG GAGGAAGCTT 
TATGAATCCT TACTGGTTGG GAGCCTTCCC GACATGAACA AGATGCTGGA TAAGGAAGAC 
TTCACTATGA TGAAGAGAGC CATCTTTGCA ACGCAGCGGC AGTCTTTCCC CCCTGTGTGC 
ACCCACAATA TGCTGGATGA CTCCTCAGAC CCCATCCTGA CCACCATCCG CCGAATCGGC 
CTCTTCAATA GCAGTGCCGA CAGGGTGAAG GTGATTTTCC ACCCGGAGTT CCTCTCCTCC 
ACAAGCCCCC TGCTCCCTGT GGACTATGAG GAGTTTGTCC GTGGCTGTCA CCTTGGAGTC 
TTCCCCTCCT ACTATGAGCC TTGGGGCTAC ACACCGGCTG AGTGCACGGT TATGGGAATC 
CCCAGTATCT CCACCAATCT CTCCGGCTTC GGCTGCTTCA TGGAGGAACA CATCGCAGAC 
CCCTCAGCTT ACGGTATCTA CATTCTTGAC CGGCGGTTCC GCAGCCTGGA TGATTCCTGC 
TCGCAGCTCA CCTCCTTCCT CTACAGTTTC TGTCAGCAGA GCCGGCGGCA GCGTATCATC 
CAGCGGAACC GCACGGAGCG CCTCTCCGAC CTTCTGGACT GGAAATACCT AGGCCGGTAC 
TATATGTCTG CGCGCCACAT GGCGCTGTCC AAGGCCTTTC CAGAGCACTT CACCTACGAG 
CCCAACGAGG CGGATGCGGC CCAGGGGTAC CGCTACCCAC GGCCAGCCTC GGTGCCACCG 
TCGCCCTCGC TGTCACGACA CTCCAGCCCG CACCAGAGTG AGGACGAGGA GGATCCCCGG 
AACGGGCCGC TGGAGGAAGA CGGCGAGCGC TACGATGAGG ACGAGGAGGC CGCCAAGGAC 
CGGCGCAACA TCCGTGCACC AGAGTGGCCG CGCCGAGCGT CCTGCACCTC CTCCACCAGC 
GGCAGCAAGC GCAACTCTGT GGACACGGCC ACCTCCAGCT CACTCAGCAC CCCGAGCGAG 
CCCCTCAGCC CCACCAGCTC CCTGGGCGAG GAGCGTAACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001155059.1
CDS	242..2263
Translation	MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN

Target ORF information:

RefSeq Version	NM_001161587.1
Organism	Homo sapiens(human)
Definition	Homo sapiens glycogen synthase 1 (GYS1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001161587.1

ORF Insert Sequence:

ATGCCTTTAA ACCGCACTTT GTCCATGTCC TCACTGCCAG GACTGGAGGA CTGGGAGGAT 
GAATTCGACC TGGAGAACGC AGTGCTCTTC GAAGTGGCCT GGGAGGTGGC TAACAAGGTG 
GGTGGCATCT ACACGGTGCT GCAGACGAAG GCGAAGGTGA CAGGGGACGA ATGGGGCGAC 
AACTACTTCC TGGTGGGGCC GTACACGGAG CAGGGCGTGA GGACCCAGGT GGAACTGCTG 
GAGGCCCCCA CCCCGGCCCT GAAGAGGACA CTGGATTCCA TGAACAGCAA GGGCTGCAAG 
TTCCTGGCAC AGAGTGAGGA GAAGCCACAT GTGGTTGCTC ACTTCCATGA GTGGTTGGCA 
GGCGTTGGAC TCTGCCTGTG TCGTGCCCGG CGACTGCCTG TAGCAACCAT CTTCACCACC 
CATGCCACGC TGCTGGGGCG CTACCTGTGT GCCGGTGCCG TGGACTTCTA CAACAACCTG 
GAGAACTTCA ACGTGGACAA GGAAGCAGGG GAGAGGCAGA TCTACCACCG ATACTGCATG 
GAAAGGGCGG CAGCCCACTG CGCTCACGTC TTCACTACTG TGTCCCAGAT CACCGCCATC 
GAGGCACAGC ACTTGCTCAA GAGGAAACCA GATATTGTGA CCCCCAATGG GCTGAATGTG 
AAGAAGTTTT CTGCCATGCA TGAGTTCCAG AACCTCCATG CTCAGAGCAA GGCTCGAATC 
CAGGAGTTTG TGCGGGGCCA TTTTTATGGG CATCTGGACT TCAACTTGGA CAAGACCTTA 
TACTTCTTTA TCGCCGGCCG CTATGAGTTC TCCAACAAGG GTGCTGACGT CTTCCTGGAG 
GCATTGGCTC GGCTCAACTA TCTGCTCAGA GTGAACGGCA GCGAGCAGAC AGTGGTTGCC 
TTCTTCATCA TGCCAGCGCG GACCAACAAT TTCAACGTGG AAACCCTCAA AGGCCAAGCT 
GTGCGCAAAC AGCTTTGGGA CACGGCCAAC ACGGTGAAGG AAAAGTTCGG GAGGAAGCTT 
TATGAATCCT TACTGGTTGG GAGCCTTCCC GACATGAACA AGATGCTGGA TAAGGAAGAC 
TTCACTATGA TGAAGAGAGC CATCTTTGCA ACGCAGCGGC AGTCTTTCCC CCCTGTGTGC 
ACCCACAATA TGCTGGATGA CTCCTCAGAC CCCATCCTGA CCACCATCCG CCGAATCGGC 
CTCTTCAATA GCAGTGCCGA CAGGGTGAAG GTGATTTTCC ACCCGGAGTT CCTCTCCTCC 
ACAAGCCCCC TGCTCCCTGT GGACTATGAG GAGTTTGTCC GTGGCTGTCA CCTTGGAGTC 
TTCCCCTCCT ACTATGAGCC TTGGGGCTAC ACACCGGCTG AGTGCACGGT TATGGGAATC 
CCCAGTATCT CCACCAATCT CTCCGGCTTC GGCTGCTTCA TGGAGGAACA CATCGCAGAC 
CCCTCAGCTT ACGGTATCTA CATTCTTGAC CGGCGGTTCC GCAGCCTGGA TGATTCCTGC 
TCGCAGCTCA CCTCCTTCCT CTACAGTTTC TGTCAGCAGA GCCGGCGGCA GCGTATCATC 
CAGCGGAACC GCACGGAGCG CCTCTCCGAC CTTCTGGACT GGAAATACCT AGGCCGGTAC 
TATATGTCTG CGCGCCACAT GGCGCTGTCC AAGGCCTTTC CAGAGCACTT CACCTACGAG 
CCCAACGAGG CGGATGCGGC CCAGGGGTAC CGCTACCCAC GGCCAGCCTC GGTGCCACCG 
TCGCCCTCGC TGTCACGACA CTCCAGCCCG CACCAGAGTG AGGACGAGGA GGATCCCCGG 
AACGGGCCGC TGGAGGAAGA CGGCGAGCGC TACGATGAGG ACGAGGAGGC CGCCAAGGAC 
CGGCGCAACA TCCGTGCACC AGAGTGGCCG CGCCGAGCGT CCTGCACCTC CTCCACCAGC 
GGCAGCAAGC GCAACTCTGT GGACACGGCC ACCTCCAGCT CACTCAGCAC CCCGAGCGAG 
CCCCTCAGCC CCACCAGCTC CCTGGGCGAG GAGCGTAACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GYS1 ( NM_001161587.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001155059.1 Homo sapiens glycogen synthase 1 (GYS1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu14737
Clone ID Related Accession (Same CDS sequence)	NM_001161587.1 , NM_001161587.2
Accession Version	NM_001161587.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2022bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	glycogen [starch] synthase, muscle isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP313940.1 and BC003182.1. On May 31, 2019 this sequence version replaced NM_001161587.1. Transcript Variant: This variant (2) is missing an in-frame coding exon at the 3' end compared to variant 1, resulting in a shorter isoform (2) lacking an internal protein segment compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC003182.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTTTAA ACCGCACTTT GTCCATGTCC TCACTGCCAG GACTGGAGGA CTGGGAGGAT 
GAATTCGACC TGGAGAACGC AGTGCTCTTC GAAGTGGCCT GGGAGGTGGC TAACAAGGTG 
GGTGGCATCT ACACGGTGCT GCAGACGAAG GCGAAGGTGA CAGGGGACGA ATGGGGCGAC 
AACTACTTCC TGGTGGGGCC GTACACGGAG CAGGGCGTGA GGACCCAGGT GGAACTGCTG 
GAGGCCCCCA CCCCGGCCCT GAAGAGGACA CTGGATTCCA TGAACAGCAA GGGCTGCAAG 
TTCCTGGCAC AGAGTGAGGA GAAGCCACAT GTGGTTGCTC ACTTCCATGA GTGGTTGGCA 
GGCGTTGGAC TCTGCCTGTG TCGTGCCCGG CGACTGCCTG TAGCAACCAT CTTCACCACC 
CATGCCACGC TGCTGGGGCG CTACCTGTGT GCCGGTGCCG TGGACTTCTA CAACAACCTG 
GAGAACTTCA ACGTGGACAA GGAAGCAGGG GAGAGGCAGA TCTACCACCG ATACTGCATG 
GAAAGGGCGG CAGCCCACTG CGCTCACGTC TTCACTACTG TGTCCCAGAT CACCGCCATC 
GAGGCACAGC ACTTGCTCAA GAGGAAACCA GATATTGTGA CCCCCAATGG GCTGAATGTG 
AAGAAGTTTT CTGCCATGCA TGAGTTCCAG AACCTCCATG CTCAGAGCAA GGCTCGAATC 
CAGGAGTTTG TGCGGGGCCA TTTTTATGGG CATCTGGACT TCAACTTGGA CAAGACCTTA 
TACTTCTTTA TCGCCGGCCG CTATGAGTTC TCCAACAAGG GTGCTGACGT CTTCCTGGAG 
GCATTGGCTC GGCTCAACTA TCTGCTCAGA GTGAACGGCA GCGAGCAGAC AGTGGTTGCC 
TTCTTCATCA TGCCAGCGCG GACCAACAAT TTCAACGTGG AAACCCTCAA AGGCCAAGCT 
GTGCGCAAAC AGCTTTGGGA CACGGCCAAC ACGGTGAAGG AAAAGTTCGG GAGGAAGCTT 
TATGAATCCT TACTGGTTGG GAGCCTTCCC GACATGAACA AGATGCTGGA TAAGGAAGAC 
TTCACTATGA TGAAGAGAGC CATCTTTGCA ACGCAGCGGC AGTCTTTCCC CCCTGTGTGC 
ACCCACAATA TGCTGGATGA CTCCTCAGAC CCCATCCTGA CCACCATCCG CCGAATCGGC 
CTCTTCAATA GCAGTGCCGA CAGGGTGAAG GTGATTTTCC ACCCGGAGTT CCTCTCCTCC 
ACAAGCCCCC TGCTCCCTGT GGACTATGAG GAGTTTGTCC GTGGCTGTCA CCTTGGAGTC 
TTCCCCTCCT ACTATGAGCC TTGGGGCTAC ACACCGGCTG AGTGCACGGT TATGGGAATC 
CCCAGTATCT CCACCAATCT CTCCGGCTTC GGCTGCTTCA TGGAGGAACA CATCGCAGAC 
CCCTCAGCTT ACGGTATCTA CATTCTTGAC CGGCGGTTCC GCAGCCTGGA TGATTCCTGC 
TCGCAGCTCA CCTCCTTCCT CTACAGTTTC TGTCAGCAGA GCCGGCGGCA GCGTATCATC 
CAGCGGAACC GCACGGAGCG CCTCTCCGAC CTTCTGGACT GGAAATACCT AGGCCGGTAC 
TATATGTCTG CGCGCCACAT GGCGCTGTCC AAGGCCTTTC CAGAGCACTT CACCTACGAG 
CCCAACGAGG CGGATGCGGC CCAGGGGTAC CGCTACCCAC GGCCAGCCTC GGTGCCACCG 
TCGCCCTCGC TGTCACGACA CTCCAGCCCG CACCAGAGTG AGGACGAGGA GGATCCCCGG 
AACGGGCCGC TGGAGGAAGA CGGCGAGCGC TACGATGAGG ACGAGGAGGC CGCCAAGGAC 
CGGCGCAACA TCCGTGCACC AGAGTGGCCG CGCCGAGCGT CCTGCACCTC CTCCACCAGC 
GGCAGCAAGC GCAACTCTGT GGACACGGCC ACCTCCAGCT CACTCAGCAC CCCGAGCGAG 
CCCCTCAGCC CCACCAGCTC CCTGGGCGAG GAGCGTAACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001155059.1
CDS	198..2219
Translation	MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN

Target ORF information:

RefSeq Version	NM_001161587.2
Organism	Homo sapiens(human)
Definition	Homo sapiens glycogen synthase 1 (GYS1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001161587.2

ORF Insert Sequence:

ATGCCTTTAA ACCGCACTTT GTCCATGTCC TCACTGCCAG GACTGGAGGA CTGGGAGGAT 
GAATTCGACC TGGAGAACGC AGTGCTCTTC GAAGTGGCCT GGGAGGTGGC TAACAAGGTG 
GGTGGCATCT ACACGGTGCT GCAGACGAAG GCGAAGGTGA CAGGGGACGA ATGGGGCGAC 
AACTACTTCC TGGTGGGGCC GTACACGGAG CAGGGCGTGA GGACCCAGGT GGAACTGCTG 
GAGGCCCCCA CCCCGGCCCT GAAGAGGACA CTGGATTCCA TGAACAGCAA GGGCTGCAAG 
TTCCTGGCAC AGAGTGAGGA GAAGCCACAT GTGGTTGCTC ACTTCCATGA GTGGTTGGCA 
GGCGTTGGAC TCTGCCTGTG TCGTGCCCGG CGACTGCCTG TAGCAACCAT CTTCACCACC 
CATGCCACGC TGCTGGGGCG CTACCTGTGT GCCGGTGCCG TGGACTTCTA CAACAACCTG 
GAGAACTTCA ACGTGGACAA GGAAGCAGGG GAGAGGCAGA TCTACCACCG ATACTGCATG 
GAAAGGGCGG CAGCCCACTG CGCTCACGTC TTCACTACTG TGTCCCAGAT CACCGCCATC 
GAGGCACAGC ACTTGCTCAA GAGGAAACCA GATATTGTGA CCCCCAATGG GCTGAATGTG 
AAGAAGTTTT CTGCCATGCA TGAGTTCCAG AACCTCCATG CTCAGAGCAA GGCTCGAATC 
CAGGAGTTTG TGCGGGGCCA TTTTTATGGG CATCTGGACT TCAACTTGGA CAAGACCTTA 
TACTTCTTTA TCGCCGGCCG CTATGAGTTC TCCAACAAGG GTGCTGACGT CTTCCTGGAG 
GCATTGGCTC GGCTCAACTA TCTGCTCAGA GTGAACGGCA GCGAGCAGAC AGTGGTTGCC 
TTCTTCATCA TGCCAGCGCG GACCAACAAT TTCAACGTGG AAACCCTCAA AGGCCAAGCT 
GTGCGCAAAC AGCTTTGGGA CACGGCCAAC ACGGTGAAGG AAAAGTTCGG GAGGAAGCTT 
TATGAATCCT TACTGGTTGG GAGCCTTCCC GACATGAACA AGATGCTGGA TAAGGAAGAC 
TTCACTATGA TGAAGAGAGC CATCTTTGCA ACGCAGCGGC AGTCTTTCCC CCCTGTGTGC 
ACCCACAATA TGCTGGATGA CTCCTCAGAC CCCATCCTGA CCACCATCCG CCGAATCGGC 
CTCTTCAATA GCAGTGCCGA CAGGGTGAAG GTGATTTTCC ACCCGGAGTT CCTCTCCTCC 
ACAAGCCCCC TGCTCCCTGT GGACTATGAG GAGTTTGTCC GTGGCTGTCA CCTTGGAGTC 
TTCCCCTCCT ACTATGAGCC TTGGGGCTAC ACACCGGCTG AGTGCACGGT TATGGGAATC 
CCCAGTATCT CCACCAATCT CTCCGGCTTC GGCTGCTTCA TGGAGGAACA CATCGCAGAC 
CCCTCAGCTT ACGGTATCTA CATTCTTGAC CGGCGGTTCC GCAGCCTGGA TGATTCCTGC 
TCGCAGCTCA CCTCCTTCCT CTACAGTTTC TGTCAGCAGA GCCGGCGGCA GCGTATCATC 
CAGCGGAACC GCACGGAGCG CCTCTCCGAC CTTCTGGACT GGAAATACCT AGGCCGGTAC 
TATATGTCTG CGCGCCACAT GGCGCTGTCC AAGGCCTTTC CAGAGCACTT CACCTACGAG 
CCCAACGAGG CGGATGCGGC CCAGGGGTAC CGCTACCCAC GGCCAGCCTC GGTGCCACCG 
TCGCCCTCGC TGTCACGACA CTCCAGCCCG CACCAGAGTG AGGACGAGGA GGATCCCCGG 
AACGGGCCGC TGGAGGAAGA CGGCGAGCGC TACGATGAGG ACGAGGAGGC CGCCAAGGAC 
CGGCGCAACA TCCGTGCACC AGAGTGGCCG CGCCGAGCGT CCTGCACCTC CTCCACCAGC 
GGCAGCAAGC GCAACTCTGT GGACACGGCC ACCTCCAGCT CACTCAGCAC CCCGAGCGAG 
CCCCTCAGCC CCACCAGCTC CCTGGGCGAG GAGCGTAACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GYS1 ( NM_002103.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002094.2 Homo sapiens glycogen synthase 1 (GYS1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19222
Clone ID Related Accession (Same CDS sequence)	NM_002103.4 , NM_002103.5
Accession Version	NM_002103.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2214bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-23
Organism	Homo sapiens(human)
Product	glycogen [starch] synthase, muscle isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP313940.1 and BC002617.2. This sequence is a reference standard in the RefSeqGene project. On Jun 6, 2009 this sequence version replaced NM_002103.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002617.2, SRR1660807.254603.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTTTAA ACCGCACTTT GTCCATGTCC TCACTGCCAG GACTGGAGGA CTGGGAGGAT 
GAATTCGACC TGGAGAACGC AGTGCTCTTC GAAGTGGCCT GGGAGGTGGC TAACAAGGTG 
GGTGGCATCT ACACGGTGCT GCAGACGAAG GCGAAGGTGA CAGGGGACGA ATGGGGCGAC 
AACTACTTCC TGGTGGGGCC GTACACGGAG CAGGGCGTGA GGACCCAGGT GGAACTGCTG 
GAGGCCCCCA CCCCGGCCCT GAAGAGGACA CTGGATTCCA TGAACAGCAA GGGCTGCAAG 
GTGTATTTCG GGCGCTGGCT GATCGAGGGA GGCCCTCTGG TGGTGCTCCT GGACGTGGGT 
GCCTCAGCTT GGGCCCTGGA GCGCTGGAAG GGAGAGCTCT GGGATACCTG CAACATCGGA 
GTGCCGTGGT ACGACCGCGA GGCCAACGAC GCTGTCCTCT TTGGCTTTCT GACCACCTGG 
TTCCTGGGTG AGTTCCTGGC ACAGAGTGAG GAGAAGCCAC ATGTGGTTGC TCACTTCCAT 
GAGTGGTTGG CAGGCGTTGG ACTCTGCCTG TGTCGTGCCC GGCGACTGCC TGTAGCAACC 
ATCTTCACCA CCCATGCCAC GCTGCTGGGG CGCTACCTGT GTGCCGGTGC CGTGGACTTC 
TACAACAACC TGGAGAACTT CAACGTGGAC AAGGAAGCAG GGGAGAGGCA GATCTACCAC 
CGATACTGCA TGGAAAGGGC GGCAGCCCAC TGCGCTCACG TCTTCACTAC TGTGTCCCAG 
ATCACCGCCA TCGAGGCACA GCACTTGCTC AAGAGGAAAC CAGATATTGT GACCCCCAAT 
GGGCTGAATG TGAAGAAGTT TTCTGCCATG CATGAGTTCC AGAACCTCCA TGCTCAGAGC 
AAGGCTCGAA TCCAGGAGTT TGTGCGGGGC CATTTTTATG GGCATCTGGA CTTCAACTTG 
GACAAGACCT TATACTTCTT TATCGCCGGC CGCTATGAGT TCTCCAACAA GGGTGCTGAC 
GTCTTCCTGG AGGCATTGGC TCGGCTCAAC TATCTGCTCA GAGTGAACGG CAGCGAGCAG 
ACAGTGGTTG CCTTCTTCAT CATGCCAGCG CGGACCAACA ATTTCAACGT GGAAACCCTC 
AAAGGCCAAG CTGTGCGCAA ACAGCTTTGG GACACGGCCA ACACGGTGAA GGAAAAGTTC 
GGGAGGAAGC TTTATGAATC CTTACTGGTT GGGAGCCTTC CCGACATGAA CAAGATGCTG 
GATAAGGAAG ACTTCACTAT GATGAAGAGA GCCATCTTTG CAACGCAGCG GCAGTCTTTC 
CCCCCTGTGT GCACCCACAA TATGCTGGAT GACTCCTCAG ACCCCATCCT GACCACCATC 
CGCCGAATCG GCCTCTTCAA TAGCAGTGCC GACAGGGTGA AGGTGATTTT CCACCCGGAG 
TTCCTCTCCT CCACAAGCCC CCTGCTCCCT GTGGACTATG AGGAGTTTGT CCGTGGCTGT 
CACCTTGGAG TCTTCCCCTC CTACTATGAG CCTTGGGGCT ACACACCGGC TGAGTGCACG 
GTTATGGGAA TCCCCAGTAT CTCCACCAAT CTCTCCGGCT TCGGCTGCTT CATGGAGGAA 
CACATCGCAG ACCCCTCAGC TTACGGTATC TACATTCTTG ACCGGCGGTT CCGCAGCCTG 
GATGATTCCT GCTCGCAGCT CACCTCCTTC CTCTACAGTT TCTGTCAGCA GAGCCGGCGG 
CAGCGTATCA TCCAGCGGAA CCGCACGGAG CGCCTCTCCG ACCTTCTGGA CTGGAAATAC 
CTAGGCCGGT ACTATATGTC TGCGCGCCAC ATGGCGCTGT CCAAGGCCTT TCCAGAGCAC 
TTCACCTACG AGCCCAACGA GGCGGATGCG GCCCAGGGGT ACCGCTACCC ACGGCCAGCC 
TCGGTGCCAC CGTCGCCCTC GCTGTCACGA CACTCCAGCC CGCACCAGAG TGAGGACGAG 
GAGGATCCCC GGAACGGGCC GCTGGAGGAA GACGGCGAGC GCTACGATGA GGACGAGGAG 
GCCGCCAAGG ACCGGCGCAA CATCCGTGCA CCAGAGTGGC CGCGCCGAGC GTCCTGCACC 
TCCTCCACCA GCGGCAGCAA GCGCAACTCT GTGGACACGG CCACCTCCAG CTCACTCAGC 
ACCCCGAGCG AGCCCCTCAG CCCCACCAGC TCCCTGGGCG AGGAGCGTAA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002094.2
CDS	242..2455
Translation	MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN

Target ORF information:

RefSeq Version	NM_002103.4
Organism	Homo sapiens(human)
Definition	Homo sapiens glycogen synthase 1 (GYS1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002103.4

ORF Insert Sequence:

ATGCCTTTAA ACCGCACTTT GTCCATGTCC TCACTGCCAG GACTGGAGGA CTGGGAGGAT 
GAATTCGACC TGGAGAACGC AGTGCTCTTC GAAGTGGCCT GGGAGGTGGC TAACAAGGTG 
GGTGGCATCT ACACGGTGCT GCAGACGAAG GCGAAGGTGA CAGGGGACGA ATGGGGCGAC 
AACTACTTCC TGGTGGGGCC GTACACGGAG CAGGGCGTGA GGACCCAGGT GGAACTGCTG 
GAGGCCCCCA CCCCGGCCCT GAAGAGGACA CTGGATTCCA TGAACAGCAA GGGCTGCAAG 
GTGTATTTCG GGCGCTGGCT GATCGAGGGA GGCCCTCTGG TGGTGCTCCT GGACGTGGGT 
GCCTCAGCTT GGGCCCTGGA GCGCTGGAAG GGAGAGCTCT GGGATACCTG CAACATCGGA 
GTGCCGTGGT ACGACCGCGA GGCCAACGAC GCTGTCCTCT TTGGCTTTCT GACCACCTGG 
TTCCTGGGTG AGTTCCTGGC ACAGAGTGAG GAGAAGCCAC ATGTGGTTGC TCACTTCCAT 
GAGTGGTTGG CAGGCGTTGG ACTCTGCCTG TGTCGTGCCC GGCGACTGCC TGTAGCAACC 
ATCTTCACCA CCCATGCCAC GCTGCTGGGG CGCTACCTGT GTGCCGGTGC CGTGGACTTC 
TACAACAACC TGGAGAACTT CAACGTGGAC AAGGAAGCAG GGGAGAGGCA GATCTACCAC 
CGATACTGCA TGGAAAGGGC GGCAGCCCAC TGCGCTCACG TCTTCACTAC TGTGTCCCAG 
ATCACCGCCA TCGAGGCACA GCACTTGCTC AAGAGGAAAC CAGATATTGT GACCCCCAAT 
GGGCTGAATG TGAAGAAGTT TTCTGCCATG CATGAGTTCC AGAACCTCCA TGCTCAGAGC 
AAGGCTCGAA TCCAGGAGTT TGTGCGGGGC CATTTTTATG GGCATCTGGA CTTCAACTTG 
GACAAGACCT TATACTTCTT TATCGCCGGC CGCTATGAGT TCTCCAACAA GGGTGCTGAC 
GTCTTCCTGG AGGCATTGGC TCGGCTCAAC TATCTGCTCA GAGTGAACGG CAGCGAGCAG 
ACAGTGGTTG CCTTCTTCAT CATGCCAGCG CGGACCAACA ATTTCAACGT GGAAACCCTC 
AAAGGCCAAG CTGTGCGCAA ACAGCTTTGG GACACGGCCA ACACGGTGAA GGAAAAGTTC 
GGGAGGAAGC TTTATGAATC CTTACTGGTT GGGAGCCTTC CCGACATGAA CAAGATGCTG 
GATAAGGAAG ACTTCACTAT GATGAAGAGA GCCATCTTTG CAACGCAGCG GCAGTCTTTC 
CCCCCTGTGT GCACCCACAA TATGCTGGAT GACTCCTCAG ACCCCATCCT GACCACCATC 
CGCCGAATCG GCCTCTTCAA TAGCAGTGCC GACAGGGTGA AGGTGATTTT CCACCCGGAG 
TTCCTCTCCT CCACAAGCCC CCTGCTCCCT GTGGACTATG AGGAGTTTGT CCGTGGCTGT 
CACCTTGGAG TCTTCCCCTC CTACTATGAG CCTTGGGGCT ACACACCGGC TGAGTGCACG 
GTTATGGGAA TCCCCAGTAT CTCCACCAAT CTCTCCGGCT TCGGCTGCTT CATGGAGGAA 
CACATCGCAG ACCCCTCAGC TTACGGTATC TACATTCTTG ACCGGCGGTT CCGCAGCCTG 
GATGATTCCT GCTCGCAGCT CACCTCCTTC CTCTACAGTT TCTGTCAGCA GAGCCGGCGG 
CAGCGTATCA TCCAGCGGAA CCGCACGGAG CGCCTCTCCG ACCTTCTGGA CTGGAAATAC 
CTAGGCCGGT ACTATATGTC TGCGCGCCAC ATGGCGCTGT CCAAGGCCTT TCCAGAGCAC 
TTCACCTACG AGCCCAACGA GGCGGATGCG GCCCAGGGGT ACCGCTACCC ACGGCCAGCC 
TCGGTGCCAC CGTCGCCCTC GCTGTCACGA CACTCCAGCC CGCACCAGAG TGAGGACGAG 
GAGGATCCCC GGAACGGGCC GCTGGAGGAA GACGGCGAGC GCTACGATGA GGACGAGGAG 
GCCGCCAAGG ACCGGCGCAA CATCCGTGCA CCAGAGTGGC CGCGCCGAGC GTCCTGCACC 
TCCTCCACCA GCGGCAGCAA GCGCAACTCT GTGGACACGG CCACCTCCAG CTCACTCAGC 
ACCCCGAGCG AGCCCCTCAG CCCCACCAGC TCCCTGGGCG AGGAGCGTAA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GYS1 ( NM_002103.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002094.2 Homo sapiens glycogen synthase 1 (GYS1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19222
Clone ID Related Accession (Same CDS sequence)	NM_002103.4 , NM_002103.5
Accession Version	NM_002103.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2214bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	glycogen [starch] synthase, muscle isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP313940.1 and BC002617.2. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_002103.4. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.34801.1, SRR1660803.122420.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000323798.8/ ENSP00000317904.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCTTTAA ACCGCACTTT GTCCATGTCC TCACTGCCAG GACTGGAGGA CTGGGAGGAT 
GAATTCGACC TGGAGAACGC AGTGCTCTTC GAAGTGGCCT GGGAGGTGGC TAACAAGGTG 
GGTGGCATCT ACACGGTGCT GCAGACGAAG GCGAAGGTGA CAGGGGACGA ATGGGGCGAC 
AACTACTTCC TGGTGGGGCC GTACACGGAG CAGGGCGTGA GGACCCAGGT GGAACTGCTG 
GAGGCCCCCA CCCCGGCCCT GAAGAGGACA CTGGATTCCA TGAACAGCAA GGGCTGCAAG 
GTGTATTTCG GGCGCTGGCT GATCGAGGGA GGCCCTCTGG TGGTGCTCCT GGACGTGGGT 
GCCTCAGCTT GGGCCCTGGA GCGCTGGAAG GGAGAGCTCT GGGATACCTG CAACATCGGA 
GTGCCGTGGT ACGACCGCGA GGCCAACGAC GCTGTCCTCT TTGGCTTTCT GACCACCTGG 
TTCCTGGGTG AGTTCCTGGC ACAGAGTGAG GAGAAGCCAC ATGTGGTTGC TCACTTCCAT 
GAGTGGTTGG CAGGCGTTGG ACTCTGCCTG TGTCGTGCCC GGCGACTGCC TGTAGCAACC 
ATCTTCACCA CCCATGCCAC GCTGCTGGGG CGCTACCTGT GTGCCGGTGC CGTGGACTTC 
TACAACAACC TGGAGAACTT CAACGTGGAC AAGGAAGCAG GGGAGAGGCA GATCTACCAC 
CGATACTGCA TGGAAAGGGC GGCAGCCCAC TGCGCTCACG TCTTCACTAC TGTGTCCCAG 
ATCACCGCCA TCGAGGCACA GCACTTGCTC AAGAGGAAAC CAGATATTGT GACCCCCAAT 
GGGCTGAATG TGAAGAAGTT TTCTGCCATG CATGAGTTCC AGAACCTCCA TGCTCAGAGC 
AAGGCTCGAA TCCAGGAGTT TGTGCGGGGC CATTTTTATG GGCATCTGGA CTTCAACTTG 
GACAAGACCT TATACTTCTT TATCGCCGGC CGCTATGAGT TCTCCAACAA GGGTGCTGAC 
GTCTTCCTGG AGGCATTGGC TCGGCTCAAC TATCTGCTCA GAGTGAACGG CAGCGAGCAG 
ACAGTGGTTG CCTTCTTCAT CATGCCAGCG CGGACCAACA ATTTCAACGT GGAAACCCTC 
AAAGGCCAAG CTGTGCGCAA ACAGCTTTGG GACACGGCCA ACACGGTGAA GGAAAAGTTC 
GGGAGGAAGC TTTATGAATC CTTACTGGTT GGGAGCCTTC CCGACATGAA CAAGATGCTG 
GATAAGGAAG ACTTCACTAT GATGAAGAGA GCCATCTTTG CAACGCAGCG GCAGTCTTTC 
CCCCCTGTGT GCACCCACAA TATGCTGGAT GACTCCTCAG ACCCCATCCT GACCACCATC 
CGCCGAATCG GCCTCTTCAA TAGCAGTGCC GACAGGGTGA AGGTGATTTT CCACCCGGAG 
TTCCTCTCCT CCACAAGCCC CCTGCTCCCT GTGGACTATG AGGAGTTTGT CCGTGGCTGT 
CACCTTGGAG TCTTCCCCTC CTACTATGAG CCTTGGGGCT ACACACCGGC TGAGTGCACG 
GTTATGGGAA TCCCCAGTAT CTCCACCAAT CTCTCCGGCT TCGGCTGCTT CATGGAGGAA 
CACATCGCAG ACCCCTCAGC TTACGGTATC TACATTCTTG ACCGGCGGTT CCGCAGCCTG 
GATGATTCCT GCTCGCAGCT CACCTCCTTC CTCTACAGTT TCTGTCAGCA GAGCCGGCGG 
CAGCGTATCA TCCAGCGGAA CCGCACGGAG CGCCTCTCCG ACCTTCTGGA CTGGAAATAC 
CTAGGCCGGT ACTATATGTC TGCGCGCCAC ATGGCGCTGT CCAAGGCCTT TCCAGAGCAC 
TTCACCTACG AGCCCAACGA GGCGGATGCG GCCCAGGGGT ACCGCTACCC ACGGCCAGCC 
TCGGTGCCAC CGTCGCCCTC GCTGTCACGA CACTCCAGCC CGCACCAGAG TGAGGACGAG 
GAGGATCCCC GGAACGGGCC GCTGGAGGAA GACGGCGAGC GCTACGATGA GGACGAGGAG 
GCCGCCAAGG ACCGGCGCAA CATCCGTGCA CCAGAGTGGC CGCGCCGAGC GTCCTGCACC 
TCCTCCACCA GCGGCAGCAA GCGCAACTCT GTGGACACGG CCACCTCCAG CTCACTCAGC 
ACCCCGAGCG AGCCCCTCAG CCCCACCAGC TCCCTGGGCG AGGAGCGTAA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002094.2
CDS	198..2411
Translation	MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN

Target ORF information:

RefSeq Version	NM_002103.5
Organism	Homo sapiens(human)
Definition	Homo sapiens glycogen synthase 1 (GYS1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002103.5

ORF Insert Sequence:

ATGCCTTTAA ACCGCACTTT GTCCATGTCC TCACTGCCAG GACTGGAGGA CTGGGAGGAT 
GAATTCGACC TGGAGAACGC AGTGCTCTTC GAAGTGGCCT GGGAGGTGGC TAACAAGGTG 
GGTGGCATCT ACACGGTGCT GCAGACGAAG GCGAAGGTGA CAGGGGACGA ATGGGGCGAC 
AACTACTTCC TGGTGGGGCC GTACACGGAG CAGGGCGTGA GGACCCAGGT GGAACTGCTG 
GAGGCCCCCA CCCCGGCCCT GAAGAGGACA CTGGATTCCA TGAACAGCAA GGGCTGCAAG 
GTGTATTTCG GGCGCTGGCT GATCGAGGGA GGCCCTCTGG TGGTGCTCCT GGACGTGGGT 
GCCTCAGCTT GGGCCCTGGA GCGCTGGAAG GGAGAGCTCT GGGATACCTG CAACATCGGA 
GTGCCGTGGT ACGACCGCGA GGCCAACGAC GCTGTCCTCT TTGGCTTTCT GACCACCTGG 
TTCCTGGGTG AGTTCCTGGC ACAGAGTGAG GAGAAGCCAC ATGTGGTTGC TCACTTCCAT 
GAGTGGTTGG CAGGCGTTGG ACTCTGCCTG TGTCGTGCCC GGCGACTGCC TGTAGCAACC 
ATCTTCACCA CCCATGCCAC GCTGCTGGGG CGCTACCTGT GTGCCGGTGC CGTGGACTTC 
TACAACAACC TGGAGAACTT CAACGTGGAC AAGGAAGCAG GGGAGAGGCA GATCTACCAC 
CGATACTGCA TGGAAAGGGC GGCAGCCCAC TGCGCTCACG TCTTCACTAC TGTGTCCCAG 
ATCACCGCCA TCGAGGCACA GCACTTGCTC AAGAGGAAAC CAGATATTGT GACCCCCAAT 
GGGCTGAATG TGAAGAAGTT TTCTGCCATG CATGAGTTCC AGAACCTCCA TGCTCAGAGC 
AAGGCTCGAA TCCAGGAGTT TGTGCGGGGC CATTTTTATG GGCATCTGGA CTTCAACTTG 
GACAAGACCT TATACTTCTT TATCGCCGGC CGCTATGAGT TCTCCAACAA GGGTGCTGAC 
GTCTTCCTGG AGGCATTGGC TCGGCTCAAC TATCTGCTCA GAGTGAACGG CAGCGAGCAG 
ACAGTGGTTG CCTTCTTCAT CATGCCAGCG CGGACCAACA ATTTCAACGT GGAAACCCTC 
AAAGGCCAAG CTGTGCGCAA ACAGCTTTGG GACACGGCCA ACACGGTGAA GGAAAAGTTC 
GGGAGGAAGC TTTATGAATC CTTACTGGTT GGGAGCCTTC CCGACATGAA CAAGATGCTG 
GATAAGGAAG ACTTCACTAT GATGAAGAGA GCCATCTTTG CAACGCAGCG GCAGTCTTTC 
CCCCCTGTGT GCACCCACAA TATGCTGGAT GACTCCTCAG ACCCCATCCT GACCACCATC 
CGCCGAATCG GCCTCTTCAA TAGCAGTGCC GACAGGGTGA AGGTGATTTT CCACCCGGAG 
TTCCTCTCCT CCACAAGCCC CCTGCTCCCT GTGGACTATG AGGAGTTTGT CCGTGGCTGT 
CACCTTGGAG TCTTCCCCTC CTACTATGAG CCTTGGGGCT ACACACCGGC TGAGTGCACG 
GTTATGGGAA TCCCCAGTAT CTCCACCAAT CTCTCCGGCT TCGGCTGCTT CATGGAGGAA 
CACATCGCAG ACCCCTCAGC TTACGGTATC TACATTCTTG ACCGGCGGTT CCGCAGCCTG 
GATGATTCCT GCTCGCAGCT CACCTCCTTC CTCTACAGTT TCTGTCAGCA GAGCCGGCGG 
CAGCGTATCA TCCAGCGGAA CCGCACGGAG CGCCTCTCCG ACCTTCTGGA CTGGAAATAC 
CTAGGCCGGT ACTATATGTC TGCGCGCCAC ATGGCGCTGT CCAAGGCCTT TCCAGAGCAC 
TTCACCTACG AGCCCAACGA GGCGGATGCG GCCCAGGGGT ACCGCTACCC ACGGCCAGCC 
TCGGTGCCAC CGTCGCCCTC GCTGTCACGA CACTCCAGCC CGCACCAGAG TGAGGACGAG 
GAGGATCCCC GGAACGGGCC GCTGGAGGAA GACGGCGAGC GCTACGATGA GGACGAGGAG 
GCCGCCAAGG ACCGGCGCAA CATCCGTGCA CCAGAGTGGC CGCGCCGAGC GTCCTGCACC 
TCCTCCACCA GCGGCAGCAA GCGCAACTCT GTGGACACGG CCACCTCCAG CTCACTCAGC 
ACCCCGAGCG AGCCCCTCAG CCCCACCAGC TCCCTGGGCG AGGAGCGTAA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Acute Hypoglycemia in Healthy Humans Impairs Insulin-Stimulated Glucose Uptake and Glycogen Synthase in Skeletal Muscle: A Randomized Clinical Study.
Diabetes66(9)2483-2494(2017 09)
Voss TS,Vendelbo MH,Kampmann U,Hingst JR,Wojtaszewski JFP,Svart MV,M?ller N,Jessen N

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
Cell systems4(4)430-444.e5(2017 Apr)
Yadav L,Tamene F,G??s H,van Drogen A,Katainen R,Aebersold R,Gstaiger M,Varjosalo M

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Nature communications711491(2016 May)
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Bhanot H,Reddy MM,Nonami A,Weisberg EL,Bonal D,Kirschmeier PT,Salgia S,Podar K,Galinsky I,Chowdary TK,Neuberg D,Tonon G,Stone RM,Asara J,Griffin JD,Sattler M

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GYS1 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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